No Abstract

Landmark trials using stem cells to treat Parkinson’s disease in the USA and Japan mark a turning point for cell therapy in neurodegeneration. Similar approaches to Alzheimer’s disease and amyotrophic lateral sclerosis are also showing early signs of promise.

Group behind Retraction Watch aims to pinpoint the most influential flawed health data.

A brief encounter.

Kári Stefánsson, who last month left the Icelandic genetics company deCODE, spoke to Nature about his legacy.

Exploitation of the high seas risks doing irreversible damage to biodiversity, climate stability and ocean equity. A consensus must be built now to save them.

Repeated damage from extreme heat over time seems to be a leading factor causing kidneys to fail.

Scientists are eyeing their legal options in anticipation of new immigration actions.

Cuts to US ‘foreign subawards’ will abruptly end hundreds of clinical trials abroad. Plus, an mpox outbreak is overwhelming Sierra Leone’s health system and a rock with a painted dot that just might represent a nose.

I can’t stop thinking about the BMA’s recent warning that as many as 1000 newly qualified GPs may struggle to find jobs this year.1 It’s not just a number: it’s a stark symbol of a system that has lost its way. We’re training highly skilled generalists, encouraging them into a specialty we claim to value, only to tell them that there’s no work for them once they arrive. But this hasn’t come out of

Growing numbers of US physicians are joining unions, seeing them as a way to regain autonomy in the face of the corporatisation of healthcare. Ella Hubbard reports “They somehow found a way to upset every single physician in the hospital,” says Bryan Haimes, explaining why he and several hundred of his colleagues at the Christiana Care hospital network voted to unionise last year. The decision was

BackgroundRelacorilant, a first-in-class selective glucocorticoid receptor antagonist, increases a tumour's sensitivity to chemotherapy by reducing cortisol signalling. This study aimed to show whether the addition of relacorilant to nab-paclitaxel improves progression-free and overall survival in females with platinum-resistant ovarian cancer. MethodsThis randomised, controlled, open-label phase 3

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BackgroundDespite improved efficacy with first-line immune checkpoint inhibitors plus platinum-based chemotherapy for extensive-stage small-cell lung cancer (ES-SCLC), survival remains poor. In this study, we aimed to compare lurbinectedin plus atezolizumab and atezolizumab alone as maintenance therapies in patients with ES-SCLC without progression after induction therapy with atezolizumab, carboplatin

Snippets from Nature’s past.

Letter to the Editor

Letter to the Editor

Letter to the Editor

Governments and institutions must shift from top-down approaches to collaborations with local communities.

Bot-made art undermines research and public trust in science, say illustrators frustrated by inaccurate and outlandish depictions.

Live-animal markets are a natural laboratory for viruses to evolve and spark deadly outbreaks, yet scientists lack support to study the risks they pose.

Delegates to a United Nations meeting on neurotechnology ethics have devised the first set of global guidelines on maintaining users’ privacy.

A clinical trial of CAR T cells is among the first to show that the treatment can work for solid tumours. Plus, humpbacks’ big eyes are nearsighted and how researchers are turbocharging ginseng.

This seventh article in a seven part series presents the Core GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach for moving from evidence to recommendations or policy decisions. Core GRADE users make strong recommendations for an intervention versus a comparator when the desirable consequences clearly outweigh the undesirable consequences, and a conditional (weak) recommendation

The principles of Core GRADE provide an important basis for achieving successful AI assisted evidence certainty rating and recommendation formulation, write Jing Wu , Gordon Guyatt , and Liang Yao Artificial intelligence (AI) is rapidly reshaping how we conduct medical research, from synthesising evidence to developing clinical guidelines.1234 Tasks that once took months—or even years—can now be accelerated

A reset of the global aid system must be guided by key principles to respond to current challenges and rebuild global solidarity, argue Martin McKee and Kent Buse Donald Trump’s rejection of long established assumptions about development assistance have forced a global reassessment.1 In autumn 2025, David Lammy, the British foreign secretary, will convene a major conference that will contribute to

Tackling the trolling received by women doctors will help to promote more constructive online spaces and discourse, write Jane Dacre and Latifa Patel At a recent meeting between the British Medical Association and the Medical Women’s Federation, we celebrated the milestone of women on the General Medical Council register with a licence to practise outnumbering men.1 The discussion soon turned to social

Correction to: Nature https://doi.org/10.1038/s41586-025-08844-z Published online 9 April 2025

Correction to: Nature https://doi.org/10.1038/s41586-025-08630-x Published online 20 January 2025

