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Clinically relevant dosing of miR-145 micelles curbs atherosclerosis in vivo J. Control. Release (IF 10.5) Pub Date : 2025-06-04
Isabella Suzuki, Anisa Ashraf, Neil Patel, Yi Huang, Brian Lam, Dawon Kim, Auveen Choroomi, Avery Liu, Kyla Johnson, Christopher Williams, Julia Chang, Shino Magaki, Harry Vinters, Eun Ji Chung -
Impact of tail unsaturation in ionizable lipids on mRNA delivery efficiency and immunogenicity of lipid nanoparticles J. Control. Release (IF 10.5) Pub Date : 2025-06-01
Xueer Ge, Zepeng He, Haihong Yang, Xiaorong Pan, Liang Yan, Yi Shi, Yongming Chen, Zhijia Liu -
Hypoxia-sensitive macrocycle inclusion complexes for targeted protein degradation J. Control. Release (IF 10.5) Pub Date : 2025-05-30
Jiachan Lin, Wenyan Wang, An-Kang Ying, Zirui Chen, Dan Zhang, Chendi Ding, Xiaowei Zeng, Dong-Sheng Guo, Hongzhong Chen -
Self-enhanced ROS-responsive camptothecin prodrug nanoparticles elicit safe and efficient intravesical instillation therapy of bladder cancer J. Control. Release (IF 10.5) Pub Date : 2025-05-29
Kunpeng Liu, Binbin Jiao, Guan Zhang, Zhihua Gan, Shicong Lai, Zhenshan Ding, Qingsong Yu -
Drug and therapeutic delivery targeting diseases in the vaginal environment: A mathematical modeling perspective J. Control. Release (IF 10.5) Pub Date : 2025-06-02
Bassam Fotouh, Anthony J. Kyser, Hermann B. Frieboes -
Effective head and neck cancer treatment combines radiation and local extended cisplatin release J. Control. Release (IF 10.5) Pub Date : 2025-06-02
Narmeen Daher-Ghanem, Shell Raveh, Awanish Kumar, Ariel M. Rubinstein, Hadas Solgi, Shay Sharon, Jawad Abu Tair, Yoram Fleissig, Jon Feldman, Yakir Rottenberg, Aron Popovtzer, Peter Siman, Abraham J. Domb, Nataly Kravchenko-Balasha -
Monocyte membrane-coated drug nanocrystals for enhanced targeted therapy of rheumatoid arthritis J. Control. Release (IF 10.5) Pub Date : 2025-06-01
Rongying Shi, Jiali Fu, Min Li, Anqi Zhang, Shiyun Huang, Xueying Yang, Yi Liang, Yuan Quan, Shanshan He, Shiqi Huang, Lin Li, Xun Sun, Tao Gong, Ling Zhang, Qing Lin, Zhirong Zhang -
Harnessing RGDS peptides to regulate bacterial-host interfaces for targeted antimicrobial therapy J. Control. Release (IF 10.5) Pub Date : 2025-06-01
Yuting Feng, Wenyue Xie, Zhuo Wan, Ying Jiang, Hongwei Xu, Jianan Qu, Zhuoling Tian, Yaqian Liu, Xiaoye Liu, Zuoying Yuan, Siying Qin, Chunyang Xiong, Jianyong Huang -
Immune regulation and repair of osteochondral defects using manganese-luteolin hydrogel scaffold J. Control. Release (IF 10.5) Pub Date : 2025-05-30
Shuai Yuan, Haobo Li, Zhengyang Xu, Zhipeng Yue, Shu Chen, Qiwei Fu, Yi Chen -
Microneedle-mediated biomimetic nanoparticles for targeted antioxidant and anti-inflammatory therapy in age-related macular degeneration J. Control. Release (IF 10.5) Pub Date : 2025-05-30
Jiaxin Liu, Jing Hu, Yang Li, Narisu Hu, Yihua Wang, Baiyu Chang, Yiyuan Guo, Xiaoyang Li, Qing Zhang, Yan Ming, Congcong Lin, Hongyu Ji, Zhenlei Yang, Jingling Tang -
