INTRODUCTION Optical diagnosis is an essential part of a high-quality colonoscopy, but highly experience-dependent. Artificial intelligence in the form of computer-aided diagnosis (CADx) may bridge the gap between trainee endoscopists and experts. The aim of this study is to evaluate the diagnostic reliability of optical diagnosis of trainee endoscopists with the help of AI compared to experts. PATIENTS

OBJECTIVES Several studies have investigated the role of linaclotide in bowel preparation; however, dosage and timing still warrant further exploration. METHODS This non-inferiority randomized controlled study was performed in sixteen medical centers. The eligible subjects were randomly assigned to three groups: the Lct + 3 L PEG group (Group A), the 3 L PEG group (Group B), or the Lct + 2 L PEG group

BACKGROUND Esophageal disorders of gut-brain interaction (E-DGBIs) are highly prevalent in patients with unproven gastro-esophageal reflux disease (GERD) who do not respond to proton pump inhibitors (PPIs). The aim of this study was to determine the prevalence and characteristics of confirmed refractory GERD and E-DGBIs in consecutive patients with refractory reflux symptoms. PATIENTS AND METHODS Patients

INTRODUCTION DeepSeek was evaluated in gastroenterology board examination performance against legacy ChatGPT offline models, which previously showed failing performance. METHODS The performances of the DeepSeek base R1 model and search-augmented R1 model were assessed using American College of Gastroenterology self-assessments (455 questions). RESULTS DeepSeek exceeded passing threshold. Search-augmented

Critical to achieving the aim of person-centered care is a patient's direct report on the impact of illness and health care interventions on their global well-being. These reports are termed patient-reported outcomes (PROs) and defined as any report of the status of a patient's health condition that comes directly from the patient, without interpretation of the patient's response by a clinician or

OBJECTIVES Little is known about the impact of gender-affirming hormone therapy (GAHT) on transgender and gender diverse adults with inflammatory bowel disease (IBD). The primary aim was to evaluate the incidence of IBD flare in the year before and after GAHT initiation. METHODS A retrospective study across five IBD centers. Flare was defined as need for steroids, IBD-associated emergency department

INTRODUCTION Immune checkpoint inhibitors (ICIs) have become the first-line treatment for unresectable hepatocellular carcinoma (HCC). Prognostic value of immune-related adverse events (irAEs) in these patients remains controversial. We aimed to investigate the association between irAEs and clinical outcomes in HCC patients treated with ICIs. METHODS We searched the PubMed, Scopus, Web of Science,

BACKGROUND AND AIMS Pelvic floor disorders are prevalent in women. Sarcopenia, or age-related muscle mass loss, may be a contributing factor. We aimed to investigate the association between sarcopenia, as measured by the Psoas Muscle Index (PMI), and pelvic floor and anal sphincter function in women with evacuation disorders. METHODS We conducted a retrospective analysis of data from women who underwent

BACKGROUND Diagnosing pediatric gastroparesis presents a significant challenge due to lack of normative data in children. We aimed to determine normative values for gastric emptying using the non-radioactive 13C-Spirulina gastric emptying breath test (13C-GEBT) in a large cohort of healthy children (HC) and examine differences compared to children with gastroparesis-like symptoms (GLS). METHODS 301

BACKGROUND AND AIMS Fecal incontinence (FI) and Chronic constipation (CC) are diagnosed as distinct problems, although, many suffer with both problems. The phenotypical features and underlying mechanisms of FI mixed with CC (FI-MC) is unclear. We investigated the clinical and pathophysiological characteristics of FI-MC and compared with FI alone and healthy controls. METHODS In a retrospective study

INTRODUCTION Gastrointestinal endoscopy depends on high utilization of resources and is associated with significant production of waste. Recycling is one strategy that could decrease the carbon footprint from endoscopic activities and reduce landfill waste. OBJECTIVE To assess the impact of recycling of endoscopic materials in a high-volume university outpatient ambulatory endoscopy center. METHODS

BACKGROUND Precutting endoscopic mucosal resection (EMR-P) is a modified EMR method for the resection of large non-pedunculated colorectal polyps. In EMR-P, a mucosal incision is made using a snare-tip or endoscopic submucosal dissection (ESD) knife. However, there are concerns that the snare-tip may have a lower procedural success rate than the ESD knife. We aimed to assess the efficacy and safety

