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Is the Molecular Classification of ERBB2 in Stage III Colon Cancer Clinically Ready? Gastroenterology (IF 25.7) Pub Date : 2025-06-04
Jianwei LiuNo Abstract
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Are ERBB2 RNA-High, Amplification-Negative Tumors a Missed Opportunity for Targeted Therapy? Gastroenterology (IF 25.7) Pub Date : 2025-06-04
Zemin Tian, Yinde Huang, Yuan QiuNo Abstract
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Safety and efficacy of MEK inhibitor treatment for gastric pre-cancerous lesions Gastroenterology (IF 25.7) Pub Date : 2025-06-03
James R. Goldenring, Bogun Jang, Takuji Gotoda, Naoyuki Yamaguchi, Eunyoung Choi, Sachiyo NomuraNo Abstract
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Skipping surgery in rectal and other solid cancers with mismatch repair deficiency using immunotherapy Gastroenterology (IF 25.7) Pub Date : 2025-06-02
Maria D. GiraldezNo Abstract
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Presentation of the AGA William Beaumont Prize in Gastroenterology to Evan S. Dellon, MD, MPH Gastroenterology (IF 25.7) Pub Date : 2025-06-02
Robert S. Sandler, Nicholas J. ShaheenSection snippets Background and FamilyEvan was born and raised in Baltimore, Maryland. His father, a prominent plastic surgeon and microsurgeon, is considered a pioneer in the field of peripheral nerve injury, and in private practice, he was promoted to full professor of plastic surgery and neurosurgery at Johns Hopkins University. His mother, originally a teacher, dedicated herself to raising Evan
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An often-forgotten complication of upadacitinib Gastroenterology (IF 25.7) Pub Date : 2025-06-02
Phillip Te, Richard Standish, Neel HeerasingNo Abstract
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A Case of Chronic Gastrointestinal Symptoms: Peeling Back the Mucosal Layers Gastroenterology (IF 25.7) Pub Date : 2025-06-02
Jeffrey Liu, Katherine O. Jones, Muhammad Baraa HammamiNo Abstract
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An Unusual Cause of Secondary Sclerosing Cholangitis: A Case Report Gastroenterology (IF 25.7) Pub Date : 2025-06-02
Qianyi Wang, Jidong Jia, Xinyan ZhaoNo Abstract
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Presentation of the 2025 AGA Distinguished Achievement Award in Basic Science to Eugene B. Chang, MD, AGAF Gastroenterology (IF 25.7) Pub Date : 2025-06-02
R.Balfour sartor, Mrinalini C. Rao, Averil MaSection snippets Impactful Body of Basic Research DiscoveriesDriven by his innate curiosity and investigative skills, Gene’s scientific accomplishments offer a remarkable compendium understanding the mechanisms involved in dynamic dialogues between microbes and hosts in diarrheal/inflammatory disorders, food allergies, type 1 diabetes, cancer, and metabolic diseases (eg, obesity, type 2 diabetes, and
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Shunting the Diagnosis of a Rapid Decline in Cognition Gastroenterology (IF 25.7) Pub Date : 2025-05-31
Maria Rosina Troppmair, Benedikt Schaefer, Martin FreundNo Abstract
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A rare cause of abdominal distension in infancy Gastroenterology (IF 25.7) Pub Date : 2025-05-30
Yu-Syuan Chen, Jui-Hung Weng, Shan-Ming ChenNo Abstract
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Expanding Nutrition Training in Gastroenterology: A Call to Action Gastroenterology (IF 25.7) Pub Date : 2025-05-30
Jason C. Lin, John C. Lin, Joy Zhao, Elizabeth G. Holt, Edwin K. McDonald, Stephanie M. MoleskiNo Abstract
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Relationship of Intra-Pancreatic Fat Deposition With Pancreatic Cancer Differs According to Carcinoma Types Gastroenterology (IF 25.7) Pub Date : 2025-05-28
Hiroki Oyama, Tsuyoshi Hamada, Daniel Nevo, Yudai Nakai, Yousuke Nakai, Maxim S. Petrov -
An International Consensus on Appropriate Management of Corticosteroids in Clinical Trials in Inflammatory Bowel Disease Gastroenterology (IF 25.7) Pub Date : 2025-05-28
