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How to approach a patient hospitalized for pneumonia who is not responding to treatment? Intensive Care Med. (IF 27.1) Pub Date : 2025-05-24
Pedro Povoa, Luís Coelho, Jordi Carratala, Kelly Cawcutt, Sara E. Cosgrove, Ricard Ferrer, Carlos A. Gomez, Michael Klompas, Thiago Lisboa, Ignacio Martin-Loeches, Saad Nseir, Jorge I. F. Salluh, Sias Scherger, Daniel A. Sweeney, Andre C. Kalil -
A critical assessment of corticosteroid trials for hospitalised patients with SARS-CoV-2 disease Intensive Care Med. (IF 27.1) Pub Date : 2025-05-23
Jean Carlet, Didier Payen, Mervyn Singer -
Beyond the dose: rethinking ketamine neurotoxicity in critical illness Intensive Care Med. (IF 27.1) Pub Date : 2025-05-21
Rongqiang Liao, Xiaoyuan Zheng -
Practical and theoretical perspectives on early decompressive craniectomy for traumatic brain injury Intensive Care Med. (IF 27.1) Pub Date : 2025-05-21
Tomoya Okazaki -
Understanding and mitigating medication errors associated with patient harm in adult intensive care units: a scoping review Intensive Care Med. (IF 27.1) Pub Date : 2025-05-20
Kathryn Puxty, Margo van Mol, María Cruz Martin Delgado, Michael Darmon, Ricardo Ferrer, Alessandro Galazzi, Entela Kondi, Lene Russell, Elena Sancho, Marlies Ostermann, Elie Azoulay, Richard S. Bourne -
Nutrition and metabolic control for ICU patients Intensive Care Med. (IF 27.1) Pub Date : 2025-05-19
Jan Gunst, Moritoki Egi, Greet Van den Berghe -
Prone positioning during VV ECMO: stay on the back or not? Intensive Care Med. (IF 27.1) Pub Date : 2025-05-19
Asger Granfeldt, Ghislaine Douflé -
Acute kidney injury: when and how to start renal replacement therapy Intensive Care Med. (IF 27.1) Pub Date : 2025-05-19
Saber Davide Barbar, Ron Wald, Jean-Pierre Quenot -
Correspondence on “Using toxidromes in the ICU”. Authors’ reply Intensive Care Med. (IF 27.1) Pub Date : 2025-05-19
Dominique Vodovar, Sophie Gosselin, Sage W. Wiener -
TRAIN study and transfusion strategies in brain injured patients Intensive Care Med. (IF 27.1) Pub Date : 2025-05-19
Fabio Silvio Taccone, Jean-Louis Vincent -
Comparing intravascular and surface cooling methods: a critical look at outcomes for out-of-hospital cardiac arrest patients Intensive Care Med. (IF 27.1) Pub Date : 2025-05-19
Yunda Fang, Huichuan Tian, Guanlu Li, Li Zeng, Yan Zhang -
Reevaluating definitions and modifiable factors in persistent severe acute kidney injury Intensive Care Med. (IF 27.1) Pub Date : 2025-05-19
Yingjian Ye, Xin Zhou, Yanli Niu, Peng An -
Antibiotics for suspected sepsis: who and when? Intensive Care Med. (IF 27.1) Pub Date : 2025-05-19
Michael Klompas, Luís Velez Lapão, Stephanie Parks TaylorThe question of when to start antibiotics in patients with possible but unconfirmed sepsis continues to vex clinicians, regulators, and quality improvement advocates. On the one hand, antibiotics are the single most effective intervention to lower mortality rates for patients with bacterial sepsis [1, 2]. On the other hand, many patients presenting with possible sepsis turn out to have non-infectious
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Reconsidering methodological choices and future research avenues in awake prone positioning studies. Author's reply Intensive Care Med. (IF 27.1) Pub Date : 2025-05-15
Mariano Esperatti, Nora Fuentes, Matias OlmosNo Abstract
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Unraveling important outcomes for elderly patients facing critical illness: a vignette-based survey Intensive Care Med. (IF 27.1) Pub Date : 2025-05-15
Ryohei Yamamoto, Hajime Yamazaki, Hiroaki Nakagawa, Akihiro Ozaka, Kazuharu Harada -
