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The Nebraska Nomogram for Autograft Planning (NNAP) a surgical planning tool for ipsilateral rotational autokeratoplasty npj Digit. Med. (IF 12.4) Pub Date : 2025-06-04
Collin Asheim, Ashok Puri, Helen Song, Brian Armstrong, Sam Navon, Ronald Krueger -
A scoping review of routinely collected linked data in research on gambling harm npj Digit. Med. (IF 12.4) Pub Date : 2025-06-04
Pippa Boering, Matthew Jones, Kishan Patel, Daniel Leightley, Simon Dymond -
Reason and responsibility as a path toward ethical AI for (global) public health npj Digit. Med. (IF 12.4) Pub Date : 2025-06-03
Esther-Maria Antao, Aadil Rasheed, Anatol-Fiete Näher, Lothar H. WielerAI can enhance public health practice, but it requires careful consideration of ethical implications. We propose a reason-based framework to guide AI co-design and use for public health. AI systems must be developed with public health expertise, lived experience insights, and human accountability to ensure responsible outcomes. We advocate for ethical principles to be embedded throughout the AI lifecycle
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Randomized comparison of AI enhanced 3D printing and traditional simulations in hepatobiliary surgery npj Digit. Med. (IF 12.4) Pub Date : 2025-06-02
Linqian Li, Shujie Cheng, Jinghua Li, Jihong Yang, Hongguang Wang, Bin Dong, Xiaoping Yin, Hongyun Shi, Shuo Gao, Feng Gu, Zhe Han, Zhi Chen, Jisen Zhao, Quan Zhang, Jie-Zhi Cheng, Yuan Wang, Fengwei Tan, Ke Zhang -
A general framework for governing marketed AI/ML medical devices npj Digit. Med. (IF 12.4) Pub Date : 2025-05-31
Boris Babic, I. Glenn Cohen, Ariel Dora Stern, Yiwen Li, Melissa Ouellet -
Psychological, economic, and ethical factors in human feedback for a chatbot-based smoking cessation intervention npj Digit. Med. (IF 12.4) Pub Date : 2025-05-31
Nele Albers, Francisco S. Melo, Mark A. Neerincx, Olya Kudina, Willem-Paul Brinkman -
From trial data to personalized medicine: a validated framework with an application to Crohn’s disease npj Digit. Med. (IF 12.4) Pub Date : 2025-05-31
Vivek A. Rudrapatna, Vignesh G. Ravindranath, Douglas V. Arneson, Arman Mosenia, Atul J. Butte, Shan Wang -
Impact of pharmacist led mobile application on medication adherence and efficacy in chronic kidney disease npj Digit. Med. (IF 12.4) Pub Date : 2025-05-30
Shaza Gamal, Ahmad Mohamad Abbas Elseasi, Nirmeen Ahmed Sabry, Samar Farghali Farid -
Comparative analysis of natural language processing methodologies for classifying computed tomography enterography reports in Crohn’s disease patients npj Digit. Med. (IF 12.4) Pub Date : 2025-05-30
Jiayi Dai, Mi-Young Kim, Reed T. Sutton, J. Ross Mitchell, Randolph Goebel, Daniel C. Baumgart -
Determinants of artificial intelligence electrocardiogram-derived age and its association with cardiovascular events and mortality: a systematic review and meta-analysis npj Digit. Med. (IF 12.4) Pub Date : 2025-05-29
Shervin Mossavarali, Ali Vaezi, Zahra Gholami, Alireza Molaei, Mir Saeed Yekaninejad, Folkert W. Asselbergs, Akbar Shafiee -
Smartphone screen time and suicide risk in daily life captured through high-resolution screenshot data npj Digit. Med. (IF 12.4) Pub Date : 2025-05-29
Ross Jacobucci, Miguel Blacutt, Nilàm Ram, Brooke A. Ammerman -
A scoping review of artificial intelligence as a medical device for ophthalmic image analysis in Europe, Australia and America npj Digit. Med. (IF 12.4) Pub Date : 2025-05-29