Jurij Hanžel, Virginia Solitano, Sudheer Kumar Vuyyuru, Remo Panaccione, Bruce E. Sands, Laurent Peyrin-Biroulet, Silvio Danese, Geert R. D'Haens, Raja Atreya, Matthieu Allez, Charles N. Bernstein, Peter Bossuyt, Brian Bressler, Robert V. Bryant, Benjamin L. Cohen, Jean-Frederic Colombel, Ferdinando D’Amico, Axel Dignass, Marla Dubinsky, Phillip Fleshner, Christopher Ma -
A Practical Guide to Incorporating a Psychologist into a Gastroenterology Practice Gastroenterology (IF 25.7) Pub Date : 2025-05-28
Jessica K. Salwen-Deremer, Sarah Ballou, Megan Petrik, Miguel Regueiro, Corey A. Siegel, Laurie KeeferNo Abstract
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AAV-mediated silencing of Sox4 leads to long-term amelioration of liver phenotypes in mouse models of Alagille syndrome Gastroenterology (IF 25.7) Pub Date : 2025-05-28
Duncan Fox, Jun Xie, Jennifer L. Burwinkel, Josh M. Adams, Kashish Chetal, Marzieh Keivandarian, Yaniv Faingelernt, Sanjay Subramanian, Mario F. Lopez, Anna L. Peters, Nathan Salomonis, Neda Zarrin-Khameh, Guangping Gao, Stacey S. Huppert, Hamed Jafar-Nejad -
A Pragmatic Trial Comparing Uptake and Cancer Mortality between Invitation to Colonoscopy and Invitation to Fecal Immunochemical Testing Approaches Gastroenterology (IF 25.7) Pub Date : 2025-05-28
Nauzer ForbesNo Abstract
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Efficacy of ACupuncTure in Irritable bOwel syNdrome (ACTION): a multi-centre randomized controlled trial Gastroenterology (IF 25.7) Pub Date : 2025-05-27
Jing-Wen Yang, Ling-Yu Qi, Shi-Yan Yan, Yan-Fen She, Ying Li, Li-Li Chi, Hui Hu, Li-Qiong Wang, Chang-Chun Ji, Bang-Qi Wu, Zi-Tong Fu, Shuang-Jing Li, Na-Na Yang, Yu Wang, Cun-Zhi LiuBACKGROUND & AIMSIrritable bowel syndrome (IBS) affects 4.1% of the adult population, with many reporting ongoing symptoms despite first-line therapies. Acupuncture is widely used for IBS, but without sufficient evidence. We aim to assess the efficacy of acupuncture in patients with diarrhea-predominant IBS (IBS-D). METHODSThis was a multi-center randomized controlled trial in six hospitals in China
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Analysis of the Article "Intestinal Epithelial Serotonin as a Novel Target for Treating Disorders of Gut-Brain Interaction and Mood" Gastroenterology (IF 25.7) Pub Date : 2025-05-23
Bin He, Yilian Zhong, Zhaochi Yue, Jun Li, Yaling LiNo Abstract
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Reply to He et al and to Wang et al Gastroenterology (IF 25.7) Pub Date : 2025-05-23
Kara Gross Margolis, Lin Y. Hung, Mark AnsorgeNo Abstract
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The Role of Artificial Intelligence in Chronic Liver Diseases and Liver Transplantation Gastroenterology (IF 25.7) Pub Date : 2025-05-22
Ashley Spann, Alexandra T. Strauss, Sharon E. Davis, Mamatha BhatIn hepatology, pattern recognition in laboratory data and clinical characteristics is the hallmark of clinical care. Artificial intelligence (AI) tools like machine or deep learning and large language models provide interesting mechanisms for facilitating care advancement. The complexity and diversity of data, alongside genetic, environmental and lifestyle factors, all contribute to individualized
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Evaluating the Translational Potential of Gut-Restricted SERT Modulation Gastroenterology (IF 25.7) Pub Date : 2025-05-23
Jiaqi Wang, Xiufeng Zhao, Xuemin JinNo Abstract
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Presentation of the Julius M. Friedenwald Medal to David Lieberman, MD, AGAF Gastroenterology (IF 25.7) Pub Date : 2025-05-21
Sarah J. Diamond, Brian Fennerty, David A. KatzkaSection snippets Early Life and EducationDavid was born in St Louis and raised in University City, Missouri. His grandparents emigrated from Ukraine and Poland, and his parents were dedicated community leaders—his father served on the city council for 25 years and his mother on the local school board for the same duration. Their strong commitment to social justice and community service instilled in
