The ancestral protein of the CRISPR–Cas9 system — less than half the size of its famous descendant — is engineered into an effective DNA-targeting tool that can be delivered by AAV as an epigenome editor for in vivo gene silencing.

中文翻译：

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复活微型 Cas9 祖先用于基因组和表观基因组编辑

CRISPR-Cas9 系统的祖先蛋白（不到其著名后代的一半）被设计成一种有效的 DNA 靶向工具，可以由 AAV 作为体内基因沉默的表观基因组编辑器提供。