Compared to traditional tumor treatment modalities, such as radiotherapy, chemotherapy, and surgical intervention, tumor immunotherapy offers potential benefits by enhancing the immune system’s functionality, diminish immune evasion, and establish enduring immune memory, ultimately aiming for the destruction or eradication of tumor cells. However, the intricate tumor microenvironment (TME) poses challenges

This study systematically evaluates the efficacy of three emulsification strategies (ultrasonication, high-pressure homogenization, and high-speed shearing) in fabricating artificial oleosomes (AOs) stabilized by hemp seed oil body proteins (OBPs) and rose essential oil. Comparative analyses revealed that ultrasonication generated AOs with superior physicochemical attributes, including reduction in

Cadmium (Cd) is a toxic metal with significant recycling value. Our previous work demonstrated that ultrasonic-enhanced Cd2+ replacement by aluminum (Al) powder outperforms non-sonicated methods, yet challenges remain in treating high-concentration Cd2+ solutions. This study introduces an ultrasonic pre-treatment for Al powder to enhance Cd2+ replacement in high-concentration solutions. The effects

This study compares the anodic dissolution of two iron-based alloys, mild steel and an FeNdB super magnet, with that of a mineral, chalcopyrite (CuFeS2), in a deep eutectic solvent formed from choline chloride and ethylene glycol under silent and ultrasonic conditions. These three materials have different granular morphologies and heterogeneities. The aim was to show how a combination of ultrasound

Listeria monocytogenes (LM) is a critical foodborne pathogen, whose exceptional environmental adaptability and biofilm-forming capacity render it resistant to effective control during food processing and storage. Sonodynamic therapy (SDT), as an emerging sterilization approach, has rapidly emerged demonstrating potent microbicidal efficacy against microorganisms. The development of novel sonosensitizers

This study investigated the effects of ultrasound treatment (UT) on the physicochemical, sensory, and structural properties of cold brew coffee. Among the examined physicochemical properties, colour changed to a light caramel shade following UT, while pH, total dissolved solids, and extraction yield increased compared to the control group. Total polyphenol content, flavonoid content, antioxidant activity

Photothermal therapy (PTT) has emerged as a promising new approach in tumor treatment, with the great advantages including non-invasiveness and temporal controllability. However, the effective delivery of photothermal agents into tumor remains a significant challenge, limiting its clinical translational application. In this study, we developed a kind of photothermal agents modified with gas vesicles

Casein-dextran colloids, with various particle and filtration properties to simulate the main pollutant (protein-polysaccharide colloids) in the membrane separation process, were selected as the research object in this study. Effects of critical-zone-intensity ultrasound (CZ-US) on the aggregation, rheological and structural properties of casein-dextran colloids were investigated by ultrasonic immersion

This study investigated the effects of Maillard reactions using various saccharides (gum arabic, dextrin, glucose) and ultrasonication on the emulsifying and physicochemical properties of spirulina protein extract. At the same heating time, ultrasound-assisted samples exhibited higher degrees of glycation up to 87.45 % than conventional heating samples for all types of saccharides. The emulsifying

This study developed a green, efficient method for extracting and purifying procyanidins (PC) from grape pomace (GP) using ultrasound-assisted extraction (UAE) with natural deep eutectic solvents (NADES). The process was optimized through single-factor experiments and Box-Behnken Design (BBD) response surface methodology (RSM). Bioactive substances and antioxidant activities in the extracts were compared

Coptidis Rhizoma (CR), a traditional Chinese medicine, has extensive pharmacological activity because it is rich in isoquinoline alkaloids. Nonetheless, the limited solubility of these alkaloids presents a significant challenge, hindering the full realization of CR’s therapeutic potential through conventional extraction methods. To address this issue and enhance the solubility of the target compounds

Wooden breast myopathy results in reduced meat tenderness, poor water retention, and diminished processing value, underscoring the urgency to mitigate economic losses caused by the deteriorated quality of wooden chicken breast. This study evaluated the effects of ultrasound-assisted tumbling (400 W, 20 kHz, 80 min) on the quality characteristics of wooden breast meat with varying severity levels, involving

