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A selenoxide for single-atom protein modification of tyrosine residues enabled by water-resistant chalcogen and hydrogen bonding Nat. Chem. (IF 19.2) Pub Date : 2025-06-04
Songyun Lin, Marina Hirao, Philipp Hartmann, Markus Leutzsch, Marie Sophie Sterling, Alessandro Vetere, Sandra Klimmek, Heike Hinrichs, Johanna Marie Mengeler, Johannes Lehmann, Jan Samsonowicz-Gόrski, Florian Berger, Tobias Ritter -
Building ultramicroporous zirconium metal‒organic frameworks with ligands of high coordination density through a reticular approach Nat. Chem. (IF 19.2) Pub Date : 2025-06-04
Liang Yu, Shenfang Li, Xin Zhou, Bochun Zhang, Kang Zhou, Qibin Xia, Sujing Wang, Jing Li, Hao Wang -
Interfacial assembly of biomimetic MOF-based porous membranes on coacervates to build complex protocells and prototissues Nat. Chem. (IF 19.2) Pub Date : 2025-06-04
Yanglimin Ji, Yiyang Lin, Yan Qiao -
Gold redox catalysis with hydrogen peroxide Nat. Chem. (IF 19.2) Pub Date : 2025-05-29
Sandip A. Bhadange, Nitin T. Patil -
Bidentate N-ligand-assisted gold redox catalysis with hydrogen peroxide Nat. Chem. (IF 19.2) Pub Date : 2025-05-29
Hongwei Shi, Matthias Rudolph, Jun Li, Yu Tian, Martin C. Dietl, Hadil Alshurafa, Yaowen Liu, Tao Wang, Henrik Habeck, Philipp M. Stein, Petra Krämer, Frank Rominger, Thomas Oeser, Ning Jiao, A. Stephen K. Hashmi -
Trinucleotide substrates under pH–freeze–thaw cycles enable open-ended exponential RNA replication by a polymerase ribozyme Nat. Chem. (IF 19.2) Pub Date : 2025-05-28
James Attwater, Teresa L. Augustin, Joseph F. Curran, Samantha L. Y. Kwok, Luis Ohlendorf, Edoardo Gianni, Philipp Holliger -
Photoinduced bulk polymerization strategy in melt state for recyclable polydiene derivatives Nat. Chem. (IF 19.2) Pub Date : 2025-05-28
Pengfei Wu, Qixuan Hu, Andrew V. Marquardt, Lawal A. Ogunfowora, Jeong Hui Kim, Yuanhao Tang, Chenjian Lin, Brett M. Savoie, Letian Dou -
Structure-informed design of an ultrabright RNA-activated fluorophore Nat. Chem. (IF 19.2) Pub Date : 2025-05-28
Mo Yang, Peri R. Prestwood, Luiz F. M. Passalacqua, Sumirtha Balaratnam, Christopher R. Fullenkamp, J. Winston Arney, Kevin M. Weeks, Adrian Ferre-D’Amare, John S. Schneekloth -
Mimicking the structure and function of tau folds associated with disease Nat. Chem. (IF 19.2) Pub Date : 2025-05-23
Joost Schymkowitz, Frederic Rousseau -
Abiotic lipid metabolism enables membrane plasticity in artificial cells Nat. Chem. (IF 19.2) Pub Date : 2025-05-22
Alessandro Fracassi, Andrés Seoane, Roberto J. Brea, Hong-Guen Lee, Alexander Harjung, Neal K. Devaraj -
Author Correction: Moiré two-dimensional covalent organic framework superlattices Nat. Chem. (IF 19.2) Pub Date : 2025-05-21
Gaolei Zhan, Brecht Koek, Yijia Yuan, Yikuan Liu, Vipin Mishra, Veniero Lenzi, Karol Strutyński, Chunxiao Li, Rongrong Zhang, Xin Zhou, Hwa Seob Choi, Zhen-Feng Cai, Joaquín Almarza, Kunal S. Mali, Aurelio Mateo-Alonso, Manuel Melle Franco, Yihan Zhu, Steven De Feyter, Kian Ping LohCorrection to: Nature Chemistry https://doi.org/10.1038/s41557-025-01748-5, published online 20 February 2025.
