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Genomics of host–microbiome interactions in humans Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-06-04
Pamela Ferretti, Kelsey Johnson, Sambhawa Priya, Ran Blekhman -
Searching for the origin of human brain tumours Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-05-28
Delilah Hendriks, Benedetta ArtegianiIn this Journal Club, Delilah Hendriks and Benedetta Artegiani recall a 2018 paper by Lee et al. that combined data from human patients and experimental model systems to reveal the complexities of how brain tumours originate.
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High-resolution imaging of RNA and proteins in thick tissues using cycleHCR Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-05-28
Jun Kim, Zhe J. Liu -
CROWN-seq reveals m6Am landscapes and transcription start site diversity Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-05-28
Jianheng Fox Liu -
A crossroads in the timeline of human evolution Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-05-22
Diyendo MassilaniIn this Journal Club, Diyendo Massilani recalls two studies by Meyer et al. that reported a mitochondrial genome and nuclear DNA sequences from mid-Ice Age Sima de los Huesos hominins.
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RNA splicing — a central layer of gene regulation Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-05-21
Technological and computational advances in recent years, from cryo-electron microscopy to sequencing technologies and machine learning, have substantially deepened our understanding of RNA splicing. Nature Reviews Genetics and Nature Reviews Molecular Cell Biology present an online collection that showcases the biological insights facilitated by these advances. Technological and computational advances
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Investigating spatial gene circuits and gene–phenotype mechanisms with Perturb-FISH Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-05-20
Loïc Binan -
Functional synonymous mutations and their evolutionary consequences Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-05-20
Jianzhi Zhang, Wenfeng Qian -
SLAM-RT&Tag: spatiotemporal profiling of RNA within nuclear compartments in situ Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-05-19
Nadiya Khyzha -
Methodological opportunities in genomic data analysis to advance health equity Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-05-15
Brieuc Lehmann, Leandra Bräuninger, Yoonsu Cho, Fabian Falck, Smera Jayadeva, Michael Katell, Thuy Nguyen, Antonella Perini, Sam Tallman, Maxine Mackintosh, Matt Silver, Karoline Kuchenbäcker, David Leslie, Nilanjan Chatterjee, Chris Holmes -
Cell-type deconvolution methods for spatial transcriptomics Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-05-14
Lucie C. Gaspard-Boulinc, Luca Gortana, Thomas Walter, Emmanuel Barillot, Florence M. G. Cavalli -
Predicting gene expression from DNA sequence using deep learning models Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-05-13
Lucía Barbadilla-Martínez, Noud Klaassen, Bas van Steensel, Jeroen de Ridder -
Simultaneous single-cell sequencing of RNA and DNA at scale with DEFND-seq Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-05-12
Timothy R. Olsen -
X-linked competition — implications for human development and disease Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-05-12
Philip M. Boone, Teresa Buenaventura, James W. D. King, Matthias Merkenschlager -
Genomics of schizophrenia, bipolar disorder and major depressive disorder Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-05-12
Michael J. Owen, Nicholas J. Bray, James T. R. Walters, Michael C. O’Donovan -
One but not the same — the many genomes of the brain Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-05-09
Tracy A. BedrosianIn this Journal Club, Tracy Bedrosian describes a 2001 paper by Rehen et al. that provided early evidence of pervasive somatic variation throughout the human brain.
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An uneasy truce between population health and the gene pools within our bodies Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-05-07
Kelley HarrisIn this Journal Club, Kelley Harris recalls a 2003 paper by Goriely et al. that identified interesting evolutionary forces acting on mutations that are beneficial for cells within our bodies but detrimental to the health of our children.
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Understanding the logic and grammar of cis-regulatory elements Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-05-07
Juan I. Fuxman BassIn this Journal Club, Juan Fuxman Bass reflects on two papers, by Melnikov et al. and Patwardhan et al., that transformed the field of regulatory genomics by devising methods to study thousands of cis-regulatory elements simultaneously.
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Revealing secrets of human genetic variation with population databases Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-05-02
Nicole J. LakeIn this Journal Club, Nicole Lake recalls a 2016 paper by Lek et al., as part of the Exome Aggregation Consortium, that presented a foundational population database for researchers and clinicians.
