OBJECTIVE The purpose of this review is to assess the effects of JIIM on growth and pubertal development. METHODS A systematic review was conducted by searching EMBASE, MEDLINE, PubMed®, PsycINFO, Cochrane, and Web of Science to identify studies published in English from inception to December 2024. Data were extracted regarding puberty- and development-related outcomes. Meta-analyses were conducted

OBJECTIVE Cutaneous polyarteritis nodosa (cPAN) is a rare necrotizing vasculitis that primarily affects small-to-medium-sized arteries in subcutaneous tissue. cPAN is often characterized by a chronic and relapsing disease that presents with skin ulcers, livedo, and painful erythema. In this study, we evaluated the efficacy of anti-TNF-α inhibitor treatment for cPAN-associated refractory leg ulcers

OBJECTIVE mucosal-associated invariant T cells (MAIT) have been involved in the pathophysiology of axial spondyloarthritis (axSpA). We aimed to further investigate the phenotype of circulating MAIT cells in patients with axSpA by assessing the expression of an activation marker and gut homing receptors as well as the impact of TNF-α blockade. The presence of MAIT cells in synovial biopsies from axSpA

OBJECTIVE Cone beam computed tomography (CBCT) can accurately assess erosive disease in the hands, wrists and feet in established rheumatoid arthritis (RA). The aim of this study was to compare CBCT with conventional radiography (CR) for the assessment of erosions in patients with early RA. METHODS CBCT and CR of the hands, wrists and feet of 17 patients with treatment naive early RA were assessed

OBJECTIVE Access to rheumatology education and care is limited in many African countries, leading to suboptimal clinical care and poor outcomes for patients. Virtual education is a feasible means to deliver curricula remotely. A virtual rheumatology course for medical residents in sub-Saharan Africa was developed. We describe the course and its evaluation. METHODS An annual 16-week virtual rheumatology

OBJECTIVE To estimate the prevalence and predictors of sustained remission (SR) in psoriatic arthritis (PsA) patients receiving biologic or targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) in Sweden. METHODS All PsA patients initiating b/tsDMARDs and who were registered in the national Swedish Rheumatology Quality register (SRQ) April 1999-December 2019 were included. Data on disease/treatment

OBJECTIVE To describe the access, effectiveness, survival and adverse events (AE) of secukinumab (SEC) in patients with axial spondyloarthritis (axSpA) and axial psoriatic arthritis (axPsA). METHODS A multicentre, observational, retrospective cohort study. Patients ≥18 years with axSpA) and patients with PsA with axial involvement who had received at least one dose of SEC were included. The number

OBJECTIVE To evaluate the effect of achieving Minimal Disease Activity (MDA) within the first year on radiologic damage at follow-up 3 years in patients with newly diagnosed Psoriatic Arthritis (PsA). METHODS Data were used from the Dutch southwest Early PsA cohort, a real-world cohort of newly diagnosed PsA patients, focusing for this manuscript on those with oligoarthritis or polyarthritis. Patients

Although arthritis among patients with psoriasis was described in the 19th century, the question of whether there was a specific form of arthritis associated with psoriasis was not raised until the middle of the 20th century. It was only after the seminal work of Moll and Wright that psoriatic arthritis (PsA) was recognized as a distinct entity. There was little interest in studying the disease until

OBJECTIVE Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are chronic immune-mediated inflammatory diseases often complicated by persistent pain and fatigue despite cutting edge pharmacological treatments. Lifestyle medicine (LM) and complementary and integrative health (CIH) offer adjuvant therapies with potential to alleviate these symptoms, but little is known about patients' experiences

OBJECTIVE To evaluate rates of clinically inactive disease and remission in patients with juvenile idiopathic arthritis (JIA) receiving tofacitinib, using the 2021 Juvenile Arthritis Disease Activity Score (JADAS) thresholds and American College of Rheumatology (ACR) criteria. METHODS This post hoc analysis included patients with active JIA (polyarticular course JIA, psoriatic arthritis, or enthesitis-related

