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Characterization of Hepatotropic Small Molecule Inhibitors of Hypoxia Inducible Factor Prolyl Hydroxylase in the Prevention of Oxygen-Induced Retinopathy J. Med. Chem. (IF 6.8) Pub Date : 2025-06-04
Christie Campla, George Hoppe, Minzhong Yu, Juliana Woda, Neal S. Peachey, Vara Prasad Josyula, Shaun R. Stauffer, Jonathan E. SearsRetinopathy of prematurity (ROP) blinds severely premature infants and is caused by oxygen supplementation. Hypoxia-inducible factor (HIF) stabilization during hyperoxia can prevent oxygen-induced retinopathy (OIR), the experimental correlate of ROP. Stabilization of hepatic HIF-1 alone can prevent OIR while contemporaneously protecting other organ systems, such as the lung and brain, from oxygen toxicity
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Target Engagement Assays in Early Drug Discovery J. Med. Chem. (IF 6.8) Pub Date : 2025-06-04
Sahra St John-Campbell, Gurdip Bhalay -
Design, Synthesis, and Evaluation of Pyrazolopyridine Derivatives as Novel Calreticulin (CALR) Ligands That Inhibit Triple-Negative Breast Cancer (TNBC) via Inducing Calcium Overloading J. Med. Chem. (IF 6.8) Pub Date : 2025-06-04
Jiaguo Lu, Anqi Yin, Shenpeng Tan, Ruihong Zhuge, Yi Liu, Peng Zhang, Li Liu, Xuan Xuan, Huirong Li, Wenyan Wang, Xiaolin Zhang, Qikun Yin, Hongbo WangTriple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, posing significant therapeutic challenges due to the lack of effective targets. Elevating intracellular calcium levels is a promising strategy in cancer therapy, and highly expressed calreticulin (CALR) in tumors has emerged as a potential target for inducing calcium overload. However, few studies on CALR ligands
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Uncovering the Unusual Inhibition Mechanism of a Trypanosome Alternative Oxidase Inhibitor Displaying Broad-Spectrum Activity against African Animal Trypanosomes J. Med. Chem. (IF 6.8) Pub Date : 2025-06-04
Godwin U. Ebiloma, Emmanuel O. Balogun, Natsumi Arai, Momoka Otani, Cecilia Baldassarri, Amani Alhejely, Eduardo Cueto-Díaz, Harry P. De Koning, Christophe Dardonville, Tomoo Shiba -
Cyclic Peptide Therapeutic Agents Discovery: Computational and Artificial Intelligence-Driven Strategies J. Med. Chem. (IF 6.8) Pub Date : 2025-06-04
Kang Lin, Chengyun Zhang, Renren Bai, Hongliang Duan -
Heparan Sulfate-Based Neoproteoglycan for Targeted Lysosomal Degradation of Amyloid-β J. Med. Chem. (IF 6.8) Pub Date : 2025-06-03
Sharath S. Vishweshwara, Saurabh Anand, Preeti Ravindra Bhoge, Virendrasinh Mahida, Ankita Chandra, Srinivas Vinod Saladi, Raghavendra Kikkeri -
Design, Synthesis, and Biological Activity Evaluation of Deuterated Diphenyl Azole Alcohol-Based CYP51 Inhibitors J. Med. Chem. (IF 6.8) Pub Date : 2025-06-03
Yixiang Sun, Zirui Luo, Kejian Li, Hongjian Wang, Zixuan Gao, Jiachen Zhang, Rongrong Liu, Rui Liu, Xudong Wu, Nian Liu, Haoyu Zhang, Xin Su, Wenbo Yin, Dongmei Zhao, Maosheng Cheng -
Discovery of a Novel and Potent MET Transcription Inhibitor Targeting Promoter G-Quadruplex for the Treatment of NSCLC J. Med. Chem. (IF 6.8) Pub Date : 2025-06-02