Quinoa (Chenopodium quinoa Willd.), an Andean grain, has garnered attention from cereal-based industries as a functional ingredient. This study evaluated functional properties, minerals, bioactive compounds and structural properties of Pre-treatments assisted germination of quinoa grains JQ-778 including, Only germinated seeds (OGS), soaked germinated seeds (SGS), ultrasound at 28 & 40 frequencies

The current investigation evaluated the impact of diverse ultrasound power levels (0, 120, 200, 320, 400, and 520 W) on the structural, functional, and antioxidant potentials of proteins derived from Bombyx batryticatus (PBB). Findings indicated a marked increase in the yield of PBB via ultrasonic treatment at the appropriate ultrasound power (UP), accompanied by a diminished β-sheet content and an

This study selected (180 min, 300 min and 60 min, 180 min) as the frequency conversion time nodes and set two modes of sequential frequency conversion (25-28-40 kHz) and reverse frequency conversion (40-28-25 kHz). The objective was to investigate the effects of variable-frequency ultrasound synergistic hot air drying (VFU-HAD) on the drying characteristics and physicochemical properties of cherry

Hydrodynamic cavitation (HC) has emerged as a promising technique for process intensification. Recently developed advanced rotational hydrodynamic cavitation reactors (ARHCRs) have attracted significant attention from both academia and industry due to their notable economic advantages, high processing capacity, and continuous operation in specific applications. However, existing evaluation and optimization

The clinical efficacy of 3D ultrasound for spinal curvature assessment was evaluated in adolescent idiopathic scoliosis (AIS) patients through comparative analysis with conventional radiography. A prospective cohort of 230 preoperative and 22 postoperative AIS patients was evaluated over a 24-month period. Spinal curvature assessments were performed using a standardized 3D ultrasound system (SCN801)

Ultrasound-induced cavitation, especially its stable and inertial regimes, plays a critical role in sonochemical processes. Thus, finding the power thresholds differentiating the appearance of stable cavitation and then transient cavitation, is essential for sonoreactor characterization since this knowledge allows the relevant choice of operating parameters leading to the expected sonochemical effects

The influence of flat ultrasound-assisted fermentation (FUAF) on the fermentation and quality of room-temperature-storage yogurt (RTSY) was investigated. Six different ultrasonic frequencies (20, 28, 35, 20/28, 28/35, and 20/35 kHz) were used in the treatments. The results showed that FUAF treatments, especially the 28 kHz, observably enhanced the quality of RTSY. Under these optimized conditions,

Spherical bubble clusters was observed at 28 kHz and 40 kHz, and the evolution of the clusters was investigated. It was found that the cluster was dense when it located at the antinode of standing waves, while it became sparse when it deviates from the antinode, and the bifurcation of period doubling was observed in this nonlinear bubble system. In clusters, there exists complex fragmentation and coalescence

The present study investigates methods to enhance liquid–gas mass transfer in total dissolved gas (TDG) supersaturated water. Using a two-part experimental setup, water is first supersaturated using air, followed by an evaluation of the influence of various operating parameters on the volumetric liquid–gas mass transfer coefficient, kLa, in a liquid batch reactor. The dependence of this coefficient

Deep eutectic solvents (DESs) are increasingly recognized as viable environmentally friendly alternatives to traditional organic solvents because of their low toxicity and exceptional dissolving capabilities. In this research, 12 DESs were synthesized and systematically integrated with ultrasonic-assisted extraction (UAE) to extract flavonoids from Scutellaria Radix. Comprehensive screening revealed

Ultrasound driven cavitation is widely used to intensify lab and industrial-scale processes. Various studies and experiments demonstrate that the acoustic energy, dissipated through the bubbles collapse, leads to intense physico-chemical effects in the processed liquid. A better understanding of these phenomena is crucial for the optimization of ultrasonic reactors, and their scale-up. In the current

Gastrodia elata polysaccharides (GEPs) have garnered attention due to their various bioactivities; however, their current extraction yield is low, limiting widespread application. This study employed ultrasonic enzyme-assisted deep eutectic solvent (DES) extraction to enhance efficiency and compared the physicochemical properties, structure, and antioxidant activity of the polysaccharides with those

