BACKGROUND Traditionally, hospital perinatal quality and rankings have been based on cesarean rates among nulliparous, term, singleton, vertex (NTSV) patients, and recently added unexpected term newborn complication rates as a separate outcome category. The drawbacks of this methodology are two-fold: first, maternal complications are not considered and second, the maternal-newborn outcomes, which may

BACKGROUND Small for Gestational Age (SGA) is a complex perinatal syndrome associated with increased neonatal morbidity, mortality, and impaired childhood growth and neurodevelopment. Current classifications rely primarily on birth weight, which does not capture the heterogeneity of the condition nor predict long-term health outcomes. Here we aim to identify and characterise distinct SGA sub-groups

BACKGROUND Recent evidence from the Chronic Hypertension and Pregnancy (CHAP) trial demonstrates that treatment of even mild chronic hypertension during pregnancy reduces the risk of severe adverse maternal, fetal, and neonatal outcomes. Black patients are disproportionately affected by hypertension-related morbidity during pregnancy. Outside of pregnancy, substantial racial and ethnic differences

BACKGROUND In monochorionic pregnancies, elevated middle cerebral artery (MCA) peak systolic velocity (PSV) in one twin is a key marker of fetal anemia, notably in TAPS, but may also occur spontaneously in sIUGR, owing to brain-sparing mechanisms or in the context of TTTS particularly following laser therapy. Distinguishing between these etiologies remains challenging, complicating clinical management

BACKGROUND Medical termination of pregnancy (using mifepristone and misoprostol) is a commonly performed health intervention. High quality cohort studies are warranted to investigate the association of second-trimester medical termination of pregnancy and subsequent pregnancy outcomes. OBJECTIVE This study aims to assess the risk of subsequent spontaneous preterm birth following second trimester medical

Cervical excision via cold knife conization is recommended in circumstances such as adenocarcinoma-in-situ or predominantly endocervical high-grade dysplasia. A successful cold knife conization involves visualization, targeting of the pathology, obtaining an unfragmented specimen, and consideration of post-excision endocervical curettage. This video demonstrates cold knife conization techniques to

OBJECTIVE The routine recommendation for detecting monogenic disease in fetuses with increased nuchal translucency (NT) remains controversial. This study aimed to evaluate the clinical significance and optimal strategy of whole exome sequencing (WES) in fetuses with increased NT. STUDY DESIGN This retrospective study included pregnancies that underwent amniocentesis due to advanced maternal age, positive

OBJECTIVE To evaluate the diagnostic accuracy of cfDNA in identifying fetal RBC antigen genotypes. DATA SOURCES A comprehensive systematic search was conducted across three databases between 2000 and 2024. STUDY ELIGIBILITY CRITERIA We included cohort studies utilizing cfDNA for fetal RBC antigen detection in pregnancies at risk of or with red cell alloimmunization. Two reviewers independently assessed

Nonimmune hydrops fetalis is well understood to be heterogenous and the common endpoint of many genetic diseases. However, less is known about the prevalence and presenting features of genetic diseases that underlie other types of fetal effusions such as single effusions, leaving uncertainty in clinical practice about optimal approaches to testing and counseling for these pregnancies. We aimed to determine

The proportion of term hypoxic-ischemic encephalopathy arising during intrapartum fetal surveillance remains unclear. Moreover, recent Cochrane review and other studies emphasized the need for research on the impact of admission cardiotocography and highlighted the necessity for a definition of “avoidable perinatal brain injury”.

