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Correction to “Broadly Applicable Copper(I)-Catalyzed Alkyne Semihydrogenation and Hydrogenation of α,β-Unsaturated Amides Enabled by Bifunctional Iminopyridine Ligands”
Journal of the American Chemical Society ( IF 14.4 ) Pub Date : 2025-06-03 , DOI: 10.1021/jacs.5c07662
Mahadeb Gorai, Jonas H. Franzen, Philipp Rotering, Tobias Rüffer, Fabian Dielmann, Johannes F. Teichert

There were two mistakes in the chemical drawings in Table 2 in the published article. Compound 12o was mistakenly depicted as the 2-substituted pyridine derivative; however, the compound prepared was the 3-pyridine derivative. Furthermore, in compound 12z the methyl ester was mistakenly shown in the 6-position of the lactam, whereas it must be correctly depicted as the regioisomeric compound with the ester in the 3-position. The complete corrected Table 2 is presented below. The correction has no influence on the data or the conclusions of the work. All data in the original Supporting Information documents are correct. All reactions were performed according to the general procedure 2 (GP2, see the Supporting Information for details) with 0.2 mmol of the substrate; isolated yields are given. Conversion was measured by GC/GC-MS and/or 1H NMR analysis. For the (Z)-isomer, 71% of amide 12s was isolated. Gram scale reaction on a 3.4 mmol scale was also performed (75% isolated yield); CCDC: 2415987. Doubly 1,4-reduced product of lactam 11z was obtained. 19% Conversion of 11ab was observed. 29% Conversion of 11ac was observed. Double 1,4-reduced product of enamide 11ah was obtained. 23% Conversion to amide 12ah was observed along with 46% of transesterification product (not isolated). Complete 1,6 and 1,4-reduction of 11ai occurred. Hydrogenation was performed in 0.4 mmol scale. Additional 18% only 1,4-reduced product was isolated (see Supporting Information). Additional 17% only 1,4-reduced product was isolated (see Supporting Information). This article has not yet been cited by other publications.

中文翻译:

更正为“广泛适用的铜 (I) 催化的炔烃半氢化和双功能亚氨基吡啶配体实现的 α,β-不饱和酰胺的加氢反应”

已发表文章表 2 中的化学图有两个错误。化合物 12o 被错误地描述为 2-取代吡啶衍生物;然而,制备的化合物是 3-吡啶衍生物。此外,在化合物 12z 中,甲酯被错误地显示在内酰胺的 6 位,而它必须被正确描述为区域异构化合物,酯位于 3 位。完整的更正表 2 如下所示。更正对数据或工作结论没有影响。原始支持信息文件中的所有数据均正确无误。所有反应均按照一般程序 2(GP2,详见支持信息)使用 0.2 mmol 底物进行;给出了分离的产量。通过 GC/GC-MS 和/或 1H NMR 分析测量转化率。对于 (Z)-异构体,分离出 71% 的酰胺 12s。还进行了 3.4 mmol 规模的革兰级反应(分离产率 75%);CCDC:2415987。获得内酰胺 11z 的双倍 1,4-还原产物。观察到 11ab 的 19% 转化率。观察到 11ac 的 29% 转化率。获得烯酰胺 11ah 的双 1,4-还原产物。观察到 23% 转化为酰胺 12ah 以及 46% 的酯交换产物(未分离)。发生了 11ai 的 1,6 和 1,4 减少。以 0.4 mmol 规模进行氢化。另外 18% 仅分离出 1,4-还原产物(参见支持信息)。另外 17% 仅分离出 1,4-还原产物(参见支持信息)。本文尚未被其他出版物引用。
更新日期:2025-06-04
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