PURPOSE The goal of this study is to describe the rates of successful corneal tomography in children with Down Syndrome (DS) and to determine whether high levels of astigmatism or myopia are reliable indicators of keratoconus in children with DS. DESIGN Retrospective, cross-sectional study. SUBJECTS AND CONTROLS Patients aged 4 to 18 years old with and without DS who underwent corneal tomography to

PURPOSE To investigate the safety and diagnostic utility of anterior chamber (AC) paracentesis in patients with ocular inflammation at the University of California, San Francisco (UCSF). DESIGN This was a two-part study including a cross-sectional survey study to assess practice patterns on AC paracentesis and a retrospective diagnostic and safety study of all outpatient AC paracentesis performed between

OBJECTIVE To evaluate the long-term risk of incident giant cell arteritis (GCA) following herpes zoster ophthalmicus (HZO). DESIGN Retrospective cohort study. PARTICIPANTS AND CONTROLS Adults aged ≥50 years with a diagnosis of HZO (ICD-10 B02.3) between May 2005 and April 2024 were identified from the TriNetX Global Collaborative Network and compared to controls without any history of zoster. All patients

PURPOSE To evaluate the usefulness of vertical asymmetry analysis of macular microvasculature for diagnosis of open-angle glaucoma (OAG) in diabetic retinopathy (DR) patients who have undergone pan-retinal photocoagulation (PRP). DESIGN Retrospective, cross-sectional diagnostic evaluation. METHODS DR patients with PRP were categorized into those without OAG (Group 1) and those with OAG (Group 2). Peripapillary

PURPOSE Research has shown that the prevalence of vision difficulty is higher among US adults with low income than among those with higher income. We aimed to examine the trends in income-related inequalities in vision difficulty and to identify the contributions of explanatory factors. DESIGN A cross-sectional and trend study. METHODS Our study estimated income-related inequalities in self-reported

TOPIC The aim of this systematic review and meta-analysis was to compare trabeculectomy augmented with anti-VEGF and trabeculectomy without anti-VEGF for the treatment of glaucoma in an adult population. CLINICAL RELEVANCE Trabeculectomy has long been established as the 'gold standard' surgical procedure in the management of glaucoma when medical and laser options are deemed to be inadequate but has

PURPOSE Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are important therapeutic options for type 2 diabetes and obesity; however, concerns about ophthalmic safety persist. This study examined associations between GLP-1 RAs and ocular adverse events (AEs). DESIGN Global observational pharmacovigilance study. METHODS We searched the US FAERS database (via OpenVigil 2.1) and WHO's VigiBase (via

BACKGROUND AND OBJECTIVE Ocular myasthenia gravis (OMG) significantly affects patients' quality of life. However, conventional serum assays often fail to detect anti-acetylcholine receptor (AChR) antibodies in more than half of OMG cases, complicating accurate diagnosis. Given the immunological role of tears in the ocular environment, they may serve as a viable alternative for antibody detection. This

PURPOSE To evaluate the accuracy of 11 intraocular lens (IOL) calculation formulas in eyes undergoing Descemet membrane endothelial keratoplasty (DMEK) combined with cataract surgery (triple DMEK). DESIGN Retrospective accuracy and validity analysis with a consecutive case series. METHODS We included 80 eyes of 80 patients (52 females, 28 males) with a mean age of 67.08 ± 7.64 years (range: 45 to 83

PURPOSE Compare surgical success, risk factors and post-operative course of the SIBS microshunt, gelatin 45μm microstent, and trabeculectomy with mitomycin C (MMC) as a primary surgical intervention in patients with glaucoma. We present a multicenter,12-month, retrospective, non-randomized, interventional case series. DESIGN Multicenter,12-month, retrospective, non-randomized, interventional case series

Purpose To identify the determinants to successfully implement a community-based intervention to increase eye care utilization in individuals at high-risk for glaucoma. Design Qualitative study with semi-structured interviews Methods Semi-structured qualitative interviews were conducted with community members in Detroit, Michigan at a trusted community site. Participants were Black Americans at least

PURPOSE To assess the efficacy and safety of adalimumab (ADA) injections (Group 1), infliximab (IFX) (Group 2), and tocilizumab (TCZ) (Group 3) infusions in pediatric non-infectious retinal vasculitis (RV). DESIGN Retrospective interventional case series. METHODS Pediatric patients who were diagnosed with non-infectious RV and treated with biologics (ADA, IFX, TCZ) for ≥6 months were included. Chart

PURPOSE To analyze the clinical and genetic characteristics of Knobloch syndrome in a large cohort, with a focus on retinal detachment (RD) characteristics, surgical outcomes, and variants in the COL18A1 gene. DESIGN Retrospective, multicenter interventional/observational case series. SUBJECTS Thirty-four patients (68 eyes) with clinically and genetically confirmed Knobloch syndrome were included.