Topical delivery of cultivated limbal stem cells via porous photocurable hydrogel: A noninvasive, convenient, and efficient stem cells delivery strategy for limbal stem cell deficiency J. Control. Release (IF 10.5) Pub Date : 2025-05-30
Shujia Guo, Yi Han, Jiani Li, Yuhan Huang, Dong Yu, Yuwen Liu, Yuqian Wang, Chaoyu Fan, Yimin Huang, Wenyin Guan, Danyi Qin, Lan Zheng, Caihong Huang, Cheng Li, Jiaoyue Hu, Zuguo Liu -
Functional lipid nanoparticles for safe delivery of macromolecular antibiotics to gram-negative bacteria J. Control. Release (IF 10.5) Pub Date : 2025-05-30
Melgious J.Y. Ang, Nithiyaa Balakrishnan, Ki Hyun Bae, Qiangqiang Wang, Zhengjie Wu, Yanming Wang, Pinzheng Zhang, Brandon Y.L. Seow, Xiaoli Liu, Yi Yan Yang -
Injectable hydrogel-based drug formulation for enhancing tertiary lymphoid structure formation and cancer immunotherapy efficacy J. Control. Release (IF 10.5) Pub Date : 2025-05-29
Chaiyaporn Kuwentrai, Weilong Tang, Xuansheng Lin, Teng Chi, Dongping Liu, Erwei Song, Matthew J. Webber, Jian-Dong Huang, Zhou Ye -
Double-layered core-shell microneedle patch integrated with microparticles for long-acting treatment of osteoporosis J. Control. Release (IF 10.5) Pub Date : 2025-05-29
Bo Xu, Suohui Zhang, Han Liu, Guozhong Yang, Zequan Zhou, Yunhua Gao -
COG133 peptide-conjugated lipid nanoparticles sensitize medulloblastoma to radiation therapy in mice J. Control. Release (IF 10.5) Pub Date : 2025-05-29
Aditya Gupta, Sohan Mahto, Rebecca E. Oberley Deegan, Donald W. Coulter, Ram I. Mahato -
Anti-CD33 antibody enhances liposomal co-delivery of cytarabine and daunorubicin for targeted combination chemotherapy J. Control. Release (IF 10.5) Pub Date : 2025-05-29
Jinyang Li, Jiasheng Lu, Xin Huang, Yuan Ding, Jianfen Zhou, Ruohan Chen, Zhixuan Jiang, Xingyan Fan, Yilin Yang, Chongbing Liao, Weiyue Lu, Wuyuan Lu -
Chitosan and mannose-modified dual-functional mRNA-LNP vaccines for robust systemic and mucosal immune responses J. Control. Release (IF 10.5) Pub Date : 2025-05-27
Jing Yi, Yicheng Lu, Nan Liu, Zengming Wang, Hui Zhang, Haonan Xing, Meng Li, Lili Jin, Aiping Zheng -
Intestinal retentive delivery system for improved disease therapy J. Control. Release (IF 10.5) Pub Date : 2025-05-28
Xin Wu, Wantao Wu, Jutaek Nam, Lei Rong, Kai Han -
Multifunctional nanocomposite hydrogel with dual-factor controlled release for stem cell recruitment, immunomodulation and bone remodeling J. Control. Release (IF 10.5) Pub Date : 2025-05-26
Yang Jiao, Haixin Wang, Mingyu Zhao, Huiling Liu, Peng Shen, Gang Wu, Tim Forouzanfar, Franklin R. Tay, Li Miao, Hongchen Liu, Qian Liu -
CD44-targeted RIP3 gene delivery strategy for enhanced cancer therapy via necroptosis and immune modulation J. Control. Release (IF 10.5) Pub Date : 2025-05-26
Sang Eun Kim, Soyeon Bak, Jung Hee Park, Ji Eun Lee, Yun Ji Lee, Min Seok Park, Soyeon Ko, Hani Choi, Kyung Hee Jung, Kun Na, Soon-Sun Hong -
Rational design of stimuli responsive nanoparticle systems for the controlled, intracellular delivery of immunotherapeutic and chemotherapeutic agents J. Control. Release (IF 10.5) Pub Date : 2025-05-27
