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Disrupted spatial but not temporal aspects of nociceptive processing determine painful polyneuropathies. Pain (IF 5.9) Pub Date : 2025-05-23
Wacław M Adamczyk,Nick Berendt,Peter Trillenberg,Janina Hanssen,Jakob Poehlmann,Camilla Kapitza,Luisa Luebke,Kerstin Luedtke,Norbert Brüggemann,Tibor M SzikszayPolyneuropathy remains a diagnostic and clinical challenge, with limited understanding of the mechanisms underlying painful and nonpainful phenotypes. While previous studies have examined various characteristics of these patients, the temporal and spatial dynamics of endogenous pain modulation remains not fully elucidated. In this study, offset analgesia (OA) and spatial summation of pain (SSp) were
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Progression trajectories of chronic overlapping pain conditions unveiled across two large clinical data warehouses. Pain (IF 5.9) Pub Date : 2025-05-23
Haiquan Li,Jungwei W Fan,Edwin Baldwin,Wenting Luo,Jin Zhou,W Michael HootenChronic overlapping pain conditions (COPCs) affect a wide population and incur a substantial disease burden including comorbid mental disorders. Although these comorbidities have been extensively documented, the longitudinal trajectories of their onset, particularly for those with three or more conditions, have been rarely studied. We conducted retrospective cohort studies to identify statistically
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A bad break: mechanisms and assessment of acute and chronic pain after bone fracture. Pain (IF 5.9) Pub Date : 2025-05-21
Haruki Nishimura,Jonathan Layne,Kohei Yamaura,Ralph Marcucio,Kazuhito Morioka,Allan I Basbaum,Jarret A P Weinrich,Chelsea S BahneyPain is one of the primary indicators of a bone fracture and serves both a functional and practical role in guiding recovery. However, fracture pain can persist long after the fracture itself has clinically healed. The neural and molecular mechanisms that drive acute pain postfracture, and how these mechanisms are pathologically usurped to trap patients into persistent, debilitating, and often difficult
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Microneurographic portrait of 19 patients with small fiber neuropathy-A pilot study. Pain (IF 5.9) Pub Date : 2025-05-20
Andrea Beisswanger,Greta Z Peschke,Noortje W M V D Braak,Christina Dumke,Andrea Fiebig,Volker Espenkott,Annette Lischka,Angelika Lampert,Roman Rolke,Maike F Dohrn,Barbara NamerSmall fiber neuropathy (SFN) is defined by dysfunction or degeneration of Aδ and C fibers, causing impaired temperature perception and spontaneous neuropathic pain. We performed microneurography (MNG) to analyze C-nociceptor properties in 19 patients with SFN. C-nociceptors were classified as mechanosensitive or mechano-insensitive, and either "normal," "hyperactive," or "hypoactive." Results were
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Psychosocial mechanisms underlying the transition from acute to chronic postsurgical pain in youth following spinal fusion: a 6-month longitudinal study. Pain (IF 5.9) Pub Date : 2025-05-20
Rui Li,Andrew H Rogers,Ayesha C Sujan,Chuan Zhou,Prishha Thiagarajan,Tonya M Palermo,Zeev N Kain,Jennifer A RabbittsTheoretical and empirical work underscores the role of postsurgical acute pain severity and psychosocial factors in the development of chronic postsurgical pain (CPSP). However, evidence on how psychosocial changes in response to acute pain influence CPSP development in adolescents is limited. In this 6-month longitudinal study, adolescents undergoing spinal fusion were assessed presurgery, monitored
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A longitudinal study of paradoxical heat sensation in 420 individuals. Pain (IF 5.9) Pub Date : 2025-05-20
Ellen L Schaldemose,Peter K Brask-Thomsen,Mustapha Itani,Francesca Fardo,Pall Karlsson,Alexander G Kristensen,Hatice Tankisi,Troels S Jensen,Ralf Baron,Nanna B Finnerup,Sandra S GylfadottirA paradoxical heat sensation (PHS) is the feeling of warmth when the skin is cooled. Paradoxical heat sensation is a pathological sign associated with neuropathy, eg, diabetic polyneuropathy (DPN). The aim of this study was to examine whether specific characteristics in the sensory nervous system are associated with PHS and to evaluate whether PHS is a predictor of thermal sensory loss or neuropathy
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Terminology and definitions of sleep problems and disorders used in chronic musculoskeletal pain research-a scoping review with recommendations for future research. Pain (IF 5.9) Pub Date : 2025-05-20