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Squeezing the mechanism out of photochemical reactions Nat. Chem. (IF 19.2) Pub Date : 2025-05-21
Andrea Rosichini, Starla D. Glover -
Gut microbiota-mediated GPCR drug metabolism affects downstream pharmacological activity Nat. Chem. (IF 19.2) Pub Date : 2025-05-21
Amy K. Bracken, Pamela V. Chang -
Discovery of acylsulfenic acid-featuring natural product sulfenicin and characterization of its biosynthesis Nat. Chem. (IF 19.2) Pub Date : 2025-05-20
Dan Xue, Hongbin Zou, Yanping Qiu, Wei Lv, Michael D. Madden, Mingming Xu, Xiaoying Lian, Conor Pulliam, Ethan A. Older, Lukuan Hou, Andrew Campbell, Tristan de Rond, Takayoshi Awakawa, Chunhua Yuan, Bradley S. Moore, Jie Li -
A framework for evaluating the chemical knowledge and reasoning abilities of large language models against the expertise of chemists Nat. Chem. (IF 19.2) Pub Date : 2025-05-20
Adrian Mirza, Nawaf Alampara, Sreekanth Kunchapu, Martiño Ríos-García, Benedict Emoekabu, Aswanth Krishnan, Tanya Gupta, Mara Schilling-Wilhelmi, Macjonathan Okereke, Anagha Aneesh, Mehrdad Asgari, Juliane Eberhardt, Amir Mohammad Elahi, Hani M. Elbeheiry, María Victoria Gil, Christina Glaubitz, Maximilian Greiner, Caroline T. Holick, Tim Hoffmann, Abdelrahman Ibrahim, Lea C. Klepsch, Yannik Köster -
High-performance recyclable polymers enabled by stereo- and sequence-controlled polymerization Nat. Chem. (IF 19.2) Pub Date : 2025-05-16
Meng-Yuan Wang, Yi-Min Tu, Qing-Qian Zeng, Kun Li, Wei Xiong, Zhongzheng Cai, Jian-Bo Zhu -
Structural insights into two thiamine diphosphate-dependent enzymes and their synthetic applications in carbon–carbon linkage reactions Nat. Chem. (IF 19.2) Pub Date : 2025-05-14
Tan Liu, Guiyang Wang, Jiahui Yu, Mengyuan Li, Tianbo Peng, Jie Wang, Houhua Li, Xiao-dong Su, Changtao Jiang, Min Ye, Donghui Yang, Ming Ma -
Connecting the dots in a pH-dependent oxygen evolution reaction Nat. Chem. (IF 19.2) Pub Date : 2025-05-13
Thomas Götsch, Travis E. Jones, Detre Teschner -
Controlled anionic polymerization mediated by carbon dioxide Nat. Chem. (IF 19.2) Pub Date : 2025-05-13
Paige E. Jacky, Alexandra D. Easley, Brett P. Fors -
Exo-templating via pseudorotaxane formation reduces pathway complexity in the multicomponent self-assembly of M12L24 nanospheres Nat. Chem. (IF 19.2) Pub Date : 2025-05-12
T. Bouwens, E. O. Bobylev, L. S. D. Antony, D. A. Poole, E. Alarcón-Lladó, S. Mathew, J. N. H. Reek -
Shining light on flavin mononucleotide Nat. Chem. (IF 19.2) Pub Date : 2025-05-07
Qinglong Shi, Juntao YeQinglong Shi and Juntao Ye discuss the history, structure, and reactivity of flavin mononucleotide in natural and non-natural reactions.
