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Atezolizumab plus paclitaxel and bevacizumab as first-line treatment of advanced triple-negative breast cancer: the ATRACTIB phase 2 trial Nat. Med. (IF 58.7) Pub Date : 2025-06-04
María Gion, Isabel Blancas, Patricia Cortez-Castedo, Alfonso Cortés-Salgado, Frederik Marmé, Salvador Blanch, Serafín Morales, Nieves Díaz, Isabel Calvo-Plaza, Sabela Recalde, Alejandro Martínez-Bueno, Manuel Ruiz-Borrego, Elisenda Llabrés, María Teresa Taberner, Michelino de Laurentiis, Silvia García-Vicente, José Antonio Guerrero, Olga Boix, Jose Rodríguez-Morató, Miguel Sampayo-Cordero, Gabriele -
Peri-operative atezolizumab in early-stage triple-negative breast cancer: final results and ctDNA analyses from the randomized phase 3 IMpassion031 trial Nat. Med. (IF 58.7) Pub Date : 2025-06-04
Elizabeth A. Mittendorf, Zoe June Assaf, Nadia Harbeck, Hong Zhang, Shigehira Saji, Kyung Hae Jung, Roberto Hegg, Andreas Koehler, Joohyuk Sohn, Hiroji Iwata, Melinda L. Telli, Cristiano Ferrario, Kevin Punie, Aditi Qamra, Max Dieterich, Yun Xu, Mario Liste-Hermoso, Esther Shearer-Kang, Luciana Molinero, Stephen Y. Chui, Carlos H. Barrios -
Individual variations in glycemic responses to carbohydrates and underlying metabolic physiology Nat. Med. (IF 58.7) Pub Date : 2025-06-04
Yue Wu, Ben Ehlert, Ahmed A. Metwally, Dalia Perelman, Heyjun Park, Andrew Wallace Brooks, Fahim Abbasi, Basil Michael, Alessandra Celli, Caroline Bejikian, Ekrem Ayhan, Yingzhou Lu, Samuel M. Lancaster, Daniel Hornburg, Lucia Ramirez, David Bogumil, Sarah Pollock, Frank Wong, Denver Bradley, Georg Gutjahr, Ekanath Srihari Rangan, Tao Wang, Lettie McGuire, P. Venkat Rangan, Helge Ræder, Zohar Shipony -
Stem cell therapies advance in Parkinson’s disease and beyond Nat. Med. (IF 58.7) Pub Date : 2025-06-04
Landmark trials using stem cells to treat Parkinson’s disease in the USA and Japan mark a turning point for cell therapy in neurodegeneration. Similar approaches to Alzheimer’s disease and amyotrophic lateral sclerosis are also showing early signs of promise.
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Pooled analysis of 3,741 stool metagenomes from 18 cohorts for cross-stage and strain-level reproducible microbial biomarkers of colorectal cancer Nat. Med. (IF 58.7) Pub Date : 2025-06-03
Gianmarco Piccinno, Kelsey N. Thompson, Paolo Manghi, Andrew R. Ghazi, Andrew Maltez Thomas, Aitor Blanco-Míguez, Francesco Asnicar, Katarina Mladenovic, Federica Pinto, Federica Armanini, Michal Punčochář, Elisa Piperni, Vitor Heidrich, Gloria Fackelmann, Giulio Ferrero, Sonia Tarallo, Long H. Nguyen, Yan Yan, Nazim A. Keles, Bilge G. Tuna, Veronika Vymetalkova, Mario Trompetto, Vaclav Liska, Tomas -
A generative AI-discovered TNIK inhibitor for idiopathic pulmonary fibrosis: a randomized phase 2a trial Nat. Med. (IF 58.7) Pub Date : 2025-06-03
Zuojun Xu, Feng Ren, Ping Wang, Jie Cao, Chunting Tan, Dedong Ma, Li Zhao, Jinghong Dai, Yipeng Ding, Haohui Fang, Huiping Li, Hong Liu, Fengming Luo, Ying Meng, Pinhua Pan, Pingchao Xiang, Zuke Xiao, Sujata Rao, Carol Satler, Sang Liu, Yuan Lv, Heng Zhao, Shan Chen, Hui Cui, Mikhail Korzinkin, David Gennert, Alex Zhavoronkov -
Anti-sporozoite monoclonal antibody for malaria prevention: secondary efficacy outcome of a phase 2 randomized trial Nat. Med. (IF 58.7) Pub Date : 2025-06-03