Anthraquinone components sublimate during heat treatment refining, causing equipment pipeline contamination and a drop in component output, which is a challenging technical problem for pharmaceutical manufacturers to resolve. Furthermore, the waste liquid generated during pipeline cleaning simultaneously increases production costs and pollutes the environment. Although nanofiltration has the technological

Calcium-based treatments have gained considerable attention in the field of electroporation, primarily, due to their comparable efficacy to conventional electro-chemotherapy. However, their applications in sonoporation remain under-investigated, despite its high potential for site-specific and temporally-controlled drug delivery.

The pollution of water and air in our world has become a global challenge that requires innovative and sustainable strategies. In this work, the ultrasound-assisted synthesis of bare strontium titanate (STO) and bismuth-doped STO (Bi-STO) is proposed to enhance the photocatalytic and piezocatalytic performance of STO in environmental remediation. The materials were fully characterized using various

Carbapenems are potent antibiotics that reach sewage systems and then the environment, causing negative impacts. Thus, research on degrading processes to limit the carbapenem discharge in sewage systems is needed. Herein, fundamental aspects of high-frequency ultrasound alone and hybridized with the (photo)Fenton process to deal with a representative carbapenem antibiotic (meropenem, MERO) in water

Aqueous zinc-ion batteries (AZIBs) have gained attention as next-generation energy storage systems due to their safety, cost-effectiveness, and eco-friendliness. However, their commercialization is hindered by the structural instability and low electrochemical performance of cathode materials. Herein, we present poly(3,4-ethylenedioxythiophene) (PEDOT)-intercalated potassium vanadate nanofibers (E-PVNF)

Spent sour cherry pomace (SSCP), a by-product from Maraschino liqueur production, is a rich source of polyphenols worth valorizing. However, its high moisture content promotes microbial spoilage and reduces extraction efficiency per unit weight, limiting their valorization. This study evaluated the impacts of freeze-drying and oven-drying and different particle sizes (≤100, ≤200, and ≥ 200 µm) for

This study aimed to valorise barley straw by using a binary acidic deep eutectic solvent (DES) made from choline chloride and lactic acid for biomass pretreatment, and a hydrated ternary DES (HDES) composed of betaine, oxalic acid, and water (BOW HDES) for downstream processing to produce nanocellulose. The ultrasound-assisted DES pretreatment significantly enhanced lignin and hemicellulose solubilisation

Prepared dishes, as a technological extension of pre-conditioned foods and representative products of the central kitchen, are becoming a major part of people’s daily diets. However, the problem of dish quality deterioration owing to freezing in the frozen supply chain has not yet been addressed, and freezing quality enhancement techniques are lacking. Herein, special equipment was used to investigate

Recent research emphasizes the potential of ultrasound technology in the food industry, particularly in tomato processing. Ultrasound’s non-invasive nature has made it a preferred choice for researchers seeking extraction and cavitation power without significantly altering sample properties. The concept of waste valorization, which involves transforming waste materials into valuable resources, is gaining

To expand the application of yeast protein (YP) in the food industry, the synergistic effects of mannoprotein (MP) and ultrasound (US) treatment were explored to improve its solubility, flavor, and structural properties. Results showed that YP and MP formed YP-MP conjugation in 1:3 (w:w), after reacting with citric acid and sodium bicarbonate for 4 h at room temperature and ultrasonic treatment at

Understanding the formation and interactions of out-of-phase cavitation bubbles is crucial for comprehensively exploring cavitation processes in both nature and engineering applications. In this study, a numerical model for the interaction of out-of-phase cavitation bubbles is developed using the hybrid thermal lattice Boltzmann method, where cavitation bubbles are solely excited by thermal nucleation

Non-alcoholic steatohepatitis (NASH) pathogenesis is primarily driven by lipotoxicity-induced oxidative stress and inflammation, yet effective treatments remain challenging to identify. In this work, a novel therapeutic approach was introduced via a ultrasound (US) −driven, reactive oxygen species (ROS) −scavenging and liver-targeted nanobubbles system, termed Apt-DTP-NBs@RSV@OCA, which co-encapsulated