Ariel Yuhan Ong, Priyal Taribagil, Mertcan Sevgi, Aditya U. Kale, Eliot R. Dow, Trystan Macdonald, Ashley Kras, Gregory Maniatopoulos, Xiaoxuan Liu, Pearse A. Keane, Alastair K. Denniston, Henry David Jeffry Hogg -
Artificial Intelligence model to predict resistances in Gram-negative bloodstream infections npj Digit. Med. (IF 12.4) Pub Date : 2025-05-29
Cecilia Bonazzetti, Ettore Rocchi, Alice Toschi, Nicolas Riccardo Derus, Claudia Sala, Renato Pascale, Matteo Rinaldi, Caterina Campoli, Zeno Adrien Igor Pasquini, Beatrice Tazza, Armando Amicucci, Milo Gatti, Simone Ambretti, Pierluigi Viale, Gastone Castellani, Maddalena Giannella -
Predicting abnormal fetal growth using deep learning npj Digit. Med. (IF 12.4) Pub Date : 2025-05-29
Kamil Wojciech Mikołaj, Anders Nymark Christensen, Caroline Amalie Taksøe-Vester, Aasa Feragen, Olav Bjørn Petersen, Manxi Lin, Mads Nielsen, Morten Bo Søndergaard Svendsen, Martin Grønnebæk Tolsgaard -
An equity analysis of remote patient monitoring programs unveils assumptions on digital health equity npj Digit. Med. (IF 12.4) Pub Date : 2025-05-29
Ibukun-Oluwa Omolade Abejirinde, Vanessa Kishimoto, Kaylen J. Pfisterer, Nishath Uddin, Katherine McGuire, Janette Brual, Kaitlyn Merriman, Payal Agarwal, Jeanette Smith, Myrtede Alfred, Michele Strom, Quynh Pham -
How secure are your health devices—stopping wearables becoming a personal and national security risk? npj Digit. Med. (IF 12.4) Pub Date : 2025-05-28
Max Ostermann, Oscar Freyer, Carsten Weinhold, Kai Martius, Stephen Gilbert -
Seasonal timing and interindividual differences in shiftwork adaptation npj Digit. Med. (IF 12.4) Pub Date : 2025-05-28
Ruby Kim, Yu Fang, Minki Lee, Dae Wook Kim, Zhengxu Tang, Srijan Sen, Daniel B. Forger -
Publisher Correction: Predicting progression events in multiple myeloma from routine blood work. npj Digit. Med. (IF 12.4) Pub Date : 2025-05-28
Maximilian Ferle,Nora Grieb,Markus Kreuz,Jonas Ader,Hartmut Goldschmidt,Elias K Mai,Uta Bertsch,Uwe Platzbecker,Thomas Neumuth,Kristin Reiche,Alexander Oeser,Maximilian Merz -
A distributional reinforcement learning model for optimal glucose control after cardiac surgery npj Digit. Med. (IF 12.4) Pub Date : 2025-05-27
Jacob M. Desman, Zhang-Wei Hong, Moein Sabounchi, Ashwin S. Sawant, Jaskirat Gill, Ana C. Costa, Gagan Kumar, Rajeev Sharma, Arpeta Gupta, Paul McCarthy, Veena Nandwani, Doug Powell, Alexandra Carideo, Donnie Goodwin, Sanam Ahmed, Umesh Gidwani, Matthew A. Levin, Robin Varghese, Farzan Filsoufi, Robert Freeman, Avniel Shetreat-Klein, Alexander W. Charney, Ira Hofer, Lili Chan, David Reich, Patricia -
Multicentre evaluation of deep learning CT autosegmentation of the head and neck region for radiotherapy npj Digit. Med. (IF 12.4) Pub Date : 2025-05-27
Eric Pei Ping Pang, Hong Qi Tan, Fuqiang Wang, Jarkko Niemelä, Gregory Bolard, Susan Ramadan, Timo Kiljunen, Marta Capala, Steven Petit, Jan Seppälä, Kristiina Vuolukka, Ingrid Kiitam, Danil Zolotuhhin, Eduard Gershkevitsh, Kaisa Lehtiö, Juha Nikkinen, Jani Keyriläinen, Miia Mokka, Melvin Lee Kiang Chua -
Advancing breast, lung and prostate cancer research with federated learning. A systematic review npj Digit. Med. (IF 12.4) Pub Date : 2025-05-27
Anshu Ankolekar, Sebastian Boie, Maryam Abdollahyan, Emanuela Gadaleta, Seyed Alireza Hasheminasab, Guang Yang, Charles Beauville, Nikolaos Dikaios, George Anthony Kastis, Michael Bussmann, Claude Chelala, Sara Khalid, Hagen Kruger, Philippe Lambin, Giorgos Papanastasiou -
