aim was to validate KFRE by frailty status and assess whether model performance could be improved by using cystatin based estimated glomerular filtration rate (eGFR) equations and to assess the impact of accounting for competing mortality risk. Methods: We studied adults from the prospective research cohort UK Biobank with CKD G3-5 (eGFR <60mL/min/1.73m2) by any of the three CKD-EPI consortium eGFR

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An abstract is unavailable. This article is available as a PDF only.

ily validated a formative objective structured clinical examination (OSCE) assessing clinical care of an uncomplicated patient initiating HHD, using a unified model of construct validity. Methods: The OSCE was developed by a nephrology fellow and five faculty (three practicing HHD). The nine-member test committee (five in HHD practice; one HHD care partner) assessed test item difficulty/relevance and

An abstract is unavailable.

study within the Veterans Health Administration included adults with an ADPKD diagnosis code who initiated SGLT2i between January 2017 and May 2023. Repeated measures models were used to evaluate eGFR slope before and after SGLT2i initiation. Among patients with ADPKD and type 2 diabetes mellitus (T2DM), a target trial emulation was used to compare the effects of SGLT2i versus dipeptidyl peptidase-4

An abstract is unavailable.

An abstract is unavailable. This article is available as a PDF only.

feeding study in 39 adults without and 11 adults with CKD. Participants were fed a phosphorus additive-enhanced diet for two weeks followed by a low additive diet for six weeks. Both diets were identical except for phosphorus additive content. Blood and urine samples were collected at regular intervals with analyses comparing follow-up measures of mineral metabolism markers to baseline values. Results:

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physical dysfunction. Factors such as uremia, systemic inflammation, oxidative stress, and inappropriate activation of the renin-angiotensin-aldosterone system may play are role on mitochondrial dysfunction. On the other hand, the accumulation of ectopic adipose tissue in skeletal muscle, also known as intermuscular adipose tissue (IMAT), is a newly recognized factor in muscle function and physical

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LIO-DKD and FIGARO-DKD phase 3 clinical trials, investigated the efficacy and safety of finerenone versus placebo according to baseline frailty index. Methods: Between September 2015 and October 2018, 12,990 people with chronic kidney disease (CKD) and type 2 diabetes (T2D) receiving the maximum tolerated dose of a renin–angiotensin system inhibitor were randomized to receive finerenone 10 or 20 mg

connectedness between these conditions, across biological and socio-ecological domains. The CKM health initiative of the AHA seeks to improve cardiovascular and kidney health at a population level by providing a holistic approach to the management of individuals with CKM syndrome, emphasizing CKM health across the lifespan with priority for primordial/primary prevention, improving short and long-term

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An abstract is unavailable. This article is available as a PDF only.

pact nephrology has on the planet, including, but not limited to its carbon footprint, is needed to promote education and research on these issues. Increasing awareness entails increasing knowledge at various levels and it is for this reason that we are presenting this review focusing on educational activities that have been and could further be undertaken to spread knowledge of these topics. We start

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ssessment of this link. This study employed multivariable Mendelian randomization (MVMR) to elucidate the causal relationship between thyroid dysfunction and kidney function in East Asian and European populations. Methods: We conducted a cross-sectional study and MVMR analysis using data from 17,733 participants in the Taiwan Biobank. Thyroid function was assessed by measuring TSH, fT4 and TPOAb levels

An abstract is unavailable.

An abstract is unavailable.

KD trials. However, differing short-term and long-term treatment effects on GFR slope can create ambiguities concerning the appropriate period for evaluating slope, in part because current methods cannot separate the distinct contributions of the acute (before 3 months) and chronic (after 3 months) slopes for treatment effects on clinical endpoints (CEs). Methods We estimated treatment effects on the

of Nephrology (ASN) Kidney Week Conferences. Methods: We analyzed 1534 archived sessions from ASN Kidney Weeks 2019, 2021, and 2023. Moderator and speaker gender, academic rank, session type, and presence of formal titles in introductions were documented. Multivariable logistic regression was conducted to evaluate the relationship between these characteristics and the frequency of formal title usage

unstructured notes. Methods: Adults (≥18 years) admitted to the University of Wisconsin (2009-20) and the University of Chicago Medicine (2016-22) were eligible for inclusion. Patients were excluded if they had no documented serum creatinine (SCr), end-stage kidney disease, an admission SCr≥3.0mg/dL, developed ≥Stage 2 AKI before reaching the wards or intensive care unit (ICU), or required dialysis