Periodontal infections and dental caries are leading causes of tooth loss, impacting overall health and quality of life. Conventional treatments involve antibiotics, antiamoebic drugs, and quaternary ammonium compounds, their prolonged use can cause resistance and toxicity. In this study, E. linguiformis essential oil (ELEO) was evaluated for chemical composition, and its nanoemulsion (ELEON) with

This study numerically explores the suppression of bubble jet formation in oscillating microbubble pairs under excitation with an ultrasonic pulse, focusing on the conditions that lead to bubble collapse without jetting. Bubble jets (i.e., liquid jets penetrating the bubble) are typically observed in collapsing bubble pairs. However, jet formation can be avoided when the distance between the bubbles

Xanthenes are an important class of heterocycles in medicinal chemistry due to their diverse pharmacological properties. These tricyclic aromatic compounds, characterised by a dibenzo[b,e]pyran core with an oxygen atom at their central position, have gained significant attention for their extensive applications. Beyond pharmaceuticals, xanthenes are widely used in textiles, food industries, electro-optical

The primary limitation associated with oil extraction through pressing is the considerable amount of residual oil in the cake. Therefore, this study focused on employing ultrasound waves to decrease the oil content in camelina seeds. For this purpose, three ultrasound treatment durations (15 to 45 min) were applied, and oil was immediately extracted from the seeds using a screw press at varying speeds

Disulfidptosis, a newly identified regulated cell death, is linked to tumor progression, particularly in cancers with elevated SLC7A11 expression. This study investigates SLC7A11 expression in liver hepatocellular carcinoma (LIHC) and evaluates the therapeutic potential of ICG@C3F8-KL nanobubbles (NBs) combined with sonodynamic therapy (SDT) for inducing disulfidptosis. Bioinformatics analysis of TCGA

Large quantities of spent coffee grounds (SCGs) are produced daily across the globe, accumulating as industrial waste in factories. Developing a process that both extracts high-value components and utilizes the bulk material would offer significant academic and industrial advantages. This study explores the use of hydrodynamic cavitation, which utilizes the chemical and physical effects produced by

Modern pharmacological investigations have shown that polysaccharides extracted from Boschniakia rossica showcase a range of biological effects. This study identified 260 primary metabolites, with carbohydrate compounds and their derivatives accounting for 80 types. We employed ultrasonic-assisted enzyme extraction (UAEE) to optimize extraction parameters, achieving a crude polysaccharide yield of

This work deals with the sonochemical synthesis of colloidal dispersions of magnetic nanoparticles formed by lanthanum-doped iron oxyhydroxides coated with citrate. Our aim is to obtain bimodal contrast agents with magnetic properties that allow their use in both resonance and X-ray techniques.

To address the growing need for high-performing and stable energy storage devices, optimizing the durability and structure of supercapacitor electrodes is crucial. Traditional electrodes frequently face challenges in achieving an optimal balance between electrochemical capacity and structural stability. This study presents the synthesis of TiO2/CC@C array electrodes through ultrasonic disorder-induced

Ultrasound is an efficient and eco-friendly friendly non-thermal technology for enhancing the extraction of bioactive ingredients from food. This study explored the impact of ultrasound on the microstructure and antioxidant properties of camellia bee pollen. Additionally, the impact of key contributors to antioxidant activity was examined through non-targeted metabolomics analysis. The results showed

The consumer demand for sustainable, nutrient-rich, and clean-label beverages is growing rapidly, so there is an urgent need to meet this demand. In response, the present study introduced the new concept of clean-label functional foods and beverages. The objective of the research was to develop novel ready-to-serve clean-label functional drink formulations by blending strawberry and cantaloupe juices

In the present study, a planar laser induced fluorescence (P-LIF) measurement, reaction rate measurement, the sonochemical luminescence (SCL) observation, and the particle image velocimetry (PIV) measurement were conducted to clarify the effect of macroscopic mass transfer on sonochemical reaction rate in an ultrasonic bath. The concentration distribution was measured by the fluorescence intensity