Wenjian Min, Chunling Chen, Zhongrui Shi, Huanaoyu Yang, Yanyin Wang, Junfeng He, Qiman Zhang, Yunchu Zhao, Yi Hou, Jiayu Ding, Yasheng Zhu, Chengliang Sun, Kai Yuan, Peng Yang, Xiao Wang -
Atezolizumab plus paclitaxel and bevacizumab as first-line treatment of advanced triple-negative breast cancer: the ATRACTIB phase 2 trial Nat. Med. (IF 58.7) Pub Date : 2025-06-04
María Gion, Isabel Blancas, Patricia Cortez-Castedo, Alfonso Cortés-Salgado, Frederik Marmé, Salvador Blanch, Serafín Morales, Nieves Díaz, Isabel Calvo-Plaza, Sabela Recalde, Alejandro Martínez-Bueno, Manuel Ruiz-Borrego, Elisenda Llabrés, María Teresa Taberner, Michelino de Laurentiis, Silvia García-Vicente, José Antonio Guerrero, Olga Boix, Jose Rodríguez-Morató, Miguel Sampayo-Cordero, Gabriele -
Peri-operative atezolizumab in early-stage triple-negative breast cancer: final results and ctDNA analyses from the randomized phase 3 IMpassion031 trial Nat. Med. (IF 58.7) Pub Date : 2025-06-04
Elizabeth A. Mittendorf, Zoe June Assaf, Nadia Harbeck, Hong Zhang, Shigehira Saji, Kyung Hae Jung, Roberto Hegg, Andreas Koehler, Joohyuk Sohn, Hiroji Iwata, Melinda L. Telli, Cristiano Ferrario, Kevin Punie, Aditi Qamra, Max Dieterich, Yun Xu, Mario Liste-Hermoso, Esther Shearer-Kang, Luciana Molinero, Stephen Y. Chui, Carlos H. Barrios -
Individual variations in glycemic responses to carbohydrates and underlying metabolic physiology Nat. Med. (IF 58.7) Pub Date : 2025-06-04
Yue Wu, Ben Ehlert, Ahmed A. Metwally, Dalia Perelman, Heyjun Park, Andrew Wallace Brooks, Fahim Abbasi, Basil Michael, Alessandra Celli, Caroline Bejikian, Ekrem Ayhan, Yingzhou Lu, Samuel M. Lancaster, Daniel Hornburg, Lucia Ramirez, David Bogumil, Sarah Pollock, Frank Wong, Denver Bradley, Georg Gutjahr, Ekanath Srihari Rangan, Tao Wang, Lettie McGuire, P. Venkat Rangan, Helge Ræder, Zohar Shipony -
Stem cell therapies advance in Parkinson’s disease and beyond Nat. Med. (IF 58.7) Pub Date : 2025-06-04
Landmark trials using stem cells to treat Parkinson’s disease in the USA and Japan mark a turning point for cell therapy in neurodegeneration. Similar approaches to Alzheimer’s disease and amyotrophic lateral sclerosis are also showing early signs of promise.
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Indo–Gem: An Activatable Theranostic Prodrug, a “Turn–On” Fluorescent Probe, and a Targetable Imaging Agent in the Zebrafish Gallbladder System Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-06-04
Neha Jain, Arkaprava Roychaudhury, JunHyuk Kim, Ruchi Dixit, Prasad M. Sonawane, Michio Iwaoka, Cheol–Hee Kim, Satish Balasaheb Nimse, David G. Churchill -
Corrigendum to “Design, Synthesis, and Biological Evaluation of Novel BTK-targeting Proteolysis Targeting Chimeras (PROTACs) with Enhanced Pharmacokinetic Properties” [Eur. J. Med. Chem. 289 (2025) 117420] Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-06-04
Ying Lin, Jing Liu, Xinjian Tian, Jin Wang, Huahua Su, Jianpin Xiang, Tao Cao, Yonghui Wang, Qiong Xie, Xufen Yu -
PSMA targeted Therapy: From molecular mechanisms to clinical breakthroughs in castration-resistant prostate cancer Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-05-30
Licheng Wang, Change Lu, Xin'an Wang, Denglong Wu -
Opioid Enantiomers: Exploring the Complex Interplay of Stereochemistry, Pharmacodynamics, and Therapeutic Potential J. Med. Chem. (IF 6.8) Pub Date : 2025-06-03