OBJECTIVE This study compares rates of school absence (SA) for all children with juvenile idiopathic arthritis (JIA) attending public Danish schools to peers both before and after JIA diagnosis. Further, we aimed to investigate the role of socioeconomic status (SES) on the possible association. METHODS We performed a register-based matched cohort study. We included all children attending public Danish

OBJECTIVE This work aims to provide an update on a previously published systematic review on quality measures (QMs) in rheumatoid arthritis (RA) to inform future measure development and endorsement efforts. METHODS We searched published and grey literature sources from January 2018 to July 2023. Included sources were limited to those that targeted patients with RA, either exclusively or alongside other

OBJECTIVE To investigate the effectiveness of the JAK 1/3 inhibitor tofacitinib in treating Blau syndrome and explore the association between various clinical and genetic features and therapeutic responses within the cohort. METHODS A five-year, multi-center, retrospective, observational study was conducted across seven centers, focusing on genetic profiles and the clinical manifestations of cohort

OBJECTIVE To describe patients' perspectives and experiences of medications for gout to inform patient-centred practice. METHODS Systematic review (MEDLINE, Embase, PsychInfo, CINAHL) and thematic analysis of studies using qualitative methodology to May 2023. RESULTS Five dominant themes were identified in 45 studies involving 1203 patients:- denying illness, negotiating uncertainty, juggling competing

OBJECTIVE To review methods for developing and endorsing Quality Measures (QMs) to inform a national quality measurement framework for rheumatology care in Canada. METHODS We conducted a rapid environmental scan of measure development organizations from Canada, the United Kingdom, the United States and Australia. Major phases in the development of QMs were abstracted. The results were reviewed and

OBJECTIVE To describe the frequency and outcomes associated with self-reported frailty in patients with vasculitis. METHODS VascStrong is a longitudinal study utilizing the Vasculitis Patient-Powered Research Network, an internet-based cohort of patients with vasculitis. Data collected included patient global assessment (PGA) and several domains of the Patient-Reported Outcomes Measurement Information

OBJECTIVE Compare the progression of systemic sclerosis-associated interstitial lung disease (SSc-ILD) based on serological status. METHODS In a post-hoc analysis of the SENSCIS trial (nintedanib vs placebo in SSc-ILD; NCT02597933), we analyzed the rate of decline in forced vital capacity (FVC) over 52 weeks in 3 subsets: positive for anti-centromere antibody (ACA), positive for anti-RNA polymerase

OBJECTIVE Intermediate treatment targets in Still disease have been proposed by the European Alliance of Associations for Rheumatology (EULAR) and the Paediatric Rheumatology European Society (PReS) in 2024. This study aimed to evaluate the utility of the targets in clinical practice. METHODS Consecutive patients with adult-onset Still disease (AOSD) based on the Yamaguchi criteria who visited Keio

OBJECTIVE To assess whether there is a rural-urban and income-related disparity in the incidence and outcomes of hospitalization for myocardial infarction (MI) in patients with rheumatoid arthritis (RA). METHODS We used the 2016-2019 US National Inpatient Sample (NIS) data and selected all patients with RA. Rural vs urban residential status was identified using NIS classifications. We categorized median

OBJECTIVE We aimed to examine fatigue and sleep disturbance in patients with recently diagnosed polymyalgia rheumatica (PMR) compared to age- and gender-matched controls, including associated characteristics and change over an 18-month follow-up period. METHODS Patients meeting the 2012 European Alliance of Associations for Rheumatology/American College of Rheumatology classification criteria for PMR

OBJECTIVE To systematically review all existing SjD-related instruments reported in clinical trials for Sjögren's disease (SjD). METHODS We systematically searched Medline (Pubmed) and EMBASE between 2002 and March 2023 to identify all randomized controlled trials (RCTs) using both a manual approach and artificial intelligence software (BIBOT). We extracted all the instruments used as primary or secondary

OBJECTIVE To understand the ordering patterns of antinuclear antibody (ANA) multiplex testing in a single, large US Department of Defense (DoD) tertiary healthcare system. METHODS Records of patients with an ANA multiplex assay ordered over a 1-year period were evaluated in a large DoD hospital system. Duplicate tests and patients with a previously established autoimmune rheumatic disease (ARD) prior