A novel approach was developed to create stable protein-based microbubbles using a vortex-driven hydrodynamic cavitation device. Such microbubbles, tiny gas-filled spheres, combined with ultrasound, can enhance drug uptake leading to inhibition of cancerous cell growth, boosting the effectiveness of anti-cancer drug molecules. The optimal conditions for the fabrication of stable bovine serum albumin

A hybrid thermal lattice Boltzmann cavitation model based on a nonorthogonal framework is developed to investigate the interaction of two attached-wall cavitation bubbles. The interaction modes are systematically analyzed, with an emphasis on how varying contact angles influence the flow and temperature distributions, as well as the evolution of wall heat flux under strong and weak interaction conditions

As miniaturized ultrasonic transducers with sophisticated structure have become increasingly demanded, the vibrating bodies made by conventional metals face the problem of fabricating difficulty and high expenses. The 3D printing metals are prospective materials for their flexibility in forming complicated configurations, but their mechanical-loss properties need clarification as they greatly affect

Due to the low density of chondrocytes and limited ability to repair damaged extracellular matrix (ECM) in cartilage, many patients with congenital or acquired craniofacial trauma require filler graft materials to support facial structure, restore function, improve self-confidence, and regain socialization. Ultrasound has the capacity to stimulate piezoelectric materials, converting mechanical energy

Ultrasonication has emerged as a promising technique for modifying physicochemical properties of proteins, enhancing their functionality in food applications. This study evaluated the effects of ultrasonic treatment on the structural and functional properties of mealworm-derived proteins (MPs) and their potential as emulsifiers. Dynamic light scattering revealed a significant reduction in MP particle

The pulsation of bubbles under dual-frequency ultrasound is closely associated with their application in medical diagnostics. In this study, we derive the analytical solution of the bubble dynamic equations in viscoelastic media under dual-frequency ultrasound and compare it with numerical solutions. The effects of the surrounding medium’s viscoelasticity, bubble equilibrium radius, incident acoustic

This study aims to evaluate the ultrasound-assisted synthesis of silver nanoparticles (AgNPs) based on an aqueous extract of Ruta graveolens L. to reduce Ag+ to Ag0. In addition, the biological activity of the synthesized AgNPs was evaluated against tumor cells. The following parameters were evaluated for the synthesis: proportion between Ag+ solution (0.1 mol L-1 Ag+) and R. graveolens L. extract

Layered double hydroxides (LDHs) are lamellar and stable nanocatalysts driven by visible light. They have received much attention in the context of advanced oxidation processes. Their catalytic performance is remarkably restricted owing to undesired aggregation and the possibility of electron-hole recombination. To address these issues, we engineered carbon-nanotube (CNT)-and biochar (BC)-based CuCr

Elastic ball motion and cavitation bubble ripples in cavitation bubble-elastic ball-curved wall interaction was investigated experimentally using single-electrode periodic discharge bubble generation technology and high-speed photography. It was found that the hard ball undergoes a process of “push-pull-push-pull” as the dimensionless bubble-ball distance increases, while the elastic ball undergoes

Perfluorocarbon nanodroplets (PFC-NDs) are promising ultrasound-responsive theranostic agents with applications in both diagnostic imaging and drug delivery. The acoustic vaporisation threshold, extravasation potential, and stability of PFC-NDs are all affected by their size. However, methods to ensure reproducible size and concentration during production by sonication are lacking. To address this

The effects of green technologies-ultrasound, microwave and their combined application-on alginate extraction from fucoidan production by-products of brown seaweed (Nizamuddinia zanardinii) were compared with the conventional alkaline method. The impact of the extraction methods on the Fourier-transform infrared spectroscopy (FT-IR) spectra, molecular weight, antioxidant, rheological, emulsifying and

While bulk PuO2 is known to be strongly resistant to dissolution, even under ultrasonic irradiation, this study demonstrates that nanometric PuO2 samples can exhibit enhanced reactivity when sonicated under an Ar/(20 %)O2 atmosphere. Sonication of powdered PuO2 nanoparticles (∼5 nm) in pure water was found to be ineffective. In contrast, colloidal PuO2 nanoparticles (∼3 nm) prepared via hydrolysis