Stress disrupts homeostasis, and although various processes in the brain quickly restore equilibrium following acute stress, this is not the case during chronic stress, which can lead to depression. A paper published in Nature identifies autophagy as an important player in this phenomenon. The authors found that chronic stress in male mice downregulated autophagy in neurons in the lateral habenula

Functional neuroimaging enables measurement of brain organization and dynamics, but it only indirectly measures the subcellular bioenergetic processes that power brain activity. As such, there has been a gap between these large-scale imaging techniques and the microscopic scale of mitochondrial bioenergetics. In their study published in Nature, Mosharov and colleagues present a method to bridge this

Approaches to assigning neurons to specific subtypes in the mouse brain are commonly based on electrophysiological, morphological and transcriptomic properties. Connectomic analyses for subtype classification have typically been restricted to electron microscopy datasets, but the authors of a study in Nature Methods instead leverage high-throughput single-neuron reconstruction datasets to classify

Correction to: Nature Neuroscience https://doi.org/10.1038/s41593-025-01942-1, published online 21 April 2025.

Eleanor Maguire was a visionary cognitive neuroscientist whose research transformed our understanding of how the brain supports memory, navigation, and imagination.

Deep learning-based analyses of neural data can extract latent representations but often lack interpretability because of their ‘black-box’ nature. Tolooshams, Matias et al. have developed a deep learning-based deconvolutional analysis framework for learning local low-rank structures that combines algorithm unrolling with convolutional sparse coding as a generative model. The approach reconstructs

Artificial intelligence (AI)-driven models can predict the risk of mental health disorders. In a five-year longitudinal study published in Nature Medicine, Hill et al. leveraged psychosocial questionnaires and magnetic resonance imaging (MRI) data from more than 11,000 children in the Adolescent Brain and Cognitive Development (ABCD) Study. The authors trained neural networks to classify general psychopathology

Aging and neurodegenerative disease often involve blood–brain barrier (BBB) dysfunction, which leads to leakiness of the brain vasculature. The glycocalyx layer is a meshwork of proteoglycans, glycoproteins and glycolipids that coats brain endothelial cells along the BBB lumen and thus is the surface that forms the interface between the BBB and the blood. In a recent paper in Nature, Shi et al. described

Correction to: Nature Neuroscience https://doi.org/10.1038/s41593-024-01728-x, published online 5 August 2024.

Correction to: Nature Neuroscience https://doi.org/10.1038/s41593-025-01896-4, published online 11 March 2025.