Persistent signs of poisoning after massive drug ingestion: move the ultrasound probe to the stomach Intensive Care Med. (IF 27.1) Pub Date : 2025-05-15
N. Lautrou-cabasson, H. Pirollet, C. Lombois, Guillaume Dumas -
Efficacy of targeting high mean arterial pressure for older patients with septic shock (OPTPRESS): a multicentre, pragmatic, open-label, randomised controlled trial Intensive Care Med. (IF 27.1) Pub Date : 2025-05-13
Akira Endo, Kazuma Yamakawa, Takashi Tagami, Yutaka Umemura, Takeshi Wada, Ryo Yamamoto, Hiroki Nagasawa, Wataru Takayama, Masayuki Yagi, Kyosuke Takahashi, Mitsuaki Kojima, Chihiro Narita, Satoshi Kazuma, Jiro Takahashi, Atsushi Shiraishi, Masaki Todani, Masaki Nakane, Toshihiko Nagata, Shohei Tanaka, Yuta Yokokawa, Kunihiko Takahashi, Haruka Ishikita, Ryo Hisamune, Junichi Sasaki, Ken-ichi Muramatsu -
The brain: an overloaded but overlooked organ Intensive Care Med. (IF 27.1) Pub Date : 2025-05-13
Juliana Caldas, Fernanda Alves, Sergio Brasil, Carla Rynkowisk -
Providing support to children during the loss of an important adult in the ICU Intensive Care Med. (IF 27.1) Pub Date : 2025-05-13
Ruth Kleinpell, Bénédicte Gaillard-Le Roux, Jozef KeseciogluManaging critically ill patients in the intensive care unit (ICU) setting is challenging for critical care clinicians, who often have to balance the demands of treating acutely ill patients, while also providing support to family members. Family-centered care practice and bereavement needs of the family are closely related as a supportive, inclusive, and communicative approach in the ICU can significantly
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ESICM—ESPNIC international expert consensus on quantitative lung ultrasound in intensive care Intensive Care Med. (IF 27.1) Pub Date : 2025-05-12
Silvia Mongodi, Andrea Cortegiani, Almudena Alonso-Ojembarrena, Daniele Guerino Biasucci, Lieuwe D. J. Bos, Belaid Bouhemad, Massimo Cantinotti, Ioana Ciuca, Francesco Corradi, Martin Girard, Rebeca Gregorio-Hernandez, Maria Rosaria Gualano, Francesco Mojoli, George Ntoumenopoulos, Luigi Pisani, Francesco Raimondi, Javier Rodriguez-Fanjul, Marilena Savoia, Marry R. Smit, Pieter R. Tuinman, Laurent -
Hemoadsorption in septic shock – CON Intensive Care Med. (IF 27.1) Pub Date : 2025-05-06
Girardis Massimo, Tosi Martina, David Sascha -
Correction: The Doppler combined assessment of splanchnic perfusion and congestion in cardiogenic shock: a physiological approach Intensive Care Med. (IF 27.1) Pub Date : 2025-05-06
Francesco Corradi, Guido Tavazzi -
Reevaluating the safety of shortened antibiotic treatment: a critical evaluation of the EUROBACT-2 study. Authors’ reply Intensive Care Med. (IF 27.1) Pub Date : 2025-05-05
Lena Gajdos, Niccolo Buetti, Alexis Tabah, Jean-François TimsitNo Abstract
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Atrial fibrillation in critical illness: state of the art Intensive Care Med. (IF 27.1) Pub Date : 2025-05-05
Stephanie Sibley, Jonathan Bedford, Mik Wetterslev, Brian Johnston, Tessa Garside, Salmaan Kanji, Tony Whitehouse, Ingeborg Welters, Marlies Ostermann, Martin Balik, Daniel Lancini, Blossom Dharmaraj, Emelia J. Benjamin, Allan J. Walkey, Brian H. Cuthbertson -
Renal tubular epithelial cells as an easily accessible biomarker for diagnosing AKI post cardiac surgery Intensive Care Med. (IF 27.1) Pub Date : 2025-05-05
Matthijs Oyaert, Joris Delanghe, Annelies Brouwers, Thierry Bové, Hannah Schaubroeck, Charlotte Delrue, Wim Vandenberghe, Marijn Speeckaert, Eric Hoste -
Maintaining ventilation with very low tidal volume and positive-end expiratory pressure versus no ventilation during cardiopulmonary bypass for cardiac surgery in adults: a randomized clinical trial Intensive Care Med. (IF 27.1) Pub Date : 2025-05-05