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Gastric Cancer Prevention in the United States: A Work in Progress Gastroenterology (IF 25.7) Pub Date : 2025-05-21
Robert J. Huang, Paul Moayyedi, Shailja C. Shah, Yanghee Woo, Andrew Y. Wang, Joo Ha HwangNo Abstract
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Elsewhere in the AGA Journals (Preview Section) Gastroenterology (IF 25.7) Pub Date : 2025-05-22
No Abstract
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Reply to He et al and to Zuo and Ji Gastroenterology (IF 25.7) Pub Date : 2025-05-21
Mimi C. Tan, Rebecca R. Richards-Kortum, Sharmila AnandasabapathyNo Abstract
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Can HRME Be Widely Adopted for Esophageal Cancer Screening in Low-Resource Settings? Gastroenterology (IF 25.7) Pub Date : 2025-05-21
He Yizi, He Haiqing, Xie YongzhiNo Abstract
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Patient Involvement and Methodological Considerations in the UGIC Endoscopy Screening Cluster Trial Gastroenterology (IF 25.7) Pub Date : 2025-05-21
Zhen-Ya Chen, Tian-Zeng Bian, Zhou-Yun Zhao, Yi-Qi Chen, Wen-Tian CaoNo Abstract
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Reply to Liu et al and Chen et al Gastroenterology (IF 25.7) Pub Date : 2025-05-21
Changfa Xia, He Li, Wanqing ChenNo Abstract
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Reimagining HRME's Global Role: Operator Expertise Gap Undermines Cost-Effective ESCN Screening Gastroenterology (IF 25.7) Pub Date : 2025-05-21
Dianbao Zuo, Kangkang JiNo Abstract
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Fidaxomicin reduces collagen expression in intestinal fibroblasts via platelet-derived growth factor receptor beta and glycogen synthase kinase-3 beta inhibition. Gastroenterology (IF 25.7) Pub Date : 2025-05-19
Sophie Irwin, Mieke van Daelen, Isabella Almaraz, Rebecca Park, Becca Nelson, Swapna Mahurkar-Joshi, Florian Rieder, David Q. Shih, Wendy Ho, Berkeley Limketkai, Hon Wai KoonIntroductionAbout 30-50% of patients with Crohn’s disease (CD) eventually develop intestinal strictures, with intestinal fibrosis being a major component of them. There is currently no approved medication to treat fibrotic strictures. Methods10X Genomics Visium spatial RNA sequencing and high-throughput screening (HTS) were used to discover the molecular targets of intestinal fibrosis. Stricturing
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DEVELOPMENT OF ACUTE KIDNEY INJURY IN A PATIENT WITH ALCOHOL-RELATED CIRRHOSIS: THE IMPORTANCE OF DIAGNOSING THE CAUSE OF AKI Gastroenterology (IF 25.7) Pub Date : 2025-05-19
Adrià Juanola, Ann T. Ma, Giuseppe Cullaro, Mariam P. Alexander, Andrew S. Allegretti, Pere GinèsNo Abstract
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Comment on “Effect of an Endoscopy Screening on Upper Gastrointestinal Cancer Mortality: A Community-Based Multicenter Cluster Randomized Clinical Trial” Gastroenterology (IF 25.7) Pub Date : 2025-05-17
Lei Liu, Chunying Jiang, Hongyu ZhaoNo Abstract
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Mis-lead by obstruction Gastroenterology (IF 25.7) Pub Date : 2025-05-17
Ashok Jhajharia, Devank Shah, Prachis AshdhirNo Abstract
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Synergies between Clinicians, Academia and Industry in the Age of AI Gastroenterology (IF 25.7) Pub Date : 2025-05-16
Michael F. Byrne, Jens Rittscher, James E. EastIn the rapidly evolving landscape of GI healthcare, the integration of artificial intelligence (AI) presents unprecedented opportunities for enhancing patient outcomes, improving efficiency, and driving innovation. Effective collaboration among clinicians, academia, and industry is crucial to harness the full potential of AI technologies.Clinicians offer invaluable insights from real-world practice