Jingwei Gao, Dingjun Jiang, Hongshuang Wang, Xiaohui Wang -
Dual Conjugation of Long- and Medium-Chain Fatty Acids to BimBH3 Peptide Yields Ultra Long-Acting Inhibitors of Intracellular PTPN1/2 J. Med. Chem. (IF 6.8) Pub Date : 2025-06-03
Chuanliang Zhang, Guozhen Dong, Xiao Wu, Jin Chen, Yanqing Wang, Liyan Gong, Xianmin Yang, Yiying Shi, Zongwen Gu, Xiang Gao, Yaning Zheng, Han Wu, Ke Zheng, Xiaochun Liu, Yuchao Gu -
Discovery of KIN-8741, a Highly Selective Type IIb c-Met Kinase Inhibitor with Broad Mutation Coverage and Quality Drug-Like Properties for the Treatment of Cancer J. Med. Chem. (IF 6.8) Pub Date : 2025-06-03
Xiaohu S. Ouyang, Kathryn B. Grandinetti, Morgan Boren, Subhas Chakravorty, Shubham Chopade, Ping Jiang, Toufike Kanouni, Tatiana Koudriakova, Om Makwana, Shawn K. Pack, Michelle Perez, Rowena Suriben, Noel Timple, Sanjeev Thohan, Sean Uryu, Scott Womble, Ding Yuan, Robert S. Kania, Jason M. Cox -
Unraveling the Efficacy of AR Antagonists Bearing N-(4-(Benzyloxy)phenyl)piperidine-1-sulfonamide Scaffold in Prostate Cancer Therapy by Targeting LBP Mutations J. Med. Chem. (IF 6.8) Pub Date : 2025-06-03
Xin Chai, Xinyue Wang, Lvtao Cai, Haiyi Chen, Siyu Wang, Jianing Liao, Huating Wang, Yuxin Zhou, Lei Xu, Luhu Shan, Xiaohong Xu, Yuhui Yang, Junzhao He, Yaqin Fu, Tingjun Hou, Rong Sheng, Dan Li -
Discovery of a Proteolysis-Targeting Chimera Degrader of JAK2 as a Potential Therapeutic Agent for JAK2-Mediated Myeloproliferative Neoplasms J. Med. Chem. (IF 6.8) Pub Date : 2025-06-03
Caolin Wang, Ziqi Chen, Siyu Wang, Jie Wang, Panpan Yu, Chulu Huang, Yunpeng Wu, Zhenjiang Zhao, Wenyi Mei, Honglin Li, Lili Zhu -
Induction of Cuproptosis with a Highly Cytotoxic Tripodal Cu(II) Complex for Anticancer Therapy J. Med. Chem. (IF 6.8) Pub Date : 2025-06-03
Ricarda Zimmermann, Nicolás Montesdeoca, Johannes Karges -
Corrections to “VHH Nanobody Versatility against Pentameric Ligand-Gated Ion Channels” J. Med. Chem. (IF 6.8) Pub Date : 2025-06-02
Dorota Nemecz, Weronika Nowak, Ákos NemeczPage 8502 Section 2: Typographical errors not caught during copy edits should be corrected as such: a comma after “peripheral,” in the second sentence of the first paragraph. An o is missing from “Drosophila melanogaster” in the second to last sentence. Page 8507 Section 4.1: Last paragraph a comma should be removed after NbR101 in the sentence “These interactions consist of NbR101 making a salt bridge
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Optimization of 1-Methyl-3-(pyridin-3-yl)-1H-indol Derivatives as ROR1 Inhibitors with Improved Activity and Selectivity J. Med. Chem. (IF 6.8) Pub Date : 2025-06-02
Qingquan Zheng, Xingyang Qiu, Dongdong Luo, Hulin Ma, Yue Ming, Wenchen Pu, Min Ai, Jianhua He, Yong Peng -
The landscape for radioligand therapies in oncology Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-06-03
Discover the world’s best science and medicine | Nature.com
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Pooled analysis of 3,741 stool metagenomes from 18 cohorts for cross-stage and strain-level reproducible microbial biomarkers of colorectal cancer Nat. Med. (IF 58.7) Pub Date : 2025-06-03
