BackgroundThis retrospective study aimed to assess the effect of horizontal bone augmentation using the circular cortical‐lamina anchoring technique (CCA) and modified split‐crest technique (MSC) on the knife ridge of the posterior mandible.MethodsPatients who underwent horizontal bone augmentation in posterior mandible sites between 2018 and 2023 were reviewed and divided into MSC and CCA groups based

BackgroundDentin hypersensitivity (DH) is common, particularly among periodontal patients. This trial evaluated magnitude of desensitizing benefit, onset of action, and complete relief of three dentifrices with distinct desensitizing technologies.MethodsHealthy adults with DH were enrolled and randomized to one of four dentifrices in this randomized, controlled, double‐blind trial: marketed potassium

BackgroundThe aim of this study was to compare the sustainability of regular use of 2 different interdental cleaning tools in 24 weeks by periodontally healthy individuals as a component of primary prevention.MethodsPeriodontally healthy individuals were randomly assigned to dental floss or rubber interdental pick group. Participants received an oral care kit and a calendar to record the times they

BackgroundThis study evaluated the efficacy of L‐ and I‐shaped collagenated block bone substitutes (BBS) compared with particulate bone substitutes (PBS) in guided bone regeneration (GBR) of maxillary anterior peri‐implant dehiscence defects. It focused on radiographic, profilometric, esthetic, and patient‐reported outcomes over a 4‐year follow‐up period.MethodsFifty‐one peri‐implant defects were treated

BackgroundPeriodontitis is among the most prevalent chronic inflammatory conditions globally, and is associated with bone resorption, tooth loss, and systemic complications. While its treatment is largely standardized, individual outcomes vary, with some patients experiencing further disease progression despite adherence.MethodsWe developed a machine learning (ML) approach to predict individual outcomes

BackgroundThis study evaluated the efficacy of concentrated growth factor (CGF) sticky bone combined with guided tissue regeneration (GTR) in treating shallow infrabony defects and explored factors influencing clinical outcomes.MethodsThirteen patients with 31 shallow defects (≤3 mm) were treated using CGF sticky bone (CGF + deproteinized bovine bone mineral), covered with a collagen membrane and CGF

BackgroundSoft tissue grafting at dental implant sites has been proposed to enhance esthetic outcomes. A xenogeneic collagen matrix (XCM) was introduced as an alternative grafting material to connective tissue. Only short‐term results are yet available.MethodsSixty patients were treated in a randomized controlled trial with a connective tissue graft (n = 20, CTG group), an XCM (n = 20, XCM group),

BackgroundGranulation tissue is routinely discarded in periodontal surgical procedures, but few studies have characterized it. The present study aimed to compare global gene expression in granulation tissue derived from different types of periodontal osseous defects.MethodsTotal RNA was isolated from granulation tissue harvested during routine periodontal surgical procedures. Nineteen sites were analyzed—seven

BackgroundDNA methylation may influence cytokine expression and clinical manifestations of periodontitis. This study assessed the interleukin (IL)‐6 DNA methylation in gingivae with and without clinical inflammation and its impact on clinical manifestations and cytokine expression.MethodsSixty‐two gingival biopsies (17 from controls and 45 from periodontitis sites) were analyzed. IL‐6 protein concentrations

BackgroundStudies have shown that Porphyromonas gingivalis (P. gingivalis) can promote the development of chronic kidney disease (CKD). In this study, we explored the epithelial–mesenchymal transition (EMT) process promoted by P. gingivalis outer membrane vesicles (OMVs) in renal interstitial fibrosis (RIF), thereby providing new ideas for the study of the relationship between periodontitis and CKD

BackgroundOne strategy to delay bone loss in periodontitis involves maintaining the osteogenic differentiation function of periodontal ligament stem cells (PDLSCs). The core circadian gene BMAL1 influences the fate of mesenchymal stem cells and is essential for regulating pyroptosis, apoptosis, and necroptosis. PANoptosis, a novel form of programmed cell death, simultaneously activates all 3 pathways

BackgroundThis study aims to assess the associations between exposures to thiocyanate and the risk of periodontitis among US adults.MethodsWe conducted a cross‐sectional study using data from the National Health and Nutrition Examination Survey (NHANES) 2009–2014. We categorized periodontitis according to the 2017 classification scheme. Restricted cubic spline analysis and weighted multivariable logistic