Nils Runge,Ishtiaq Ahmed,Julya Perea,Céline Labie,Aurore Roland,Zosia Goossens,Olivier Mairesse,Jo Nijs,Anneleen Malfliet,Sabine Verschueren,Dieter Van Assche,Kurt de Vlam,Nicole Tang,Bruno Saconi,Aamir Raoof Memon,Liesbet De BaetsSleep problems and disorders are prevalent in individuals with chronic musculoskeletal pain (CMP). Yet, previous reviews have struggled to draw precise conclusions due to inconsistent terminology and definitions of sleep problems and disorders. This review analyzed 225 studies to map terminology and definitions for sleep problems and disorders in CMP research. The included studies provided 326 definitions
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Expectations and patient outcomes: a framework for intervention development in chronic pain management. Pain (IF 5.9) Pub Date : 2025-05-19
Patrick H Finan,Luana Colloca -
Long-term impact of physiotherapy attendance on rehabilitation of workers with low back pain. Pain (IF 5.9) Pub Date : 2025-06-01
Liangping Zhang,Lei Pan -
The nucleus accumbens-prefrontal connectivity as a predictor of chronic low back pain. Pain (IF 5.9) Pub Date : 2025-05-15
Adam Sunavsky,Muhammad Ali Hashmi,Jason William Robertson,Jennika Veinot,Javeria Ali HashmiThe nucleus accumbens (NAc) and its prefrontal connections are implicated in the aetiology of chronic low back pain (CLBP). Animal and human studies suggest that the NAc and its connections play a critical role in the transition from acute to CLBP. However, whole-brain connectivity in individuals with longstanding CLBP has not been systematically investigated. Using a functional connectomics approach
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Spatial distribution of pain in complex regional pain syndrome. Pain (IF 5.9) Pub Date : 2025-05-15
Peter D Drummond,Mariana Rossen-Abercromby,Annie Quartermaine,Di Ye,Marco Barbero,Philip M FinchPain often spreads away from the injured site in complex regional pain syndrome (CRPS), but what drives this process is unclear. To explore this, pain drawings were investigated in 136 patients in relation to the type and location of injury, pain intensity and quality, CRPS duration, subtypes, and hyperalgesia to thermal and mechanical stimuli. Areas of pain were quantified using the ImageJ polygon
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Relevance of chronic pain related to infection for the ICD-11. Pain (IF 5.9) Pub Date : 2025-05-14
Philipp Niklas Ostermann,Victoria J Madden,Harriet I Kemp,Daniel Ciampi de Andrade -
How to classify patients suffering from chronic pain associated with infectious diseases. Pain (IF 5.9) Pub Date : 2025-05-14
Rolf-Detlef Treede -
Reduced motivation to seek opioid reward in preclinical studies of pain: a commentary on Lueptow et al. Pain (IF 5.9) Pub Date : 2025-05-13
Cristina D Peterson,Carolyn A Fairbanks -
Chronic pain selectively reduces the motivation to work for remifentanil but not food reward. Pain (IF 5.9) Pub Date : 2025-05-13
Lindsay Lueptow,Leeza Shashkova,Emma Twombly,Hugo Greenhill,Hongyan Yang,Anna M W Taylor,Courtney M Cameron,Christopher J Evans,Anne M Andrews,Catherine M CahillCurrently, preclinical research has reported conflicting evidence as to whether chronic pain imparts resilience or vulnerability to opioid drug seeking. Here, we investigated the impact of chronic pain on the intravenous self-administration (IVSA) profile of the short-acting opioid analgesic remifentanil in a mouse model. Using a chronic constriction injury model of chronic neuropathic pain, 7 days
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The association between pain-related cognitive biases and their impact upon task interference by anticipating pain: a virtual reality approach. Pain (IF 5.9) Pub Date : 2025-05-13
Jiaojing Xu,Linda M G Vancleef,Erik Bongaerts,Dimitri M L Van RyckeghemContemporary pain theories postulate that pain-related attention bias (AB) and interpretation bias (IB) uniquely and synergistically impact upon poor pain outcomes. As yet, available research findings are scarce and mixed. The current study aimed to investigate the association between pain-related AB and IB and their impact upon task interference by impending pain. A total of 85 healthy participants
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Mortality among patients with long-term prescription opioid use in Norway: a nationwide registry-based cohort study. Pain (IF 5.9) Pub Date : 2025-05-13