Jean-Marc Tadié, Alexandre Ouattara, Bruno Laviolle, Mathieu Lesouhaitier, Maxime Esvan, Chloé Rousseau, Murielle Grégoire, Baptiste Gaudriot, Nicolas Nesseler, François Labaste, Pascale Sanchez, Bertrand Marcheix, Antoine Beurton, Pauline Dureau, Pierre Demondion, Olivier Fouquet, Emmanuel Rineau, Julien Amour, Jean-philippe Verhoye, Alain Mercat, Nicolas Terzi, Karin Tarte, Adrien Bouglé, Erwan Flecher -
Corticosteroids for adult patients hospitalised with non-viral community-acquired pneumonia: a systematic review and meta-analysis Intensive Care Med. (IF 27.1) Pub Date : 2025-05-05
Tyler Pitre, Ellen Pauley, Dipayan Chaudhuri, Rohit Saha, Kristina E. Rudd, Jesús Villar, Lindsay R. Berry, Elizabeth Lorenzi, Thomas Hills, Alistair Nichol, David A. Harrison, Simon Finfer, Jeremy Cohen, John Myburgh, Naomi Hammond, Domingo Martínez, Cristina Fernández, David Antcliffe, Anthony Gordon, André Scherag, Holger Bogatsch, Frank M. Brunkhorst, Balasubramanian Venkatesh, Djillali Annane -
Association of low-dose ketamine with hallucinations in critically ill patients: a target trial emulation Intensive Care Med. (IF 27.1) Pub Date : 2025-05-05
Ary Serpa Neto, Marcus Young, Jian Wen Chan, Natasha E. Holmes, Kartik Kishore, Dinesh Pandey, Hossein Jahanabadi, Andrew Casamento, Rinaldo Bellomo -
Monitoring left ventricular function with MAPSE and critical care echocardiography Intensive Care Med. (IF 27.1) Pub Date : 2025-05-05
Jinyang Yu, Svend Aakhus, Michelle S. Chew -
Stop asking if AI will replace ICU doctors! Start asking how it will radically transform their practice Intensive Care Med. (IF 27.1) Pub Date : 2025-05-05
Cyril Goulenok, Nancy Kentish-Barnes, Wulfran Bougouin -
Left atrial reservoir strain: an essential tool for evaluating left ventricular diastolic dysfunction in 2025—response. Authors’ reply Intensive Care Med. (IF 27.1) Pub Date : 2025-05-05
Philippe Vignon, Julien Vaidie, Marine Goudelin, Bruno Evrard -
Carbon dioxide pathophysiology and targets following acute brain injury Intensive Care Med. (IF 27.1) Pub Date : 2025-05-05
Shaurya Taran, Mypinder Sekhon, Chiara Robba -
A mechanism-based prognostic enrichment strategy for the development of the TREM-1 inhibitor nangibotide in septic shock Intensive Care Med. (IF 27.1) Pub Date : 2025-05-05
Bruno François, Mitchell Levy, Ricard Ferrer, Pierre-François Laterre, Derek C. Angus -
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Correspondence about the VENTIBRAIN study. Authors’ reply Intensive Care Med. (IF 27.1) Pub Date : 2025-05-05
Giuseppe Citerio, Daniele Giardiello, Paola Rebora, Fabio S. Taccone, Chiara RobbaNo Abstract
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Left atrial reservoir strain: an essential tool for evaluating left ventricular diastolic dysfunction in 2025 Intensive Care Med. (IF 27.1) Pub Date : 2025-05-05
Christophe Beyls, Osama Abou-Arab, Yazine MahjoubNo Abstract
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Delirium in ICU and Macbeth’s dagger: author’s reply Intensive Care Med. (IF 27.1) Pub Date : 2025-05-05
Marcus Young, Katarzyna Kotfis, Rinaldo BellomoWe read Dr Gusmao-Flores and colleagues’ correspondence with great pleasure [1] and are delighted that our article on AI and delirium [2], triggered such literary analogies. We think that, in this complex field involving theory of mind, Shakespearean insights have much to teach us as they describe Macbeth’s fluctuating delirious state. Indeed, we have recently focused on the role of hallucinations
