Uraemic calciphylaxis is a rare disease characterized by subcutaneous vessel thrombosis and ulcerative skin necrosis that predominantly affects patients with kidney failure. The disease results in substantial morbidity and mortality, but the pathogenesis is unclear and no curative therapies are available. Now, a new study reports a pathogenic role of IL-6–tissue factor (TF) signalling in uraemic calciphylaxis

The administration of anti-inflammatory macrophages has been proposed as an approach to reduce tissue injury in response to inflammation; however, this approach is limited by the instability of macrophages and their potential to switch to a pro-inflammatory phenotype. To overcome these limitations, researchers have now developed a chimeric antigen receptor (CAR) macrophage (CAR-M) that demonstrates

Remarkable progress has been made in the discovery of autoantigens in membranous nephropathy. With increasing testing for membranous antigens in daily practice, it is important to consider the varying strength of association between certain antigens and underlying conditions. This review explores questions and caveats which arise when assessing results of membranous antigen testing. Specifically, we

Although undocumented people are eligible for kidney transplant from a regulatory standpoint, undocumented individuals are often excluded from federal health insurance, leading to difficulty accessing kidney transplant. Menon et al. highlight lower mortality and graft failure rates for presumed undocumented immigrants compared with residents and citizens post-transplant. In this commentary, we emphasize

The pathogenic mechanisms of chronic kidney disease-induced osteoporosis are not well understood and might involve metabolic alterations and apoptosis of osteocytes. In this issue, Hsu et al. present experimental work in uremic mice and cultured mouse osteoblasts showing that impaired mitochondrial function and mitophagy in osteocytes contribute to chronic kidney disease-associated osteoporosis. They

Chronic kidney disease (CKD) has become a public health issue. Rapid urbanization in China has been intimately linked to shifts in the spectrum of CKD, particularly as regards CKD related to diabetes mellitus. By amalgamating diverse data streams and harnessing cutting-edge technologies, the China Kidney Disease Network aspires to evolve into a comprehensive surveillance framework for kidney diseases

INTRODUCTION Chronic active antibody-mediated rejection (AMR) is the leading cause of death-censored kidney allograft loss, with no proven treatments. While intravenous immunoglobulin (IVIG) has been used in certain cases, its efficacy is unknown. METHODS In this open-label multicenter randomized controlled trial (VIPAR), participants with biopsy-proven chronic active AMR, were assigned to six doses

BACKGROUND Failure to develop protective immunity in response to vaccination is common among kidney transplant recipients, rendering them susceptible to severe infection. Novel strategies are required. Here, we investigated the potential of mechanistic-target-of-rapamycin (mTOR) inhibitors to improve vaccine responses. METHODS Humoral and cellular responses to primary COVID-19 vaccination (ChAdOx1

INTRODUCTION Patients with metabolic syndrome and heart failure (HF) often have accompanying kidney dysfunction, which was recently defined as cardiovascular-kidney-metabolic (CKM) syndrome. Prior metabolomics profiling of metabolic syndrome patients identified a plasma branched chain amino acid (BCAA) signature, and BCAAs themselves are elevated in the myocardium of patients with HF, potentially due

BACKGROUND Visual scoring of tubular damage has limitations in capturing the full spectrum of structural changes and prognostic potential. Here, we investigated if computationally quantified tubular features can enhance prognostication and reveal spatial relationships with interstitial fibrosis. METHODS Deep-learning and image-analysis approaches were employed on 254/266 Periodic acid Schiff-stained

BACKGROUND Mechanistic-target-of-rapamycin-complex-1 (mTORc1) plays a role in maintaining K + homeostasis. We now examine whether mTORc1 of distal-convoluted-tubule (DCT) regulates Kir4.1/Kir5.1 channels and thiazide-sensitive-Na-Cl cotransporter, which plays a role in regulating renal K + excretion. METHODS We used patch-clamp-technique to examine basolateral Kir4.1/Kir5.1 in early-DCT, immunoblotting

BACKGROUND The novel calcineurin inhibitor (CNI) voclosporin is effective in treating lupus nephritis but has been associated with acute kidney injury (AKI) through largely unknown mechanisms. Voclosporin-induced AKI revealed that voclosporin reduces the expression of indolethylamine N-methyltransferase (Inmt), an enzyme responsible for detoxifying local uremic toxins such as indole. This study investigates

aim was to validate KFRE by frailty status and assess whether model performance could be improved by using cystatin based estimated glomerular filtration rate (eGFR) equations and to assess the impact of accounting for competing mortality risk. Methods: We studied adults from the prospective research cohort UK Biobank with CKD G3-5 (eGFR <60mL/min/1.73m2) by any of the three CKD-EPI consortium eGFR

An abstract is unavailable. This article is available as a PDF only.

An abstract is unavailable. This article is available as a PDF only.

ily validated a formative objective structured clinical examination (OSCE) assessing clinical care of an uncomplicated patient initiating HHD, using a unified model of construct validity. Methods: The OSCE was developed by a nephrology fellow and five faculty (three practicing HHD). The nine-member test committee (five in HHD practice; one HHD care partner) assessed test item difficulty/relevance and

An abstract is unavailable.

study within the Veterans Health Administration included adults with an ADPKD diagnosis code who initiated SGLT2i between January 2017 and May 2023. Repeated measures models were used to evaluate eGFR slope before and after SGLT2i initiation. Among patients with ADPKD and type 2 diabetes mellitus (T2DM), a target trial emulation was used to compare the effects of SGLT2i versus dipeptidyl peptidase-4