Jeff Skinner, Kassoum Kayentao, Aissata Ongoiba, Sara A. Healy, Zonghui Hu, Anne C. Preston, Amadou Niangaly, Philipp Schwabl, Hamidou Cisse, Safiatou Doumbo, Didier Doumtabe, Abdrahamane Traore, Shanping Li, Mary E. Peterson, Annette M. Seilie, Chris Chavtur, Weston Staubus, Ming Chang, Katrina Kelley, Hamadi Traore, Adama Djiguiba, Mamadou Keita, Adama Ouattara, M’Bouye Doucoure, Mohamed Keita, Djelika -
An international Delphi consensus for reporting of setting in psychedelic clinical trials Nat. Med. (IF 58.7) Pub Date : 2025-06-03
Chloé Pronovost-Morgan, Kyle T. Greenway, Leor Roseman -
Bridging the vaccine divide Nat. Med. (IF 58.7) Pub Date : 2025-06-02
Nicaise Ndembi, Leon Mutesa, Claude Mambo Muvunyi, Jerome H. KimThe African Union (AU) has prioritized local production of health countermeasures since its inception, with heightened focus following the COVID-19 pandemic and challenges such as cholera, Ebola, malaria, mpox, Marburg and other emerging diseases. One of its efforts was the development of the Pharmaceutical Manufacturing Plan for Africa in 20071. The plan aims to strengthen the continental capacity
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Intracerebroventricular bivalent CAR T cells targeting EGFR and IL-13Rα2 in recurrent glioblastoma: a phase 1 trial Nat. Med. (IF 58.7) Pub Date : 2025-06-01
Stephen J. Bagley, Arati S. Desai, Joseph A. Fraietta, Dana Silverbush, Daniel Chafamo, Nelson F. Freeburg, Gayathri Konanur Gopikrishna, Andrew J. Rech, Ali Nabavizadeh, Linda J. Bagley, Jungmin Park, Danuta Jarocha, Rene Martins, Nicolas Sarmiento, Eileen Maloney, Lester Lledo, Carly Stein, Amy Marshall, Rachel M. Leskowitz, Julie K. Jadlowsky, Shane Mackey, Shannon Christensen, Bike Su Oner, Gabriela -
Sasanlimab plus BCG in BCG-naive, high-risk non-muscle invasive bladder cancer: the randomized phase 3 CREST trial Nat. Med. (IF 58.7) Pub Date : 2025-05-31
Neal D. Shore, Thomas B. Powles, Jens Bedke, Matthew D. Galsky, Joan Palou Redorta, Ja Hyeon Ku, Michal Kretkowski, Evanguelos Xylinas, Boris Alekseev, Dingwei Ye, Félix Guerrero-Ramos, Alberto Briganti, Girish S. Kulkarni, Julia Brinkmann, Anna-Maria Calella, Rossano Cesari, Anthony Eccleston, Elisabete Michelon, Jennifer Vermette, Caimiao Wei, Gary D. Steinberg -
Perioperative durvalumab plus chemotherapy plus new agents for resectable non-small-cell lung cancer: the platform phase II NeoCOAST-2 trial Nat. Med. (IF 58.7) Pub Date : 2025-05-31
Tina Cascone, Laura Bonanno, Florian Guisier, Amelia Insa, Moishe Liberman, Olivier Bylicki, Lorenzo Livi, Thomas Egenod, Romain Corre, Dong-Wan Kim, Maria Rosario Garcia Campelo, Mariano Provencio Pulla, Byoung Yong Shim, Giulio Metro, Jaafar Bennouna, Agata A. Bielska, Alula R. Yohannes, Yun He, Adam Dowson, Gozde Kar, Lara McGrath, Rakesh Kumar, Italia Grenga, Jonathan Spicer, Patrick M. Forde -
Patritumab deruxtecan in leptomeningeal metastatic disease of solid tumors: the phase 2 TUXEDO-3 trial Nat. Med. (IF 58.7) Pub Date : 2025-05-30
Matthias Preusser, Javier Garde-Noguera, Juan José García-Mosquera, María Gion, Richard Greil, Miriam Arumi, Manuel Ruiz-Borrego, Antonio Llombart-Cussac, María Valero, Javier Cortés, Marta Campolier, José Antonio Guerrero, Paula González-Alonso, Carlos Jiménez-Cortegana, Jose Rodríguez-Morató, Marta Vaz-Batista, Felicitas Oberndorfer, Maximilian Marhold, Anna Sophie Berghoff, Julia Furtner, Thorsten -
Rebuilding global health after the demise of USAID Nat. Med. (IF 58.7) Pub Date : 2025-05-29