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Low versus high positive end expiratory pressure in noninvasive ventilation for hypoxemic respiratory failure: a multicenter randomized controlled trial Intensive Care Med. (IF 27.1) Pub Date : 2025-04-30
Jun Duan, Xiaoyi Liu, Weiwei Shu, Shijing Tian, Mingjin Yang, Mengyi Ma, Anchao Song, Qin Liu, Ke Wang, Fuxun Yang, Tao Huang, Lei Jiang, Yueling Hong, Xiaoli Han, Zhi Ao, Linfu Bai, Yiwei Min, Wenhui Hu, Jiao He -
Correspondence about the VENTIBRAIN study Intensive Care Med. (IF 27.1) Pub Date : 2025-04-30
Russell Chabanne, Claire Dahyot-Fizelier, Matthieu JabaudonNo Abstract
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Prone positioning during veno-venous extracorporeal membrane oxygenation: a systematic review and meta-analysis Intensive Care Med. (IF 27.1) Pub Date : 2025-04-29
Tommaso Pettenuzzo, Eleonora Balzani, Nicolò Sella, Marco Giani, Mara Bassi, Valentina Fincati, Rossella Cescon, Giorgia Pacchiarini, Giovanna Pandolfo, Roberta Ceccato, Lars Grønlykke, Dawid L. Staudacher, Nicolas Nesseler, Senta Jorinde Raasveld, Michele Carron, Elisa Pistollato, Giulia Mormando, Francesco Zarantonello, Alessandro De Cassai, Annalisa Boscolo, Emanuele Rezoagli, Giuseppe Foti, Paolo -
Decision analysis model of rapid versus deferred antibiotic initiation in patients with suspected sepsis in the emergency department Intensive Care Med. (IF 27.1) Pub Date : 2025-04-29
Terra M. Hill, Lauren T. Kerivan, Katherine A. Vilain, Sam Windham, Nima Sarani, Steven Q. Simpson, Christopher A. Guidry -
Optimizing non-intubated respiratory support in COVID-19: evaluating the impact of bundle of care strategy on awake prone positioning tolerance. Author’s reply Intensive Care Med. (IF 27.1) Pub Date : 2025-04-29
Mariano Esperatti, Nora Fuentes, Matias OlmosNo Abstract
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Persistent severe AKI is bad—where to go now? Intensive Care Med. (IF 27.1) Pub Date : 2025-04-29
Zoltan Endre, Paola Rebora, Marlies Ostermann -
Reevaluating the safety of shortened antibiotic treatment: a critical evaluation of the EUROBACT-2 study Intensive Care Med. (IF 27.1) Pub Date : 2025-04-29
Michal Pruc, Maciej Maslyk, Andrzej Krupa, Lukasz SzarpakNo Abstract
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Personalized strategies for high-risk acute pulmonary embolism: addressing the “catastrophic” subgroup. Author’s reply Intensive Care Med. (IF 27.1) Pub Date : 2025-04-24
Sabine Hoffmann, Michael Schomaker, Leonhard Binzenhöfer, Holger Thiele, Enzo LüsebrinkWe appreciate the opportunity to engage in discussion with Petit et al. regarding our study on management strategies for high-risk acute pulmonary embolism (PE) [1, 2]. We fully agree that causal inference in observational studies is challenging, both in general and in our study, in particular because of the presence of treatment switches and combined treatment strategies and given the baseline heterogeneity
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Reconsidering methodological choices and future research avenues in awake prone positioning studies Intensive Care Med. (IF 27.1) Pub Date : 2025-04-24
Danyang Liu -
Intravascular vs. surface cooling in out-of-hospital cardiac arrest patients receiving hypothermia after hospital arrival: a post hoc analysis of the TTM2 trial Intensive Care Med. (IF 27.1) Pub Date : 2025-04-28
Akil Awad, Martin Jonsson, Johan Holgersson, Janus Christian Jakobsen, Jacob Hollenberg, Matthew Thomas, Pedro D. Wendel Garcia, Mattias Ringh, Anders M. Grejs, Thomas R. Keeble, Jan Bělohlávek, Alain Cariou, Filippo Annoni, Gisela Lilja, Fabio Silvio Taccone, Christian Rylander, Niklas Nielsen, Josef Dankiewicz, Per Nordberg -
From surface to core: does better cooling make a difference after cardiac arrest? Intensive Care Med. (IF 27.1) Pub Date : 2025-04-28
