In conventional studies, radicals and nonradicals were often considered independent mechanisms for organic pollutant oxidation, with their potential interaction between radicals and nonradicals largely overlooked in Fenton-like reactions. Herein, Cu-Co3O4 catalysts (x wt% Cu-Co3O4/OVs) featuring bifunctional bonding centers were fabricated, which enabled simultaneous co-capture of electron-rich contaminants

Intrinsically stretchable organic solar cells (IS-OSCs) are among the most promising technologies for wearable power applications. However, the development of electron acceptors that simultaneously meet the demands for high performance and mechanical stretchability remains a significant challenge. In this study, we creatively synthesized three oligomeric acceptors with flexible linkers (2YF-Br, 4YF-T

Ammonia (NH3) is an important feedstock for industry, an ideal energy carrier, and a perspective storage media for hydrogen. Recently, electrochemical NO3− reduction under acidic conditions has received considerable attention but it suffers from limited efficiency especially under low NO3− concentration. Here, we report an in-situ formed positively charged polyethyleneimine-modified Cu under acidic

Azobenzenes are versatile photoswitches that can be used to generate elaborate optical tools including photopharmaceuticals. However, the targeted application-guided design of new photoswitches with specific properties remains challenging. We have developed synthetic protocols for derivatives of the dfdc (di-ortho-fluoro-di-ortho-chloro) azobenzene scaffold with chemical alterations in the para-/ortho-positions

Accurately predicting the spin crossover (SCO) temperature (T1/2) in spin crossover compounds remains a significant challenge, due to their extreme sensitivity to minor variations in ligand and crystal structure. In this study, we uncover a critical link between the redox potential of ligands and SCO behavior within Hofmann-type clathrates {Fe(R-pbpy+)2[µ2-M(CN)4]2} (R = electron-donating or electron-withdrawing

Crosslinking strategies have emerged as an attractive technology for deciphering protein complexes and protein–protein interactions (PPIs). However, commonly used crosslinking strategies present significant challenges for the precise analysis of protein complexes and dynamic PPIs in native biological environments. Here, we report the development of the first visible-light-inducible lysine-specific

The inherent O2 sensitivity of Ni–Fe carbon monoxide dehydrogenases (CODHs), crucial for rapid CO to CO2 interconversion, presents substantial challenges for industrial application. Transforming CO/CO2, a prevalent anthropogenic air pollutant, into valuable carbon chemicals either directly or through intermediate steps via biocatalytic methods offers a promising pathway to achieve net-zero emissions

Understanding the hydrogenation behavior of *NO during electrochemical nitrate reduction reaction (NO3RR) is essential for designing catalysts with high selectivity toward ammonia (NH3) and valuable intermediates like hydroxylamine. Spinel cobalt oxides (Co3O4) are promising NO3RR electrocatalysts, yet the exact *NO hydrogenation mechanism remains unclear. Here, we integrate theoretical calculations

Antimicrobial resistance (AMR) is a severe threat to modern health care and must be addressed to prevent millions of deaths in the coming decades. Antimicrobial polymers (APs) do not provoke resistances and are promising alternatives to conventional antibiotics. Classic APs possess an amphiphilic structure (cationic and hydrophobic). Herein we question the necessity of amphiphilicity in APs and find

Luminescent emitters based on lanthanide ions are of ubiquitous importance in the biological sciences, but typically need sensitisation from a covalently attached adjacent chromophore – an “antenna” – to have suitable emission intensities. Here we show that the mechanical bond can be used to connect the antenna to the emitter, providing unique dynamic features and stimuli-responsiveness to the resulting

Recent advances in materials development for organic light-emitting diodes (OLEDs) have been driven by an emerging design concept known as multiple-resonance (MR), which provides the benefits of high efficiency and color purity required for commercial OLED displays. Borylation reaction constructing MR frameworks is a key step for developing new π-conjugated systems, while this reaction includes the

