Photoelectrochemical (PEC) sensors have attracted significant attention due to their high sensitivity and rapid response. However, traditional PEC sensors are based on the principle that the target directly or indirectly modulates Faradaic reactions on the photoelectrode surface, making them highly susceptible to interference from complex biological samples. In this study, we employed vacuum filtration

Glutathione (GSH), a pivotal antioxidant, plays a critical role in Parkinson’s disease (PD) pathogenesis, where oxidative stress drives neuronal damage. However, the dynamic changes of GSH in the brain remain poorly understood. Here, we develop a cyclometalated iridium complex (Ir-DO) for GSH monitoring via multiphoton phosphorescence lifetime imaging. Ir-DO exhibits exceptional optical properties

Drug-facilitated crimes (DFC) involve the administration of illicit substances, leaving traces in biological samples within particular period of time. A reliable method for detecting and monitoring illicit drug in biofluids is critical for forensic and clinical applications. Herein, we introduce the hotspot-driven molecular entrapment (HDME) method as highly sensitive strategy for trapping and label-free

Nerve agents pose a significant threat to public health and security, necessitating the development of rapid and highly sensitive detection technologies. Dimethyl methylphosphonate (DMMP), a widely used simulant of sarin, serves as a benchmark for evaluating sensor performance. In this work, we report a single-walled carbon nanotube field-effect transistor (CNTFET) gas sensor fabricated via electrostatic

Accurate diagnosis and effective treatment of primary liver tumors are crucial, and optical imaging is widely used in clinical image-guided surgery. The poor stability of traditional dyes and the non-specific binding of proteins can easily lead to misdiagnosis in qualitative assays. We have developed a protein-actived nano-fluorescent probe, ND-TPE-COOH, to label normal liver cells/tissues safely for

Catecholamines, including dopamine, epinephrine, norepinephrine, L-DOPA, and tyrosine, are considered as neurotransmitters. Since these neurotransmitters play an important role in the nervous system and are considered an indicator for measuring neurological diseases, the separation and simultaneous measurement of these compounds is very important. For this purpose, a nanozyme sensor array based on

Although fluorogenic RNA aptamers can achieve label-free detection by binding to fluorophores, the signal intensity is limited by single target-binding events and still relies on enzymes or complex cascade reactions. In this work, we have developed an enzyme-free fluorogenic RNA amplifier utilizing trans-cleaving aptazymes as the molecule recognition module is designed to detect multiple small molecules

Ribonuclease H (RNase H) is an essential ribonuclease in the human body participating in maintaining genomic stability, including DNA replication, damage response, and self-repair. Considering its medical significance, a digested crRNA switchable CRISPR-Cas13a system was established to provide an ultrasensitive detection method for RNase H activity. Herein, a crRNA/DNA (CD) chimeric duplex probe was

Urinary extracellular vesicles (EVs) have emerged as promising biomarkers for urologic tumors. However, current detection methods often require pre-enrichment steps, and the simultaneous analysis of multiple EV proteins remains challenging. In this study, we introduced an integrated platform that combines EV-imprinted hydrogels with multiple Raman probes to detect surface proteins and diagnose various

Two-dimensional (2D) nanostructured semiconductors with abundant active sites and specific surface area are promising non-precious metal catalysts for flexible electrochemical biosensors. Here, we reported the cost-effective and high-performance strain electrocatalytic uric acid (UA) sensors based on 2D Co3O4 nanosheets prepared by a simple hydrothermal method. The corresponding electrocatalytic efficiencies

Agricultural products from different origins often exhibit variations in quality due to the influence of natural environments. This paper proposes an efficient, nondestructive method for agricultural products traceability based on electronic nose and hyperspectral system. First, given the characteristics of gas and spectral information, an efficient fusion interaction module is introduced to fully

Early warning of mine fires is an important guarantee of safe underground energy extraction. However, the current fire gas monitoring technology is difficult to achieve effective early diagnosis of internal and external causes of fire in the mine as well as comprehensive grading early warning, while the dust in the mine environment will further interfere with and affect the detection accuracy of the

Accurate detection of microRNA concentrations is essential for early cancer diagnosis and monitoring. Existing methods typically provide a linear response within a limited concentration range, which hinders their precise clinical application. This study presents a novel sensing approach using the fluorescence properties of nitrogen vacancy (NV) centers. Magnetic particles capture and enrich fluorescent

A taper-enhanced U-shaped probe-type hybrid fiber optic sensor, integrating surface plasmon resonance (SPR) with Mach-Zehnder interference (MZI) mechanisms, is developed for the concurrent measurement of seawater temperature and salinity. The sensor adopts the SPR-MZI cascade configuration and incorporates a novel fiber optic SPR sensitivity amplification strategy, which introduces a taper into the

