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Base editors model mitochondrial disease
Nature Biotechnology ( IF 33.1 ) Pub Date : 2025-06-03 , DOI: 10.1038/s41587-025-02706-9
Patrick Buchholz, Jens Boch

Optimized TALE base editors are used to generate a rat model of mitochondrial disease and then revert the disease mutation in the next generation.

中文翻译:

碱基编辑器对线粒体疾病进行建模

优化的 TALE 碱基编辑器用于生成线粒体疾病的大鼠模型,然后在下一代中恢复疾病突变。
更新日期:2025-06-03
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