Chiral covalent organic frameworks (CCOFs) are promising candidates for chiral optoelectronics and sensing, but their weak solid-state fluorescence and chiroptical responses often limit practical utility. Here, we introduce a novel CCOF synthesized from achiral monomers, 2-hydroxy-1,3,5-benzenetricarbaldehyde and hydrazine, via imine condensation with chiral induction strategy, yielding salicylaldehyde

Achieving effective exciton dissociation and charge transport in linear polymer photocatalysts for H2O2 photosynthesis remains a formidable challenge. Herein, we fabricated three-motif cross-linked polymers by rationally introducing a third functional component into a two-motif linear polymer, which were employed for circulation-flow photocatalytic H2O2 production. By strategically modulating the third

Sodium metal batteries (SMBs) with gel polymer electrolytes (GPEs) are considered promising candidates for high energy-density batteries due to their high theoretical capacity and cost effectiveness. However, the intrinsic flammability of GPE poses challenges for their widespread application. Inspired by the concept of the capsules, a triethyl phosphate (TEP)-based GPE with co-sustained-release effect

Bioconjugation chemistry has been a powerful avenue in expanding the repertoire of druggable proteome, as well as in identifying new E3 ligases to support targeted protein degradation (TPD). However, a large fraction of proteome remains inaccessible with existing covalent probes. Herein, we incorporated various electron-withdrawing groups into styrene derivatives and identified β-nitrostyrene as a

Nonradiative (NR) processes are pivotal in engineering materials with tailored properties for energy utilization. However, their intrinsic rapidity and competitiveness pose huge challenges in on-demand manipulation. Herein, radical-assisted multiple NR processes were achieved to couple photothermy and photosensitization based on a unique near-infrared-absorbing diradical-featured croconium (CR) dendrimer

We synthesize and evaluate a diverse range of Mn/TiO2 catalysts with varying physical and redox properties for the methane-to-methyl-ester reaction using molecular oxygen in a diluted acid medium (10 wt% trifluoroacetic acid). Despite initial differences in manganese distributions, nearly all catalysts are active under the reaction conditions, and the degree of activity is partially correlated to catalyst

We report the synthesis and characterization of thio-tetracosulene 3, a highly twisted chiral macrocycle constructed via sulfur fluorine annulative substitution from a cyclometaphenylene derivative. It is the first macrocyclic aromatic compound with a plectonemic configuration, and the structure is unambiguously confirmed by single crystal X-ray diffraction study. The two enantiomers of 3 can be resolved

The fullerene family is known for its unique properties, facilitating the formation of large, lubricated nano-onions and the fragmentation into small carbon clusters through various processes. In this study, we explore the thermal evolution of C60 islands in Pt(111), focusing on the segregation of C60 islands, the formation of fullerene dimers, and the subsequent development of large graphene sheets

In this work, we introduce a modified dip-and-pull electrochemical X-ray photoelectron spectroscopy (ECXPS) approach that offers new mechanistic insight into the alkaline carbon monoxide reduction reaction (CORR) over a Cu(111) single crystal surface. We tackle two major unresolved questions in the CORR mechanism that persist in the literature. Firstly, we address the mechanism for methane formation

Supramolecular stereocomplexation is an important tool to advance sustainable polymers, and oxygen-containing polymers represent the most widely studied materials for stereocomplexation. However, the sulfur-containing analogues, a newly emerged class of sustainable polymers, remain essentially unexplored because of a significant challenge encountered in the synthesis of stereoregular polymers and relatively

In optimizing the trade-off between power density and phosphoric acid retention in PA-doped polybenzimidazole (PA-PBI) membrane for improving performance of high temperature proton exchange membrane fuel cells (HT-PEMFCs), the self-reinforcing network of interfacial interactions of the HT-PEMs has to be deeply investigated. Herein, a breakthrough strategy employing a quaternary ammonium (QA)-functionalized