Dennis Huang, Ishaan Duggal, Brandon Chau Matthews, Elaine Lee, Eric Tong, Nicholas A. Peppas -
Peptide-based nanoassembly enhances ferroptosis in cancer to overcome paclitaxel resistance J. Control. Release (IF 10.5) Pub Date : 2025-05-27
Congcong Lin, Jiamin Sun, Yun Yang, Xinyao Pan, Shiyu Wang, Xiaoyang Li, Yan Zhang, Huile Gao, Chunli Gan -
A novel cationic liposome-formulated toll like receptor (TLR) 7/8 agonist enhances the efficacy of a vaccine against fentanyl toxicity J. Control. Release (IF 10.5) Pub Date : 2025-05-27
Fatima A. Hamid, Nguyet-Minh Nguyen Le, Daihyun Song, Hardik Amin, Linda Hicks, Sophia Bird, Karthik Siram, Brooke Hoppe, Borries Demeler, Jay T. Evans, David J. Burkhart, Marco Pravetoni -
Polymer-based coating of adeno-associated viral particles as a new strategy to evade immune response for DMD treatment J. Control. Release (IF 10.5) Pub Date : 2025-05-27
María Stampa-López Pinto, Laia Martí-Melero, Jennifer Fernandez-Alarcon, Giovanni Sitia, Cristina Fornaguera, Salvador Borrós, Marta Guerra-Rebollo -
Gene therapy and nanomedicine for meningioma treatment J. Control. Release (IF 10.5) Pub Date : 2025-05-26
Deepshikha Shahdeo, Taskeen Iqbal Janjua, Matthieu Peyre, Ritu Kulshreshtha, Amirali Popat -
Lanthanide nanocrystals-based direct triple-state energy converters for mitophagy and ferroptosis-induced antitumor immunoreaction J. Control. Release (IF 10.5) Pub Date : 2025-05-26
Qianqian Sun, Yanrong Qian, Junrong Wang, Man Wang, Guanghui Zhao, Guangqiang Wang, Chunxia Li -
Effects of modification modules-adjusted intermolecular forces on docetaxel prodrug Nanoassemblies: From assembly mechanisms to in vivo fate J. Control. Release (IF 10.5) Pub Date : 2025-05-26
Wenxiao Li, Haiyu Zhao, Jiayu Guo, Xianbao Shi, Yixin Sun, Zhonggui He, Bingjun Sun -
Screening scaffold proteins for improved functional delivery of luminal proteins using engineered extracellular vesicles J. Control. Release (IF 10.5) Pub Date : 2025-05-26
Zheyu Niu, Houze Zhou, Wenyi Zheng, Oliver G. Hayes, Vicky W.Q. Hou, André Görgens, Samantha Roudi, Guannan Zhou, Rim Jawad Wiklander, Taras Sych, Erdinc Sezgin, Joel Z. Nordin, Ying Zhao, Xiuming Liang, Samir E.L. Andaloussi -
Tertiary amine N-oxide zwitterionic lipids facilitate muscle-selective mRNA vaccine delivery for enhancing cDC1-mediated antitumor efficacy J. Control. Release (IF 10.5) Pub Date : 2025-05-26
Haihong Yang, Zhan Gao, Yizi Zhou, Xueer Ge, Xiaorong Pan, Jiakun Li, Zhihui Zhang, Xuanli Jin, Guotao Liu, Zepeng He, Hong Liu, Zhijia Liu, Lixin Liu, Yongming Chen -
Injectable thermosensitive hydrogel for local and controlled delivery of siRNA-STAT3 polyplexes to treat advanced-stage ovarian cancer J. Control. Release (IF 10.5) Pub Date : 2025-05-26
Cristina Casadidio, Marcel H.A.M. Fens, Lies A.L. Fliervoet, Roberta Censi, Tina Vermonden -
In vivo FAP-CAR macrophages enhance chemotherapy and immunotherapy against pancreatic cancer by removing the fibrosis barrier J. Control. Release (IF 10.5) Pub Date : 2025-05-25