Gianmarco Piccinno, Kelsey N. Thompson, Paolo Manghi, Andrew R. Ghazi, Andrew Maltez Thomas, Aitor Blanco-Míguez, Francesco Asnicar, Katarina Mladenovic, Federica Pinto, Federica Armanini, Michal Punčochář, Elisa Piperni, Vitor Heidrich, Gloria Fackelmann, Giulio Ferrero, Sonia Tarallo, Long H. Nguyen, Yan Yan, Nazim A. Keles, Bilge G. Tuna, Veronika Vymetalkova, Mario Trompetto, Vaclav Liska, Tomas -
A generative AI-discovered TNIK inhibitor for idiopathic pulmonary fibrosis: a randomized phase 2a trial Nat. Med. (IF 58.7) Pub Date : 2025-06-03
Zuojun Xu, Feng Ren, Ping Wang, Jie Cao, Chunting Tan, Dedong Ma, Li Zhao, Jinghong Dai, Yipeng Ding, Haohui Fang, Huiping Li, Hong Liu, Fengming Luo, Ying Meng, Pinhua Pan, Pingchao Xiang, Zuke Xiao, Sujata Rao, Carol Satler, Sang Liu, Yuan Lv, Heng Zhao, Shan Chen, Hui Cui, Mikhail Korzinkin, David Gennert, Alex Zhavoronkov -
Anti-sporozoite monoclonal antibody for malaria prevention: secondary efficacy outcome of a phase 2 randomized trial Nat. Med. (IF 58.7) Pub Date : 2025-06-03
Jeff Skinner, Kassoum Kayentao, Aissata Ongoiba, Sara A. Healy, Zonghui Hu, Anne C. Preston, Amadou Niangaly, Philipp Schwabl, Hamidou Cisse, Safiatou Doumbo, Didier Doumtabe, Abdrahamane Traore, Shanping Li, Mary E. Peterson, Annette M. Seilie, Chris Chavtur, Weston Staubus, Ming Chang, Katrina Kelley, Hamadi Traore, Adama Djiguiba, Mamadou Keita, Adama Ouattara, M’Bouye Doucoure, Mohamed Keita, Djelika -
An international Delphi consensus for reporting of setting in psychedelic clinical trials Nat. Med. (IF 58.7) Pub Date : 2025-06-03
Chloé Pronovost-Morgan, Kyle T. Greenway, Leor Roseman -
A Medicinal Chemistry Perspective on ATR: Current Status and Future Directions Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-06-02
Kun Li, Xiangxi Sun, Shengyu Liu, Yidong Liu, Xue Feng, Guogang Zhang -
Discovery of an ALK Degrader for Lorlatinib-Resistant Compound Mutations Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-06-02
Fei Gao, Zhenhua Wu, Anqi Lin, Xinyu Wu, Baoding Zhang, Liqing Liu, Yue Lu, Shangshang Geng, Zhen Huang, Yiyu Chen, Jianming Zhang, Li Li, Xianming Deng -
An exploration of molecular signaling in drug reprocessing for Oral Squamous Cell Carcinoma Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-05-31
Ali Nakhaei, Sarah Marzoughi, Sahar Ghoflchi, Hossein Hosseini, Amir R. Afshari, Mohammad Jalili-Nik, Prashant Kesharwani, Amirhossein Sahebkar -
Discovery of indane and naphthalene derivatives as USP7 inhibitors Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-05-29
Xian Zhang, Shudan Tan, Dalin Wang, Huayun Zhu, Di Chen, Yueting Chen, Guangqing Wu, Zhizhen Zhu, Fengyi Zhang, Zijiang Liang, Li Xu, Xing Li, Haoliang Yuan, Qinglong Xu, Liang Dai, Zhiqi Feng, Caiping Chen, Liu Liu, Xiaoan Wen -
Lead Optimization of a Butyrylcholinesterase Inhibitor for the Treatment of Alzheimer’s Disease J. Med. Chem. (IF 6.8) Pub Date : 2025-06-02
Urban Košak, Nika Strašek Benedik, Damijan Knez, Simon Žakelj, Jurij Trontelj, Anja Pišlar, Selena Horvat, Aljoša Bolje, Neža Žnidaršič, Neža Grgurevič, Tanja Švara, Jakob Kljun, Anna Skrzypczak-Wiercioch, Bingbing Lv, Yucheng Xiong, Qinjie Wang, Rui Bian, Jikuan Shao, José Dias, Florian Nachon, Xavier Brazzolotto, Jure Stojan, Haopeng Sun, Kinga Sałat, Stanislav Gobec -