OBJECTIVE We estimated the prevalence of potential functional disability among those with systemic lupus erythematosus (SLE), by receipt of disability benefits. METHODS Participants (N = 443, mean age 46.2 years, 91.7% women, 82.6% Black) were recruited from a population-based SLE cohort. Indicators of potential disability included functioning impairments (Short Physical Performance Battery score ≤

OBJECTIVE Type 1 interferons (IFNs) have been identified as potentially important measures of disease activity in juvenile dermatomyositis (JDM). An IFN response gene (IRG) score has been defined using NanoString technology and appears to correlate with disease activity in cross-sectional samples of patients with JDM. This study aimed to determine if there is evidence of a correlation between disease

OBJECTIVE Despite the high risk for permanent vision loss in elderly individuals with giant cell arteritis (GCA), initiation of subcutaneous tocilizumab (TCZ) is often delayed. We used chart review for GCA patients prescribed subcutaneous TCZ to investigate delays in drug initiation. METHODS We included 82 patients with GCA at the University of Washington prescribed subcutaneous TCZ between 2017 and

Idiopathic inflammatory myopathies (IIMs) comprise a spectrum of autoinflammatory disease characterized primarily by muscle inflammation, with secondary involvement of diverse organs including joints, skin, lungs, heart, and the gastrointestinal system. Managing these conditions poses considerable challenges, often inflicting profound distress on the afflicted individuals. Encouragingly, the deployment

OBJECTIVE To examine demographic and geographic diversity in axial spondyloarthritis (axSpA) drug trials. METHODS We performed a descriptive epidemiological study using ClinicalTrials.gov data. We included completed phase II-IV drug trials in adults with axSpA, conducted between 2000 and 2023, with results posted on ClinicalTrials.gov. We extracted and analyzed data on sex, race, ethnicity, trial characteristics

OBJECTIVE Access to rheumatology services in Canada is becoming increasingly challenging because of the rising burden of rheumatic and musculoskeletal diseases in a rapidly growing population, and a workforce supply deficit that is projected to worsen in coming years. Specialist physician remuneration has been demonstrated to influence physician practices, thereby affecting access to health services

OBJECTIVE To evaluate the risk of heart failure (HF) in patients with immune-mediated inflammatory diseases (IMIDs) compared to the general population with and without diabetes mellitus (DM). METHODS A population-based cohort study was conducted in patients with rheumatoid arthritis (RA), radiographic axial spondyloarthritis (r-axSpA), psoriatic arthritis, and psoriasis (PsO) in Ontario from 2011 until

OBJECTIVE To develop a web-based self-monitoring tool including motivational elements to improve empowerment of patients with rheumatoid arthritis (RA). METHODS Following a design-thinking approach, the development included 3 iterative, cocreative phases involving different stakeholders. In the empathize and define phase, 2 focus groups gave insight into patients' wishes and needs regarding self-monitoring

OBJECTIVE Patients with rheumatoid arthritis (RA) have an increased risk of developing herpes zoster (HZ) compared to the general population. We aimed to measure healthcare utilization (HCU) and related costs of HZ among patients with RA, from the public payer's perspective. METHODS Adult patients with RA diagnosed with HZ between 2008 and 2020 were matched by sex, age, and date of HZ infection to

OBJECTIVE We surveyed physicians in the United States to assess knowledge, awareness, and attitudes toward axial spondyloarthritis (axSpA). The objective was to identify barriers for referral and opportunities for intervention to reduce diagnostic delay of axSpA. METHODS An online questionnaire was distributed nationwide to nonrheumatology physicians (NRPs) serving patients with chronic back pain (CBP)

OBJECTIVE The disease course and burden of rheumatoid arthritis (RA) may differ between female and male individuals, but existing data on these differences are limited and often contradictory. Therefore, we investigated whether clinical outcomes and patient-reported outcomes (PROs) differ between female and male patients with RA over time. METHODS All female (n = 286) and male (n = 139) patients with