Chiral covalent organic frameworks (CCOFs) are promising candidates for chiral optoelectronics and sensing, but their weak solid-state fluorescence and chiroptical responses often limit practical utility. Here, we introduce a novel CCOF synthesized from achiral monomers, 2-hydroxy-1,3,5-benzenetricarbaldehyde and hydrazine, via imine condensation with chiral induction strategy, yielding salicylaldehyde azine units with aggregation-induced emission. Optimized catalyst and chiral inducer stoichiometry endow the framework with exceptional chiroptical properties (|gabs| = 2.2 × 10-2, ellipticity ≈ 1000 mdeg). In the solid state, the CCOF exhibits intense red fluorescence (λem ≈ 645 nm) and favorable circularly polarized luminescence (CPL, |glum| = 5.2 × 10-2), marking the first CCOF derived solely from achiral building blocks with robust solid-state CPL. When integrated into polydimethylsiloxane, it forms flexible and semitransparent composite films suitable for CPL-based applications. The CCOF also functions as highly enantioselective fluorescent sensors for chiral analytes, including 2-aminocyclohenanol and dimethyl-1,2-cyclohexanediamine. Furthermore, it demonstrates reversible hydrochromism, transitioning from yellow to orange (ΔE ≈ 42.7), and water-induced chiroptical enhancement (ellipticity up to 2100 medg, |gabs| = 5.5 × 10-2), achieving the highest ground-state chirality reported for CCOFs through enol-to-keto tautomerism upon water adsorption. This stimulus-responsive CCOF with solid-state CPL properties provides new insights into chiral functional materials.

中文翻译：

---

AIE 驱动的手性共价有机框架，用于固态圆偏振发光、水变色和水诱导手性增强

手性共价有机框架 （CCOF） 是手性光电子学和传感的有前途的候选者，但它们较弱的固态荧光和手光反应通常会限制实际实用性。在这里，我们介绍了一种由非手性单体、2-羟基-1,3,5-苯三甲醛和肼合成的新型 CCOF，通过手性诱导策略的亚胺缩合，产生具有聚集诱导发射的水杨醛嗪单元。优化的催化剂和手性诱导剂化学计量学赋予该框架卓越的手性特性 （|gabs| = 2.2 × 10-2，椭圆度 ≈ 1000 mdeg）。在固态下，CCOF 表现出强烈的红色荧光 （λem ≈ 645 nm） 和有利的圆偏振发光 （CPL， |glum| = 5.2 × 10-2），标志着第一个仅源自具有稳健固态 CPL 的非手性结构单元的 CCOF。当集成到聚二甲基硅氧烷中时，它会形成柔性和半透明复合膜，适用于基于 CPL 的应用。CCOF 还可用作手性分析物（包括 2-氨基环海宁和二甲基-1,2-环己二胺）的高对映选择性荧光传感器。此外，它表现出可逆的水变色作用，从黄色转变为橙色 （ΔE ≈ 42.7） 和水诱导的手性增强（椭圆度高达 2100 medg，|gabs| = 5.5 × 10-2），通过水吸附时的烯醇-酮互变异构实现了 CCOF 报道的最高基态手性。这种具有固态 CPL 特性的刺激响应 CCOF 为手性功能材料提供了新的见解。