The assembly of metal clusters with organic building units by covalent bonds to form crystalline metal cluster-based covalent-organic frameworks (MCCOFs) material is a novel strategy in the field of reticular synthesis. However, only 2, 3, and 6 connectivity (valency) of metal cluster-based MCCOFs have been achieved in reported structures. Developing a higher connectivity remains a great challenge

In various types of intelligent devices, such as bionic robots, flexible polymeric elastomeric materials are essential for their operation, alongside the rigid skeleton. Conventional polymeric elastomeric materials, however, encounter a compromise between intelligence and mechanical robustness. Here we construct ionic gel-based elastomers that harmoniously merge high intelligence with superior mechanical

A series of novel samarium complexes bearing cyclopentadienyl–amide chelate ligands were synthesized and characterized by X-ray analysis. The complexes function as effective proton-coupled electron transfer (PCET) catalysts, facilitating molybdenum-catalyzed ammonia formation from dinitrogen under ambient conditions. In this reaction system, the Sm complexes could be recycled over 300 times, and they

The development of high-energy-density batteries operable over a wide temperature range is critical for sustainable energy storage. Sodium-chlorine (Na-Cl2) batteries show promising high theoretical energy densities but face significant safety challenges due to gaseous chlorine, particularly at high temperatures. Replacing Cl2 with liquid Br2 to construct a new Na-Br2 battery mitigates gas risks but

Silylamides are important ligands in coordination chemistry for their ability to stabilize low-coordination numbers and provide soluble, and even volatile, metal complexes. Such compounds provide valuable insights into the fundamental bonding and reactivity of their respective metals. Despite the wealth of homo- and heteroleptic hexamethyldisilazide complexes of divalent 3d ions (Sc-Ni, Zn), attempts

Using a combination of metal-promoted reactivity, in-situ covalent bond modification, and hydrogen bonding-promoted fluorine labilization, a unified approach was developed to self-assemble a library of customizable ligand architectures directly at the nickel center via selective cleavage of C‒F or C‒O bonds and the formation of C‒C or C‒N bonds. As a result, a structurally diverse set of nickelacarbatrane

Achieving efficient and selective light‐driven CO2 conversion to formic acid is a significant scientific challenge, particularly when utilizing purely organic, metal‐free, and earth‐abundant element‐based molecule photocatalysts. Herein, we first reported the discovery of acridine derivatives (DADN, PXZN, PTZN) as new‐type, metal‐free, self‐sensitized molecule catalysts that enabled exceptional performance

This study introduces a novel electrofermentation platform integrating polycarbazole‐based porous organic polymer (VJ‐POP) coated electrodes to enhance selective Acetic acid (AA) biosynthesis by Bacillus subtilis. Impressive high surface area and tailored porosity facilitate efficient CO2 capture, modulate intracellular metabolic fluxes, and improve electron transfer, thereby driving product specificity

The development of high‐performance Zn‐ion batteries is hindered by sluggish reaction kinetics and inadequate redox activity in conventional vanadium‐based cathodes. Herein, a thermal oxidation phase‐engineering strategy is proposed to construct a comprising VSSe core and oxygen‐enriched VO2 and V2O5 interfaces‐phase heterojunction cathode. This unique architecture leverages a significantly increased

Molecular machines rely on their capacity to exploit non‐equilibrium processes to perform work. However, the development of these non‐equilibrium processes, such as molecular ratchets, is still in its early stages. Here, we report a diazocine‐containing ligand (L) harbouring two distinct chelating coordination sites that can self‐sort into dinuclear homo‐ and heterobimetallic helicates ([FeII2L](OTf)4

Electrochemical nitrate reduction reaction (NO3−RR) to ammonia (NH3) offers a sustainable route for NH3 synthesis and environmental remediation, yet it is hindered by sluggish kinetics due to inefficient proton‐coupled electron transfer (PCET) processes and inadequate electrocatalyst design. Conventional approaches primarily focus on regulating the bulk electronic modulation of the electrocatalyst

