The role of Yes-associated protein (YAP) in osteoblasts during subchondral bone remodeling in aberrant mechanical loading-induced OA was investigated.

Within the first phase of developing classification criteria for Early-stage Symptomatic Knee Osteoarthritis, among individuals with knee osteoarthritis (OA) we explored: 1) symptoms within the first year of noticing their knee(s); 2) features that indicated OA was the cause; and 3) timing and reasons that initially prompted seeking healthcare.

Classification criteria for early-stage symptomatic knee osteoarthritis (EsSKOA) should discriminate individuals with EsSKOA from those with other causes of knee symptoms. We sought to identify conditions in the differential diagnosis of EsSKOA in adults with knee symptoms.

Epigenetic clocks have emerged as powerful tools for quantifying biological aging. Degenerative musculoskeletal disorders (e.g., osteoarthritis [OA], osteoporosis) represent a group of age-related conditions characterized by progressive tissue deterioration. While their epidemiological association with aging is well-established, the precise relationship with epigenetic aging markers remains to be systematically

To investigate the associations between total and regional fat-to-muscle mass ratio (FMR) and incident osteoarthritis among adults.

To investigate associations between meniscal tear, bone marrow lesions (BMLs), and post-injury knee loading, with cartilage T2 relaxation times on knee magnetic resonance imaging (MRI) in the subacute phase following acute anterior cruciate ligament (ACL) injury.

Post-traumatic osteoarthritis (PTOA) is known to be influenced by sex. This study aimed to comprehensively characterize PTOA development in male and female mice following anterior cruciate ligament (ACL) injury through longitudinal mobility assessments, radiographic imaging, histologic evaluation, and untargeted proteomics.

Late-life diseases result from the poorly understood process of senescence (aging), which is largely genetically determined. According to a recently proposed evolutionary physiology-based account, the multifactorial model, senescence is largely caused by evolved but non-adaptive programmatic mechanisms specified by the wild-type (i.e. normal) genome. These act together with disruptions to wild-type

To investigate the association between long-term exposure to ambient air pollution and the risk of developing osteoarthritis (OA) in a large nationwide cohort in Taiwan.

To evaluate the capabilities, opportunities, and motivations of community pharmacists and pharmacy assistants to deliver osteoarthritis (OA) care, aligned with the Australian Osteoarthritis of the Knee Clinical Care Standard.

The temporomandibular joint (TMJ) is essential for maxillofacial mechanics, with the condyle serving as the primary site for mandibular growth and development. Mechanical forces regulate condylar development and homeostasis, while aberrant loading contributes to temporomandibular joint osteoarthritis (TMJOA). Although mechanical stimuli are known to influence TMJ function, the role of mechanosensitive

To investigate whether bone activity adjacent to collateral ligaments is present and results in collateral ligament lesions (CLLs) of the proximal and distal interphalangeal joints in patients with hand osteoarthritis (OA), and vice versa.

Determine optimal dose, efficacy, and safety of MM-II, a suspension of large empty liposomes, for knee osteoarthritis (OA) pain.

To evaluate the incidence and severity of knee magnetic resonance imaging (MRI) findings and their associated lifestyle and health factors in a relatively healthy subset of a general population-based birth cohort.

To critically appraise the literature on the cost-effectiveness of guideline-recommended treatments for osteoarthritis (OA).

Mechanical loading is an important, modifiable risk factor for knee osteoarthritis. Identifying walking loads associated with disease worsening presents intervention opportunities. Our purpose was to evaluate the longitudinal relation of the baseline vertical ground reaction force (GRF) during walking to worsening bone marrow lesions (BMLs) and cartilage damage using cohort data from the Multicenter

To quantitatively evaluate hyaluronic acid (HA) efficacy for osteoarthritis (OA) and identify potential responders who would benefit most from HA.

Drug delivery to cartilage is limited by its complex architecture and avascularity. Cationic peptide carriers (CPCs) have previously been optimized for improved cartilage transport and retention of drugs in vitro. In this study, we evaluated the kinetics, stability, and immunogenicity of CPCs after a single intra-articular injection using a rabbit knee injury model.

The aim of this study was to examine the relationship between testosterone levels (total and free) and the prevalence, incidence and progression of radiographic osteoarthritis (OA) and chronic pain outcomes in the knee and hand joints.

To evaluate the efficacy and safety of methotrexate (MTX) for osteoarthritis (OA).

To identify and quantify risk factors for incident knee osteoarthritis (KOA) across the lifespan.

Exosomes are nano-sized cell-secreted vesicles naturally involved in joint tissue crosstalk and hold promise as drug carriers. Their negatively charged lipid bilayer, however, results in electrostatic repulsion from the anionic cartilage matrix limiting their applications in tissue targeting and drug delivery. Here we engineer cartilage targeting exosomes by reversing their net surface charge and use

Developmental dysplasia of the hip (DDH) is a developmental disorder that has long-term chronic pain and limited hip joint mobility. The aim of the current study is to understand the specific chondrocyte composition involved in DDH development, identify effective biomarkers for DDH prediction, and elucidate the gene regulatory elements driving DDH progression.

To explore the role of bone marrow adipocytes (BMAds) in osteoarthritis (OA).