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Carnot batteries for dispatchable renewables Nat. Chem. (IF 19.2) Pub Date : 2025-05-07
Bruce C. Gibb -
Efficient and selective energy transfer photoenzymes powered by visible light Nat. Chem. (IF 19.2) Pub Date : 2025-05-06
Rebecca Crawshaw, Ross Smithson, Johannes Hofer, Florence J. Hardy, George W. Roberts, Jonathan S. Trimble, Anna R. Kohn, Colin W. Levy, Deborah A. Drost, Christian Merten, Derren J. Heyes, Richard Obexer, Thorsten Bach, Anthony P. Green -
Sharpening the lens of NMR spectroscopy to study large proteins Nat. Chem. (IF 19.2) Pub Date : 2025-05-05
Yun Huang, David Eliezer -
Leveraging relaxation-optimized 1H–13CF correlations in 4-19F-phenylalanine as atomic beacons for probing structure and dynamics of large proteins Nat. Chem. (IF 19.2) Pub Date : 2025-05-05
Andras Boeszoermenyi, Denitsa L. Radeva, Sebastian Schindler, Veronica Valadares, Krishna M. Padmanabha Das, Abhinav Dubey, Thibault Viennet, Max Schmitt, Peter Kast, Vladimir M. Gelev, Nikolay Stoyanov, Nikola Burdzhiev, Ognyan Petrov, Scott Ficarro, Jarred Marto, Ezekiel A. Geffken, Sirano Dhe-Paganon, Hyuk-Soo Seo, Nathan D. Alexander, Richard B. Cooley, Ryan A. Mehl, Helena Kovacs, Clemens Anklin -
Macrocyclic β-arch peptides that mimic the structure and function of disease-associated tau folds Nat. Chem. (IF 19.2) Pub Date : 2025-04-30
Isaac J. Angera, Xueyong Xu, Benjamin H. Rajewski, Grace I. Hallinan, Xiaoqi Zhang, Bernardino Ghetti, Ruben Vidal, Wen Jiang, Juan R. Del Valle -
Synthesis of zwitterionic open-shell bilayer spironanographenes Nat. Chem. (IF 19.2) Pub Date : 2025-04-30
Juan Lión-Villar, Jesús M. Fernández-García, Samara Medina Rivero, Josefina Perles, Shaofei Wu, Daniel Aranda, Jishan Wu, Shu Seki, Juan Casado, Nazario Martín -
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Porous metal–organic polyhedra with a gecko’s grip Nat. Chem. (IF 19.2) Pub Date : 2025-04-24
Vincent Guillerm -
Transition-metal-free ammonia synthesis Nat. Chem. (IF 19.2) Pub Date : 2025-04-24
Yeqin Guan, Ping Chen -
Lanthanide–nickel molecular intermetallic complexes featuring a ligand-free Ni2− anion in endohedral fullerenes Nat. Chem. (IF 19.2) Pub Date : 2025-04-23
Panfeng Chuai, Ziqi Hu, Yang-Rong Yao, Zhanxin Jiang, Aman Ullah, Ya Zhao, Weiren Cheng, Muqing Chen, Eugenio Coronado, Shangfeng Yang, Zujin Shi -
Synthesis of strained, air-stable boracycles via boron–carbon-centred diradicals Nat. Chem. (IF 19.2) Pub Date : 2025-04-23
Xinmou Wang, Peiqi Zhang, Zhiyi Yang, Weixuan Sun, Hairong Lyu, Zhenyang Lin, Yangjian Quan -
4f-orbital covalency enables a single-crystal-to-single-crystal ring-opening isomerization in a CeIV–cyclopropenyl complex Nat. Chem. (IF 19.2) Pub Date : 2025-04-23
Brett D. Vincenzini, Xiaojuan Yu, Sébastien Paloc, Patrick W. Smith, Himanshu Gupta, Pragati Pandey, Greggory T. Kent, Osvaldo Ordonez, Taylor Keller, Michael R. Gau, Alexandra M. Bacon, Stefan G. Minasian, Trevor W. Hayton, Jochen Autschbach, Eric J. Schelter -
An enzymatic dual-oxa Diels–Alder reaction constructs the oxygen-bridged tricyclic acetal unit of (–)-anthrabenzoxocinone Nat. Chem. (IF 19.2) Pub Date : 2025-04-22
Xiaoli Yan, Xinying Jia, Zhenyao Luo, Shunjia Ji, Meng-Jie Zhang, Hui Zhang, Mingjia Yu, Julien Orts, Kai Jiang, Zhi Lin, Zixin Deng, Xu-Dong Kong, Bostjan Kobe, Yi-Lei Zhao, Mehdi Mobli, Xudong Qu -
Small-molecule-catalysed deamination enables transcriptome-wide profiling of N6-methyladenosine in RNA Nat. Chem. (IF 19.2) Pub Date : 2025-04-17