Gabriela Rolová,Anders Engeland,Line Pedersen,Ingvild Odsbu,Aleksi Hamina,Svetlana SkurtveitThe aim was to estimate all-cause and cause-specific mortality in long-term prescription opioid users compared to the general population. This nationwide registry-based cohort study used data of patients aged 15 to 69 years with no previous cancer diagnosis and a recorded episode of long-term opioid analgesics use (anatomical therapeutic chemical [ATC] group N02A; N = 116,006) in Norway between 2011
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Neuropathic pain in diabetic polyneuropathy: a 5-year prospective study. Pain (IF 5.9) Pub Date : 2025-05-13
Peter Kolind Brask-Thomsen,Mustapha Itani,Páll Karlsson,Alexander Gramm Kristensen,Thomas Krøigård,Troels Staehelin Jensen,Hatice Tankisi,Søren Hein Sindrup,Nanna Brix Finnerup,Sandra Sif GylfadottirThere are few prospective studies on neuropathic pain in diabetic polyneuropathy (P-DPN). We aimed to examine the development of P-DPN over time as well as factors associated with both the development of and relief from pain. In this 5-year follow-up study, we included 102 patients with at least probable DPN at baseline, according to the Toronto consensus criteria, recruited from a nationwide Danish
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Melatonin for neuropathic pain: a double-blind, placebo-controlled, randomized, crossover trial. Pain (IF 5.9) Pub Date : 2025-05-13
Ian Gilron,Hala Elkerdawy,Dongsheng Tu,Ronald R Holden,Dwight E Moulin,Scott Duggan,Roumen MilevNeuropathic pain (NP) is a common challenging problem, and there is a growing need to develop safe and effective nonopioid treatments. Sleep disturbance is commonly associated with NP because pain intensity of NP conditions is often worse at night. Some evidence suggests that the pineal hormone, melatonin, may reduce pain in clinical settings. We conducted a clinical trial to evaluate the efficacy
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Opioid dose trajectories and associations with opioid- and nonopioid-related emergency department presentations and hospital admissions. Pain (IF 5.9) Pub Date : 2025-05-12
Ting Xia,Louisa Picco,Bosco Rowland,Grant Russell,Jenni Ilomaki,Nadine Andrew,Samanta Lalic,Rachelle Buchbinder,Dan I Lubman,Suzanne NielsenOpioid deprescribing is a key strategy for reducing opioid-related adverse effects. However, although deprescribing can be associated with clinical benefits, international studies suggest that rapid dose reduction in those on long-term opioids may be associated with poorer outcomes. This study examines the association between different opioid dose trajectories and emergency department presentations
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Neuroanatomy and lesion networks of central poststroke pain. Pain (IF 5.9) Pub Date : 2025-05-09
Hassan A Karoam,Joel Bruss,Katharine Champoux,Marcelo Delboni Lemos,Isabelle Faillenot,Daniel Ciampi de Andrade,Kai Hwang,Emine Bayman,Jatin Vaidya,Evan M Gordon,Daniel Tranel,Joel C Geerling,Aaron D BoesIdentifying lesion sites associated with central poststroke pain (CPSP) may facilitate targeted screening for early symptoms, possibly even paving the way for preventive measures and earlier treatment initiation. Here, we test the hypothesis that damage to a nociceptive pathway extending from the brainstem to the cerebral cortex, and including white matter tracts, is associated with CPSP. We investigated
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Minimum clinically important differences in acute pain: a patient-level re-analysis of randomized controlled analgesic trials submitted to the US Food and Drug Administration. Pain (IF 5.9) Pub Date : 2025-05-09
Christopher J Miller,Warren B Bilker,Ian DeLorey,Charles E Argoff,Russell L Bell,Andrew Conroy,Jennifer S Gewandter,Ian Gilron,Jennifer A Haythornthwaite,Nathaniel P Katz,Tara McWilliams,Katherine N Theken,John T FarrarThe lack of established minimum clinically important differences in acute pain has made it challenging to interpret efficacy in analgesic trials. We performed a patient-level re-analysis of double-blind, placebo-controlled trials submitted to the US Food and Drug Administration to estimate minimum clinically important differences in acute postoperative pain. Trials were categorized by acute surgical
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Effects of acute stress exposure on pain sensitivity: the role of individual stress responsiveness and orientation to pain and stress. Pain (IF 5.9) Pub Date : 2025-05-09
Orna Gera,Karni Ginzburg,Noga Gur,Ruth DefrinAcute stress exposure has been reported to result in stress-induced hypoalgesia (SI-hypo), hyperalgesia (SI-hyper), or no response (SI-NR). The inconsistency may stem from individual variability in acute stress response and/or individual orientation to stress and pain, factors not commonly examined. We aimed to identify patterns of SI-hypo and SI-hyper, their relation to stress responsiveness, and