To identify mechanisms and treatment targets in painful intervertebral disc (IVD) degeneration (IVDD) progression with a focus on pro-inflammatory tumor necrosis factor-alpha (TNFα)-receptor-1 (TNFR1) and pro-reparative TNFα receptor-2 (TNFR2) signaling.

In preclinical models of osteoarthritis (OA), histology is commonly used to evaluate joint remodeling. The current study introduces a deep learning driven histological analysis pipeline for the spatial evaluation of knee osteoarthritis (SEKO) focused on quantifying and visualizing joint remodeling in the medial compartment of rodent knees.

During daily activity, the knee joint experiences a range of complex joint motion and loading patterns. However, few studies have investigated the effects of combined motion and load to understand how interactions between these factors may affect articular hyaline cartilage at the tissue and cell level. Our objective was to quantify the effects of varying combinations of physiologically relevant analogs

Ectodysplasin-A (EDA) has been reported to be involved in mouse condylar development, but the specific functions of EDA in maintaining homeostasis of the temporomandibular joint (TMJ) remain unclear. This study aimed to explore the underlying roles and related mechanisms of EDA in temporomandibular joint osteoarthritis (TMJOA).

Anterior cruciate ligament (ACL) tears frequently cause chronic inflammation and posttraumatic osteoarthritis (PTOA), with therapies failing to resolve persistent post-injury inflammation. Specialized pro-resolving mediators (SPMs), including Maresin1 (MaR1), show promise in resolving inflammation and promoting tissue repair. However, their role in PTOA remains underexplored. This study investigated

Altered subchondral bone mineral density (BMD) may be a possible contributor to osteoarthritis (OA) pain. We evaluated the relation of compartment-specific proximal tibial BMD, at varying depths beneath the subchondral surface, to knee pain.

To investigate the association between intestinal permeability alteration and erosive hand osteoarthritis (EHOA).

To describe the associations of endogenous sex hormones with the prevalence and occurrence of knee osteoarthritis (KOA) in women.

Beta-defensin 1 (DEFB1), is a member of the defensin family involved in inflammation, cell apoptosis and senescence. We hypothesized that DEFB1 is essential for intervertebral disc (IVD) homeostasis. Our objective was to elucidate the roles of DEFB1 in IVD degeneration (IDD).

Pain phenotypes (PP) have been identified across different stages of knee osteoarthritis (KOA) and understanding the stability of PPs prior to the development of symptomatic KOA can help to inform preventative strategies. We aimed to identify PPs and their transitions in people without radiographic KOA and profile participant characteristics.

Osteoarthritis (OA) is a prevalent and disabling joint disorder. Minimally invasive interventions targeting the genicular nerves are widely used for the clinical management of knee OA, but evidence on their efficacy and safety remains uncertain.

While physiological loads maintain cartilage health, both joint overload and abnormal joint mechanical loading contribute to osteoarthritis (OA) development. Here, we examined the role of abnormal mechanical loading on joint health by comparing the severity of OA development following a single overload event and repetitive joint overloads.

Low back pain (LBP) is one of the most prevalent musculoskeletal disorders and has a significant global impact. Intervertebral disc degeneration (IVDD) is an important cause of LBP. The aim of this study was to test a hypothesis that elucidates the potential role and molecular mechanisms of cytokine receptor-like factor 1 (CRLF1) in IVDD and LBP.

To investigate the interaction among the cells thought to be foundational to inflammation, fibrosis, and angiogenesis in the synovial membrane.

To explore the mechanism of action and structural effects of MM-II, a dispersion of “empty” multilamellar large liposomes composed of dimyristoyl phosphatidylcholine (DMPC) and dipalmitoyl phosphatidylcholine (DPPC), which durably reduced pain in a phase 2b study in knee osteoarthritis (OA) patients.

Abnormal mechanical stress is a key factor in osteoarthritis (OA) pathogenesis. This study aims to investigate the role of the mechanosensitive ion channel Piezo1 in activating the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway and its contribution to cartilage degradation in OA.

Small studies in athletes showed that primary cam morphology (PCM) gradually develops during skeletal growth. However, the prevalence of PCM in early adolescents is poorly understood. We aimed to estimate the overall and birth-assigned sex-specific prevalence of PCM in early adolescents from the general population.

Senescent nucleus pulposus mesenchymal stem cells (NPMSCs) are key instigators of local chronic inflammation and disruptions in nucleus pulposus tissue repair in intervertebral disc degeneration (IVDD). This study aimed to investigate the interplay between EZH2 and NPMSCs senescence-associated inflammation.

To examine the association of pain sensitization with knee joint loading during walking in people with knee osteoarthritis (OA).

To conduct a bibliographic analysis of English language, non-surgical research pertaining to foot osteoarthritis (OA).

Knee-adjacent subcutaneous fat (kaSCF) has emerged as a potential biomarker and risk factor for osteoarthritis (OA) progression. This study aims to develop an artificial intelligence-based tool for the automatic segmentation of kaSCF thickness and evaluate the cross-sectional associations between kaSCF, cartilage thickness, magnetic resonance imaging-based cartilage T2 relaxation time, knee pain, and