Recognition of the CREB-Binding Protein/Mixed Lineage Leukemia Interface by Sulfonyl-γ-AApeptides: Beyond Mimicry of Mixed Lineage Leukemia J. Med. Chem. (IF 6.8) Pub Date : 2025-06-02
Bo Huang, Minghui Wang, Emily Gregory-Lott, Bingbing X. Li, Yu Yu Win, Ning Shen, Jianyu Chen, Sihao Li, Chuanhai Cao, Xiangshu Xiao, Gary W. Daughdrill, Jianfeng Cai -
Metalla-Aromatic Oligomers: Efficient Photocatalytic Activation for Phototherapy J. Med. Chem. (IF 6.8) Pub Date : 2025-06-01
Shiyan Chen, Guotao Yuan, Liu Wang, Jungryun Kim, Haobing Wang, Jiyoung Yoo, Fengshu Cao, Xintong Lin, Huaiyi Huang, Jong Seung Kim, Haiping Xia, Pingyu Zhang -
Lowering pathological α-synuclein Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-06-02
Discover the world’s best science and medicine | Nature.com
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Prolonging the antidepressant effects of ketamine Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-06-02
Discover the world’s best science and medicine | Nature.com
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Towards a universal snake antivenom Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-06-02
Discover the world’s best science and medicine | Nature.com
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Blocking a cell surface protein beats AML Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-06-02
Discover the world’s best science and medicine | Nature.com
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The gut microbiome as a target in cancer immunotherapy: opportunities and challenges for drug development Nat. Rev. Drug. Disc. (IF 122.7) Pub Date : 2025-06-02
Arielle Elkrief, Reilly Pidgeon, Saman Maleki Vareki, Meriem Messaoudene, Bastien Castagner, Bertrand Routy -
Triptolide-based cleavable antibody-drug conjugates for pancreatic cancer Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-05-29
Huihui Wang, Shangwei Huangfu, Ding Wei, Ziyu Sun, Yifan Wu, Xianqiang Yu, Biao Jiang, Hongli Chen -
Bridging the vaccine divide Nat. Med. (IF 58.7) Pub Date : 2025-06-02
Nicaise Ndembi, Leon Mutesa, Claude Mambo Muvunyi, Jerome H. KimThe African Union (AU) has prioritized local production of health countermeasures since its inception, with heightened focus following the COVID-19 pandemic and challenges such as cholera, Ebola, malaria, mpox, Marburg and other emerging diseases. One of its efforts was the development of the Pharmaceutical Manufacturing Plan for Africa in 20071. The plan aims to strengthen the continental capacity
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Intracerebroventricular bivalent CAR T cells targeting EGFR and IL-13Rα2 in recurrent glioblastoma: a phase 1 trial Nat. Med. (IF 58.7) Pub Date : 2025-06-01
Stephen J. Bagley, Arati S. Desai, Joseph A. Fraietta, Dana Silverbush, Daniel Chafamo, Nelson F. Freeburg, Gayathri Konanur Gopikrishna, Andrew J. Rech, Ali Nabavizadeh, Linda J. Bagley, Jungmin Park, Danuta Jarocha, Rene Martins, Nicolas Sarmiento, Eileen Maloney, Lester Lledo, Carly Stein, Amy Marshall, Rachel M. Leskowitz, Julie K. Jadlowsky, Shane Mackey, Shannon Christensen, Bike Su Oner, Gabriela -
Optimization of Tambjamines Active against Multiple Stages of Malaria Parasites J. Med. Chem. (IF 6.8) Pub Date : 2025-06-01