McCartney expresses concern that “prescribing” parkrun implies a top-down approach,1 but in practice it legitimises group physical activity. Like all good medical management, prescribing anything should never be instructional, but a collaborative exploration driven by the patient’s wishes. Robust data confirm that community physical activity improves outcomes,2 yet many remain unaware of its effectiveness

For a moment, McCartney’s article had me questioning the role of a consultant in exercise medicine.1 Exercise isn’t a medication; we do not need to prescribe parkrun. These points are valid for people already enabled to be active. Parkrun as a community driven initiative has lowered the bar for access brilliantly. But what about those who can’t get to the start …

Hepatitis B virus infection remains a pervasive global health challenge, affecting an estimated 254 million people worldwide. This review summarizes the current landscape of hepatitis B, including its epidemiology and the clinical spectrum of acute and chronic infection. It discusses the interplay between host and virus that underlies the progression from acute hepatitis to chronic liver disease, cirrhosis

Lorna Benton and colleagues argue that including planetary health in guidance for researchers would help to prioritise effective responses to current environmental and human crises Human activity has pushed Earth’s natural systems beyond safe and just planetary boundaries, creating threats to human health and survival (box 1).1 Evidence shows that six out of nine identified planetary boundaries have

BackgroundCurrently, no worldwide approved therapies exist for adults with neurofibromatosis type 1 (NF1) and symptomatic, inoperable plexiform neurofibromas. The KOMET study aimed to evaluate selumetinib (ARRY-142886, AZD6244) efficacy and safety in this population. MethodsThis ongoing multicentre, international, randomised, placebo-controlled, phase 3, parallel, double-blind trial randomly assigned

The African Union (AU) has prioritized local production of health countermeasures since its inception, with heightened focus following the COVID-19 pandemic and challenges such as cholera, Ebola, malaria, mpox, Marburg and other emerging diseases. One of its efforts was the development of the Pharmaceutical Manufacturing Plan for Africa in 20071. The plan aims to strengthen the continental capacity

Plant scientist Johan Sukweenadhi uses ‘hairy-root culture’ to improve ginseng yields at the University of Surabaya in Indonesia.

Trial in China is one of the first times the immune therapy has worked against solid tumours.

Automated programs gathering training data for artificial-intelligence tools are overwhelming academic websites.

Richard Clarke, a good natured, mild mannered, and distinguished looking man, with a full mane of white hair, had a highly distinguished career in anaesthetics in Belfast. He played a key role in developing the regional intensive care and cardiac intensive care units after postgraduate training at St Bartholomew’s Hospital, London, involving early work in cardiopulmonary bypass. He was also Ireland’s

The poles hold 70% of Earth’s fresh water and are crucial to science; what’s unfolding there as the planet warms deserves greater attention.

Academia relies on unpaid labour — but researchers should think carefully about what kind of work they’re willing to give to for-profit organizations for free, says Dritjon Gruda.

A computer scientist is struggling to trust their postdoctoral research adviser after negative experiences with the previous two. How do you find one that’s right for you?

The Artemis programme and others aim to send humans to the Moon and, eventually, to Mars. Innovations in health care that support the mission crew could also benefit people at home.

How the smells of outer space could lead us to extraterrestrial life. Plus, an ancient ‘ambidextrous’ protein that can function in both mirror-image forms and the month’s best science images.

Consultant pathologist Debra Milne tells Helen Jones about her love of jazz—from performing in a band to helping to run a local music venue “I’ve always loved music but particularly jazz and the great singers,” says Debra Milne, a consultant pathologist at Gateshead Health NHS Foundation Trust. “One of my earliest memories of somebody singing what I recognised to be jazz is as a teenager listening

This study assesses colorectal neoplasia yields at screening colonoscopy in adults aged 45 to 49 years vs 50 to 54 years in a large US health system after the US Preventive Services Task Force (USPSTF) began recommending that average-risk adults begin colorectal cancer screening at age 45 years.

This JAMA Insights explores the spread of harmful algal blooms due to climate change and how exposure to toxic algae can negatively affect human health.

This study analyzes current US-marketed disposable e-cigarettes, US Food and Drug Administration (FDA)–approved products, and nicotine-free products for presence of the high-intensity artificial sweetener neotame.

This Viewpoint explores how a publicly searchable US Food and Drug Administration database of medical device labels could improve decision-making, transparency, and public health.

BackgroundClaudin-18 isoform 2 (CLDN18.2) has emerged as a promising therapeutic target in gastric or gastro-oesophageal junction cancer. Satricabtagene autoleucel (satri-cel; also known as CT041), an autologous CLDN18.2-specific chimeric antigen receptor (CAR) T-cell therapy, showed encouraging activity in previously treated patients with advanced gastric or gastro-oesophageal junction cancer in phase