Charles Coughlan, Arpan R. MehtaMany commentators anticipated a downturn in the fortunes of the United States Agency of International Development (USAID) after the re-election of President Trump. Nonetheless, its abrupt demise has sent shockwaves through low- and middle-income countries (LMICs). Optimists may hope that this is a Trumpian flash in the pan, which will be quickly reversed with a change in government. However, overseas
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Semaglutide treats MASH liver disease Nat. Med. (IF 58.7) Pub Date : 2025-05-29
GLP-1 receptor agonist semaglutide significantly outperformed placebo in an ongoing phase 3 trial, showing reductions in steatohepatitis and liver fibrosis, in addition to cardiometabolic benefits.
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Hyperimmune volunteer enables discovery of a potent snake antivenom Nat. Med. (IF 58.7) Pub Date : 2025-05-29
Researchers studied the antibody library of a venom-immune person with extensive snakebite exposure — and generated a three-agent, broadly neutralizing cocktail that protected mice against venoms from high-priority species.
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How to sustain a public-health genomics and bioinformatics workforce in Africa Nat. Med. (IF 58.7) Pub Date : 2025-05-29
Harris Onywera, Nicola Mulder, Yenew Kebede, Sofonias K. Tessema -
Implementing digital health to support self-care of chronic diseases Nat. Med. (IF 58.7) Pub Date : 2025-05-28
Marie Löf, Ralph MaddisonHere we propose six recommendations for researchers to consider for the successful implementation of evidence-based digital health interventions into routine clinical practice.
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Lifeline: a musical about antimicrobial resistance that raises awareness and inspires action Nat. Med. (IF 58.7) Pub Date : 2025-05-28
Jaime Garcia-Iglesias, Katharine Relph, Robin Hiley, Jess Conway, Graham Richardson, Mary Stahl, Claire Oxlade, Rebecca Murphy-Hoefer, CarriAyne Jones, Meghan Perry -
Molecular determinants of sotorasib clinical efficacy in KRASG12C-mutated non-small-cell lung cancer Nat. Med. (IF 58.7) Pub Date : 2025-05-28
Ferdinandos Skoulidis, Bob T. Li, Adrianus Johannes de Langen, David S. Hong, Herve Lena, Juergen Wolf, Grace K. Dy, Alessandra Curioni Fontecedro, Pascale Tomasini, Vamsidhar Velcheti, Anthonie J. van der Wekken, Christophe Dooms, Luis Paz-Ares Rodriguez, Giannis Mountzios, Adrian Sacher, Ernest Nadal, Sebastien Couraud, Sang-We Kim, Kenneth O’Byrne, Danilo Rocco, Ryo Toyozawa, Izabela Chmielewska -
Patient-centered integration of tumor and germline genetic results can improve cancer care Nat. Med. (IF 58.7) Pub Date : 2025-05-27
Alanna J. Church, Oindrila Bhattacharyya, Julie O. Culver, Yonatan Amzaleg, Erin Linnenbringer, Maeve Smart, Christina Ip-Toma, Adan Reinosa Rivera, Bethany Davis, Charité Ricker, Heinz-Josef Lenz, Stacy W. Gray, Heather Hampel, David W. Craig -
Feasibility of multiomics tumor profiling for guiding treatment of melanoma Nat. Med. (IF 58.7) Pub Date : 2025-05-27
Nicola Miglino, Nora C. Toussaint, Alexander Ring, Ximena Bonilla, Marina Tusup, Benedict Gosztonyi, Tarun Mehra, Gabriele Gut, Francis Jacob, Stephane Chevrier, Kjong-Van Lehmann, Ruben Casanova, Andrea Jacobs, Sujana Sivapatham, Laura Boos, Parisa Rahimzadeh, Manuel Schuerch, Bettina Sobottka, Natalia Chicherova, Shuqing Yu, Rebekka Wegmann, Julien Mena, Emanuela S. Milani, Sandra Goetze, Cinzia -