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Sex-related differences in cannabidiol's antinociceptive efficacy in a trigeminal neuralgia rodent model. Pain (IF 5.9) Pub Date : 2025-05-09
Airam Vivanco-Estela,Sanderson Araujo da Rocha,Daniela Escobar-Espinal,Gabriela Gonçalves Bálico,Robert M Caudle,Francisco S Guimaraes,Elaine Del-Bel,Glauce Crivelaro NascimentoTrigeminal neuralgia (TN) is a severe orofacial pain condition with sex-specific differences in pain responses. Standard treatments offer limited efficacy and significant side effects. We hypothesized that cannabidiol (CBD) alleviates TN-induced allodynia more effectively than carbamazepine in a sex- and dose-dependent manner through neuroimmune mechanisms, including modulation of glia, Fos protein
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Clinical features and functional analysis of novel SCN9A variants causing congenital insensitivity to pain. Pain (IF 5.9) Pub Date : 2025-05-09
Peter Sparber,Nikolai Zernov,Tatiana Markova,Inna Sharkova,Irina Nikishina,Valeria Matkava,Fedor Konovalov,Philipp Sviridov,Victoria Zabnenkova,Oxana Ryzhkova,Olga Shchagina,Vyacheslav Tabakov,Mikhail SkoblovPain perception is a fundamental protective mechanism that enables us to detect noxious stimuli. With a focus on finding treatments for pain, the molecular mechanisms and key players involved in pain perception are currently under intense study. Congenital insensitivity to pain is one of the rarest and most unusual pain disorders. One of the reasons of pure congenital absence of pain are pathogenic
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Postacute COVID-19 syndrome and fibromyalgia syndrome are associated with anti-satellite glial cell IgG serum autoantibodies but only fibromyalgia syndrome serum-IgG is pronociceptive. Pain (IF 5.9) Pub Date : 2025-05-06
Richard J Berwick,Peyman Sahbaie,Grace Kenny,Tian-Zhi Guo,Harvey Neiland,David A Andersson,J David Clark,Patrick Mallon,Andreas GoebelPostacute COVID-19 syndrome (PACS) describes the persistence of symptoms following severe acute respiratory syndrome coronavirus 2 clearance. PACS is sometimes associated with pain and fatigue resembling fibromyalgia syndrome (FMS). Severe FMS has recently been associated with pronociceptive immunoglobulin G (IgG) autoantibodies and anti-satellite glial cell (SGC) IgG autoreactivity, suggesting an
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Exploring the presence of long COVID-like symptoms in patients with chronic pain: a large-scale internet-based cross-sectional study in Japan. Pain (IF 5.9) Pub Date : 2025-05-06
Saki Takaoka,Hanako Saito,Morihiko Kawate,Chisato Tanaka,Yihuan Wu,Shizuko Kosugi,Takashige Yamada,Takahiro Tabuchi,Kenta WakaizumiIndividuals with chronic pain not only endure the direct burden of pain but also experience various symptoms, including sleep disturbances and fatigue, which deteriorate their quality of life. Notably, these symptoms closely resemble those observed in "long COVID," a prolonged health complication that can arise after coronavirus disease 2019 (COVID-19) infection. Because the similarities between chronic
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Application of neurite orientation dispersion and density imaging in characterizing brain microstructural changes in classical trigeminal neuralgia and a comparison between the left and right sides. Pain (IF 5.9) Pub Date : 2025-05-06
Ying Xiong,Wen Shao,Juan Wang,Shaolin Yang,Wenzhen Zhu,Qiang ZhangDiffusion tensor imaging can detect brain white matter changes in classical trigeminal neuralgia (TN). However, it lacks specificity for individual tissue microstructural features, such as neurite density, orientation dispersions, and extracellular edema. Neurite orientation dispersion and density imaging (NODDI), a novel diffusion magnetic resonance imaging (MRI) technique, can provide these distinct
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The bradykinin-1 receptor antagonist fulmetibant in patients with diabetic neuropathic pain: the randomized, crossover, placebo-controlled, double-blind, phase 2a BRADiNP study. Pain (IF 5.9) Pub Date : 2025-05-06
Brigitte Stemper,Stephanie Löwen,Achim Fritsch,Anja Hoffmann,Arnab SarkarThe BRADiNP study was a multicenter, randomized, double-blind, placebo-controlled, 2-treatment complete crossover study evaluating the efficacy and safety of the bradykinin 1 receptor antagonist fulmetibant in patients with diabetic neuropathic pain (DNP) (ClinicalTrials.gov NCT05219812). To be eligible for enrollment, patients had to be adults with type 1 or type 2 diabetes mellitus with painful distal