Situating governance and regulatory concerns for generative artificial intelligence and large language models in medical education npj Digit. Med. (IF 12.4) Pub Date : 2025-05-27
Michael Tran, Chinthaka Balasooriya, Jitendra Jonnagaddala, Gilberto Ka-Kit Leung, Neeraj Mahboobani, Subha Ramani, Joel Rhee, Lambert Schuwirth, Neysan Sedaghat Najafzadeh-Tabrizi, Carolyn Semmler, Zoie SY Wong -
Fostering inclusive co-creation in digital health npj Digit. Med. (IF 12.4) Pub Date : 2025-05-26
Alessandro Blasimme, Constantin Landers, Effy VayenaResearch on responsible digital health innovation has typically focused on technical aspects such as the reliability and trustworthiness. More recently, work in responsible digital health innovation has started to recognize that, to address those concerns, stakeholder involvement is key. Aligning technological advancements with stakeholders’ needs requires deliberate and inclusive processes. Such processes
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A systematic review of clinicians’ acceptance and use of clinical decision support systems over time npj Digit. Med. (IF 12.4) Pub Date : 2025-05-26
Nicki Newton, Adeola Bamgboje-Ayodele, Rowena Forsyth, Amina Tariq, Melissa T. Baysari -
Agile evaluation including two pragmatic trials on the uptake of a digital screening service npj Digit. Med. (IF 12.4) Pub Date : 2025-05-26
Taavi Tillmann, Andrew Copas, Paul Stokes, Nick Udell, Jo Stead, Jin Lim, Gene Libow -
Approved trends and product characteristics of digital therapeutics in four countries npj Digit. Med. (IF 12.4) Pub Date : 2025-05-26
Jun Liang, Qichuan Fang, Xiaoyi Jiao, Peng Xiang, Junhao Ma, Zijiao Zhang, Yongcheng Liu, Yunfan He, Yingjun Li, Zhixu He, Jianbo Lei -
Platform matters -- Differences in COVID data collected from Android and iOS app users npj Digit. Med. (IF 12.4) Pub Date : 2025-05-24
Elizabeth J. Enichen, Kimia Heydari, Ben Li, Joseph C. KvedarWinter et al.’s recent investigation, “A Comparison of Self-Reported COVID-19 Symptoms Between Android and iOS CoronaCheck App Users,” reveals differences in the demographics and COVID-19 symptoms reported by users of Android and iOS systems. These findings not only provide more information about the varied experiences of individuals during the COVID-19 pandemic but also suggest that conclusions reached
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Advancing efficacy prediction for electronic health records based emulated trials in repurposing heart failure therapies npj Digit. Med. (IF 12.4) Pub Date : 2025-05-24
Nansu Zong, Shaika Chowdhury, Shibo Zhou, Sivaraman Rajaganapathy, Yue Yu, Liewei Wang, Qiying Dai, Pengyang Li, Xiaoke Liu, Suzette J. Bielinski, Jun Chen, Yongbin Chen, James R. Cerhan -
Classification grid and evidence matrix for evaluating digital medical devices under the European union landscape npj Digit. Med. (IF 12.4) Pub Date : 2025-05-24
Magali Boers, Aude Rochereau, Louisa Stuwe, Lorena San Miguel, Jochen Klucken, Fruzsina Mezei, Jérôme Fabiano, Sandrine Boulet, Aymeric Perchant, Rosanna Tarricone, Francesco Petracca, Barbara Hoefgen, Corinne Collignon, Sarah Zohar -
Enhanced staging of renal cell carcinoma using tumor morphology features: model development and multi-source validation npj Digit. Med. (IF 12.4) Pub Date : 2025-05-24