Amrendra Kumar, Yuexin Li, Xiaowei Zhang, Xiannu Jin, William E. Dennis, Ravi Chetree, Cameron Blount, Diana Caridha, Michael S. Madejczyk, Patricia J. Lee, Kristina Pannone, Jesse DeLuca, Chau Vuong, Susan Leed, Hieu T. Dinh, Kennedy Mdaki, Rohit Mahato, Priyam Sen, Trisha Mondal, Karabi Phukan, Ankur Saha, Anongruk Chim-Ong, Liwang Cui, Rajachandrasekhar Valmon, Sivanna Chithanna, Rozalia A. Dodean -
Sasanlimab plus BCG in BCG-naive, high-risk non-muscle invasive bladder cancer: the randomized phase 3 CREST trial Nat. Med. (IF 58.7) Pub Date : 2025-05-31
Neal D. Shore, Thomas B. Powles, Jens Bedke, Matthew D. Galsky, Joan Palou Redorta, Ja Hyeon Ku, Michal Kretkowski, Evanguelos Xylinas, Boris Alekseev, Dingwei Ye, Félix Guerrero-Ramos, Alberto Briganti, Girish S. Kulkarni, Julia Brinkmann, Anna-Maria Calella, Rossano Cesari, Anthony Eccleston, Elisabete Michelon, Jennifer Vermette, Caimiao Wei, Gary D. Steinberg -
Perioperative durvalumab plus chemotherapy plus new agents for resectable non-small-cell lung cancer: the platform phase II NeoCOAST-2 trial Nat. Med. (IF 58.7) Pub Date : 2025-05-31
Tina Cascone, Laura Bonanno, Florian Guisier, Amelia Insa, Moishe Liberman, Olivier Bylicki, Lorenzo Livi, Thomas Egenod, Romain Corre, Dong-Wan Kim, Maria Rosario Garcia Campelo, Mariano Provencio Pulla, Byoung Yong Shim, Giulio Metro, Jaafar Bennouna, Agata A. Bielska, Alula R. Yohannes, Yun He, Adam Dowson, Gozde Kar, Lara McGrath, Rakesh Kumar, Italia Grenga, Jonathan Spicer, Patrick M. Forde -
How generative Artificial Intelligence can transform drug discovery? Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-05-27
Ainin Sofia Jusoh, Muhammad Akmal Remli, Mohd Saberi Mohamad, Tristan Cazenave, Chin Siok Fong -
Novel Carbamate-Based o-aminobenzamide Derivatives as Potent Antigastric Carcinoma Agents via Disrupting NAD+ Salvage Synthesis J. Med. Chem. (IF 6.8) Pub Date : 2025-05-31
Siyi Zhang, Zhen Li, Bo Li, Zhiyi Li, Huiqian Peng, Lixian Shen, Lejing Zhu, Tong Mo, Jialiang Peng, Linsheng Zhuo, Zhen Wang, Weifan Jiang -
Lysine-Targeted Covalent Strategy Leading to the Discovery of Novel Potent PROTAC-Based PI3Kδ Degraders J. Med. Chem. (IF 6.8) Pub Date : 2025-05-31
Bo Yuan, Jiaxin Liu, Yujie Wu, Mengyao Chen, Ying Lai, Hong-Yi Zhao, Zhe Yang, San-Qi Zhang, Minhang Xin -
Discovery of Novel Potent Molecule for Treating Cisplatin-Induced Acute Kidney Injury Driven by Phenotypic Screening J. Med. Chem. (IF 6.8) Pub Date : 2025-05-31
Yan Lou, Feilong Zhou, Daxing Shi, Yu Zhang, Jin Dong, Xiaobao Shen, Xing Chen, Xinhua Liu -
Harder than Metal: Challenging Antimicrobial Resistance with Metallo-β-lactamase Inhibitors J. Med. Chem. (IF 6.8) Pub Date : 2025-05-30
Antonietta De Falco, Antonella Ilenia Alfano, Luigi Cutarella, Mattia Mori, Margherita Brindisi -
Developing Potent and Selective Anticancer Therapy through Chemical Approaches and the Combination of Cationic Amphipathic Oncolytic Peptides J. Med. Chem. (IF 6.8) Pub Date : 2025-05-30
Hai Bui Thi Phuong, Bao Loc Nguyen, Linyu Huang, Thi Oanh Oanh Nguyen, Ngoc Duy Le, Beomsu Kim, Basavaraj Rudragouda Patil, Thang Nguyen Quoc, Jeonghwan Kim, Huy Xuan Luong, and Jong Oh Kim -