Early detection of multiple cancer types using multidimensional cell-free DNA fragmentomics Nat. Med. (IF 58.7) Pub Date : 2025-05-27
Hua Bao, Shanshan Yang, Xiaoxi Chen, Guangqiang Dong, Yuan Mao, Shuyu Wu, Xi Cheng, Xuxiaochen Wu, Wanxiangfu Tang, Min Wu, Shiting Tang, Wenhua Liang, Zheng Wang, Liu Yang, Jiaqi Liu, Tao Wang, Bingzhong Zhang, Kuirong Jiang, Qin Xu, Jierong Chen, Hairong Huang, Junjie Peng, Xiaomeng Xia, Yumei Wu, Shun Xu, Ji Tao, Li Chong, Dongqin Zhu, Ruowei Yang, Shuang Chang, Peng He, Xiuxiu Xu, JinPeng Zhang -
Lutetium-177–PSMA-617 or cabazitaxel in metastatic prostate cancer: circulating tumor DNA analysis of the randomized phase 2 TheraP trial Nat. Med. (IF 58.7) Pub Date : 2025-05-27
Edmond M. Kwan, Sarah W. S. Ng, Sofie H. Tolmeijer, Louise Emmett, Shahneen Sandhu, James P. Buteau, Amir Iravani, Anthony M. Joshua, Roslyn J. Francis, Vinod Subhash, Sze-Ting Lee, Andrew M. Scott, Andrew J. Martin, Martin R. Stockler, Gráinne Donnellan, Matti Annala, Cameron Herberts, Ian D. Davis, Michael S. Hofman, Arun A. Azad, Alexander W. Wyatt -
Lentiviral gene therapy with reduced-intensity conditioning for sickle cell disease: a phase 1/2 trial Nat. Med. (IF 58.7) Pub Date : 2025-05-26
Michael Grimley, Stella M. Davies, Archana Shrestha, Amy Shova, Monika Asnani, Michael Kent, Farzana Sayani, Charles T. Quinn, Omar Niss, Carolyn Lutzko, Parinda A. Mehta, Pooja Khandelwal, Courtney Little, Sharat Chandra, Sydney Felker, Mengna Chi, Theodosia A. Kalfa, Jennifer Knight-Madden, Paritha I. Arumugam, Kristie N. Ramos, Scott Witting, Teresa Latham, Frederic D. Bushman, Punam Malik -
How US politics is undermining global science Nat. Med. (IF 58.7) Pub Date : 2025-05-23
Jeremy W. Jacobs, Garrett S. BoothIn June 2025, the International Society on Thrombosis and Haemostasis (ISTH) will convene its annual congress in Washington, DC — a gathering that has long exemplified global scientific exchange. However, this year, international attendees are being urged to take unusual precautions. The society’s recent travel guidance advises participants to limit personal data on devices, edit social media profiles
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Surgery avoidable with immunotherapy in mismatch repair-deficient tumors Nat. Med. (IF 58.7) Pub Date : 2025-05-22
In a phase 2 trial, complete responses to neoadjuvant dostarlimab allowed most patients with early-stage solid tumors to avoid surgery, which allowed preservation of affected organs.
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Nutrition research must go local Nat. Med. (IF 58.7) Pub Date : 2025-05-20
Understanding the health impacts of local, culturally relevant diets will be critical to advancing precision nutrition across diverse populations in a sustainable way.
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Cancer treatment paradigms in the precision medicine era Nat. Med. (IF 58.7) Pub Date : 2025-05-20
Vivek Subbiah, Giuseppe Curigliano, Jason K. Sicklick, Shumei Kato, Kjetil Tasken, Arielle Medford, Damian T. Rieke, Hui-Zi Chen, Adam Wahida, Lars Buschhorn, Denis Horgan, Razelle KurzrockTo fully harness precision medicine and transform cancer care for the better will require a strategic shift to highly personalized interventions that embrace innovation and adaptability.
