This work demonstrates the rapid optimization and scale-up of biocatalytic cascades in early development programs, achieving efficient results without the need for lengthy upfront evolution campaigns which are expensive and often do not meet project delivery timelines, which range from 6 to 12 months. By utilizing readily available enzymes, we were able to streamline the process from initial screening

A unique methodology has been developed to identify and quantify gas evolution associated with a chemical reaction, where multiple gas components are generated. This methodology employs the use of multiple process analytical technologies: reaction calorimetry, online mass spectrometry, and gas evolution measurement via a thermal mass flow meter. The technique is supported by an in-house Excel macro

Photoredox catalysis plays an important role in the synthesis of pharmaceutically relevant compounds such as C(sp3)-rich tertiary amines. The difficulty of identifying underlying mechanistic models for such novel transformations, coupled with the large reaction space of this reaction class, means that developing a robust process is challenging. In this work, we demonstrate the machine learning-driven

This article has not yet been cited by other publications.

This article has not yet been cited by other publications.

This article has not yet been cited by other publications.

The following affiliations should be designated in the exact order shown below for Gaolei Zuo. This change is reflected in the authorship of this Correction. 1. Jiangsu Key Laboratory of Neuropsychiatric Diseases and Department of Medicinal Chemistry, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, China 2. Jiangsu Province Engineering Research Center of Precision Diagnostics

Published as part of Organic Process Research & Development special issue “Excellence in Industrial Organic Synthesis 2024”. In the chemical industry, alongside the discovery of new substances and their properties, the development and optimization of chemical reactions and processes play a decisive role, not least for economic reasons. (1,2) This is nothing new. The interplay between research and development