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TACIT and CoTACIT for histone modification profiling in single cells and lineage tracing Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-04-30
Min Liu, Aibin He -
Advances in single-cell DNA sequencing enable insights into human somatic mosaicism Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-04-25
Diane D. Shao, Andrea J. Kriz, Daniel A. Snellings, Zinan Zhou, Yifan Zhao, Liz Enyenihi, Christopher Walsh -
Emerging roles of transcriptional condensates as temporal signal integrators Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-04-16
Kirstin Meyer, Bo Huang, Orion D. Weiner -
SHOX value: the pseudoautosomal gene underlying short stature in Turner syndrome Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-04-14
Adrianna K. San RomanIn this Journal Club, Adrianna San Roman describes a 1997 study by Rao et al. that exemplifies how thorough measuring of genotypes and phenotypes in a variable human cohort is instrumental to identifying the genetic basis of clinical phenotypes.
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Leveraging genetics to understand ADAR1-mediated RNA editing in health and disease Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-04-14
Jin Billy Li, Carl R. Walkley -
A tour de force of ancient DNA analysis Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-04-11
Ian BarnesIan Barnes discusses how a seminal paper by Krings et al. invoked renewed interest in the field of ancient DNA, inspiring both researchers and the wider public.
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The regulation and function of post-transcriptional RNA splicing Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-04-11
Karine Choquet, Ines L. Patop, L. Stirling Churchman -
The genetic basis of human height Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-04-07
Louise S. Bicknell, Joel N. Hirschhorn, Ravi Savarirayan -
Epigenome dynamics in early mammalian embryogenesis Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-04-03
Adam Burton, Maria-Elena Torres-Padilla -
Reactivation of retrotransposable elements is associated with environmental stress and ageing Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-04-02
Francesco Della Valle, Pradeep Reddy, Alain Aguirre Vazquez, Juan Carlos Izpisua Belmonte -
Computational analysis of DNA methylation from long-read sequencing Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-03-28
Yilei Fu, Winston Timp, Fritz J. Sedlazeck -
Transcriptomics in the era of long-read sequencing Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-03-28
Carolina Monzó, Tianyuan Liu, Ana Conesa -
The genesis of paleogenetics Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-03-27
Maanasa RaghavanIn this Journal Club, Maanasa Raghavan recalls a 1984 paper by Higuchi et al. that demonstrated how sequencing ancient DNA provides unique evolutionary insights.
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From genome to drug: the hidden story of diversity Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-03-20
Minoli PereraIn this Journal Club, Minoli Perera reflects on a 2005 sequencing study by Cohen et al., who discovered two common loss-of-function mutations with large effects on plasma cholesterol levels thanks to the inclusion of African American study participants.
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Challenges and solutions to the sustainability of gene and cell therapies Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-03-10
Celeste Scotti, Alessandro Aiuti, Luigi NaldiniThe promise of gene and cell therapy has become a clinical reality for several devastating diseases. However, major hurdles constrain their economic sustainability and endanger their survival on the drug market, especially those for rare diseases, which calls for innovative solutions. Despite their immense potential, gene and cell therapies that target rare diseases are at risk of market withdrawal
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Integrating model systems and genomic insights to decipher mechanisms of cancer metastasis Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-03-10
Michelle M. Leung, Charles Swanton, Nicholas McGranahan -
Adapting systems biology to address the complexity of human disease in the single-cell era Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-03-10
David S. Fischer, Martin A. Villanueva, Peter S. Winter, Alex K. Shalek -
Beyond the black box with biologically informed neural networks Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-03-04
David A. Selby, Maximilian Sprang, Jan Ewald, Sebastian J. Vollmer -
Progress in understanding the vertebrate segmentation clock Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-03-04
Akihiro Isomura, Ryoichiro Kageyama -
Tracking protein binding to cis-regulatory elements with PRINT Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-02-21
Yan Hu -
Decoding cell–cell communication using spatial transcriptomics Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-02-21
Ankit Agrawal -
Intrinsically disordered regions as facilitators of the transcription factor target search Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-02-21
Felix Jonas, Yoav Navon, Naama Barkai -
Genomic data sharing: you don’t know what you’ve got (till it’s gone) Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-02-12
Kathryn E. Holt, Michael InouyeGenomics research has thrived under a culture of data sharing, formalized during the genome-project era. As the field’s complexity has increased to the population scale this culture risks being eroded, yet the core principles still apply. The community would benefit from more open discussion and consensus-building around biological data sharing, recognizing that the answer will shape what the practice
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Spatial miRNomics: towards the integration of microRNAs in spatial biology Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-02-06
Agustín Robles-Remacho, Mats NilssonSpatial transcriptomics tools enable the detection and localization of hundreds to thousands of transcripts in biological tissues. However, most technologies are not designed to detect microRNAs. Existing technologies should be expanded to incorporate these key molecular regulators and enable more-comprehensive transcriptomic studies that will shape the new field of spatial miRNomics. In this Comment
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Integrating ELSI study teams in paediatric genomic research efforts Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-02-03
Raquel G. Hernandez, Simoné Guambaña, Melissa W. VonDran, Patrick M. Van Hoose, Thomas J. Bell, Melissa A. FaithAddressing ethical, legal and social implications (ELSI) in genomics requires early integration of specialized teams to enhance community engagement, address disparities and promote health equity. Lessons learnt from the human Developmental Genotype-Tissue Expression (dGTEx) project show how implementing a collaborative framework can support genomic discovery. The promise of paediatric genomics depends
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The early days of transcriptome sequencing and functional genomics Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-01-28
Ayako SuzukiAyako Suzuki recalls two papers published in the early 2000s by the Functional Annotation of the Mammalian Genome (FANTOM) consortium and the Full-Length Long Japan (FLJ) project, which provided reference catalogues of full-length transcripts in mice and humans, respectively.