INTRODUCTION Monoclonal gammopathy of renal significance (MGRS) is increasingly recognized as an important causes of kidney failure. A kidney biopsy remains an important diagnostic measure. However, a kidney biopsy is not without risks. Here, we devised the Mayo MGRS Prediction Tool to assess the probability of finding MGRS in patients with chronic kidney disease with monoclonal gammopathy (MG). METHODS

Attention is increasingly turning toward the individualization of hemodialysis prescriptions through an incremental start. This approach prioritizes patient's clinical needs over rigid metrics like dialysis urea depuration, begins with fewer sessions (one or two per week), and gradually increases in frequency and/or duration based on patient's evolving clinical condition. Clinical manifestations related

INTRODUCTION Vascular calcification is prevalent in chronic kidney disease (CKD), but existing medical treatments fail to achieve satisfactory therapeutic effects. Vascular calcification is now recognized as an active multifactorial process involving diverse mechanisms. Alpha-ketoglutarate (AKG), an intermediate in tricarboxylic acid cycle, has been demonstrated to extend lifespan and ameliorate age-related

Thrombotic microangiopathy (TMA) is a complex condition involving endothelial damage and microvascular thrombi. The International Society of Nephrology’s HUS International Forum identified genetic variants as crucial for tailored therapies like plasma exchange and anti-complement therapy. Recent studies suggested that new pathogenic genes beyond complement, and coagulation pathways contribute to TMA

INTRODUCTION Women with preeclampsia often deliver preterm (under37 weeks gestation). Preterm birth is associated with an increased risk of offspring kidney disease, but whether preeclampsia is independently associated with kidney disease risk is unknown. Here, we conducted a register-based cohort study to explore associations between maternal preeclampsia and offspring kidney disease after accounting

INTRODUCTION Disease recurrence after kidney transplantation (KTx) remains a major challenge in patients with primary focal segmental glomerulosclerosis (pFSGS). Antibodies targeting the slit diaphragm protein nephrin have been identified in patients with early disease recurrence. Here, we describe monitoring and effective pre-transplant elimination of anti-nephrin antibodies in an adolescent with

Rare kidney stone diseases typically present with nephrolithiasis or nephrocalcinosis in childhood or adolescence. Affected individuals might face kidney injury and even kidney failure related to associated complications. Screening blood and urine tests recommended for patients with nephrolithiasis/nephrocalcinosis help guide further evaluation, and the increased availability and decreased costs of

The pathophysiology of heart failure (HF) with kidney dysfunction is represented by several maladaptive bidirectional pathways wherein acute or chronic dysfunction of one organ drives acute or chronic dysfunction in the other organ. Suboptimal decongestion, diuretic resistance, and low use rates of guideline-directed medical therapy in individuals with kidney dysfunction and HF contribute to poor cardiovascular

An abstract is unavailable.

RATIONALE & OBJECTIVE Metals/metalloids in drinking water, including uranium and arsenic, may damage kidney function and increase chronic kidney disease (CKD) risk. We evaluated exposure to these contaminants in community water supplies (CWS) and CKD risk in the California Teachers Study. STUDY DESIGN Prospective cohort study. SETTING & PARTICIPANTS 88,185 women who were California teachers and school

RATIONALE & OBJECTIVES Accurate ascertainment of end-stage kidney disease (ESKD) in electronic health records (EHRs) data is important for much epidemiological research. This study aimed to develop and validate an algorithm using diagnosis and procedure codes to identify patients with ESKD (treated with maintenance dialysis or kidney transplantation) in EHRs data. STUDY DESIGN Study of diagnostic algorithms

RATIONALE & OBJECTIVE Chronic kidney disease (CKD) is associated with a proinflammatory state caused by maladaptive immune response, predisposing to cardiovascular (CVD) and inflammatory/infectious disease outcomes. We sought to examine the association of chronic inflammation-related disease (ChrIRD) as compared to CVD events with worsening kidney function. STUDY DESIGN Longitudinal, observational

In recent years, there have been significant changes in the lifestyle and dietary habits of the population characterized by an increased intake of high-calorie food and a sedentary lifestyle without physical activity. The increased prevalence of overweight and obesity has led to metabolic dysfunction and related complications, such as cardiovascular disease and chronic kidney disease. The purpose of

An abstract is unavailable.

An abstract is unavailable.

BACKGROUND Vadadustat's global clinical program was comprised of four noninferiority trials comparing vadadustat and darbepoetin alfa for CKD-related anemia: two in dialysis-dependent (DD)-CKD and two in non-dialysis-dependent (NDD)-CKD. While vadadustat met prespecified noninferiority criteria for hematological efficacy globally, it did not meet noninferiority criteria for cardiovascular safety in

An abstract is unavailable. This article is available as a PDF only.

feeding study in 39 adults without and 11 adults with CKD. Participants were fed a phosphorus additive-enhanced diet for two weeks followed by a low additive diet for six weeks. Both diets were identical except for phosphorus additive content. Blood and urine samples were collected at regular intervals with analyses comparing follow-up measures of mineral metabolism markers to baseline values. Results:

Fibrates are a commonly utilized medication in the management of dyslipidaemia and cardiovascular risk. These agents have a well-documented association with reversible elevations in serum creatinine and in some instances acute kidney injury. The mechanism underlying the renal effects of fibrates are currently not well-understood. We describe a case of acute kidney injury in a patient who was administered

BACKGROUND Acute kidney injury (AKI) is a severe condition leading to the sudden loss of kidney function. Activation of type 2 innate lymphoid cells (ILC2s) by neuromedin U (NMU) is highly selective and key in controlling mucosal tissue repair and homeostasis. Renal ILC2s are associated with renoprotective effects in AKI. Here, we explored the therapeutic potential of an engineered NMU analogue (LIMM102)