Wenguang Wang, Kaiyuan Hu, Junjie Xue, Jingyi Chen, Xiuli Du, Tian Zhao, Yiwei Chen, Xinying Tang, Lu Xu, Xinbao Hao, Xianjing Li, Yong Yang -
Genetically engineered extracellular vesicles expressing decoy protein TACI provide a therapeutic effect in systemic lupus erythematosus mouse model J. Control. Release (IF 10.5) Pub Date : 2025-05-25
Menghua Cai, Feng Tian, Jingyi Han, Liang Wang, Shikai Hu, Peng Dong, Wenhua Qiao, Han Zhang, Yue Wang, Hui Chen, Wei He, Jianmin Zhang -
Dual targeted ferritin-based delivery system blocks the crosstalk between cancer cells and cancer-associated fibroblasts to potentiate immunotherapy of colorectal cancer J. Control. Release (IF 10.5) Pub Date : 2025-05-25
Zhian Chen, Jinmei Cheng, Zhenhao Li, Huilin Huang, Yingxin Ren, Yang Zhou, Jinhui Li, Qianbing Zhang, Xiaopin Duan, Yanfeng Hu -
Advances in transcription factor delivery: Target selection, engineering strategies, and delivery platforms J. Control. Release (IF 10.5) Pub Date : 2025-05-25
Yeji Lee, Seongkyeong Yoo, Seongeon Cho, Iljin Kim, In-San Kim -
Synergistic blockade of SHP-2 and A2AR signal pathways with targeted nanoparticles restores anti-tumor immunity of CD8+ T cells J. Control. Release (IF 10.5) Pub Date : 2025-05-25
Mingshui Chen, Lingyu Zhang, Wansong Lin, Zhifeng Zhou, Yang Wang, Ling Wang, Hexi Gu, Jieyu Li, Zhi Ping Xu -
New insights of transition metal sulfide nanoparticles for tumor precision diagnosis and treatment J. Control. Release (IF 10.5) Pub Date : 2025-05-24
Zhusheng Liu, Yagui Lv, Yanzi Sun, Chengyuan Hong, Yubo Fan, Xuehua Ma, Changyong Gao, Jie Lin, Tianxiang Chen, Junge Chen, Aiguo Wu -
Engineered cell membrane-based nano therapies fight infectious diseases J. Control. Release (IF 10.5) Pub Date : 2025-05-24
Jiaxin Ma, Yijia Xie, Zihao Teng, Lili Jiang, Gang Liu -
Multi-modality imaging for precise intra-arterial delivery of mRNA, AAVs, and antibodies to the head and neck area in mice J. Control. Release (IF 10.5) Pub Date : 2025-05-24
Chengyan Chu, Guanda Qiao, Shriya Madan, Lucia Fadon-Padilla, Jinghui Wang, Abdallah Salemdawod, Shalini Sharma, David Gulisashvili, Lorissa McDougall, Yajie Liang, Miroslaw Janowski, Piotr Walczak -
Corrigendum to “Enhancing diabetic wound healing with a pH-responsive nanozyme hydrogel featuring multi-enzyme-like activities and oxygen self-supply” [Journal of Controlled Release, volume 365 (2024) 905–918] J. Control. Release (IF 10.5) Pub Date : 2025-05-24
Qiulan Li, Miaodan Dong, Qinqin Han, Yijing Zhang, Dezhi Yang, Daqiao Wei, Yaling YangThe authors regret errors occured in Figs. 7 and 8 of the published manuscript. Please find below the corrected images. Download: Download high-res image (522KB) Download: Download full-size image
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Amphiphilic dendrimer-assisted delivery of antisense nucleic acid mimics against E. coli J. Control. Release (IF 10.5) Pub Date : 2025-05-23