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Dietary fiber modulates the window of susceptibility to Clostridioides difficile infection Gastroenterology (IF 25.7) Pub Date : 2025-05-16
Katharine K. Hewlett, Amanda PeBenito, Aaron L. Hecht, Connor Tiffany, Ceylan Tanes, Rochelle C. Glover, Jibraan A. Fawad, Elliot S. Friedman, James C. Reynolds, Kyle Bittinger, James D. Lewis, Gary D. Wu, Nitin K. Ahuja, Joseph P. ZackularBackground & AimsClostridioides difficile epidemiology is rapidly evolving, and understanding the factors that contribute to one’s risk of C. difficile infection (CDI) is urgently needed. Based on our observations in a dietary intervention study, we hypothesized that fiber modulates susceptibility to C. difficile post-antibiotic exposure and investigated this using human specimens and murine models
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Cost-effectiveness of regular surveillance versus endoscopy at need for patients with Barrett’s esophagus: economic evaluation alongside the BOSS randomized controlled trial Gastroenterology (IF 25.7) Pub Date : 2025-05-16
Manuela Deidda, Oliver Old, Janusz Jankowski, Stephen Attwood, Clive Stokes, Catherine Kendall, Cathryn Rasdell, Alex Zimmermann, Sofia Massa, Sharon Love, Scott Sanders, Julie Hapeshi, Chris Foy, Andrew Briggs, Hugh Barr, Paul MoayyediIntroductionThe Barrett’s esophagus surveillance study (BOSS) was the first randomized study of surveillance. This study reports the costs and quality of life outcomes from the BOSS trial and models the outcomes and cost-effectiveness of surveillance beyond the follow up period of the BOSS study. This trial showed similar stages and rates of esophageal cancer in both arms, but the regular surveillance
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Tumor Necrosis Factor-Like Ligand 1A/Death Receptor 3 Signaling Regulates the Generation of Pathogenic T Helper 9 Cells in Experimental Crohn’s Disease Gastroenterology (IF 25.7) Pub Date : 2025-05-15
Paola Menghini, Ludovica F. Buttó, Adrian Gomez-Nguyen, Natalia Aladyshkina, Kristine-Ann Buela, Abdullah Osme, Ricky Chan, Hannah L. Wargo, Stefania De Santis, Giorgos Bamias, Theresa Pizarro, Fabio Cominelli -
Enhanced Analytical Framework for Complex Biological Data: Beyond Principal Component Analysis in Cancer Research Gastroenterology (IF 25.7) Pub Date : 2025-05-15
Yoshiyasu TakefujiNo Abstract
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Pharmacomicrobiomics: The role of the gut microbiome in immunomodulation and cancer therapy Gastroenterology (IF 25.7) Pub Date : 2025-05-15
Laura A. Bolte, Johannes R. Björk, Ranko Gacesa, Rinse K. WeersmaThere is a large heterogeneity among individuals in their therapeutic responses to the same drug and in the occurrence of adverse events. A key factor increasingly recognized to contribute to this variability is the gut microbiome. The gut microbiome can be regarded as a second genome, holding significant metabolic capacity. Consequently, the field of pharmacomicrobiomics has emerged as a natural extension
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Reply to Jing and Song, Tang et al, and Takefuji Gastroenterology (IF 25.7) Pub Date : 2025-05-15
Jinsheng Ding, Tianxing Zhou, Jihui HaoNo Abstract
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Mechanistic Insights and Perspectives on AVL9-Mediated Chemoresistance in Pancreatic Ductal Adenocarcinoma Gastroenterology (IF 25.7) Pub Date : 2025-05-15
Xinyi Tang, Jiaruo Xu, Qingzhi Ran, Yongkang ZhangNo Abstract
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Comments on “Hypoxic and acidic tumor microenvironment-driven AVL9 promotes chemoresistance of pancreatic ductal adenocarcinoma via the AVL9-IκBα-SKP1 complex” Gastroenterology (IF 25.7) Pub Date : 2025-05-15
Saisai Jing, Jiazhao SongNo Abstract
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Associations of alcohol consumption and genetic predisposition to hepatic steatosis with liver-related events: results from large population-based cohort studies Gastroenterology (IF 25.7) Pub Date : 2025-05-14