OBJECTIVES Forceps-assisted cannulation has been reported to facilitate difficult papillary cannulation during ERCP, especially in the context of abnormal papillary anatomy or associated papillary diverticula. We performed a randomized, controlled trial to evaluate if forceps-assisted cannulation improves cannulation success rates, reduces the incidence of difficult cannulations, and decreases the

BACKGROUND Hereditary alpha-tryptasemia (HαT) is caused by increased copy number of TPSAB1 when encoding for alpha-tryptase, resulting in elevated basal serum tryptase (BST). Many affected individuals report irritable bowel syndrome-like and reflux symptoms. We aimed to assess the prevalence of HαT in celiac disease (CeD) and whether this genetic trait modifies disease course. Methods: Prospective

BACKGROUND Social media platforms like TikTok are major sources of health information but raise concerns about misinformation. METHODS We conducted a content analysis of the top 200 TikTok videos on colorectal cancer (CRC), irritable bowel syndrome (IBS), and inflammatory bowel disease (IBD). Videos were categorized by content focus and narrator type. RESULTS CRC videos were largely healthcare-provider

BACKGROUND There is an urgent need for effective and safe treatment of gastroparesis. Metopimazine, a selective, peripherally restricted dopamine D2 receptor antagonist, is used in France for the symptomatic treatment of nausea and vomiting and chemotherapy-induced nausea and vomiting. AIM To assess the safety and efficacy of oral NG101, the mesylate salt of metopimazine, for the treatment of gastroparesis

BACKGROUND Irritable bowel syndrome (IBS) affects between 10% and 20% of the global population. The therapeutic effect of Yoga on IBS symptoms has been investigated by several randomized controlled trials (RCTs) with inconsistent findings. We conducted this review to synthesize the current evidence on yoga's effect on IBS symptoms. METHODS A systematic review and meta-analysis through systematically

Malnutrition, defined as deficiency, excess, or imbalance of nutrients, is a common complication in patients with liver disease, especially those with cirrhosis. Malnutrition may present as an isolated micronutrient deficiency, such as zinc deficiency, and it commonly presents as frailty and/or sarcopenia in patients with advanced liver disease. Patients with cirrhosis and/or alcohol-associated hepatitis

OBJECTIVES Celiac disease (CeD) is an immune-mediated enteropathy driven by gluten ingestion. Gluten challenges (GC) are commonly used to evaluate novel therapeutics and CeD mechanisms, but their associated symptom burden has not been well characterized. We aim to evaluate the proportion of subjects with gastrointestinal and extraintestinal symptoms during an experimental GC. METHODS Pubmed, Embase

INTRODUCTION To compare metachronous colorectal cancer (CRC) and advanced adenoma (AA) risk in patients with proximal vs. distal adenomas. METHODS We searched Pubmed, Embase, and Cochrane for cohort studies and clinical trials. Proximal adenomas were those located proximal to the descending colon. Pooled incidence rate ratios and 95% confidence intervals (CI) for CRC and AA were calculated using a

Endoscopy plays a pivotal role in managing inflammatory bowel disease (IBD). The role of endoscopy has evolved over the years, from diagnostic to surveillance to now doing therapeutic procedures to manage patients with IBD. From the initial diagnostic endoscopy, describing the extent and severity of the disease is an essential step in differentiating between Crohn`s disease and ulcerative colitis.

OBJECTIVES Little is known about the effect of social isolation on psychological outcomes of adults with chronic liver disease (CLD). METHODS Using the US National Health Interview Survey (2014-2018), we explored the associations between social isolation from living alone and serious psychological distress and the moderating effect of neighborhood social cohesion (NSC) among adults with CLD. RESULTS

Parkinson disease (PD) is a chronic, progressive movement disorder and the fastest growing neurological condition worldwide, affecting over 6 million individuals. In 2017, the economic burden of PD in the United States alone reached $52 billion. Gastrointestinal symptoms and dysfunction such as constipation, gastroparesis, and dysphagia are common in PD, are difficult to manage, and negatively affect

