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CRISPR screen reveals a simultaneous targeted mechanism to reduce cancer cell selenium and increase lipid oxidation to induce ferroptosis
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4 ) Pub Date : 2025-05-30 , DOI: 10.1073/pnas.2502876122
Sophia M. LamperisKaylin M. McMahonAndrea E. CalvertJonathan S. RinkKarthik VasanMadhura R. PandkarEliana U. CrentsilZachary R. ChalmersNatalie R. McDonaldCameron J. KosmalaMarcelo G. BoniniDaniela MateiLeo I. GordonNavdeep S. ChandelC. Shad ThaxtonaDepartment of Urology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611bSimpson Querrey Institute for BioNanotechnology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611cRobert H. Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611dDepartment of Medicine, Division of Hematology/Oncology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611eDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611fDepartment of Biochemistry and Molecular Genetics, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611gDepartmen..
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4 ) Pub Date : 2025-05-30 , DOI: 10.1073/pnas.2502876122
Sophia M. LamperisKaylin M. McMahonAndrea E. CalvertJonathan S. RinkKarthik VasanMadhura R. PandkarEliana U. CrentsilZachary R. ChalmersNatalie R. McDonaldCameron J. KosmalaMarcelo G. BoniniDaniela MateiLeo I. GordonNavdeep S. ChandelC. Shad ThaxtonaDepartment of Urology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611bSimpson Querrey Institute for BioNanotechnology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611cRobert H. Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611dDepartment of Medicine, Division of Hematology/Oncology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611eDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611fDepartment of Biochemistry and Molecular Genetics, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611gDepartmen..
Proceedings of the National Academy of Sciences, Volume 122, Issue 22, June 2025.
SignificanceFerroptosis is an iron-dependent cell death mechanism that results from increased oxidation of cell membrane lipids. We conducted a CRISPR-based positive selection screen in clear cell ovarian cancer cells treated with a nanoparticle drug to ...
中文翻译：
CRISPR 筛选揭示了减少癌细胞硒和增加脂质氧化以诱导铁死亡的同时靶向机制
美国国家科学院院刊，第 122 卷，第 22 期，2025 年 6 月。
意义铁死亡是一种铁依赖性细胞死亡机制，由细胞膜脂质氧化增加引起。我们在用纳米颗粒药物治疗的透明细胞卵巢癌细胞中进行了基于 CRISPR 的阳性选择筛选，以...
更新日期：2025-06-04
SignificanceFerroptosis is an iron-dependent cell death mechanism that results from increased oxidation of cell membrane lipids. We conducted a CRISPR-based positive selection screen in clear cell ovarian cancer cells treated with a nanoparticle drug to ...
中文翻译：
CRISPR 筛选揭示了减少癌细胞硒和增加脂质氧化以诱导铁死亡的同时靶向机制
美国国家科学院院刊，第 122 卷，第 22 期，2025 年 6 月。
意义铁死亡是一种铁依赖性细胞死亡机制，由细胞膜脂质氧化增加引起。我们在用纳米颗粒药物治疗的透明细胞卵巢癌细胞中进行了基于 CRISPR 的阳性选择筛选，以...
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