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Author Correction: Prediction of mental health risk in adolescents Nat. Med. (IF 58.7) Pub Date : 2025-05-19
Elliot D. Hill, Pratik Kashyap, Elizabeth Raffanello, Yun Wang, Terrie E. Moffitt, Avshalom Caspi, Matthew Engelhard, Jonathan PosnerCorrection to: Nature Medicine https://doi.org/10.1038/s41591-025-03560-7, published online 5 March 2025.
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Addendum: Sensitive in vivo imaging of T cells using a membrane-bound Gaussia princeps luciferase Nat. Med. (IF 58.7) Pub Date : 2025-05-19
Elmer B Santos, Raymond Yeh, James Lee, Yan Nikhamin, Blesida Punzalan, Blesserene Punzalan, Krista La Perle, Steven M Larson, Michel Sadelain, Renier J BrentjensAddendum to: Nature Medicine https://doi.org/10.1038/nm.1930, published online 15 February 2009.
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Using metformin to stall clonal hematopoiesis Nat. Med. (IF 58.7) Pub Date : 2025-05-16
Three translational studies reveal elevated mitochondrial metabolism as a driver of age-related clonal hematopoiesis and suggest that targeting this process — for example, with metformin — could reduce the risk of associated diseases.
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Atezolizumab plus bevacizumab and chemotherapy in metastatic nonsquamous NSCLC: the randomized double-blind phase 3 IMpower151 trial Nat. Med. (IF 58.7) Pub Date : 2025-05-16
Caicun Zhou, Xiaorong Dong, Gongyan Chen, Zhehai Wang, Xianghua Wu, Yu Yao, Yiping Zhang, Ying Cheng, Hongming Pan, Xiaodong Zhang, Jiuwei Cui, Lifeng Wang, Xi Chen, Xiaoling Li, Ziping Wang, Qiming Wang, Jianxing He, Mengzhao Wang, Iris Yan, Li Qian, Miao Xu, Xiayu Huang, Chun Sun, Jun Cai, Qiong Wu, Marcus Ballinger, Monika Kaul, Minu K. Srivastava -
Health impacts of exposure to synthetic chemicals in food Nat. Med. (IF 58.7) Pub Date : 2025-05-16
Jane Muncke, Mathilde Touvier, Leonardo Trasande, Martin Scheringer -
Measles to become endemic in the USA if vaccination rates continue to fall Nat. Med. (IF 58.7) Pub Date : 2025-05-14
A modeling study predicts a resurgence of previously eliminated infectious diseases, including measles, rubella, poliomyelitis and diphtheria, if current child vaccination rates continue to fall — with measles being the first to reach endemic levels.
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Parallel worlds in pharma and academia Nat. Med. (IF 58.7) Pub Date : 2025-05-13
Hans CleversPharma and academia require different ways of working and speaking, but teamwork always wins.
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Ubrogepant for the treatment of migraine prodromal symptoms: an exploratory analysis from the randomized phase 3 PRODROME trial Nat. Med. (IF 58.7) Pub Date : 2025-05-12
Peter J. Goadsby, Jessica Ailani, David W. Dodick, Amaal J. Starling, Chengcheng Liu, Yingyi Liu, Sung Yun Yu, Jonathan H. Smith, Elimor Brand-Schieber, Joel M. Trugman -
The innate power of natural killer cells in cancer therapy Nat. Med. (IF 58.7) Pub Date : 2025-05-12
Ebba Sohlberg, Karl-Johan Malmberg -
Artificial intelligence improves breast cancer detection in mammography screening Nat. Med. (IF 58.7) Pub Date : 2025-05-09
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Three decades of global dietary iron deficiency trends and disparities across populations Nat. Med. (IF 58.7) Pub Date : 2025-05-09
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RANO criteria for response assessment of brain metastases based on amino acid PET imaging Nat. Med. (IF 58.7) Pub Date : 2025-05-08
Nathalie L. Albert, Norbert Galldiks, Benjamin M. Ellingson, Martin J. van den Bent, Susan M. Chang, Francesco Cicone, Eng-Siew Koh, Ian Law, Emilie Le Rhun, Maximilian J. Mair, Jan-Michael Werner, Anna S. Berghoff, Julia Furtner, Giuseppe Minniti, Andrew M. Scott, Susan C. Short, Jana Ivanidze, Derek R. Johnson, Bogdana Suchorska, Nelleke Tolboom, Joerg-Christian Tonn, Antoine Verger, Eva Galanis -
Cardiac and liver impairment on multiorgan MRI and risk of major adverse cardiovascular and liver events Nat. Med. (IF 58.7) Pub Date : 2025-05-07
Edward Jackson, Andrea Dennis, Naim Alkhouri, Niharika Samala, Raj Vuppalanchi, Arun J. Sanyal, Mark Muthiah, Rajarshi Banerjee, Amitava Banerjee -
The trials that could transform treatment for serious liver disease Nat. Med. (IF 58.7) Pub Date : 2025-05-07
After years of false starts, metabolic dysfunction-associated steatohepatitis is finally seeing therapeutic breakthroughs — from the first approved drug to candidates that reverse cirrhosis.