Dielectric fluids, including polymers, oils, and organic solvents, are integral to applications such as microreactors, optical devices, and thermal management systems due to their stability and resistance to evaporation. However, precise manipulation of dielectric droplets, especially those with high viscosity, remains challenging due to low surface tension and small contact angles. This study introduces

The detection of circulating tumor cells (CTCs) has emerged as a promising approach for the early diagnosis, therapeutic monitoring, and prognosis of malignant tumors. In this study, we present a novel magnetic nanoparticle (MP) functionalized with dual recognition peptides targeting the epithelial cell adhesion molecule (EpCAM) and human epidermal growth factor receptor 2 (HER2). Additionally, bovine

NO is a major factor in blood pressure regulation, but it is also one of the major sources of air pollution. Currently, WO3 is becoming a promising material for developing low temperature gas sensors. However, due to its relatively low sensitivity and high operating temperature, its performance is not satisfactory, which limits its application. Hydrogen substituted graphyne (HsGY), as a new type of

Foods with high concentration of oxalic acid (OA) are prone to cause kidney stones, calcium loss and other diseases in humans, but all the existing detection methods have the drawbacks of specialized operation and time-consuming. Photoelectrochemical (PEC) sensors are a promising technology to realize the detection of OA in food due to their simple operation, real-time detection and low detection limit

Resistive gas sensors are utilized to identify target gases, particularly those with similar chemical properties, which poses a significant challenge in achieving selectivity. In this study, we fabricated a sensor with an Er-doped SnO2 (S1-xExO2-δ) thin film to investigate the adsorption behavior of O2, CO, and H2 on gas-sensing materials under varying temperatures and atmospheric conditions. This

In the pursuit of advanced sensing technologies, the integration of chipless RFID (Radio Frequency Identification) systems has emerged as a promising solution for various applications, including environmental monitoring and smart packaging. This paper presents a novel high-sensitivity paper-based humidity sensor consisting of an LC resonant structure. The sensor operates at 2.45 GHz and is designed

Hydrogen, as a clean energy source, significantly contributes to the sustainable progression of societal development, while its practical application is presented with substantial technical challenges, particularly in ensuring safe utilization. Therefore, in situ real-time monitoring of hydrogen concentrations has attained paramount importance. Pd/SnO2-based sensors have shown considerable potential

Electrically conductive metal-organic frameworks (EC-MOFs) exhibit significant potential application as sensing materials for chemical resistance gas sensors. Herein, we developed a flexible gas sensor based on Ni3(HITP)2 nanosheets co-functionalized with noble metal nanoparticles (NPs) and WS2 quantum dots (QDs) for NO2 detection at room temperature. The gas sensing performance was regulated by optimizing

The improvement of detection sensitivity and accuracy have been the focus on the development of biosensing analysis. In this work, a dual-function sensing interface with valence transition and antifouling strategies was designed to realize this target. On the one hand, the transition of Cu+/Cu2+ was utilized to catalyze the generation of more SO4•-, thus improving the electrochemiluminescence (ECL)

Hydrogen sulfide(H2S), as a highly toxic gas, is crucial for real-time monitoring of the atmospheric environment, so it is particularly important to prepare sensors with fast response/recovery and low detection limits. In this study, MOF-derived Bi2O3/In2O3 hollow nanotube heterojunctions were developed for ultrasensitive H2S detection. Due to the formation of p-n heterojunctions and abundant oxygen

With the rapid advancements in sensor technology, modern detection systems possess advanced detection capabilities. However, for detection of confusable liquid with similar colors or odors, traditional single-modal detection systems still struggle with poor classification performance. Here, we develop an innovative visual-olfactory bionic sensing system inspired by the signal fusion mechanism of the

The demand for deep learning-based surface-enhanced Raman scattering (SERS) sensing, which requires rapid processing of large datasets, has been increasing. This has highlighted the critical need for uniform hotspot regions with enhanced sensitivity. We assessed the difference between the redox potential of the electrolytes and the Fermi level of the semiconductors. Plasmonic nanoparticles were synthesized

Rapid, convenient and multi-modal lateral flow immunochromatographic assays (LFIAs) are encouraging and preferable in food safety detection. Herein, based on the easily available, photo-heat sensitive natural cuttlefish ink nanoparticles (CINPs) and strongly fluorescent AIE microspheres, a colorimetric/fluorescence/photothermal triple-modal multiplex LFIA was developed for the rapid determination of

CuO is a typical p-type semiconductor with the advantage of narrow bandgap, making it a gas sensing material for detecting CO gas at lower operating temperatures.However, the poor response value limits its application. As a classical wide-band gap n-type gas sensing metal oxide semiconductor, TiO2 has the advantages of high response to CO. However, high operating temperature becomes the big obstacle