Enyu Yuan, Yuntian Chen, Lei Ye, Ben He, ChunLei He, Junchao Ma, Ting Yang, Hao Zeng, Ling Yang, Jin Yao, Bin Song -
Advanced and interpretable corneal staining assessment through fine grained knowledge distillation npj Digit. Med. (IF 12.4) Pub Date : 2025-05-23
Yuqing Deng, Pujin Cheng, Ruiwen Xu, Lirong Ling, Hongliang Xue, Shiyou Zhou, Yansong Huang, Junyan Lyu, Zhonghua Wang, Kenneth K. Y. Wong, Yimin Zhang, Kang Yu, Tingting Zhang, Xiaoqing Hu, Xiaoyi Li, Xiaoying Tang, Yan Lou, Jin Yuan -
Iterative refinement and goal articulation to optimize large language models for clinical information extraction npj Digit. Med. (IF 12.4) Pub Date : 2025-05-23
David Hein, Alana Christie, Michael Holcomb, Bingqing Xie, AJ Jain, Joseph Vento, Neil Rakheja, Ameer Hamza Shakur, Scott Christley, Lindsay G. Cowell, James Brugarolas, Andrew R. Jamieson, Payal Kapur -
Multimodal fusion model for prognostic prediction and radiotherapy response assessment in head and neck squamous cell carcinoma npj Digit. Med. (IF 12.4) Pub Date : 2025-05-23
Ruxian Tian, Feng Hou, Haicheng Zhang, Guohua Yu, Ping Yang, Jiaxuan Li, Ting Yuan, Xi Chen, Ying Chen, Yan Hao, Yisong Yao, Hongfei Zhao, Pengyi Yu, Han Fang, Liling Song, Anning Li, Zhonglu Liu, Huaiqing Lv, Dexin Yu, Hongxia Cheng, Ning Mao, Xicheng Song -
Postoperative remote first care for financially and environmentally sustainable healthcare npj Digit. Med. (IF 12.4) Pub Date : 2025-05-21
Ross Lathan, Louise Hitchman, Josephine Walshaw, Bharadhwaj Ravindhran, Daniel Carradice, George Smith, Ian Chetter, Marina Yiasemidou -
A systematic review of developments in mHealth smartphone applications for Transgender and Gender Diverse individuals npj Digit. Med. (IF 12.4) Pub Date : 2025-05-21
Marina Bonato, Andrea Garolla, Marina Miscioscia -
A framework for considering the use of generative AI for health npj Digit. Med. (IF 12.4) Pub Date : 2025-05-21
Isabella Joy de Vere Hunt, Kang-Xing Jin, Eleni Linos -
A randomized controlled trial of a digital lifestyle intervention involving postoperative patients with colorectal cancer npj Digit. Med. (IF 12.4) Pub Date : 2025-05-20
Young Il Kim, In Ja Park, Jun-Soo Ro, Jong Lyul Lee, Chan Wook Kim, Yong Sik Yoon, Seok-Byung Lim, Chang Sik Yu, Yura Lee, Yae Won Tak, Seockhoon Chung, Kyung Won Kim, Yousun Ko, Sung-Cheol Yun, Min-Woo Jo, Jong Won Lee -
A multivariate model incorporating subharmonic measurements for evaluating vocal roughness npj Digit. Med. (IF 12.4) Pub Date : 2025-05-20
Itsuki Kitayama, Kiyohito Hosokawa, Shinobu Iwaki, Misao Yoshida, Akira Miyauchi, Kenji Aruga, Takanari Kawabe, Toshihiro Kishikawa, Hidenori Tanaka, Takeshi Tsuda, Takashi Sato, Yukinori Takenaka, Makoto Ogawa, Hidenori Inohara -
Deep Gaussian process with uncertainty estimation for microsatellite instability and immunotherapy response prediction from histology npj Digit. Med. (IF 12.4) Pub Date : 2025-05-19
Sunho Park, Morgan F. Pettigrew, Yoon Jin Cha, In-Ho Kim, Minji Kim, Imon Banerjee, Isabel Barnfather, Jean R. Clemenceau, Inyeop Jang, Hyunki Kim, Younghoon Kim, Rish K. Pai, Jeong Hwan Park, N. Jewel Samadder, Kyo Young Song, Ji-Youn Sung, Jae-Ho Cheong, Jeonghyun Kang, Sung Hak Lee, Sam C. Wang, Tae Hyun Hwang -
Engaging an advisory board in discussions about the ethical relevance of algorithmic bias and fairness npj Digit. Med. (IF 12.4) Pub Date : 2025-05-18
Laura Brandt, Larry Au, Clinton Castro, Gabriel J. Odom -