Pingluan Wang, Chang Ye, Michelle Zhao, Bochen Jiang, Chuan He -
Reactivity of syn-CH3CHOO with H2O enhanced through a roaming mechanism in the entrance channel Nat. Chem. (IF 19.2) Pub Date : 2025-04-16
Yiqiang Liu, Lijie Liu, Yanlin Fu, Haotian Jiang, Hao Wu, Yue Liu, Xiaoxiao Lu, Xiaohu Zhou, Hongwei Li, Rex T. Skodje, Xingan Wang, Bina Fu, Wenrui Dong, Dong H. Zhang, Xueming Yang -
Author Correction: Synthesis of triple-decker sandwich compounds featuring a M–M bond through cyclo-Bi5 and cyclo-Sb5 rings Nat. Chem. (IF 19.2) Pub Date : 2025-04-15
Yu-He Xu, Xing Yang, Ya-Nan Yang, Lili Zhao, Gernot Frenking, Zhong-Ming SunCorrection to: Nature Chemistry https://doi.org/10.1038/s41557-025-01765-4, published online 18 March 2025.
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Valence-delocalized trithorium nanocluster superatoms with open-shell exalted diamagnetism Nat. Chem. (IF 19.2) Pub Date : 2025-04-11
John A. Seed, Xinglan Deng, Josef Tomeček, Adam Brookfield, David Collison, Floriana Tuna, Ashley J. Wooles, George F. S. Whitehead, Nikolas Kaltsoyannis, Stephen T. Liddle -
Universal membranization of synthetic coacervates and biomolecular condensates towards ultrastability and spontaneous emulsification Nat. Chem. (IF 19.2) Pub Date : 2025-04-10
Da Tang, Jun Zhu, Hao Wang, Nannan Chen, Hui Wang, Yongqi Huang, Lingxiang Jiang -
A photoswitchable DNA G-quadruplex ligand enables optical control of transcription Nat. Chem. (IF 19.2) Pub Date : 2025-04-08
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Nuclear spins are active in ultracold atom–molecule collisions Nat. Chem. (IF 19.2) Pub Date : 2025-04-08
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Author Correction: Monitoring the formation of infinite-layer transition metal oxides through in situ atomic-resolution electron microscopy Nat. Chem. (IF 19.2) Pub Date : 2025-04-07
Yaolong Xing, Inhwan Kim, Kyeong Tae Kang, Jinho Byun, Woo Seok Choi, Jaekwang Lee, Sang Ho OhCorrection to: Nature Chemistry https://doi.org/10.1038/s41557-024-01617-7, published online 27 August 2024.
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Hyperfine-to-rotational energy transfer in ultracold atom–molecule collisions of Rb and KRb Nat. Chem. (IF 19.2) Pub Date : 2025-04-07
Yi-Xiang Liu, Lingbang Zhu, Jeshurun Luke, Mark C. Babin, Marcin Gronowski, Hela Ladjimi, Michał Tomza, John L. Bohn, Timur V. Tscherbul, Kang-Kuen Ni -
Switchable skeletal editing of quinolines enabled by cyclizative sequential rearrangements Nat. Chem. (IF 19.2) Pub Date : 2025-04-07
Di Tian, Yu-Ping He, Lu-Sen Yang, Zhuo-Chen Li, Hua Wu -
Progress and future directions in borophene research Nat. Chem. (IF 19.2) Pub Date : 2025-04-07
Qiucheng Li, Eden B. Aklile, Albert Tsui, Mark C. Hersam -
Praseodymium in the formal +5 oxidation state Nat. Chem. (IF 19.2) Pub Date : 2025-04-07
Andrew C. Boggiano, Chad M. Studvick, Sabyasachi Roy Chowdhury, Julie E. Niklas, Haruko Tateyama, Hongwei Wu, Johannes E. Leisen, Florian Kleemiss, Bess Vlaisavljevich, Ivan A. Popov, Henry S. La Pierre -
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Milking riboflavin for all it’s worth Nat. Chem. (IF 19.2) Pub Date : 2025-04-03
Zoe A. Hoffpauir, Audrey L. LambZoe Hoffpauir and Audrey Lamb outline the history and prospects of riboflavin, also known as vitamin B2, a molecule found in food that is required for the formation of coenzymes involved in metabolic processes.