Claudio Sandroni, Louis Delamarre, Jerry P. Nolan -
Planetary intelligence in the ICU Intensive Care Med. (IF 27.1) Pub Date : 2025-04-22
Enrique Castro-Sánchez, Timothy M. RawsonNo Abstract
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The endpoint of fluid responsiveness: is cardiac output enough? Intensive Care Med. (IF 27.1) Pub Date : 2025-04-22
Jingyuan Xu, Ling Liu, Haibo Qiu -
Outcomes in immunocompromised patients with acute hypoxemic respiratory failure treated by high-flow nasal oxygen Intensive Care Med. (IF 27.1) Pub Date : 2025-04-22
Elie Azoulay, Mélanie Métais, Virginie Lemiale, Djamel Mokart, Anne-Sophie Moreau, Emmanuel Canet, Achille Kouatchet, Laurent Argaud, Peter Pickkers, Philippe R. Bauer, Andry van de Louw, Ignacio Martin-Loeches, Sangeeta Mehta, Christophe Girault, Florent Wallet, Frédéric Pène, Alexandre Demoule, Alexis Maillard -
Visualizing the burden of brain tissue hypoxia and metabolic dysfunction assessed by multimodal neuromonitoring in subarachnoid hemorrhage patients: the TITAN study Intensive Care Med. (IF 27.1) Pub Date : 2025-04-22
Elisa Gouvêa Bogossian, Bavo Kempen, Michael Veldeman, Soojin Park, Verena Rass, Stephane Marinesco, Miriam Weiss, Gerrit Alexander Schubert, Nick Kastenholz, Jan Claassen, Philipp Kindl, Anna Berek, Marco Anderloni, Catharina Conzen-Dilger, Sophie Schuind, Baptiste Balança, Yannick Tholance, E. Sander Connolly, Geert Meyfroidt, Raimund Helbok, Giorgia Carra, Fabio Silvio Taccone -
Effect of hydrocortisone on mortality in patients with severe community-acquired pneumonia Intensive Care Med. (IF 27.1) Pub Date : 2025-04-22
Derek C. Angus -
Identification and validation of robust hospital-acquired pneumonia subphenotypes associated with all-cause mortality: a multi-cohort derivation and validation Intensive Care Med. (IF 27.1) Pub Date : 2025-04-22
Florian Pierre Martin, Cécile Poulain, Jelle Haitsma Mulier, Ana Motos, Victor Gourain, Ismaël Ogan, Emmanuel Montassier, Yoann Launey, Sigismond Lasocki, Raphaël Cinotti, Claire Dahyot Fizelier, Otavio Ranzani, Luis Felipe Reyes, Ignacio Martin-Loeches, Lennie Derde, Antoni Torres, Olaf Cremer, Antoine Roquilly -
“Fake” or real hypoxia?: A brainy dilemma Intensive Care Med. (IF 27.1) Pub Date : 2025-04-22
Mathieu van der Jagt, Chiara Robba, Mypinder Sekhon -
Bidirectional ventricular tachycardia, a very rare and severe complication of digoxin poisoning Intensive Care Med. (IF 27.1) Pub Date : 2025-04-22
Pablo Nicolás-Morales, Pau Torrella, Xavier Peris Cuello -
Black holes and revelations Intensive Care Med. (IF 27.1) Pub Date : 2025-04-17
Laurent PapazianA few years ago, I Googled my name to find a picture for my resume and was surprised to discover that the two main topics associated with it were ‘accident’ and ’burns’—not ‘NMBA,’ ‘Cytomegalovirus,’ or ‘Société de Réanimation de Langue Française.’ After an initial period of shock and hesitation, I chose to share my life journey through a television show broadcast in Corsica and now with my professional
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Selection bias in the “TRAIN” randomized clinical trial: implications for meta-analyses—Author's reply Intensive Care Med. (IF 27.1) Pub Date : 2025-04-17
Pierre-Louis Blot, Maxime Renaux, Timothée Ayasse, Jean-Michel Constantin, Rayan Braïk -
Selection bias in the “TRAIN” randomized clinical trial: implications for meta-analyses Intensive Care Med. (IF 27.1) Pub Date : 2025-04-16
Ravi Garg -
Should we move beyond the concept of fluid responsiveness? Authors’ reply Intensive Care Med. (IF 27.1) Pub Date : 2025-04-16
Xavier Monnet, Daniel De Backer, Michael R. Pinsky