OBJECTIVE AND PURPOSE To evaluate the association between intraocular pressure (IOP) measurements and concurrent rates of retinal nerve fiber layer (RNFL) thinning in primary open-angle glaucoma (POAG) eyes previously implanted with a sulcus-based IOP sensor. DESIGN This case series is part of the prospective, open-label, multicenter interventional EYEMATE-SC trial. SUBJECTS, PARTICIPANTS, AND/OR CONTROLS

PURPOSE To ascertain the refractive accuracy of 36 intraocular lens (IOL) power calculation formulas in unoperated eyes. DESIGN Retrospective accuracy and validity analysis. PARTICIPANTS Six hundred fifty-five patients undergoing phacoemulsification and implantation of the Tecnis 1 ZCB00 IOL (Johnson & Johnson Vision, Jacksonville, FL, USA). METHODS Thirty-six formulas were evaluated including some

PURPOSE To investigate peripheral vascular changes and their progression in intermediate uveitis characterized by a fern-like leakage pattern and examine their relationship with macular vascular changes to elucidate their pathogenesis, natural history, and clinical implications. DESIGN Retrospective, observational case series with healthy-eyes comparison. PARTICIPANTS 43 eyes (28 patients) with intermediate

PURPOSE To determine utility of cytomegalovirus retinitis (CMVR) screening among patients with CMV bloodstream infection (viremia) in the context of multiple and recently implemented state-wide policies in heightening congenital screening. DESIGN Retrospective diagnostic testing evaluation. STUDY POPULATION - All patients with CMV viremia and ophthalmologic examination during the study period between

To provide guidance primarily for the academic researcher for the translation from research of novel ophthalmic drugs for improved patient treatment to early-stage development including clinical trials.

To determine the epidemiology, mechanisms, and trends of lawnmower-related eye injuries in the U.S., focusing on national estimates, injury types, and high-risk populations.

PURPOSE To investigate the relationship between ganglion cell layer (GCL) thickness and photoreceptor alterations in eyes with resolved chronic central serous chorioretinopathy (CSC). DESIGN Retrospective, cross-sectional "case-control" comparison study. METHODS We collected data from 70 eyes from 70 male individuals with chronic CSC, pachychoroid pigment epitheliopathy (PPE), and healthy controls

OBJECTIVES This study aimed to evaluate the effectiveness, stability, and influencing factors of femtosecond laser-assisted arcuate keratotomy (FSAK) performed during cataract surgery for correcting corneal astigmatism (CA). METHOD A systematic literature review was conducted to identify clinical trials adopting a pre-post study design. Data sources included electronic databases such as PubMed, Scopus

Eye injuries are a leading cause of monocular vision impairment and disability in children and adolescents. Unlike adults, eye injuries in children exhibit significant age specificity, with worse visual outcomes due to immature vision, the risk of long-term damage, and amblyopia. However, research on the global distribution and trends of eye injury burdens in this population is limited.

To report the efficacy and safety of scleral-suture fixation of intraocular lens (SFIOL) in children with nontraumatic ectopia lentis (EL) in a real-world setting.

To determine the impact of progression of central visual field (VF) and global VF on vision-related quality of life (VRQOL).

Clinical trials have demonstrated remarkable benefits from intravitreal injections of anti–vascular endothelial growth factor (anti-VEGF) agents in patients with retinal or choroidal vascular diseases, but observational studies have shown poor outcomes in the same patient populations treated in clinical practice, and this is associated with less frequent injections. Current treatment strategies in

To describe the natural history of optical coherence tomography (OCT) and mesopic microperimetry (MP) parameters in the Rate of Progression of USH2A-related Retinal Degeneration (RUSH2A) study.