Access to abortion has changed dramatically in the United States in recent years, both at the federal and state level. For nearly 50 years, the right to abortion was considered a federally protected right under the Roev. Wade (1973) recognition of privacy rights under the 14th Amendment. In September 2021, Texas passed State Bill 8 which implemented a 6-week restriction on access to abortion. The following

BACKGROUND Current evidence indicates that administration of vaginal progesterone to women with a twin gestation and a short cervix reduces the risk of preterm birth occurring at early gestational ages and of neonatal morbidity and mortality. However, the potential long-term effects of prenatal administration of vaginal progesterone for preventing preterm birth on the psychopathological and cognitive

OBJECTIVE Understanding the rates and timing of postpartum complications can facilitate timely screening and management to reduce preventable morbidity and mortality. The aim of this study was to summarize the frequency (prevalence or incidence) and timing of complications from hospital delivery to one year postpartum in the United States and Canada. DATA SOURCES PubMed MEDLINE, Web of Science, EBSCO

Recognized by the World Health Organization as a disease, infertility carries emotional and financial burdens. With treatments like in vitro fertilization costing approximately $12,400 (not including medications), many Americans may allocate a substantial portion of their annual income to a single assisted reproductive technology cycle. To mitigate this burden, a minority of states mandate varying

To estimate the impact of detection and treatment of early gestational diabetes mellitus on short-term maternal, fetal, and neonatal outcomes. We defined 2 maternal (gestational diabetes prevalence and cesarean section) and 2 neonatal (preterm birth and macrosomia) primary outcomes. We also defined 5 maternal and 12 fetal-neonatal secondary outcomes.

Down syndrome, first systematically characterized by John Langdon Down in 1866 and later identified as trisomy 21 by Jérôme Lejeune in 1959, has seen dramatic improvements in life expectancy due to advances in medical care and social support. Despite this progress and the National Institutes of Health’s INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE project’s

Infants affected by late fetal growth restriction are at risk of adverse perinatal outcomes, either due to placental insufficiency or the consequences of late iatrogenic prematurity. There is no randomized trial reporting the optimal timing of delivery, and recommending delivery at 37 weeks can cause harm. Antenatal ultrasound parameters can be used to risk-stratify these pregnancies into low-risk

Enhanced recovery after cesarean delivery protocols include evidence-based interventions which are designed to improve patient experience and maternal and neonatal outcomes, whilst reducing healthcare related costs. This is the first update to the Enhanced Recovery After Surgery Society guidelines for intraoperative care in cesarean delivery published in 2018. Interventions were selected based on expert

Enhanced recovery after cesarean delivery protocols include evidence-based interventions designed to improve patient experience, pregnancy, and neonatal outcomes while reducing healthcare-related costs. This is the first update of the Enhanced Recovery After Surgery Society guidelines for antenatal and preoperative care before cesarean delivery after the original publication in 2018.

Enhanced Recovery After Cesarean Delivery (ERAC) protocols include evidence-based interventions designed to improve maternal and neonatal outcomes and patient experiences while reducing healthcare-related costs. This is the first update to the Enhanced Recovery After Surgery Society guidelines for postoperative care in cesarean delivery published in 2019. Interventions were selected based on expert

Mainstreaming genetic testing refers to genetic testing for cancer susceptibility genes following cancer diagnosis, which is provided by nongenetic health professionals of the cancer-treating team. Mainstreaming can be used to guide cancer treatment and secondary cancer prevention in the patient and to identify carriers in the family members of patients who test positive through cascade testing. We

To determine the absolute and relative risks of adverse maternal, perinatal, and longer-term child outcomes for pregnancies with antenatally detected early-onset small for gestational age fetuses, compared with baseline population rates.

This comprehensive review aimed to provide insights into the Asherman syndrome’s historical background, clinical manifestations, classifications, obstetrical challenges, and current treatment approaches. The syndrome is characterized by intrauterine adhesions and fibrotic changes within the uterine tract as well as symptoms including menstrual irregularities, pelvic pain and infertility. The primary

Generative artificial intelligence chatbots are sophisticated conversational artificial intelligence tools that have the capability to interpret natural language inputs and produce responses that closely resemble human speech. Artificial intelligence chatbots hold significant promise in revolutionizing medical education by offering invaluable support across various educational domains, including teaching