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White matter microstructural associations with pain experiences in a large community sample of youth. Pain (IF 5.9) Pub Date : 2025-05-02
Scott A Jones,Carmen I Bango,Sara Shao,Dani Y Del Rubin,Arturo Lopez Flores,Bonnie J Nagel,Amy L Holley,Anna C WilsonPain experiences in adolescence are increasing and represent a major public health concern. However, little is known about the neurobiological phenotype of pain experiences in adolescents, particularly outside of a clinical setting. A better neurobiological understanding of pain experiences in community youth may shed light on potential vulnerabilities present before clinical diagnoses of chronic pain
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A glutamatergic brain neural circuit is critical for modulating trigeminal neuropathic pain. Pain (IF 5.9) Pub Date : 2025-05-01
Sufang Liu,Joshua Crawford,Hui Maltezos,Yanjun Sun,Ran Tao,Feng TaoTrigeminal neuropathic pain is a predominant symptom in patients with trigeminal neuralgia. However, the underlying neural circuit mechanism is still elusive. In this study, we investigated the role of a brain neural circuit in the modulation of trigeminal neuropathic pain. We used "Targeted Recombination in Active Populations" to identify activated neurons in brain structures. Anterograde and retrograde
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Predicting placebo analgesia responses in clinical trials: where to look next? A meta-analysis of individual patient data. Pain (IF 5.9) Pub Date : 2025-04-30
Sigrid Juhl Lunde,Lene Vase,Kathryn T Hall,Karin Meissner,David Hohenschurz-Schmidt,Ted J Kaptchuk,Christoph Maier,Jan VollertEstimating the magnitude of placebo responses across pharmacological and nonpharmacological trials is important for understanding their influence on trial outcomes. Yet, the extent to which more intense placebo interventions like sham acupuncture yield larger analgesic responses than placebo pills, and the factors predicting these responses, remain unclear. This meta-analysis investigated the magnitude
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Unraveling the puzzle of pain in pancreatic diseases. Pain (IF 5.9) Pub Date : 2025-04-29
Asbjørn Mohr Drewes -
Can quantitative sensory testing predict treatment outcomes in hip and knee osteoarthritis? A systematic review and meta-analysis of individual participant data. Pain (IF 5.9) Pub Date : 2025-04-29
Myles C Murphy,Andrea B Mosler,Ebonie K Rio,Molly Coventry,Isaac Selva Raj,Paola T Chivers,Lars Arendt-Nielsen,Fabio Marcon Alfieri,Martin F Bjurström,Dennis Boye Larsen,Wei-Ju Chang,Anne Estrup Olesen,Emma Hertel,Paetur Mikal Holm,Thomas Graven-Nielsen,Cid André Fidelis de Paula Gomes,Marius Henriksen,N Jennifer Klinedinst,Jerin Mathew,Asbjørn Mohr Drewes,Guilherme S Nunes,Helen O'Leary,Håvard ØsteråsAn individual participant data (IPD) meta-analysis can assess the predictive value of data on outcomes at the individual level, offering a potential tool for developing personalized pain management. Pretreatment quantitative sensory testing (QST) may stratify patient groups, which are then linked to treatment outcomes. Our objective was to determine if measures of QST at baseline are related to treatment
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Neuronal STING-GAT1 signaling maintains paclitaxel-induced neuropathic pain in the spinal cord. Pain (IF 5.9) Pub Date : 2025-04-29
Thuy Linh Pham,Ramesh Sharma,Chiranjivi Neupane,Feifei Gao,Guang-Ho Cha,Hyunjin Kim,Min-Ho Nam,Seung Eun Lee,Sunjung Yang,Hunju Sim,Sanghoon Lee,Gang Min Hur,Hyun-Woo Kim,Jin Bong ParkStimulator of interferon genes (STING), a pivotal immune regulator, has emerged as a contributor to nociception, yet its role in chronic pains remains still unknown. Here, we demonstrate that STING plays a dual role in normal and neuropathic pain in mature male rodents. Stimulator of interferon genes maintains type I interferon (IFN-I) level restraining pain sensitivity in normal and sham control,
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cGMP-dependent protein kinase I in the dorsal hippocampus protects against synaptic plasticity and cognitive deficit induced by chronic pain. Pain (IF 5.9) Pub Date : 2025-04-29
