People with disabilities are under-represented in general (non-disability-specific) precision medicine research (PMR), limiting access to its benefits. We examine key reasons for this, focusing on the role of (dis)trust, and identify areas for further inquiry to guide researchers and enhance PMR’s trustworthiness for people with disabilities.

Huntington’s disease belongs to a class of repeat expansion disorders whose pathology is marked by the expression of toxic polyglutamine-containing proteins that assemble into insoluble protein aggregates. To study factors that influence the solubility of native polyglutamine-containing proteins, Saad et al. focused on FOXP2, a transcription factor harboring a stretch of 40 consecutive glutamines.

The mechanisms underlying the extreme folding and contraction of genomic DNA into mitotic chromosomes remain incompletely understood. To address this, Jan Ellenberg and colleagues applied a DNA-tracing approach previously established for interphase cells that is based on fitting of sequentially resolved DNA fluorescence in situ hybridization (FISH) signals, using a FISH probe library they designed

In eukaryotes, transcription factors (TFs) are known to regulate transcription by binding to the enhancers and promoters of target genes. Despite extensive research on this topic, numerous questions about TF specificity, cooperativity and function remain unanswered. To address some of these in a systematic way, Mahendrawada et al. used yeast as a model organism, owing to its relatively small number

Living ape species are close evolutionary relatives of humans and their genomes are essential for human genomic and evolutionary studies. Yoo et al. generated complete genome assemblies of six ape species: chimpanzee (Pan troglodytes), bonobo (Pan paniscus), gorilla (Gorilla gorilla), Bornean orangutan (Pongo pygmaeus), Sumatran orangutan (Pongo abelii) and siamang (Symphalangus syndactylus). For diploid

Correction to: Nature Genetics https://doi.org/10.1038/s41588-025-02153-x, published online 8 April 2025.

Solanum is a diverse genus that includes crops such as tomato (Solanum lycopersicum), potato (Solanum tuberosum), eggplant (Solanum melongena) and African eggplant (Solanum aethiopicum), a crop that is indigenous to sub-Saharan Africa. Benoit et al. constructed a pan-genome of the Solanum genus from chromosome-scale genome assemblies for 22 species, capturing the rich phenotypic and genomic diversity

Polycystic ovary syndrome (PCOS) is linked to endometrial issues and associated with comorbidities such as insulin resistance, type 2 diabetes and obesity. Current treatments, including lifestyle changes and metformin administration, mainly manage symptoms rather than tackling the underlying causes, and their cell-type-specific effects are poorly understood. To gain mechanistic insight, Eriksson et

Variation in coronary artery anatomy occurs among healthy individuals with respect to positioning of the posterior descending artery, which can arise from the right coronary artery (right dominant), left circumflex artery (left dominant), or both (co-dominant). To identify genetic variants contributing to this anatomical variation, Rios Coronado et al. performed genome-wide association analyses on

It is well established that somatic mutations are pervasive in normal tissues. What is less clear is how these mutations set the stage for diseases such as cancer. Coorens et al. addressed this question in the stomach. The team analyzed whole-genome data from 238 gastric glands from 30 participants, of which 18 had gastric cancer. In addition, they generated targeted sequencing data from 829 microdissections