Hybrid machine learning for real-time prediction of edema trajectory in large middle cerebral artery stroke npj Digit. Med. (IF 12.4) Pub Date : 2025-05-17
Ethan Phillips, Odhran O’Donoghue, Yumeng Zhang, Panos Tsimpos, Leigh Ann Mallinger, Stefanos Chatzidakis, Jack Pohlmann, Yili Du, Ivy Kim, Jonathan Song, Benjamin Brush, Stelios Smirnakis, Charlene J. Ong, Agni Orfanoudaki -
The DRAGON benchmark for clinical NLP npj Digit. Med. (IF 12.4) Pub Date : 2025-05-17
Joeran S. Bosma, Koen Dercksen, Luc Builtjes, Romain André, Christian Roest, Stefan J. Fransen, Constant R. Noordman, Mar Navarro-Padilla, Judith Lefkes, Natália Alves, Max J. J. de Grauw, Leander van Eekelen, Joey M. A. Spronck, Megan Schuurmans, Bram de Wilde, Ward Hendrix, Witali Aswolinskiy, Anindo Saha, Jasper J. Twilt, Daan Geijs, Jeroen Veltman, Derya Yakar, Maarten de Rooij, Francesco Ciompi -
FedWeight: mitigating covariate shift of federated learning on electronic health records data through patients re-weighting npj Digit. Med. (IF 12.4) Pub Date : 2025-05-17
He Zhu, Jun Bai, Na Li, Xiaoxiao Li, Dianbo Liu, David L. Buckeridge, Yue Li -
Social determinants of health extraction from clinical notes across institutions using large language models npj Digit. Med. (IF 12.4) Pub Date : 2025-05-17
Vipina K. Keloth, Salih Selek, Qingyu Chen, Christopher Gilman, Sunyang Fu, Yifang Dang, Xinghan Chen, Xinyue Hu, Yujia Zhou, Huan He, Jungwei W. Fan, Karen Wang, Cynthia Brandt, Cui Tao, Hongfang Liu, Hua Xu -
Fair ultrasound diagnosis via adversarial protected attribute aware perturbations on latent embeddings npj Digit. Med. (IF 12.4) Pub Date : 2025-05-17
Zikang Xu, Fenghe Tang, Quan Quan, Qingsong Yao, Qingpeng Kong, Jianrui Ding, Chunping Ning, S. Kevin Zhou -
Development and prospective implementation of a large language model based system for early sepsis prediction npj Digit. Med. (IF 12.4) Pub Date : 2025-05-17
Supreeth P. Shashikumar, Sina Mohammadi, Rishivardhan Krishnamoorthy, Avi Patel, Gabriel Wardi, Joseph C. Ahn, Karandeep Singh, Eliah Aronoff-Spencer, Shamim Nemati -
Monitoring the opioid epidemic via social media discussions npj Digit. Med. (IF 12.4) Pub Date : 2025-05-15
Delaney A. Smith, Adam Lavertu, Aadesh Salecha, Tymor Hamamsy, Keith Humphreys, Anna Lembke, Mathew V. Kiang, Russ B. Altman, Johannes C. Eichstaedt -
A review on generative AI models for synthetic medical text, time series, and longitudinal data npj Digit. Med. (IF 12.4) Pub Date : 2025-05-15
Mohammad Loni, Fatemeh Poursalim, Mehdi Asadi, Arash Gharehbaghi -
EMR usability and patient safety: a national survey of physicians npj Digit. Med. (IF 12.4) Pub Date : 2025-05-15
David Schwappach, Wolf Hautz, Gert Krummrey, Yvonne Pfeiffer, Raj M. Ratwani -
Reducing outpatient visits for FIT-positive participants of colorectal cancer screening programs with home-based digital counselling npj Digit. Med. (IF 12.4) Pub Date : 2025-05-15
Fleur E. Marijnissen, Elyse E. C. Rijnders, Merel M. Tielemans, Désiree van Noord, Leonieke M. M. Wolters, Jeroen M. Jansen, Ingrid Schot, Frank C. Bekkering, Agnes N. Reijm, Sophia M. van Baalen, Tingting Wang, Marijke Melles, Richard Goossens, Sohal Y. Ismail, Iris Lansdorp–Vogelaar, Pieter Jan F. de Jonge, Manon C. W. Spaander -
Digital twins for the era of personalized surgery npj Digit. Med. (IF 12.4) Pub Date : 2025-05-15
Yosra Magdi Mekki, Gijs Luijten, Elisabet Hagert, Sirajeddin Belkhair, Chris Varghese, Junaid Qadir, Barry Solaiman, Muhammad Bilal, Jaghtar Dhanda, Jan Egger, Jun Deng, Vikas Khanduja, Alejandro F. Frangi, Susu M. Zughaier, Mitchell A. Stotland -