Xing-Xing Zheng,Fei Wang,Hui Ding,Hai-Tao Li,Xin-Jiang Yang,Xiang-Chen Li,Zhi-Wei Dou,Wen-Chao Hu,Wen-Juan Han,Zhen-Zhen Li,Ying-Chun Li,Wen-Guang Chu,Hua Yuan,Sheng-Xi Wu,Rou-Gang Xie,Ceng LuoPatients with chronic pain often experience an exacerbated pain response and complain of memory deficits. However, the mechanistic link between pain and cognitive function remains unclear. The dorsal hippocampus (dHPC), a well-defined region responsible for learning and memory, displays maladaptive plasticity upon injury, which involves the activation of N-methyl-d-aspartic acid receptors. Mounting
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Multimodal hypersensitivity and somatic symptoms predict adolescent postmenarchal widespread pain. Pain (IF 5.9) Pub Date : 2025-04-29
Natalie R Osborne,Kevin M Hellman,Emily M Burda,Sarah E Darnell,Lavisha Singh,Andrew D Schrepf,Lynn S Walker,Frank F TuWidespread pain in adolescence is linked with poor mental health, pain, and somatic symptoms in childhood. This prospective study in 207 premenarchal adolescents used quantitative sensory testing (QST) and multimodal hypersensitivity (MMH) measures to assess somatosensory system function and identify predictors for widespread pain (≥3/7 sites). We hypothesized that premenarchal pain, somatic symptoms
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Functional signatures of human somatosensory C fibers by microneurography. Pain (IF 5.9) Pub Date : 2025-04-28
Barbara Namer,Angelika LampertMicroneurography allows the recording of single C-fiber action potentials of a peripheral nerve innervating the skin in the awake, conscious human. The method is highly relevant to assess and understand the function of human peripheral nociceptors and correlate nociceptor discharges to human sensation. Given the current translational gap between preclinical and clinical research, in-depth understanding
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A multivariate statistical index, the fibromyalgia analog model, identifies Dahl S rats as a model of fibromyalgia with improved face validity. Pain (IF 5.9) Pub Date : 2025-04-25
Luiz F Ferrari,Ashley Wilkinson,Gary W Donaldson,Jincheng Shen,Anna Ramirez,Charles Rey,Christian Cahoon,Dashiell Miner,Akiko Okifuji,Norman E TaylorFibromyalgia syndrome (FMS) is clinically diagnosed using a widespread pain index and symptom severity scores. Despite this, multivariate statistical models using clinical data consistently suggest the presence of single overarching factor that can capture much of the variation across a spectrum of biomarkers for FMS, potentially aiding diagnosis. We hypothesized that a comparable single index could
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Dopaminergic modulation: revisiting a promising novel pathway for pharmacologic treatment of chronic pain. Pain (IF 5.9) Pub Date : 2025-04-25
Paul Geha,Aron Sulovari,Roy Freeman,Jennifer S Gewandter -
CRMP2 phosphorylation regulates polarization and spinal infiltration of CD4+ T lymphocytes, inhibits spinal glial activation, and arthritic pain. Pain (IF 5.9) Pub Date : 2025-04-22
Yue-Peng Jiang,Jun-Jun Wen,Xiao Ma,Cun-Rui Yuan,Feng Zhou,Meng-Jia Zheng,Xin Tang,Xi-Kang Yu,Wei-Dong Lai,Yi-Han Zhou,Wen-Hua Yu,Wen-Ting You,Yan Jin,Ki Duk Park,Rajesh Khanna,Cheng-Ping Wen,Jie YuChronic pain, a hallmark symptom of rheumatoid arthritis (RA), is strongly linked to central sensitization driven by spinal glial cell activation. Despite its clinical significance, the precise mechanisms remain unclear. Recent findings highlight the crucial role of interactions between circulating monocytes and central nervous system glial cells in chronic pain associated with autoimmune conditions
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Enhancing precision in pain management for inflammatory arthritis: exploring the potential role of lidocaine in pain mechanism differentiation. Pain (IF 5.9) Pub Date : 2025-05-01
Jianguo Zhang,Hongwei Jiao -
Preclinical and clinical evaluation of a novel TRPA1 antagonist LY3526318. Pain (IF 5.9) Pub Date : 2025-04-18
Lisa M Broad,Jeffrey G Suico,P Kellie Turner,Si Nie,Kirk W Johnson,Helen E Sanger,Lindsay A Wegiel,David C Sperry,David Remick,Magdalene Moran,Sam Malekiani,Donato Del Camino,Xinyuan Wu,Jayhong A Chong,Nathaniel T Blair,August V WilkeThe transient receptor potential cation channel member A1 (TRPA1) is heavily implicated in nociceptive signaling in both physiological and pathological pain states. However, it has been challenging to develop TRPA1 antagonists with appropriate properties to advance into clinical development. Herein, we describe the preclinical characterization and early clinical development of LY3526318, a potent,
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Interpretation bias and its relationship with pain: a systematic review and meta-analysis. Pain (IF 5.9) Pub Date : 2025-04-17
