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Genomic analyses identify 15 risk loci and reveal HDAC2, SOX2-OT, and IGF2BP2 in a naturally occurring canine model of gastric cancer
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4 ) Pub Date : 2025-05-30 , DOI: 10.1073/pnas.2416723122
Shawna R. CookSanne HugenJessica J. HaywardThomas R. FamulaJanelle M. BelangerElizabeth McNielHille FietenAnita M. OberbauerPeter A. J. LeegwaterElaine A. OstranderPaul J. J. MandigersJacquelyn M. EvansaBaker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853bDepartment of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853cExpertisecentre of Genetics, Department of Clinical Sciences, Utrecht University, Utrecht 3584 CM, The NetherlandsdDepartment of Animal Science, University of California, Davis, CA 95616eCummings School of Veterinary Medicine, Tufts University, Grafton, MA 01536fCancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4 ) Pub Date : 2025-05-30 , DOI: 10.1073/pnas.2416723122
Shawna R. CookSanne HugenJessica J. HaywardThomas R. FamulaJanelle M. BelangerElizabeth McNielHille FietenAnita M. OberbauerPeter A. J. LeegwaterElaine A. OstranderPaul J. J. MandigersJacquelyn M. EvansaBaker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853bDepartment of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853cExpertisecentre of Genetics, Department of Clinical Sciences, Utrecht University, Utrecht 3584 CM, The NetherlandsdDepartment of Animal Science, University of California, Davis, CA 95616eCummings School of Veterinary Medicine, Tufts University, Grafton, MA 01536fCancer Genetics and Comparative Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892
Proceedings of the National Academy of Sciences, Volume 122, Issue 22, June 2025.
SignificanceGastric cancer is the fifth most common cause of human cancer deaths, but the genetic underpinnings are poorly understood. Harnessing the genetic homogeneity of purebred dogs, we identify 18 loci governing gastric cancer susceptibility in a ...
中文翻译：
基因组分析确定了 15 个风险位点，并揭示了自然发生的胃癌犬模型中的 HDAC2、SOX2-OT 和 IGF2BP2
美国国家科学院院刊，第 122 卷，第 22 期，2025 年 6 月。
意义胃癌是人类癌症死亡的第五大常见原因，但人们对其遗传基础知之甚少。利用纯种狗的遗传同质性，我们确定了 18 个控制胃癌易感性的位点......
更新日期：2025-06-04
SignificanceGastric cancer is the fifth most common cause of human cancer deaths, but the genetic underpinnings are poorly understood. Harnessing the genetic homogeneity of purebred dogs, we identify 18 loci governing gastric cancer susceptibility in a ...
中文翻译：
基因组分析确定了 15 个风险位点，并揭示了自然发生的胃癌犬模型中的 HDAC2、SOX2-OT 和 IGF2BP2
美国国家科学院院刊，第 122 卷，第 22 期，2025 年 6 月。
意义胃癌是人类癌症死亡的第五大常见原因，但人们对其遗传基础知之甚少。利用纯种狗的遗传同质性，我们确定了 18 个控制胃癌易感性的位点......
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