Copper dyshomeostasis is associated with various diseases, making in vivo spatiotemporal imaging of mobile Cu(II) dynamics crucial for understanding pathophysiological mechanisms. However, imaging mobile Cu(II) dynamics remains a long‐standing challenge due to the limitations of conventional probes in distinguishing between mobile and bound Cu(II). Herein, we developed a design strategy based on catalytic

Liquid organic electrolytes (LOEs) are of crucial significance in secondary battery deposition processes. Based on Sand's time formula, this study proposes a novel bidirectional ion kinetic regulator concept. Verified in lithium‐sulfur batteries (LSBs), it is demonstrated that regulating the migration of anions and cations simultaneously can effectively promote the realization of dendrite‐free batteries

The integration of multi‐photon absorption phenomenon (MPA) with thermally activated delayed fluorescence (TADF) materials opens new avenues for bio‐optoelectronic applications. However, the development of TADF emitters that simultaneously exhibit triplet harvesting and MPA is hindered by the challenge of balancing molecular planarity, reduced orbital overlap, and large oscillator strength. In this

Visualizing cholesterol dynamics in living systems in situ remains a fundamental challenge in biomedical imaging. While fluorescence microscopy requires bulky tags that perturb small molecule behavior, stimulated Raman scattering (SRS) microscopy enables label‐free detection of CH‐rich molecules. However, conventional SRS probes only polarized Raman components, limiting molecular specificity by seemingly

The one‐step conversion of biomass‐derived furfural (FUR) to tetrahydrofuran (THF) via combining decarbonylation and hydrogenation offers a sustainable alternative to the industrial Reppe process, while the selectivity control remains a significant challenge. Herein, we identify carbon monoxide (CO), in situ generated during FUR decarbonylation, as a major hindrance, significantly inhibiting subsequent

Disentangling the activity‐selectivity trade‐off in hydrodeoxygenation (HDO) of biomass‐derived oxygenates has been a great challenge in biomass valorization and related tandem catalysis, by virtue of involving a series of reactions in parallel and in cascade. Herein, we demonstrate the importance of La modulation for Ru‐zeolite combinations in the case of direct HDO of neat ethyl levulinate (EL) into

Highly efficient electrocatalytic nitrate reduction to ammonia (NH3) relies on the balanced activation of various substrates including nitrate and water, but is currently hindered by the inherent scaling relations governing the adsorption of key reaction intermediates, such as *NO and *H. Herein, we develop a strategy to circumvent these limitations by introducing f‐d‐p gradient orbital coupling in

Lithium–sulfur (Li–S) batteries are promising next‐generation energy storage devices due to their theoretical energy density of 2600 Wh kg−1. Employing weakly solvating electrolyte (WSE) effectively alleviates the polysulfide shuttle effect and improves the cycling lifespan. However, the sulfur cathode kinetics in WSE is highly sluggish to render degraded rate performances. Herein, the sulfur cathode

Typical nanopore sensing depends on slowed translocation through the pore to acquire effective blockade signals. However, this paradigm often suffers from low signal precision and poor resolution, making it challenging to resolve pools of analytes with diverse, similar structures. Here we present a non‐translocation blockade sensing based on an engineered aerolysin S278K that enables the identification

Cost‐effective redox‐active materials are essential for advancing redox flow batteries (RFBs). Iron, with its abundance and suitability as a redox couple, is a promising candidate; however, achieving stable and fast redox reactions in aqueous RFBs remains a challenge. This study presents an Fe‐based negolyte stabilized by a hexadentate ligand, where Fe–ligand bonds are enhanced through intermolecular

Here, the addition of H–H, Be–Be, B–B, and B–H bonds to SnII is studied by experimental and theoretical means. We report the first examples of B–B and Be–Be bond additions to a main group metal centre, along with the first example of borazine B–H bond addition to any element of the Periodic Table. Quantum chemical calculations suggest that the classification of these reactions as prototypical ‘oxidative’