Jemma Todd,Brydee Pickup,Daelin Coutts-Bain,Marloes Duijzings,Louise SharpeThe aim of this review was to systematically review and meta-analyse evidence for the presence of interpretation bias in pain and to establish the likely role of interpretation bias in chronic pain. The primary questions were whether people experiencing pain showed a greater interpretation bias than people without pain and whether interpretation bias was associated with pain outcomes. We were also
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Beyond the ambiguity of interpretation bias for pain-related information. Pain (IF 5.9) Pub Date : 2025-04-16
Dimitri M L Van Ryckeghem,Justine Mac Goris -
Developing consensus on the most important equity-relevant items to include in pain research: a modified e-Delphi study. Pain (IF 5.9) Pub Date : 2025-04-16
Emma L Karran,Aidan G Cashin,Trevor Barker,Mark A Boyd,Alessandro Chiarotto,Lara J Maxwell,Vina Mohabir,Saurab Sharma,Peter Tugwell,G Lorimer MoseleyThere is increasing recognition of the need for routine measurement and reporting of data that can reveal social factors that contribute to health inequities for people with pain. Prioritising what data to collect and understanding how to collect it can be challenging, and no clear guidance exists. We conducted a 3-round Delphi study to develop consensus on the most important items to include in a
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Forebrain networks driving brainstem pain modulatory circuits during nocebo hyperalgesia in healthy humans. Pain (IF 5.9) Pub Date : 2025-04-15
Lewis S Crawford,Sora Yang,Noemi Meylakh,Leana Sattarov,Alister Ramachandran,Vaughan G Macefield,Kevin A Keay,Luke A HendersonPrior experiences, conditioning cues, and expectations of improvement are essential for nocebo hyperalgesia expression. The neural circuits that communicate with brainstem pain modulatory nuclei during nocebo hyperalgesia responsivity are underexplored. In this study, we employed a classical conditioning and expectation model in 25 healthy human participants and measured brain activity using ultra-high
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Investigating the potential of minocycline in reducing brain inflammation in chronic low back pain: a randomized, placebo-controlled mechanistic clinical trial. Pain (IF 5.9) Pub Date : 2025-04-09
Mehrbod Mohammadian,Erin J Morrissey,Paulina C Knight,Ludovica Brusaferri,Minhae Kim,Nikolaos Efthimiou,Jennifer P Murphy,Zeynab Alshelh,Grace Grmek,Jack H Schnieders,Courtney A Chane,Angelica Sandström,Ciprian Catana,Jodi M Gilman,Joseph J Locascio,Robert R Edwards,Yi Zhang,Vitaly Napadow,Marco L LoggiaOur group has shown that translocator protein (TSPO) levels, a putative marker of neuroinflammation, are increased in the brain and spinal cord of patients with chronic low back pain (cLBP). Whether neuroinflammation might be a therapeutic target for this condition is unknown. In this phase II double-blind, placebo-controlled, randomized clinical trial, we sought to evaluate whether the tetracycline
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Somatosensory profiling to differentiate distinct painful diseases of the pancreas-a quantitative sensory testing case-control study. Pain (IF 5.9) Pub Date : 2025-04-04
Philipp Göltl,Paul Merz,Alexander Schneider,Matthias P Ebert,Michael Hirth,Walter MagerlMechanisms of pancreatic pain are insufficiently understood, and quantitative sensory testing (QST) may help to identify the underlying mechanisms. Accordingly, this study assessed comprehensive somatosensory profiles encompassing nociceptive and nonnociceptive parameters in 70 patients with distinct pancreatic diseases, namely acute (n = 23), chronic (n = 20), or autoimmune pancreatitis (n = 10) and
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Ribosome profiling reveals that post-transcriptional control of Nalf1 by heterogeneous nuclear ribonucleoprotein L is required for paclitaxel-induced neuropathic pain. Pain (IF 5.9) Pub Date : 2025-04-02
June Bryan de la Peña,Guadalupe García,Zachary T CampbellSensory neurons are integral to the genesis and maintenance of neuropathic pain. The molecular mechanisms that mediate long-lived changes in their excitability are unclear. Here, we leverage functional genomics approaches to survey changes in RNA abundance and translation in dorsal root ganglion neurons from a mouse model of paclitaxel-induced neuropathic pain. We focus specifically on females as paclitaxel
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Differences in the clinical presentation of chronic whiplash-associated disorders and nontraumatic neck pain: a systematic review and meta-analysis. Pain (IF 5.9) Pub Date : 2025-04-01