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Aliens among us Nat. Chem. (IF 19.2) Pub Date : 2025-04-03
Michelle FranclDid meteorites fall between the interdisciplinary cracks? Michelle Francl tells the nineteenth-century tale of the extraterrestrial origin of meteorites and suggests that there are lessons for those studying topics that involve multiple disciplines today.
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Activity of GPCR-targeted drugs influenced by human gut microbiota metabolism Nat. Chem. (IF 19.2) Pub Date : 2025-04-03
Qihao Wu, Deguang Song, Yanyu Zhao, Andrew A. Verdegaal, Tayah Turocy, Brianna Duncan-Lowey, Andrew L. Goodman, Noah W. Palm, Jason M. Crawford -
Optical control of gene expression using a DNA G-quadruplex targeting reversible photoswitch Nat. Chem. (IF 19.2) Pub Date : 2025-04-03
Xiaoyun Zhang, Somdutta Dhir, Larry Melidis, Yuqi Chen, Zutao Yu, Angela Simeone, Jochen Spiegel, Santosh Adhikari, Shankar Balasubramanian -
Secret action of gastric acid controlling drug Nat. Chem. (IF 19.2) Pub Date : 2025-04-01
Linghao Kong, Chu Wang -
Recyclable plastics from a manganese catalyst Nat. Chem. (IF 19.2) Pub Date : 2025-03-31
Georgina L. Gregory -
Secondary nucleation as a strategy towards hierarchically organized mesoscale topologies in supramolecular polymerization Nat. Chem. (IF 19.2) Pub Date : 2025-03-31
Sougata Datta, Hiroki Itabashi, Takuho Saito, Shiki Yagai -
Publisher Correction: High-pressure pump–probe experiments reveal the mechanism of excited-state proton-coupled electron transfer and a shift from stepwise to concerted pathways Nat. Chem. (IF 19.2) Pub Date : 2025-03-28
Daniel Langford, Robin Rohr, Stefan Bauroth, Achim Zahl, Alicja Franke, Ivana Ivanović-Burmazović, Dirk M. GuldiCorrection to: Nature Chemistry https://doi.org/10.1038/s41557-025-01772-5, published online 20 March 2025.
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Noncovalent interactions enable optical initialization of spin-based quantum states Nat. Chem. (IF 19.2) Pub Date : 2025-03-28
Subrata Ghosh, Natia L. Frank -
Bilayer covalent organic frameworks take a twist Nat. Chem. (IF 19.2) Pub Date : 2025-03-28
Cheng-Hao Liu, Dmytro F. Perepichka -
Checking out metal cluster chemistry from living libraries Nat. Chem. (IF 19.2) Pub Date : 2025-03-28
Takane Imaoka, Kimihisa Yamamoto -
Oxidation of interfacial cobalt controls the pH dependence of the oxygen evolution reaction Nat. Chem. (IF 19.2) Pub Date : 2025-03-28
Jinzhen Huang, Adam H. Clark, Natasha Hales, Kenneth Crossley, Julie Guehl, Radim Skoupy, Thomas J. Schmidt, Emiliana Fabbri -
Solid oxide electrolysis cell for the super-dry reforming of methane Nat. Chem. (IF 19.2) Pub Date : 2025-03-27