Mariana Gomes, Igor Resende, Yana Zamoshchak, Daniela Araújo, Joana Castro, Dinesh Dhumal, Ling Peng, Rita S. Santos, Nuno F. Azevedo -
Conductive bioadhesive hydrogel with controlled astragaloside IV release for ferroptosis-mediated cardiac repair J. Control. Release (IF 10.5) Pub Date : 2025-05-23
Xiaopei Li, Xiao Zhang, Yuanpu Qi, Wanjun Jin, Ziang Wen, Yixin Zhao, Xiangyu Li, Xin Yao, Zihao Shen, Feng Zhang, Peng Lu, Ningping Huang, Xiaowei Wang, Yun Liu -
Postoperative tumor suppression via ROS scavenging, VEGF capture, and photothermal therapy using a split aptamer-loaded hydrogel J. Control. Release (IF 10.5) Pub Date : 2025-05-23
Seongmin Kim, Jihye Lee, Huiguk Byun, Jinseong Kim, Won Jong Kim -
Cell microparticles loaded with pro-inflammatory factors and chloroquine collaborate with mechanical force to facilitate orthodontic tooth movement J. Control. Release (IF 10.5) Pub Date : 2025-05-23
Jiwei Sun, Baoying Zhao, Keqi Wo, Yutian Xia, Yuhan Liu, Shue Li, Cheng Yang, Silin Liu, Yumei Ding -
VPS9D1-AS1 antisense therapy via lipid nanoparticles reprograms cold tumors and enhances immunotherapy in colorectal cancer J. Control. Release (IF 10.5) Pub Date : 2025-05-22
Lei Yang, Zhen Li, Xiaoxi Huang, Lei Huang, Yangkai Fu, Baocheng Zhao, Yudong Zhang, Liangang Ma, Shuai Jing, Liyuan Fu, Dong Zhang, Hao Qu -
A TCR nanovesicle antibody for redirecting T cells and reversing immunosuppression as a tumor immunotherapy strategy J. Control. Release (IF 10.5) Pub Date : 2025-05-22
Luo Li, Bozhi Wang, Qian Li, Liang Zhang, Chunli Li, Aishun Jin, Hongbo Qi, Yu Tang -
A novel lipopolyplex platform for dual mRNA delivery via core- and surface-loading J. Control. Release (IF 10.5) Pub Date : 2025-05-22
Aljoscha Gabelmann, Elham Mansouri-Ghahnavieh, Marcus Koch, Prashant Shinde, Carlos A. Guzmán, Brigitta Loretz, Claus-Michael Lehr -
Red blood cell membrane-derived phototherapeutic nanodiscs: A new platform for enhanced phototherapy J. Control. Release (IF 10.5) Pub Date : 2025-05-22
Deli Zhuge, Li Li, Xueying Sun, Hui Liang, Chenjie Jin, Ailing Lu, Wenli Gao, Yutong Zhong, Wenlu Li, Sihao Chen, Fang Wang, Linzhi Yan, Weiyang Meng, Xiaoji Lin, Xufei Zhang, Yong Liu, Yuanfeng Li, Yingzheng Zhao, Xiang Zhang, Mengchun Chen, Yijie Chen -
“Actual” peptide properties required for nanoparticle development in precision cancer therapeutic delivery J. Control. Release (IF 10.5) Pub Date : 2025-05-22
Yazid Zaiki, Pei Gee Yap, Chee Yuen Gan, Mohammed Fauzi Abdul Rani, Daniela Traini, Tin Wui Wong -
A perspective on the apparent pKa of ionizable lipids in mRNA-LNPs J. Control. Release (IF 10.5) Pub Date : 2025-05-21
Jens B. Simonsen, Per Larsson -
Dependence of endothelial drug delivery on monodisperse microbubble dynamics J. Control. Release (IF 10.5) Pub Date : 2025-05-21
Yuchen Wang, Hongchen Li, Bram Meijlink, Robert Beurskens, Benjamin R.G. Johnson, Klazina Kooiman -
Antibody polymer drug conjugates with increased drug to antibody ratio: CD38-targeting nanomedicines for innovative therapy of relapsed lymphomas J. Control. Release (IF 10.5) Pub Date : 2025-05-21