Junze Chen,Scott F Farrell,Wanyun Irene Huang,Barbara Cagnie,Carlos Murillo,Michele SterlingHealth outcomes may be worse for individuals with whiplash-associated disorders (WAD) compared to nontraumatic neck pain (NTNP), and clinical characteristics may differ. This systematic review examined evidence comparing WAD and NTNP in terms of pain, disability, psychological status, quality of life, measures of nociceptive processing, movement, sensorimotor, and muscle function. Studies were identified
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A revisit of soreness and acidosis-related pain. Pain (IF 5.9) Pub Date : 2025-04-01
I-Wen Su,Chih-Hsien Hung,Jiann-Her Lin,Chih-Cheng Chen -
Effects of sleep and circadian rest-activity rhythms on daily pain severity in women with temporomandibular disorders. Pain (IF 5.9) Pub Date : 2025-03-28
Chung Jung Mun,Siny Tsang,Matthew J Reid,Howard Tennen,Jennifer A Haythornthwaite,Patrick H Finan,Michael T SmithAlthough a robust connection between sleep and pain is established, the extent to which circadian rest-activity rhythms contribute toward unique variations in pain, beyond what is elucidated by sleep, remains uncertain. Furthermore, it is largely unknown whether sleep and circadian rest-activity rhythms have interactive effects on daily pain severity. Using wrist actigraphy and daily pain diaries,
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What you don't know can hurt others. A systematic review on calibration of stimulus intensity in pain research. Pain (IF 5.9) Pub Date : 2025-03-27
Julia Badzińska,Magdalena Żegleń,Łukasz Kryst,Przemysław BąbelCalibration of pain stimuli is critical in experimental pain research because it makes it possible to adjust stimulus intensity to match individual pain sensitivity. Despite its importance, precise descriptions of calibration procedures are lacking in the literature, thus hindering the ability to replicate studies. The aim of this systematic review is to fill this gap by evaluating and categorizing
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Is a career in science still viable for emerging scholars in pain and health equity? Pain (IF 5.9) Pub Date : 2025-03-20
Troy C Dildine -
Impacts of opioid stewardship in surgical settings: a scoping review. Pain (IF 5.9) Pub Date : 2025-03-20
Dereje Zewdu Assefa,Ting Xia,Yonas Getaye Tefera,Monica Jung,Suzanne NielsenOpioid stewardship programs have been implemented in many countries to reduce harms related to prescription opioid use. Yet, there is an evidence gap on the impact of these programs in surgical settings. This systematic scoping review aimed to examine the impact of opioid stewardship on opioid use and clinical outcomes, alongside assessing adherence, and barriers to its implementation in surgical settings
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Validation of ICD-11 chronic pain severity specifiers for children and adolescents: an important step forward. Pain (IF 5.9) Pub Date : 2025-03-20
Laura E Simons -
Differential pain perception among females with or without nonspecific chronic low back pain and comorbid insomnia: a quantitative sensory testing analysis. Pain (IF 5.9) Pub Date : 2025-03-20
Jeremy R Chang,Rachel L C Kwan,Eliza R Sun,Shirley X Li,Ping Liang,Jae Q J Liu,Daniel K Y Zheng,Zhixing Zhou,Frank F Huang,Dino Samartzis,Siu Ngor Fu,Arnold Y L WongSleep disturbance is a prevalent condition in individuals with chronic low back pain (CLBP). Despite a strong association between the 2 conditions, the potential mechanisms underlying the role of sleep disturbance in CLBP remain unclear. This case-control study aimed to examine pain perception among females with or without nonspecific CLBP and comorbid insomnia. One hundred females were recruited (mean
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Spontaneous pain dynamics characterized by stochasticity in neural recordings of awake humans with chronic pain. Pain (IF 5.9) Pub Date : 2025-03-20
Jihye Ryu,Jonathan C Kao,Ausaf BariChronic pain is characterized by spontaneous fluctuations in pain intensity, a phenomenon that remains poorly understood. The aim of this study is to elucidate the neural mechanisms underlying pain fluctuations in patients with chronic pain undergoing deep brain stimulation surgery. We recorded local field potentials (LFPs) from pain-processing hub structures, including the ventral posteromedial nucleus
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The precarious use of group data to understand individual processes in pain science. Pain (IF 5.9) Pub Date : 2025-03-19
Johan W S Vlaeyen,Christopher Milde