BackgroundRecent evidence suggests that chronic inflammation may play a role in the development and clinical course of cancer. In this context, periodontitis (PE) has been associated with prostate cancer (PC), but the results are still inconsistent. Therefore, the aim of this study was to evaluate the potential association between PE and PC, and their shared risk factors.MethodsThis case–control study

BackgroundBisphosphonates (BPs) are effective in managing bone diseases due to their anti‐resorptive properties but are linked to medication‐related osteonecrosis of the jaw (MRONJ), particularly concerning dental implants. This study explored the combined impact of ligature‐induced peri‐implant inflammation and zoledronic acid (ZA), a BP, using a murine model.MethodsTwenty‐four mice underwent bilateral

BackgroundThe widespread adoption of digital technologies in dentistry has transformed workflows and practices. However, limited, if any, information is available on the extent of digital workflow integration in periodontics. This study aims to evaluate literacy, utilization, and knowledge of digital technologies, specifically implant navigation systems, among American board‐certified periodontists

BackgroundThe aim of this study was to evaluate the effect of surgical guide design and type of blade, in relation to soft tissue thickness, on the accuracy of computer‐assisted crown lengthening.MethodsA set of fully dentate anatomic maxilla models was implemented, using 2 types of soft‐tissue masks with a mean thickness of 1.5 and 3.5 mm, respectively, to simulate a clinical scenario of altered passive

BackgroundPeriodontitis is a destructive disease that affects periodontal tissue. While current research focuses on disease management, research on tissue repair remains limited. Metformin, a first‐line medication for diabetes treatment, has positive effects on bone health in nondiabetic patients. However, its potential for repairing periodontal tissue remains unclear. Therefore, this study aimed to

BackgroundCollagenated bovine bone mineral (CBBM) is used for maxillary sinus elevation‐based augmentation. We compared collagen degradation in cross‐linked (CL) CBBM and non‐cross‐linked (NCL) CBBM (in vitro) and preclinical results in CBBM‐CL, CBBM‐NCL, deproteinized bovine bone mineral (DBBM), and DBBM with fibrin sealant grafts (in vivo) after repair of perforated Schneiderian membrane (SM).Me

BackgroundPeri‐implantitis has become an important health issue in implant dentistry in the past years. Despite the magnitude of this problem and the potential grave consequences, the predictability and long‐term stability of its treatment is still a matter of controversy. The aim of this study was to assess clinical and radiographic results 5 years after the peri‐implantitis reconstructive treatment

BackgroundChronic rhinosinusitis (CRS) and chronic periodontitis (CP) are prevalent inflammatory conditions with significant impacts on health. Previous research has suggested a potential link between these diseases, primarily through odontogenic sources, but comprehensive population‐based studies are scarce. This study aimed to explore the association of CRS with prior CP.MethodsWe performed a case‐control

BackgroundThe purpose of this randomized, three‐armed clinical trial is to determine if a postoperative injection of 0.5% bupivacaine is more effective than 2% lidocaine in controlling pain after periodontal flap surgery.MethodsSeventy‐six patients planned for similar periodontal surgeries were included. Prior to surgery, patients were randomized to receive one cartridge (1.7 mL) of either 2% lidocaine

BackgroundPeriodontitis is a chronic inflammatory condition that affects the supporting structures of the teeth. It is closely associated with oxidative stress and inflammation. Taurine, a semi‐essential amino acid recognized for its antioxidant and anti‐inflammatory properties, has not been extensively investigated in the context of periodontitis. This pilot study sought to evaluate the levels of

BackgroundPeri‐implantitis is an oral inflammatory disease with increased incidence across the population as linked to the wide use of dental implants to replace missing teeth. While the recent World Workshop Classifications provided a framework for clinicians to diagnose and assess the severity of peri‐implantitis, an objective assessment of the mucosal inflammatory burden around the dental implant

BackgroundPeri‐implantitis poses a major challenge as contemporary nonsurgical treatments show dissatisfactory results and mucosal flap surgery is often needed. Diode lasers can remove granulation tissue and submucosal bacteria, and if it achieves similar clinical results, then it could be used as a less invasive first approach. The aim was to compare the healing of peri‐implantitis lesions 6 months

