Isoxazolines are an important class of nitrogen- and oxygen-containing heterocycles that belong to the azole family. Recently, it has gained great attention in the field of agrochemical development. However, systematic reviews on the advancements of isoxazolines containing bioactive molecules are relatively lacking. To provide insight into advancements in discovering isoxazoline-containing molecules with agrochemical activities, we systematically reviewed and summarized bioactive isoxazoline compounds based on their structural diversity and active characteristics. The brief structure–activity relationship and mechanism of action of isoxazoline-containing compounds are also discussed. This article is meant to enable researchers in the discovery of novel agrochemicals to quickly understand and provide new ideas for developing novel agrochemicals with novel structures, potent activity, and new mechanism of action.

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异恶唑啉：农用化学品发现的特权支架

异恶唑啉是一类重要的含氮和含氧杂环，属于唑类。最近，它在农用化学品开发领域受到了极大的关注。然而，关于含有生物活性分子的异恶唑啉进展的系统评价相对缺乏。为了深入了解发现具有农用化学活性的含异恶唑啉分子的进展，我们根据其结构多样性和活性特性系统地回顾和总结了生物活性异恶唑啉化合物。还讨论了含异恶唑啉的化合物的简要构效关系和作用机制。本文旨在使发现新型农用化学品的研究人员能够快速了解并为开发具有新颖结构、有效活性和新作用机制的新型农用化学品提供新思路。