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Proofreading and single-molecule sensitivity in T cell receptor signaling by condensate nucleation
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4 ) Pub Date : 2025-05-30 , DOI: 10.1073/pnas.2422787122
William L. WhiteHailemikael K. YirdawAriel J. Ben-SassonJay T. GrovesDavid BakerHao Yuan KuehaDepartment of Bioengineering, University of Washington, Seattle, WA 98195bInstitute for Protein Design, University of Washington, Seattle, WA 98195cDepartment of Chemistry, University of California Berkeley, Berkeley, CA 94720dInstitute for Digital Molecular Analytics and Science, Nanyang Technological University, Singapore 636921, SingaporeeDepartment of Biochemistry, University of Washington, Seattle, WA 98195fHHMI, Seattle, WA 98195gInstitute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4 ) Pub Date : 2025-05-30 , DOI: 10.1073/pnas.2422787122
William L. WhiteHailemikael K. YirdawAriel J. Ben-SassonJay T. GrovesDavid BakerHao Yuan KuehaDepartment of Bioengineering, University of Washington, Seattle, WA 98195bInstitute for Protein Design, University of Washington, Seattle, WA 98195cDepartment of Chemistry, University of California Berkeley, Berkeley, CA 94720dInstitute for Digital Molecular Analytics and Science, Nanyang Technological University, Singapore 636921, SingaporeeDepartment of Biochemistry, University of Washington, Seattle, WA 98195fHHMI, Seattle, WA 98195gInstitute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98109
Proceedings of the National Academy of Sciences, Volume 122, Issue 22, June 2025.
SignificanceTo fight infections and cancer, T cells must selectively recognize low levels of foreign peptides from pathogens or cancer cells, but the mechanisms that enable these properties remain unclear. Using computational modeling and experiments, we ...
中文翻译：
通过凝聚物成核对 T 细胞受体信号传导的校对和单分子敏感性
美国国家科学院院刊，第 122 卷，第 22 期，2025 年 6 月。
意义为了对抗感染和癌症，T 细胞必须选择性地识别来自病原体或癌细胞的低水平外来肽，但实现这些特性的机制仍不清楚。使用计算建模和实验，我们...
更新日期：2025-06-04
SignificanceTo fight infections and cancer, T cells must selectively recognize low levels of foreign peptides from pathogens or cancer cells, but the mechanisms that enable these properties remain unclear. Using computational modeling and experiments, we ...
中文翻译：
通过凝聚物成核对 T 细胞受体信号传导的校对和单分子敏感性
美国国家科学院院刊，第 122 卷，第 22 期，2025 年 6 月。
意义为了对抗感染和癌症，T 细胞必须选择性地识别来自病原体或癌细胞的低水平外来肽，但实现这些特性的机制仍不清楚。使用计算建模和实验，我们...
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