Hongliang Xue, Liqing Wang, Dianjianyi Sun, Yuankai Wu, Canqing Yu, Yating Huang, Sun On Chan, Wenhua Ling, Jun Lv, Liming Li, Xu Chen, Yuanjie Pang, Chao YuBackground & AimsThe new classification for steatotic liver disease (SLD) identifies three phenotypes based on alcohol consumption. We aimed to evaluate the associations between alcohol intake and liver-related events (LREs) across different drinking categories and whether genetic predisposition influences these associations. MethodsWe analyzed data from 301,673 UK Biobank participants. Alcohol consumption
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The Patient Prescription for Integrating AI into GI Care Gastroenterology (IF 25.7) Pub Date : 2025-05-14
Kate Mason, Megan Marsiglio, Sam JactelNo Abstract
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A Rare Treatable Cause of Dysphagia and Odynophagia in a Lung Transplant Recipient Gastroenterology (IF 25.7) Pub Date : 2025-05-14
Abdillahi Ahmed, Lehar Khanna, Anil SharmaNo Abstract
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Revisiting Helicobacter pylori eradication: evolving evidence and global implications for gastric cancer prevention Gastroenterology (IF 25.7) Pub Date : 2025-05-14
Zong-Chao Liu, Wen-Qing LiNo Abstract
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Fatigue, weakness, shoulder pains after achieving remission for 8 years – a rare case with an even more unusual presentation Gastroenterology (IF 25.7) Pub Date : 2025-05-14
Xuan-Qiu He, Zhen Yang, Guo-Xin HuNo Abstract
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Artificial Intelligence in Gastroenterology and Hepatology: Potential and Perils Gastroenterology (IF 25.7) Pub Date : 2025-05-13
Dennis L. Shung, Marietta IacucciNo Abstract
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Rifaximin Prophylaxis and “Collateral Damage” in Patients with Advanced Liver Disease Gastroenterology (IF 25.7) Pub Date : 2025-05-08
Henry F. Chambers, Cesar A. AriasNo Abstract
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In Memoriam: John S. Fordtran, MD Gastroenterology (IF 25.7) Pub Date : 2025-05-03
Lawrence R. Schiller, Raj K. Goyal, Rhonda Souza, Byron CryerNo Abstract
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Reply to Yang et al., He et al., and Mahapatra et al. Gastroenterology (IF 25.7) Pub Date : 2025-05-02
Kirles Bishay, Zhao Wu Meng, Nauzer ForbesNo Abstract
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Methanogens in Colorectal Cancer: Association or Causation? Gastroenterology (IF 25.7) Pub Date : 2025-05-02
Jiawen Bu, Xudong Zhu, Hong ZhangNo Abstract
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Critical Analysis of Random Forest Feature Selection: Implications for Gut Microbiome Cancer Research Gastroenterology (IF 25.7) Pub Date : 2025-05-02
Yoshiyasu TakefujiNo Abstract
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Reply to Kelm and Flemming and to Zhang et al Gastroenterology (IF 25.7) Pub Date : 2025-05-02
Weiwei Liu, Florian RiederNo Abstract
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Regarding “Fecal Hemoglobin Levels in Prior Negative Screening and Detection of Colorectal Neoplasia: A Dose-Response Meta-Analysis” Gastroenterology (IF 25.7) Pub Date : 2025-05-02
Giulio Antonelli, Leonardo Frazzoni, Lorenzo Fuccio, Cesare HassanNo Abstract
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Advances in Locoregional and Systemic Treatments for HCC Gastroenterology (IF 25.7) Pub Date : 2025-05-02
Amit G. Singal, Riad Salem, David J. Pinato, Anjana PillaiThere have been significant advances in the locoregional and systemic therapy landscape for hepatocellular carcinoma (HCC), with the most notable being the introduction of immune checkpoint inhibitor (ICI) combinations. ICI combinations have significantly improved the overall survival of patients with unresectable HCC, affording median survival over 2 years and long-term survival exceeding 5 years
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