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PD-L1 and the dawn of modern cancer immunotherapy Nat. Med. (IF 58.7) Pub Date : 2025-05-05
Lieping Chen describes how his discoveries with PD-L1 yielded life-saving treatments for several cancers.
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Targeting blood pressure to protect the brain Nat. Med. (IF 58.7) Pub Date : 2025-05-02
Josef Coresh, Salim S. Virani, Rebecca F. Gottesman -
Author Correction: Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury Nat. Med. (IF 58.7) Pub Date : 2025-04-30
Seiji Okada, Masaya Nakamura, Hiroyuki Katoh, Tamaki Miyao, Takuya Shimazaki, Ken Ishii, Junichi Yamane, Akihiko Yoshimura, Yukihide Iwamoto, Yoshiaki Toyama, Hideyuki Okano -
Antibiotics reduce vaccine responses in infants Nat. Med. (IF 58.7) Pub Date : 2025-04-30
Neonatal antibiotic exposure was found to negatively impact vaccine responses, probably mediated by decreased Bifidobacterium levels — which highlights potential strategies for enhancing vaccine efficacy in infants.
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Progress with stem cell therapy in Parkinson’s disease Nat. Med. (IF 58.7) Pub Date : 2025-04-30
Two early-phase trials demonstrate the safety of stem cell-based therapies in patients with Parkinson’s disease and suggest promising clinical activity — paving the way for larger efficacy studies.
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The quandary of high-quality evaluation in complex child welfare systems Nat. Med. (IF 58.7) Pub Date : 2025-05-01
Bethany Kotlar, Henning TiemeierA randomized controlled trial of a family-focused intervention for children in care in England and Scotland takes a bold step in filling the gap in high-quality evaluation of child welfare, but novel trial designs will be required to truly know what is best for children.
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Modeling the impact of vaccine campaigns on the epidemic transmission dynamics of chikungunya virus outbreaks Nat. Med. (IF 58.7) Pub Date : 2025-05-01
Pastor E. Pérez-Estigarribia, Gabriel Ribeiro dos Santos, Simon Cauchemez, Cynthia Vazquez, Ana Karina Ibarrola-Vannucci, Guillermo Sequera, Shirley Villalba, María José Ortega, Jose Luis Di Fabio, Danny Scarponi, Christinah Mukandavire, Arminder Deol, Águeda Cabello, Elsi Vargas, Cyntia Fernández, Liz León, Henrik Salje -
Infant mental health services for birth and foster families of maltreated pre-school children in foster care (BeST?): a cluster-randomized phase 3 clinical effectiveness trial Nat. Med. (IF 58.7) Pub Date : 2025-05-01
Karen Crawford, Robin Young, Philip Wilson, Manuela Deidda, Matt Forde, Susanne Millar, Alex McConnachie, Kathleen Boyd, Emma McIntosh, Dennis Ougrin, Marion Henderson, Christopher Gillberg, Gary Kainth, Fiona Turner, Edmund J. S. Sonuga-Barke, Bridie Fitzpatrick, Helen Minnis -
Promoting transparency in AI for biomedical and behavioral research Nat. Med. (IF 58.7) Pub Date : 2025-04-30
Tina Hernandez-Boussard, Aaron Y. Lee, Julia Stoyanovich, Laura BivenRecent advancements in artificial intelligence (AI) in healthcare have highlighted the need for transparency, including explainability, interpretability, and accountability across the AI lifecycle1,2. Transparency ensures stakeholders can make informed decisions about data and model reuse, fostering trust and fairness while aligning with regulatory frameworks. However, the concept of transparency lacks