BackgroundPeriodontitis has been linked to various systemic health conditions. This study investigated whether the association between periodontitis and prostate‐specific antigen (PSA) is direct or mediated through intermediary systemic diseases.MethodsThree data cycles (2001–2002, 2003–2004, and 2009–2010) from the National Health and Nutrition Examination Survey (NHANES) comprising 12,874 subjects

BackgroundThis systematic review summarized the features of human experimental gingivitis (EG) in terms of immune responses and tissue remodeling in the gingival crevicular fluid (GCF).MethodsSystematic searches were conducted to screen the literature published from January 1960 to June 2024 from MEDLINE (PubMed), EMBASE, and Web of Science. The selected studies were prospective trials evaluating the

BackgroundPeriodontal disease, a prevalent oral health condition, is exacerbated by smoking, which accelerates tissue destruction and complicates disease management. This study investigates the association between smoking and periodontal health by comparing key periodontal indicators between smokers and nonsmokers in Afghanistan, where smoking prevalence is rising.MethodsA case–control study was conducted

BackgroundThe use of omega‐3 (Ω‐3) polyunsaturated fatty acids and acetylsalicylic acid (ASA, aspirin) has shown better clinical outcomes in the treatment of periodontitis compared to nonsurgical periodontal therapy (NSPT) alone. This randomized clinical trial aimed to evaluate the use of 900 mg Ω‐3 and 100 mg ASA for 180 days as adjuncts to NSPT for generalized stage III–IV grade C periodontitis (GCP)

BackgroundIt has been well documented that periodontal treatment decreases the levels of certain disease‐associated species in subgingival plaque. Few studies, however, investigate to which extent periodontal therapy restores a health‐like subgingival community. Here, we conducted a secondary analysis to evaluate microbiome outcomes of nonsurgical periodontal therapy alone or followed by an intensive

BackgroundSupportive periodontal therapy (SPT) reduces the probability of infection reoccurrence further disease progression. Despite that, several patient/tooth related variables have been linked to tooth loss during SPT. This longitudinal study examines the correlation between periodontal staging, grading, initial therapy, and frequency, cost, and time‐to‐re‐treatment following active periodontal

BackgroundThis study focused on whether the effectiveness of nonsurgical periodontal therapy (NSPT) on second molars (M2s) varies with the status of adjacent nonimpacted third molars (N‐M3s).MethodsIn this retrospective cohort study, 776 regions from 268 patients were evaluated. Based on the adjacent N‐M3 status, quadrants with M2s were categorized into three groups: N‐M3 group (present N‐M3), A‐M3

BackgroundIn the present study, we aim to assess a novel silk‐fibroin (SF) chitosan (CH) film to treat oral mucosa wounds.MethodsThe SF/CH films, sterilized with 130 Gy in a gamma cell, were subjected to tests for thickness, water vapor permeability, tensile strength, elongation, and swelling as well as scanning electron microscopy. Additionally, in vitro cytotoxicity and genotoxicity were evaluated

BackgroundThe purpose of the present study was to evaluate the role of sexual dimorphism (SD) in the clinical manifestation of plaque‐induced periodontal inflammation by analyzing the association between patient‐related factors and the full‐mouth prevalence of bleeding on probing (BOP%) within 2 cohorts of male and female individuals.MethodsData on BOP (dichotomously recorded as present/absent after

BackgroundThe global burden and trend of severe periodontitis, as well as its association with sociodemographic development, among women of childbearing age (WCBA) have been unclear so far. This study aims to assess the epidemiological pattern of severe periodontitis in WCBA from 1990 to 2021 and provide projections through 2040.MethodsData on the incidence, prevalence, and disability‐adjusted life

BackgroundThe clinical evidence about alveolar ridge changes following molar extraction and how the alveolar bone morphology influences the ridge dimensional changes remains limited.MethodsA total of 192 patients with 199 molar extractions were included in this retrospective study. Cone‐beam computed tomography (CBCT) images of patients were obtained 0–3 months pre extraction and 6–12 months post extraction

BackgroundThe host immune response plays a major role in the pathogenesis of periodontitis. A bibliometric study can be crucial to understanding the different processes involved in this area; however, to our knowledge, it has not been published until now. Therefore, a bibliometric analysis was conducted to assess research hotspots and global trends in scientific articles about the immune response in

