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Label-free high-throughput live-cell sorting of genome-wide random mutagenesis libraries for metabolic traits by Raman flow cytometry
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4 ) Pub Date : 2025-05-30 , DOI: 10.1073/pnas.2503641122
Xixian WangSen WangZhidian DiaoXibao HouYanhai GongQing SunJiaping ZhangLihui RenYuandong LiYuetong JiWei ShenYifeng YinShi HuangXiaojin SongQiu CuiYingang FengJian XuBo MaaState Key Laboratory of Photoelectric Conversion and Utilization of Solar Energy, Key Laboratory of Shandong Energy Biological Genetic Resources, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, ChinabShandong Energy Institute, Qingdao 266101, ChinacQingdao New Energy Shandong Laboratory, Qingdao 266101, ChinadUniversity of Chinese Academy of Sciences, Beijing 100049, ChinaeQingdao Engineering Laboratory of Single Cell Oil, Shandong Engineering Laboratory of Single Cell Oil, Qingdao 266101, ChinafQingdao Single-Cell Biotechnology Co., Ltd, Qingdao 266101, ChinageCyte, Inc, Sunnyvale, CA 94085hFaculty of Dentistry, University of Hong Kong, Hong Kong 999077, Special Administrative Region of China
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4 ) Pub Date : 2025-05-30 , DOI: 10.1073/pnas.2503641122
Xixian WangSen WangZhidian DiaoXibao HouYanhai GongQing SunJiaping ZhangLihui RenYuandong LiYuetong JiWei ShenYifeng YinShi HuangXiaojin SongQiu CuiYingang FengJian XuBo MaaState Key Laboratory of Photoelectric Conversion and Utilization of Solar Energy, Key Laboratory of Shandong Energy Biological Genetic Resources, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, ChinabShandong Energy Institute, Qingdao 266101, ChinacQingdao New Energy Shandong Laboratory, Qingdao 266101, ChinadUniversity of Chinese Academy of Sciences, Beijing 100049, ChinaeQingdao Engineering Laboratory of Single Cell Oil, Shandong Engineering Laboratory of Single Cell Oil, Qingdao 266101, ChinafQingdao Single-Cell Biotechnology Co., Ltd, Qingdao 266101, ChinageCyte, Inc, Sunnyvale, CA 94085hFaculty of Dentistry, University of Hong Kong, Hong Kong 999077, Special Administrative Region of China
Proceedings of the National Academy of Sciences, Volume 122, Issue 22, June 2025.
SignificanceSorting cells with target metabolic functions from a mutant pool exhibiting substantial genetic diversity is often the rate-limiting step in synthetic biology. Here, we developed a label-free, high-throughput Raman-activated cell sorting ...
中文翻译：
通过拉曼流式细胞术对代谢性状的全基因组随机诱变文库进行无标记高通量活细胞分选
美国国家科学院院刊，第 122 卷，第 22 期，2025 年 6 月。
意义从表现出大量遗传多样性的突变体库中分选具有靶代谢功能的细胞通常是合成生物学中的限速步骤。在这里，我们开发了一种无标记、高通量的拉曼激活细胞分选......
更新日期：2025-06-04
SignificanceSorting cells with target metabolic functions from a mutant pool exhibiting substantial genetic diversity is often the rate-limiting step in synthetic biology. Here, we developed a label-free, high-throughput Raman-activated cell sorting ...
中文翻译：
通过拉曼流式细胞术对代谢性状的全基因组随机诱变文库进行无标记高通量活细胞分选
美国国家科学院院刊，第 122 卷，第 22 期，2025 年 6 月。
意义从表现出大量遗传多样性的突变体库中分选具有靶代谢功能的细胞通常是合成生物学中的限速步骤。在这里，我们开发了一种无标记、高通量的拉曼激活细胞分选......
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