INTRODUCTION Multiple randomized studies have demonstrated that computer-assisted detection (CADe) improves the colonoscopic adenoma detection rate (ADR); however, these improvements have not been consistently reproduced in some more recent studies. METHODS Patients aged ≥50 years undergoing outpatient colonoscopy in 12 German institutions were randomized to either the CADe group or the control group

INTRODUCTION The risk of progression to esophageal adenocarcinoma (EAC) in Barrett's esophagus (BE) increases with advancing degrees of dysplasia. There is a critical need to improve the diagnosis of BE dysplasia, given substantial interobserver variability and overcalls of dysplasia during manual community pathologist reads. We aimed to externally validate a previously cross-validated BE dysplasia

BACKGROUND Hepatocellular carcinoma (HCC) surveillance is underused in clinical practice, and few contemporary data have assessed patients' perceptions of surveillance effectiveness and net benefit. METHODS We conducted a survey study among adult patients with cirrhosis at 7 health systems in the United States. The survey was based on validated measures, when available, and assessed patient knowledge

INTRODUCTION This article explores the association between leisure-time physical activity (PA) patterns and constipation using 2007-2010 National Health and Nutrition Examination Survey data. METHODS Participants were categorized into inactive, insufficiently active, and sufficiently active groups, with the latter split into weekend warriors and regularly active subgroups. Constipation was defined

BACKGROUND Visual analog scales (VAS) are simple, easy for patients to comprehend, and require limited translation. We evaluated the value of esophageal global symptom severity (GSS) measured using VAS in assessing initial reflux symptom burden as compared to other validated questionnaires, esophageal symptom burden, and outcome following reflux management. METHODS We analyzed pooled data from published

INTRODUCTION Electronic health records (EHRs) provide cancer screening reminders to patients and clinicians, but they are not always accurate. Updating the EHR after a colonoscopy for colorectal cancer screening is typically performed manually by the endoscopist when pathology results are available but may be error prone. We evaluated an electronic tool embedded in patient result letters that automatically

Carbohydrate intolerance is a poorly understood and potentially overlooked cause of unexplained gastrointestinal symptoms, particularly among patients with disorders of gut-brain interaction. Symptoms related to carbohydrate intolerance arise from bacterial fermentation of unabsorbed carbohydrates leading to increased gases and osmotic load within the gastrointestinal tract. This mechanism is shared

INTRODUCTION Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most used medications worldwide. A major limitation of these drugs is gastrointestinal mucosal injury. Several gastroprotective agents have been recommended but are limited by their long-term effects. Rebamipide is a promising mucoprotective agent, but its efficacy is not established. We performed a meta-analysis assessing the

INTRODUCTION Patients with type 2 diabetes mellitus (T2DM) are at increased risk of metabolic dysfunction-associated steatotic liver disease, advanced liver fibrosis, and metabolic dysfunction-associated steatohepatitis (MASH). We evaluated the prevalence and severity of metabolic dysfunction-associated steatotic liver disease among patients with T2DM at their first referral to diabetes clinics and

INTRODUCTION Recent data suggest emerging rural-urban disparities in hepatocellular carcinoma (HCC) burden in the United States. We aimed to assess (i) trends in rural vs urban HCC-related mortality and (ii) differences in underlying chronic liver disease etiologies contributing to HCC-related deaths. METHODS We used the National Vital Statistics System to examine crude and age-adjusted HCC death rates

INTRODUCTION We used New Hampshire Colonoscopy Registry data to examine the association between postcolonoscopy colorectal cancer (PCCRC) risk and an adenoma detection rate (ADR) which was calculated using examinations with all indications, as compared with ADR restricted to only screening examinations. METHODS Our cohort study included New Hampshire Colonoscopy Registry patients with an index examination

BACKGROUND AND AIMS Fluoroquinolones (FQ) have a favorable safety profile, but the risk of drug-induced liver injury (DILI) is well described. The aim of this study was to identify clinical features and HLA genetic variants associated with FQ-DILI in a large national registry. METHODS Analysis of FQ-DILI cases enrolled in DILIN between 2004-2022. HLA class I and II alleles were sequenced by the Illumina