Lessons from Henrietta Lacks inform a transparency framework to catalyze generative artificial intelligence in medicine npj Digit. Med. (IF 12.4) Pub Date : 2025-05-14
Tej D. Azad, Anmol Warman, Deven McGraw, Suchi SariaThe integration of generative artificial intelligence (AI) tools into healthcare poses significant challenges concerning data privacy and governance. Drawing on the historical vignette of Henrietta Lacks, this perspective examines the implications of using generative AI in clinical settings. We discuss current health data governance practices and their potential limitations in the generative AI era
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Aligning AI principles and healthcare delivery organization best practices to navigate the shifting regulatory landscape npj Digit. Med. (IF 12.4) Pub Date : 2025-05-14
Alifia Hasan, Noah Prizant, Jee Young Kim, Shreya Rao, David Vidal, Keo Shaw, Danny Tobey, Alexandra Valladares, Shira Zilberstein, Manesh Patel, Suresh Balu, Mark Sendak, Mark Lifson -
Development and validation of a deep learning model for diagnosing neuropathic corneal pain via in vivo confocal microscopy npj Digit. Med. (IF 12.4) Pub Date : 2025-05-14
Neslihan Dilruba Koseoglu, Eric Chen, Rudraksh Tuwani, Benjamin Kompa, Stephanie M. Cox, M. Cuneyt Ozmen, Mina Massaro-Giordano, Andrew L. Beam, Pedram Hamrah -
A quantitative analysis of the use of anonymization in biomedical research npj Digit. Med. (IF 12.4) Pub Date : 2025-05-14
Thierry Meurers, Karen Otte, Hammam Abu Attieh, Farah Briki, Jérémie Despraz, Mehmed Halilovic, Bayrem Kaabachi, Vladimir Milicevic, Armin Müller, Grigorios Papapostolou, Felix Nikolaus Wirth, Jean Louis Raisaro, Fabian Prasser -
Patient perceptions of empathy in physician and artificial intelligence chatbot responses to patient questions about cancer npj Digit. Med. (IF 12.4) Pub Date : 2025-05-13
David Chen, Kabir Chauhan, Rod Parsa, Zhihui Amy Liu, Fei-Fei Liu, Ernie Mak, Lawson Eng, Breffni Louise Hannon, Jennifer Croke, Andrew Hope, Nazanin Fallah-Rad, Phillip Wong, Srinivas Raman -
A framework to assess clinical safety and hallucination rates of LLMs for medical text summarisation npj Digit. Med. (IF 12.4) Pub Date : 2025-05-13
Elham Asgari, Nina Montaña-Brown, Magda Dubois, Saleh Khalil, Jasmine Balloch, Joshua Au Yeung, Dominic Pimenta -
Integrating personalized shape prediction, biomechanical modeling, and wearables for bone stress prediction in runners npj Digit. Med. (IF 12.4) Pub Date : 2025-05-13
Liangliang Xiang, Yaodong Gu, Kaili Deng, Zixiang Gao, Vickie Shim, Alan Wang, Justin Fernandez -
Multimodal generative AI for interpreting 3D medical images and videos npj Digit. Med. (IF 12.4) Pub Date : 2025-05-13
Jung-Oh Lee, Hong-Yu Zhou, Tyler M. Berzin, Daniel K. Sodickson, Pranav Rajpurkar -
Scaling enterprise AI in healthcare: the role of governance in risk mitigation frameworks npj Digit. Med. (IF 12.4) Pub Date : 2025-05-13
Andreea Bodnari, John TravisThis perspective article examines the role of governance frameworks in mitigating risks and building trust in AI implementations within healthcare organizations. As AI technologies rapidly evolve, robust governance is essential to manage potential adverse incidents and ensure fair, equitable, and effective innovation. This article highlights key risks associated with AI deployments and proposes enhancements