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s and clinical variables during the first 3-6 months of therapy. Methods: Using a cohort of 187 patients from the GEMRITUX, MENTOR and STARMEN clinical trials with antibody levels at baseline ≥14 RU/ml, we derived logistic regression models to predict proteinuria remission at 12 months that can be used at baseline or after three or six months of treatment. Treatment exposures in the trials included

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ssess the patient-reported benefits of video-assisted electronic consent (eConsent) compared with the usual consent practices for percutaneous kidney biopsies (PKB). Methods: In this single-center, open-label, randomized controlled trial, consecutive patients undergoing PKB between July 2021 and January 2024 were randomized (1:1) to either video-assisted eConsent (intervention) or usual practice of

were enrolled in CureGN, a multi-center observational cohort study. Children and adults were analyzed separately in four cohorts 1) full, 2) incident, 3) prevalent, and 4) histology. Groups were defined using latent class trajectory modeling using proteinuria measurements over two years. Linear mixed models were used to calculate predicted estimated glomerular filtration rate (eGFR) slope. In adults

se knowledge is among the strongest and most modifiable predictors of the KRT decision readiness, its quality, and home dialysis choice. Background Kidney disease stakeholders recommend a system-wide increase in home dialysis use. KRT decision readiness is associated with higher selection and use of home dialysis; however, KRT decision making is complex, and factors informing KRT decision readiness

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factors. Methods: We used an incident user design with active comparator analysis to derive SGLT2i and glucagon-like peptide-1 receptor agonist (GLP1ra) user cohorts from US nationwide insurance claim data. We used both covariate-adjusted Cox models and Cox models with inverse probability of treatment weighting to investigate the risk of non-candida UTI and candida UTI following drug exposure. We compared

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An abstract is unavailable.

n ranges from 4% to 29% compared with (1) 30%–67%, (2) 39%–54%, (3) 41%–79%, and (4) 9%–49% in patients with CKD, on hemodialysis, on peritoneal dialysis (PD), or in kidney transplant recipients (KTRs), respectively. RLS occurs in approximately 1%–15% of the general population compared with (1) 5%–18%, (2) 24%–33%, (3) 23%–64%, and (4) 6%–8% in patients with CKD, on hemodialysis, on PD, or in KTRs

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of this study is to examine the association of fibrate use with incident chronic kidney disease (CKD), end-stage kidney disease (ESKD), and mortality in a large national cohort of United States (US) Veterans. Methods: A retrospective cohort study was conducted to examine the association of de novo prescription of fibrate medications with incident CKD, ESKD, and mortality over up to 14 years of follow-up

We investigated the relationship between temperature and healthcare utilization among patients with chronic kidney disease (CKD). We utilized panel regression models with individual and year fixed effects to evaluate how exposure to different levels of temperature (measured by heat index) was associated with changes in weekly healthcare utilization from October 1, 2015, to March 31, 2023. Data were

nd walking training (WT) versus usual care controls on walking capacity among hemodialysis patients. Methods Patients treated with maintenance hemodialysis were recruited from two dialysis units in Suzhou, China between February to June 2024, and were randomly allocated into three groups using block randomization. The control group received usual care. The WT group received eight weeks of low-to-moderate

An abstract is unavailable.

s.The use of SGLT-2i did not increase the incidence of AKI, urine infections, fractures, or treatment discontinuation due to adverse events. Background The efficacy and safety of sodium-glucose cotransporter-2 inhibitor (SGLT-2i) in patients with advanced CKD, defined as an eGFR <30 ml/min per 1.73 m2, has not been adequately studied. Methods We conducted a systematic review and meta-analysis of phase