To assess the relationship between cataract surgery and the 30-day incidence of post-operative endophthalmitis (POE) (analysis 1) and serious systemic adverse events (analysis 2) in diabetic patients with varying preoperative hemoglobin A1c (HbA1c) levels.

PURPOSE This study aimed to investigate histological changes of trabecular meshwork (TM) in normal tension glaucoma (NTG) and determine whether trabeculectomy (TRAB) specimens from NTG patients can serve as normal controls for analyzing other types of high-tension glaucoma using TM analysis software (TMAS) based on light microscopy (LM). DESIGN Prospective comparative case series METHODS: TRAB specimens

To analyze the clinical characteristics, natural history, and genetics of Leber congenital amaurosis (LCA) early-onset severe retinal dystrophy (EOSRD) associated with uncommon genes.

To evaluate the postmarketing ocular adverse events (AEs) reported for avacincaptad pegol and pegcetacoplan, the only Food and Drug Administration (FDA)–approved treatments for geographic atrophy (GA).

To develop imaging and consensus-based guidelines on the application of multimodal imaging in noninfectious multifocal choroiditis and panuveitis (MFCPU) and punctate inner choroiditis (PIC).

To investigate the success of strabismus surgery in older adults and determine the impact of age and underlying etiology on surgical outcomes.

To compare the visual outcomes of two extended depth-of-focus (EDOF) intraocular lenses (IOLs).

Choroidal neovascularization caused by age-related macular degeneration, among other diseases, causes significant visual impairment. Intravitreal therapeutics inhibiting vascular endothelial growth factor (VEGF) signaling have shown excellent safety and efficacy in regressing choroidal neovascularization and improving vision. Current US Food and Drug Administration (FDA)–approved treatments deliver

To report 12-month results from the GALE open-label extension study (NCT04770545), evaluating up to 36 months of intravitreal pegcetacoplan treatment for geographic atrophy (GA) in age-related macular degeneration (AMD).

To compare surgical outcomes following penetrating keratoplasty (PK), Descemet stripping endothelial keratoplasty (DSEK), and Descemet membrane endothelial keratoplasty (DMEK) in patients with iridocorneal endothelial (ICE) syndrome.

To investigate the rate of structural and functional progression in different age groups of highly myopic glaucoma patients and identify risk factors associated with rate of change in functional parameters.

Chronic neuropathic ocular pain (NOP) can develop alongside chronic dry eye (DE) post–laser-assisted in-situ keratomileusis (LASIK), yet its specific characteristics remain poorly understood. This study aims to compare the clinical characteristics of patients who developed both DE and NOP after LASIK to those with only DE and to asymptomatic LASIK patients, to facilitate the diagnosis of NOP.

Reducing unnecessary retinopathy of prematurity (ROP) screenings in neonates is important for minimizing morbidity associated with such examinations including pain for the child, anxiety in parents, and conserving healthcare resources. The Seminal Canadian Recommendations for Evidence-Based Examination of Neonates for Retinopathy of Prematurity (SCREEN-ROP) guidelines recommend only screening babies

To evaluate and classify the magnetic resonance imaging (MRI) features of anomalous orbital structures (AOS) and correlate these findings with clinical manifestations.

Retinal vein occlusion (RVO) is the second most common cause of vision loss from retinal vascular disease. Clinical trials often lack adequate representation of minority groups, limiting the external validity and equity of trial results. We aimed to characterize the evolution of ethnoracial demographic reporting, changes in the racial and ethnic composition of RVO trial participants, and correlations

The aim of this study was to assess whether vitamin D (Vit D) supplementation affects local disease progression, as well as systemic inflammation, collagen degradation, and oxidative stress in adolescents affected by keratoconus (KC) and Vit D deficiency.

To compare choroidal layer thickness beneath flat irregular pigment epithelial detachments (PEDs) between uncomplicated chronic central serous chorioretinopathy (uCSC) and CSC complicated by type 1 macular neovascularization (cCSC).

To use community engaged research to understand barriers to eye care utilization and explore participant experiences with free glaucoma screenings through the Michigan Screening and Intervention for Glaucoma and eye Health through Telemedicine (MI-SIGHT) program.