Correction to: Nature Cell Biology https://doi.org/10.1038/s41556-025-01655-4, published online 21 April 2025.

Phosphorylation regulates the transition between phases of the RNA polymerase II (RNAPII) transcription cycle. The elongation factor SPT5 is phosphorylated by the CDK9 kinase on a flexible linker and in C-terminal repeat 1 (CTR1) to regulate promoter-proximal pausing and termination. In this study, Sun and Fisher report that the C-terminal repeat 2 (CTR2) region in SPT5 is also phosphorylated by CDK9

Previous studies have developed an approach to derive midbrain dopaminergic neurons from human embryonic stem (hES) cells. Tabar et al. now use these cells in an open, phase 1 clinical trial aiming to treat Parkinson’s disease (PD). The authors primarily assessed the safety and tolerability of bilateral grafts of cryopreserved dopaminergic neuron progenitor cells into the putamen of individuals with

Treatments that aim to alleviate the symptoms of Parkinson’s disease (PD) are only effective at the early stages and eventually lead to complications. Sawamoto et al. conduct an open-label, phase 1/2 clinical trial to test induced pluripotent stem (iPS) cell-derived dopaminergic cells as a therapeutic approach for PD. The researchers bilaterally transplanted allogeneic iPS cell-derived dopaminergic

Correction to: Nature Cell Biology https://doi.org/10.1038/s41556-024-01356-4, published online 1 March 2024.

Time-restricted feeding regulates lipid metabolism and muscle endurance differently when restricted to the day versus the night. Recently, Chen et al. identified that the timing of AMPKα2 signalling in adipocytes enhances endurance in mice by modulating diurnal rhythms in skeletal muscle. Multi-omics on adipocytes from mice entrained to different time-restricted feeding modes showed circadian rhythmicity

Skeletal stem cells (SSCs) have been identified in the human fetal growth plate and in regenerating adult bones. Ambrosi et al. now dissect the functional heterogeneity of human SSCs. The researchers isolated SSCs from ten skeletal sites of the human fetus and performed multiple analyses, including single-cell and spatial transcriptomics, as well as functional assays. SSCs isolated from different bone

Integrating protocols.io into the submission process makes collaborative protocol sharing and peer review seamless for authors and referees in a step towards open science.

Autophagy has long been presumed to decline with age, underpinning its designation as a hallmark of ageing. However, emerging evidence challenges this notion, showing tissue-specific variability and, in some cases, age-related increases in autophagic activity. Understanding these dynamics is vital for targeted therapeutic strategies.

Correction to: Nature Cell Biology https://doi.org/10.1038/s41556-023-01212-x, published online 7 September 2023.

Effector CD8+ T cells are important for the host response to infection or cancer, but over time they become dysfunctional and enter a state of exhaustion. A recent study from Ma et al. suggests that T cell exhaustion is partly driven by a shift in nutrient metabolism. T cell exhaustion is accompanied by altered histone acetylation, which in turn relies on the availability of acetyl-CoA. In mammalian

Induced pluripotent stem (iPS) cells from individuals with Parkinson’s disease (PD) are a promising tool for autologous cell replacement therapy. A preclinical study reports on the safety and efficacy of clinical-grade iPS cell-derived midbrain dopaminergic cells (mDACs). The authors previously generated iPS cell-derived mDACs from a patient with PD (PD01), and transplanted the mDACs at day 28 of differentiation

Correction to: Nature Cell Biology https://doi.org/10.1038/s41556-025-01616-x, published online 21 February 2025.