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in the general population, phosphorus retention and overload can affect four critical aspects of the cardiovascular system: increased arterial blood pressure, vascular and valvular calcification and left ventricular hypertrophy. All of these factors contribute to increased cardiovascular risk and mortality. The contribution of dietary phosphorus in the pathogenesis of chronic kidney disease associated

e.Increasing plant diversity, in addition to usual diet care, resulted in a substantial reduction in potential renal acid load of 47%. Background Research suggests that eating a plant-dominant dietary pattern is beneficial to people with CKD. The aim was to investigate how increasing the diversity of plant food intake would affect metabolomic, microbiome, and clinical parameters in people with CKD

erapy,” approach to management of individuals with CKD and those at risk for it. This is the reverse of the current approach in which pharmacologic therapy is considered as foundational to CKD management. Diet is gaining traction as a major chronic kidney disease (CKD)-related risk factor for death and disability. Furthermore, a “healthy” diet in patients with CKD is associated with reduced mortality

ociated with slower progression of coronary artery calcium score compared with calcium-based agents. Background It is necessary to update the evidence of each phosphate-lowering agent on dialysis patients. Methods From the CENTRAL, MEDLINE, Embase, and ClinicalTrial.gov databases, randomized controlled trials using oral phosphate-lowering agents on adult patients requiring maintenance dialysis were

on and is associated with poor outcomes in the general population, obese individuals with CKD often display complex metabolic patterns such as sarcopenic obesity, and obesity can be associated with better survival in individuals with advanced CKD. Weight loss interventions are proven to improve glycemic control and cardiovascular risk factors, and successful weight loss is associated with improved

prove with implementing interdisciplinary care in CKD. Background Despite their prevalence, prognostic significance, and prioritization by patients, key geriatric syndromes, such as cognitive impairment, frailty, and depression, are not routinely addressed in CKD care in the United States (US). In an interdisciplinary care model, health professionals with diverse expertise collaborate to address all

lthcare providers (HCPs) involved in their management. A potential key element in improving PA in CKD includes better provisions around education, tools, and training resources amongst nephrology healthcare providers on PA recommendations, counselling, prescription, and referral to appropriate professionals for assessment, implementation, and monitoring. Much like other pharmacological therapies, an

.A multibiomarker approach could help capture tubulointerstitial health in persons with diabetes and CKD. Background Individual kidney tubule biomarkers are associated with risks of CKD progression and mortality in persons with diabetes. Integrating multiple kidney biomarkers using a latent variable method of exploratory factor analysis could define distinct dimensions of kidney health and their associations

An abstract is unavailable. This article is available as a PDF only.

An abstract is unavailable.

An abstract is unavailable.

An abstract is unavailable.

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s of dialysis dependence were similar.This suggests much of the risk observed may have been due to starting dialysis (versus never starting) rather than starting slightly earlier. Background The Standard versus Accelerated Initiation of Renal Replacement Therapy in AKI Trial showed that among critically ill patients with AKI, an accelerated KRT initiation strategy resulted in more KRT dependence at

egrate into risk stratification tools.Urinary albumin/creatinine, monocyte chemotactic protein-1/creatinine, and serum copeptin are independently associated with kidney outcomes, even in early disease and MIC 1C. Background Risk stratification tools for autosomal dominant polycystic kidney disease (ADPKD) predict kidney outcomes on a group level but lack precision in patients. Methods We assessed the

ering metabolomic markers of dietary potassium may help improve dietary assessment of potassium and trace the effect of dietary potassium on CKD development. Methods We included adults from the Atherosclerosis Risk in Communities study without CKD at visit 1 (N=3812). Cross-sectional associations between dietary potassium and serum metabolites were assessed using multivariable linear regression models

and ultimately exacerbate kidney damage. Understanding the dynamics of the gut-kidney axis provides new insights into potential therapeutic strategies to mitigate CKD progression. Diet is the primary driver of gut microbiota composition. Therefore, an approach emphasizing healthy nutritional patterns is recommended for improving overall health, cardiovascular disease, and profoundly altered metabolic