AI can enhance public health practice, but it requires careful consideration of ethical implications. We propose a reason-based framework to guide AI co-design and use for public health. AI systems must be developed with public health expertise, lived experience insights, and human accountability to ensure responsible outcomes. We advocate for ethical principles to be embedded throughout the AI lifecycle

We read with interest the Comment that suggests a taxonomy for brain–computer interfaces (BCIs) based on application1, and we agree that a nomenclature of different types of BCI may be useful for discussing this broad and expanding field comprised of stakeholders with different backgrounds and expertise, including groups new to BCI, such as media, investors and students. Nevertheless, we feel compelled

BackgroundHypoallergenic recombinant fold‐variants of major allergens have been suggested as safer and more effective AIT candidates. The Bet v 1‐fold variant BM41, with confirmed preclinical hypoallergenicity and increased immunogenicity, was proposed for the treatment of birch pollen allergy.MethodsWe performed a 6‐month randomized, double‐blind, placebo‐controlled first‐in‐human clinical trial with

BackgroundNasal microbiota composition of patients with diffuse type 2 chronic rhinosinusitis with nasal polyps (CRSwNP) is altered compared to healthy individuals. Dupilumab, an anti‐IL‐4Rα‐mAb, modulates type 2 inflammation, but the effect on microbiota composition in CRSwNP is unknown. The aim of this study was to investigate longitudinal effects of dupilumab on the nasal passage and gastrointestinal

The causative agents of respiratory allergies are bioaerosols, such as house dust mite feces, pollen grains, and fungal spores. Climate change and urbanization are considered to lead to an increase in the load of allergenic bioaerosols due to impacts on plant phenophases and allergenicity. Continuous and efficient monitoring of the atmospheric composition worldwide is essential, given the major changes

Chronic pain remains a global health challenge, often resistant to available treatments with socioeconomic and psychological burdens. All chronic pain is believed due to neuronal signaling imbalances, resulting in increased excitability. Gene therapy represents a promising molecular therapy targeting molecular pain processing pathways, by offering precise, localized, long-lasting neuromodulation while

Focal Cortical Dysplasia Type II (FCD II) is a leading cause of refractory epilepsy in children, yet treatment options remain limited. The most frequent genetic cause of FCD II is mosaic and somatic variants in genes of the PI3K-AKT-mTOR pathway, leading to hyperactivation of mTOR signaling. The presence of dysmorphic neurons (DNs) resulting from hyperactive mTOR signaling is critical for the development

Peritoneal metastasis (PM) is a prevalent mode of metastasis in colorectal cancer (CRC) with rapid disease progression and limited treatment options. Locoregional infusion of immune cells have been explored in different types of solid tumors, but the feasibility and safety of locoregional CAR-NK cells in treating CRC-PM is still unknown. We report the results of a phase I dose-escalation clinical trial

Poor tumor trafficking and the immunosuppressive tumor microenvironment (TME) limit chimeric antigen receptor (CAR) T cell efficacy in solid tumors, such as neuroblastoma. We previously optimized GPC2 CARs in human neuroblastoma xenografts leading to clinical translation; however, there have not been preclinical studies using immunocompetent models. Thus, here we generated murine GPC2 CAR T cells using

There remain several unmet clinical needs in Parkinson's disease (PD) including waning and incomplete efficacy of symptomatic therapies, development of medication side-effects (i.e., levodopa-induced dyskinesias (LID)) and unfettered disease progression. CaV1.3 calcium channels are therapeutic targets of intense interest in PD. We developed an RNA interference (RNAi)-based vector approach utilizing

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) replication depends on the NSP12-NSP8-NSP7 complex, which plays a critical role in enhancing RNA-dependent RNA polymerase (RdRp) activity. NSP8 is particularly essential, stabilizing the RdRp complex and supporting viral replication across diverse variants. To disrupt this crucial interaction, we designed four NSP8-derived peptides-N8-Pepα

Diseases and disorders of dental, oral, and craniofacial (DOC) tissues represent a significant global health burden and have been found to have the greatest age‐standardized prevalence and incidence of all reported diseases worldwide. While the application of novel therapies has been suggested to address the different types of oral health diseases, only a limited number of interventional regenerative

Research on responsible digital health innovation has typically focused on technical aspects such as the reliability and trustworthiness. More recently, work in responsible digital health innovation has started to recognize that, to address those concerns, stakeholder involvement is key. Aligning technological advancements with stakeholders’ needs requires deliberate and inclusive processes. Such processes