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Spatial metabolomics to unravel cellular metabolism Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-01-28
Arafath K. Najumudeen, Johan Vande Voorde -
The hidden diversity of tumours Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-01-27
Mariana BoroniIn this Journal Club, Mariana Boroni recalls a 2012 study by Gerlinger et al. that revealed the complex and branched evolution of cancer and challenged the prevailing view of linear tumour progression.
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Cytoplasmic mRNA decay and quality control machineries in eukaryotes Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-01-27
Megan E. Dowdle, Jens Lykke-Andersen -
Diversity and consequences of structural variation in the human genome Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-01-21
Ryan L. Collins, Michael E. Talkowski -
Profiling the total transcriptome of single nuclei in archived samples with snRandom-seq Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-01-17
Ziye Xu, Yongcheng Wang -
Indirect recognition of pathogen virulence proteins to activate plant immune receptors Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-01-15
Xiu-Fang XinXiu-Fang Xin recalls several papers that described one of the most influential and widely accepted examples of indirect activation of nucleotide-binding, leucine-rich repeat receptors in plants.
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Epigenetic ageing clocks: statistical methods and emerging computational challenges Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-01-13
Andrew E. Teschendorff, Steve Horvath -
The therapeutic potential of circular RNAs Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-01-09
Eoghan O’Leary, Yanyi Jiang, Lasse S. Kristensen, Thomas B. Hansen, Jørgen Kjems -
Epigenetics and individuality: from concepts to causality across timescales Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-01-09
Amy K. Webster, Patrick C. Phillips -
A phylogenetic approach to comparative genomics Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-01-08
Anna E. Dewar, Laurence. J. Belcher, Stuart A. West -
The effects of loss of Y chromosome on male health Nat. Rev. Genet. (IF 39.1) Pub Date : 2025-01-02
Bozena Bruhn-Olszewska, Ellen Markljung, Edyta Rychlicka-Buniowska, Daniil Sarkisyan, Natalia Filipowicz, Jan P. Dumanski -
Gene therapy for deafness: we can do more Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-12-18
Yuxin Chen, Jiake Zhong, Yilai ShuChallenges in the development of treatments for hereditary hearing loss include the exploration of the underlying pathological mechanisms, the comprehensive evaluation of safety and efficacy of gene therapies in clinical trials, the optimization of surgical approaches for drug delivery, and effective collaboration between industry and academia. Gene therapy for congenital deafness has made a breakthrough
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Genomic landscape of cancer in racially and ethnically diverse populations Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-11-28
Claire E. Thomas, Ulrike Peters -
The maternal-to-zygotic transition: reprogramming of the cytoplasm and nucleus Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-11-25
Mina L. Kojima, Caroline Hoppe, Antonio J. Giraldez -
The lives of cells, recorded Nat. Rev. Genet. (IF 39.1) Pub Date : 2024-11-25
Amjad Askary, Wei Chen, Junhong Choi, Lucia Y. Du, Michael B. Elowitz, James A. Gagnon, Alexander F. Schier, Sophie Seidel, Jay Shendure, Tanja Stadler, Martin Tran
更新日期：2024-11-25
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