X. X. Li, C. L. Jiao, X. Q. Zhang, X. Y. Xu, S. Gul, F. Y. Liang, J. Caro, H. Q. Jiang, Angew. Chem. Int. Ed. 2025, 64, e202416919 (https://doi.org/10.1002/anie.202416919) In this communication, the “+” symbols indicating equal contributions by co-first authors (Xinxin Li and Chengli Jiao), were omitted at the proof stage. The corrected authors list should therefore be as follows: Xinxin Li+, Chengli

Melanoma is characterized by rapid growth and high invasiveness, resulting in an exceptionally high malignancy and a significant propensity for metastasis. Current therapeutic modalities, such as chemotherapy and radiotherapy, exhibit limited efficacy due to severe side effects and immunosuppressive effects. Consequently, the development of precise and effective integrated therapeutic strategies is

Giant birefringent crystal with large band‐gap is of paramount importance for modern optical devices but simultaneous achievement of giant birefringence and large band‐gap is a great challenge stemming from their inherent contradictory relationship according to Kramers‒Kronig equation. Herein, an organic‐inorganic hybrid uniformly‐stacked two‐dimensional crystal [Be2(μ‐OH)2(C7H3NO4)(H2O)]·H2O (I) was

Chiral hybrid metal halides (HMHs), characterized by their non‐centrosymmetric crystal structures and exceptional photophysical properties, are promising for second‐order nonlinear and linear optics, including second harmonic generation (SHG) and circularly polarized luminescence (CPL). However, chiral HMHs with simultaneously strong SHG response and efficient CPL still presents a challenge, due to

Catalytic hydrogen‐deuterium exchange (HDE) has emerged as a valuable tool for achieving site‐selective deuteration and the precision labelling of bioactive molecules. Incorporation of deuterium at metabolically labile positions, enabled by such methods, can potentially improve drug efficacy through the kinetic isotope effect. However, achieving precise, site‐selective incorporation of deuterium at

Protein‐based tools are emerging as innovative solutions to interfere with biological pathways in molecular biology and medicine. They offer advantages over traditional small molecules due to their adaptable structural diversity and their ability to engage previously inaccessible cellular targets. However, most proteins do not penetrate the lipid bilayer of mammalian cells and are therefore restricted

Enabling large‐area deposition of dopant‐free organic hole transport layers (HTLs) with high reproducibility and uniformity is crucial for fully printed n‐i‐p perovskite solar cell (pero‐SC) modules. However, typical polymer hole transport materials (HTMs), with non‐Newtonian fluid characteristics, show shear rate‐dependent viscosity during the printing process, whereas blade‐coated small‐molecule

This study presents the first mechanochemical borrowing hydrogenation (BH) strategy, offering a direct and efficient route to N‐alkylated amines and heterocycles. This solvent‐free approach overcomes many challenges associated with conventional solution‐based syntheses, such as toxic reagents, inert atmospheres, high temperatures, lengthy reaction times, excessive catalyst loadings, and the use of

The limited design strategy of three‐dimensional covalent organic frameworks (3D COFs) greatly restricts their structural diversification and potential applications. Herein, we propose inwardly directed linker propagation strategy to targeted assemble of 3D COFs (COF‐IN‐1 and COF‐IN‐2), and comparing them with outwardly directed expanded COFs (COF‐OUT‐1 and COF‐OUT‐2). COF‐OUTs exhibits planar heteroporous

Electrochemical oxidation of organic nucleophiles to value‐added chemicals using nickel‐based catalysts is promising yet hindered by the dynamic evolution of nickel coordination structures during catalysis. Herein, we engineered atomically exposed nickel single‐site catalysts anchored on functional carbon black through tailored aromatic ligands coordination. This unique spatial coordination structure

Achieving high binding strength and efficient delivery of molecular cargo to cells expressing biomarker targets is a significant challenge in drug delivery. Here, we investigated how altering the surface immobilization residue (i.e. anchor point) within a non‐antibody binding scaffold called Anticalin can enhance particle adhesion to the immune checkpoint protein CTLA‐4 on mammalian cells under shear