BackgroundTo investigate the differences in health care expenditure (HCE) due to the comorbidity status of periodontal disease (PD) and diabetes mellitus (DM).MethodsThis cohort study used health care claims and oral health screening data to identify participants with PD or DM and followed them for 1 year to assess their HCE. PD and DM were determined based on PD screening and medical claims data,

BackgroundThe study aims to analyze the effectiveness of nonsurgical re‐instrumentation of residual pockets as step 3 of periodontal therapy and the stability of treatment outcomes at 18 months.MethodsThe study sample consisted of 489 patients diagnosed and treated nonsurgically for periodontitis. After a 6‐month evaluation, residual pockets (≥5 mm) were re‐instrumented. A final examination was performed

BackgroundGingivitis, a widely prevalent oral health condition, affects up to 80% of the population. Traditional assessment methods for gingivitis rely heavily on subjective clinical evaluation. This study seeks to explore the efficacy of interpreting the color metrics from intraoral scans to objectively differentiate between healthy and inflamed gingiva.MethodsThis study used the percentage of bleeding

BackgroundPrevious research has indicated a potential connection between smoking and tooth loss, but it remains unclear how the metabolites of nicotine, cotinine (COT) and trans‐3′‐hydroxycotinine (HC), and the nicotine metabolite ratio (NMR) affect the occurrence and progress of tooth loss. In this study, we aimed to investigate the relationship between tooth loss and smoking metabolites, then verify

BackgroundCrown cementation is a common technique for implant‐supported prosthodontics. However, for possible slipping of the cement below the mucosal margin, its thorough removal poses some issues. The objective of this study was to evaluate the presence of submucosal cement residues in patients with peri‐implant disease by endoscopic visualization and to investigate the potential correlation between

BackgroundTo investigate the effect of rheumatoid arthritis (RA) on the incidence of peri‐implantitis (PI) and peri‐implant mucositis (PIM).MethodsRadiographic and clinical chart reviews were conducted to measure the probing depth (PD), bleeding on probing, and marginal bone loss (MBL) around the implants to diagnose peri‐implant diseases based on the 2017 workshop classification. Values were recorded

BackgroundPeriodontitis can induce systemic inflammation, and it may affect the testicles and male reproductive performance. This study investigated the effects of periodontitis on the testicles, reproductive performance, and offspring development in male rats.MethodsMale Wistar rats were induced with periodontitis by ligating their first molars. After 14 days of inducing periodontal lesions, the animals

BackgroundIntrinsic apoptosis plays a critical role in immune defense and inflammation. Its dysregulation is involved in various chronic diseases. The B‐cell lymphoma 2 (Bcl‐2) family primarily mediates this mitochondrial pathway. This study aimed to investigate the proapoptotic Bcl‐2‐associated X protein (Bax) and antiapoptotic B‐cell lymphoma‐extra large (Bcl‐xl) levels and their association with

BackgroundThe relationship between humans and volatile organic compounds (VOCs) is a persistent concern due to their widespread sources and high evaporation rates. However, there is currently limited direct evidence linking VOC exposure to the development of periodontitis.MethodsThis cross‐sectional study analyzed 1525 participants and 21 urinary VOCs in the National Health and Nutrition Examination

BackgroundThis study aimed to evaluate the role of fibulin‐3 (FBLN3) in macrophage polarization, its mechanism, and its effect on periodontitis.MethodsWe conducted studies on periodontitis using both clinical samples and ligature‐induced mouse periodontitis model. The inflammatory state was assessed using microcomputed tomography, hematoxylin and eosin staining, immunohistochemical staining, and immunofluorescence

BackgroundThere is limited evidence on the effect of osseodensification drilling (OD) on alveolar ridge dimension changes and implant stability compared to standard drilling (SD). The purpose of this study was to compare the effect of both drilling protocols on ridge dimensional changes and implant stability.MethodsFifteen patients were recruited for a total of 20 pairs of implants. Pre‐ and postdrilling

BackgroundAdvanced glycation end products (AGE) and their receptors (RAGE) have been implicated in developing periodontal complications in diabetic patients. This study aimed to identify salivary AGE, RAGE, soluble RAGE (sRAGE), and active‐matrix metalloproteinase‐8 (aMMP‐8) levels at varying glycemic levels in periodontitis patients.MethodsNinety‐eight participants were categorized into uncontrolled