Ondřej Lidický, Nicol Renešová, Júlia Kudláčová, Marcela Filipová, Tereza Běláková, Petra Kovaříková, Dmitry Manakov, Jan Pankrác, Alexandra Dolníková, Eva Pokorná, Pavel Klener, Tomáš Etrych -
Fully biodegradable dendrimers as novel nanodrugs for Amyloid-β-induced neurotoxicity J. Control. Release (IF 10.5) Pub Date : 2025-05-21
Débora A. Moreira, Eva D. Carvalho, Frederico Ferreira-da-Silva, Sofia D. Santos, Victoria Leiro, Ana P. Pêgo -
Direct structural investigation of pH responsiveness in mRNA lipid nanoparticles: Refining paradigms J. Control. Release (IF 10.5) Pub Date : 2025-05-20
Christoph Wilhelmy, Lukas Uebbing, Bastian Kolb, Melissa A. Graewert, Thomas Nawroth, Heinrich Haas, Peter Langguth -
Microenvironment-responsive MOF nanozymes armored cryogels promoted wound healing via rapid hemostasis, infection elimination and angiogenesis J. Control. Release (IF 10.5) Pub Date : 2025-05-19
Fupeng Li, Yun Du, Yumeng Zheng, Yihao Liu, Xinchen Zhu, Yuehan Cui, Yiqi Yang, Qirui Wang, Danru Wang -
Toward successful retinal drug delivery after intravitreal injection: Current strategies to overcome the inner limiting membrane J. Control. Release (IF 10.5) Pub Date : 2025-05-18
Kaat De Clerck, Stefaan De Smedt, Katrien Remaut, Karen Peynshaert -
Modulating binding affinity of aptamer-based loading constructs enhances extracellular vesicle-mediated CRISPR/Cas9 delivery J. Control. Release (IF 10.5) Pub Date : 2025-05-18
Charlotte V. Hegeman, Omnia M. Elsharkasy, Tom A.P. Driedonks, Kate R.J. Friesen, Pieter Vader, Olivier G. de Jong -
Predicting lymphatic transport potential using graph transformer based on limited historical data from in vivo studies J. Control. Release (IF 10.5) Pub Date : 2025-05-18
Yunfeng Li, Ruiya Liu, Zonghao Ji, Li Gao, Xiaolu Wang, Jiazhi Zhang, Luojuan Hu, Youyang Qu, Jun Bai, Di Wu, Sifei Han -
Receptor-mediated transcytosis of nanobodies targeting the heparin-binding EGF-like growth factor in human blood-brain barrier models J. Control. Release (IF 10.5) Pub Date : 2025-05-18
Boning Qiu, Sara Pompe, Katerina T. Xenaki, Alessia Di Maggio, Clara Belinchón Moreno, Paul M.P. van Bergen en Henegouwen, Enrico Mastrobattista, Sabrina Oliveira, Massimiliano Caiazzo -
Broadly active intranasal influenza vaccine with a nanocomplex particulate adjuvant targeting mast cells and toll-like receptor 9 J. Control. Release (IF 10.5) Pub Date : 2025-05-18
Luis Ontiveros-Padilla, Dylan A. Hendy, Erik S. Pena, Grace L. Williamson, Connor T. Murphy, Nicole R. Lukesh, Kathleen A. Ashcraft, Mathew A. Abraham, Chelsea D. Landon, Herman F. Staats, Soman N. Abraham, Michael Carlock, Ted M. Ross, Nikolai Petrovsky, Mark T. Heise, Eric M. Bachelder, Kristy M. Ainslie -
Single particle charge detection mass spectrometry enables molecular characterization of lipid nanoparticles and mRNA packaging J. Control. Release (IF 10.5) Pub Date : 2025-05-18
Zachary M. Miller, Lokesh Narsineni, Yue-Xuan Li, Matthew R. Gardner, Justin W. Torpey, Evan R. Williams
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