Patritumab deruxtecan in leptomeningeal metastatic disease of solid tumors: the phase 2 TUXEDO-3 trial Nat. Med. (IF 58.7) Pub Date : 2025-05-30
Matthias Preusser, Javier Garde-Noguera, Juan José García-Mosquera, María Gion, Richard Greil, Miriam Arumi, Manuel Ruiz-Borrego, Antonio Llombart-Cussac, María Valero, Javier Cortés, Marta Campolier, José Antonio Guerrero, Paula González-Alonso, Carlos Jiménez-Cortegana, Jose Rodríguez-Morató, Marta Vaz-Batista, Felicitas Oberndorfer, Maximilian Marhold, Anna Sophie Berghoff, Julia Furtner, Thorsten -
Rational Design of Novel Quinazolinone–Pyrrolodihydropyrrolone Analogs as PIM/HDAC Dual-Target Inhibitors for the Treatment of Acute Myelocytic Leukemia J. Med. Chem. (IF 6.8) Pub Date : 2025-05-30
Yabing Xin, Can Xiao, Nan Wang, Huidan Wu, Wenjing Kang, Xuetao Chen, Chihong Liu, Qidong You, Zhengyu Jiang, Xiaoke Guo -
Design of an Oral STING Agonist through Intramolecular Hydrogen Bond Ring Mimicking to Achieve Complete Tumor Regression J. Med. Chem. (IF 6.8) Pub Date : 2025-05-29
Hong-Yi Zhao, Jinsong Tao, Luchen Zhang, Qiuxia Li, Miao He, Bo Wen, Zhongwei Liu, Hannah Myatt, Duxin Sun -
Structural Optimization of Next-Generation TRK Inhibitors against Acquired Drug Resistance Mutations for the Treatment of Solid Tumors J. Med. Chem. (IF 6.8) Pub Date : 2025-05-29
Zichao Xu, Yueling Liu, Peng Wang, Xia Peng, Jiawei Cheng, Yinchun Ji, Xutong Li, Dongze Lin, Jing Zhao, Songbin Chen, Zhiyang Xu, Mingyue Zheng, Meiyu Geng, Hong Liu, Jing Ai, Chunpu Li -
Discovery of CYP1A1 Inhibitors for Host-Directed Therapy against Sepsis J. Med. Chem. (IF 6.8) Pub Date : 2025-05-29
Fangjie Wang, Sheng-Li Niu, Wei Li, Hong-Yuan Liu, Xue Gong, Xiaoyuan Ma, Bo Zhao, Dongmei He, Jinyu Xia, Liang Gong, Yiqin Cui, Rui Gao, Huaping Liang, Jing Gu, Qin Ouyang -
Correction to “A NIR-II Photoacoustic/NIR-IIa Fluorescent Probe for Targeted Imaging of Glioma under NIR-II Excitation” J. Med. Chem. (IF 6.8) Pub Date : 2025-05-29
Shuxin Lyu, Siyu Lu, Conghao Gui, Chunyan Guo, Juanjuan Han, Yuling Xiao, Ruiping Zhang, Xuechuan HongWe apologize for the error in the acknowledgments section. The funding number for the National Key R&D Program of China was incorrectly listed as Nos. 2023YFC3605502 and 2020YFA0908800. The correct grant number is No. 2023YFC3605500. This article has not yet been cited by other publications.
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Innovative zinc-binding inhibitors of Legionella pneumophila ProA reduce collagen and flagellin degradation, TLR5 evasion, and human lung tissue inflammation Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-05-30
Lina Scheithauer, Camilla Ornago, Jolanda Selmar, Christian Schütz, Gabriele Bianchi, Alexander.F. Kiefer, Jörg Haupenthal, Ansgar Dellmann, Duc.T. Huynh, Ruoyu Zhang, Wulf Blankenfeldt, Anna.K.H. Hirsch, Michael Steinert -
Picomolar bivalent inhibitors of protein kinase CK2 active against β-coronavirus replication Eur. J. Med. Chem. (IF 6.0) Pub Date : 2025-05-29
Dylan Grenier, Dennis Salomon Lopez Molina, Muriel Gelin, Angélique Mularoni, Jean-François Guichou, Jean-Guy Delcros, Charlotte Martinasso, Yinshan Yang, Nazim Ahnou, Jean-Michel Pawlotsky, Abdelhakim Ahmed-Belkacem, Isabelle Krimm
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