当前位置：
X-MOL 学术
›
Proc. Natl. Acad. Sci. U.S.A.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Solution structure and synaptic analyses reveal determinants of bispecific T cell engager potency
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4 ) Pub Date : 2025-05-30 , DOI: 10.1073/pnas.2425781122
Alexander LeithnerOskar StauferTanmay MitraFalk LibertaSalvatore ValvoMikhail KutuzovHannah DadaJacob SpaethWeijie ZhouFelix SchieleSophia ReindlHerbert NarStefan HoererMaureen CramesStephen ComeauDavid YoungSarah LowEdward JenkinsSimon J. DavisDavid KlenermanAndrew NixonNoah PefaurDavid WyattOmer DushekSrinath KasturiranganMichael L. DustinaThe Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Roosevelt Drive, Oxford OX3 7FY, United KingdombINM - Leibniz Institute for New Materials, Campus D2 2, 66117 Saarbrücken, GermanycChinese Academy of Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford OX3 7BN, United KingdomdBoehringer Ingelheim Pharma GmbH & Co. Kg., Biberach an der Riss 88397, GermanyeSir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United KingdomfBiotherapeutics Dis..
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4 ) Pub Date : 2025-05-30 , DOI: 10.1073/pnas.2425781122
Alexander LeithnerOskar StauferTanmay MitraFalk LibertaSalvatore ValvoMikhail KutuzovHannah DadaJacob SpaethWeijie ZhouFelix SchieleSophia ReindlHerbert NarStefan HoererMaureen CramesStephen ComeauDavid YoungSarah LowEdward JenkinsSimon J. DavisDavid KlenermanAndrew NixonNoah PefaurDavid WyattOmer DushekSrinath KasturiranganMichael L. DustinaThe Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS), University of Oxford, Roosevelt Drive, Oxford OX3 7FY, United KingdombINM - Leibniz Institute for New Materials, Campus D2 2, 66117 Saarbrücken, GermanycChinese Academy of Medical Sciences Oxford Institute, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford OX3 7BN, United KingdomdBoehringer Ingelheim Pharma GmbH & Co. Kg., Biberach an der Riss 88397, GermanyeSir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United KingdomfBiotherapeutics Dis..
Proceedings of the National Academy of Sciences, Volume 122, Issue 22, June 2025.
SignificanceBispecific T cell engagers (TcEs) are immunotherapeutic drugs that trigger the destruction of cancer cells by linking T cells to cancer cells through specific surface molecules (antigens). We designed a series of TcEs with varying distances ...
中文翻译：
溶液结构和突触分析揭示了双特异性 T 细胞接合器效力的决定因素
美国国家科学院院刊，第 122 卷，第 22 期，2025 年 6 月。
意义双特异性 T 细胞接合器 （TcE） 是一种免疫治疗药物，通过特定表面分子（抗原）将 T 细胞与癌细胞连接，从而触发对癌细胞的破坏。我们设计了一系列具有不同距离的 TcE ...
更新日期：2025-06-04
SignificanceBispecific T cell engagers (TcEs) are immunotherapeutic drugs that trigger the destruction of cancer cells by linking T cells to cancer cells through specific surface molecules (antigens). We designed a series of TcEs with varying distances ...
中文翻译：
溶液结构和突触分析揭示了双特异性 T 细胞接合器效力的决定因素
美国国家科学院院刊，第 122 卷，第 22 期，2025 年 6 月。
意义双特异性 T 细胞接合器 （TcE） 是一种免疫治疗药物，通过特定表面分子（抗原）将 T 细胞与癌细胞连接，从而触发对癌细胞的破坏。我们设计了一系列具有不同距离的 TcE ...
京公网安备 11010802027423号