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Transmission through a heavy-tailed sexual contact network explains the New York City mpox outbreak Nat. Med. (IF 58.7) Pub Date : 2025-04-30
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Low-voltage-area ablation for persistent atrial fibrillation: a randomized controlled trial Nat. Med. (IF 58.7) Pub Date : 2025-04-30
Masaharu Masuda, Akihiro Sunaga, Nobuaki Tanaka, Tetsuya Watanabe, Hitoshi Minamiguchi, Yasuyuki Egami, Takafumi Oka, Tomoko Minamisaka, Takashi Kanda, Masato Okada, Masato Kawasaki, Yasuhiro Matsuda, Koji Tanaka, Tomomi Yamada, Shungo Hikoso, Tomoharu Dohi, Koichi Inoue, Yohei Sotomi, Yasushi Sakata -
Precision nutrition for cardiometabolic diseases Nat. Med. (IF 58.7) Pub Date : 2025-04-30
Marta Guasch-Ferré, Clemens Wittenbecher, Marie Palmnäs, Orly Ben-Yacov, Ellen E. Blaak, Christina C. Dahm, Tove Fall, Berit L. Heitmann, Tine R. Licht, Marie Löf, Ruth Loos, Chirag J. Patel, Carmelo Quarta, Leanne M. Redman, Eran Segal, Nicola Segata, Michael Snyder, Qi Sun, Deirdre K. Tobias, Frank B. Hu, Paul W. Franks, Rikard Landberg, Jennifer L. Sargent, Jordi Merino -
Author Correction: Autologous T cell therapy for PRAME+ advanced solid tumors in HLA-A*02+ patients: a phase 1 trial Nat. Med. (IF 58.7) Pub Date : 2025-04-29
Martin Wermke, Dejka M. Araujo, Manik Chatterjee, Apostolia M. Tsimberidou, Tobias A. W. Holderried, Amir A. Jazaeri, Ran Reshef, Carsten Bokemeyer, Winfried Alsdorf, Katrin Wetzko, Peter Brossart, Katrin Aslan, Linus Backert, Sebastian Bunk, Jens Fritsche, Swapna Gulde, Silvana Hengler, Norbert Hilf, Mohammad B. Hossain, Jens Hukelmann, Mamta Kalra, Delfi Krishna, M. Alper Kursunel, Dominik MaurerCorrection to: Nature Medicine https://doi.org/10.1038/s41591-025-03650-6, published online 9 April 2025.
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The stochasticity of biological aging Nat. Med. (IF 58.7) Pub Date : 2025-04-29
David H. Meyer, Björn SchumacherThe recent Nature Medicine World View by M. Arfan Ikram1 cites our article on the role of stochasticity in aging clocks as evidence for limited biological information from age predictors2. Following a further Correspondence by Ferrucci et al.3, we find it important to clarify the roles of stochasticity in aging and in age prediction and to have an open debate on this topic. The idea of aging as a genetically
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Effect of felzartamab on the molecular phenotype of antibody-mediated rejection in kidney transplant biopsies Nat. Med. (IF 58.7) Pub Date : 2025-04-29
Matthias Diebold, Patrick T. Gauthier, Katharina A. Mayer, Martina Mackova, Christian Hinze, Jessica Chang, Uptal D. Patel, Ekkehard Schütz, Bernd Jilma, Eva Schrezenmeier, Klemens Budde, Georg A. Böhmig, Philip F. Halloran -
Broad rim lesions are a new pathological and imaging biomarker for rapid disease progression in multiple sclerosis Nat. Med. (IF 58.7) Pub Date : 2025-04-29
Luisa Klotz, Joost Smolders, Jussi Lehto, Markus Matilainen, Lukas Lütje, Luzia Buchholz, Stefanie Albrecht, Carolin Walter, Julian Varghese, Heinz Wiendl, Marjo Nylund, Christian Thomas, Maria Gardberg, Aletta M. R. van den Bosch, Laura Airas, Inge Huitinga, Tanja Kuhlmann