Nucleosomes — the basic unit of chromatin architecture — have intrinsic biophysical features of large-scale genome organization.

Section snippets Main textMean body weight continues to rise worldwide despite intensive prevention and treatment focused on energy restriction, leading to formulation of new models of obesity pathogenesis. In the carbohydrate-insulin model (CIM),1 a diet high in glycemic load (GL) (the multiplicative product of glycemic index [GI] and carbohydrate amount) initiates a sequence of hormonal responses

Section snippets Main textThank you for the opportunity to respond to the letter by Ludwig and colleagues1 generated in response to our paper where we tested some predictions of the carbohydrate-insulin model (CIM).2 The CIM proposes that obesity arises because high glycemic-load (GL) diets cause a set of hormonal changes that shift substrate partitioning toward fat storage, leading to greater hunger

This year, Cell Metabolism is celebrating its 20th anniversary! We are taking this opportunity to highlight authors that have published with us as they developed, and keep developing, their research careers. In 2005, Cell Metabolism was just starting an exciting journey to become a reference forum for interdisciplinary, high-quality metabolism studies. Throughout these years, it has been an honor to

There is no cure for polycystic ovary syndrome (PCOS), only treatment for its highly prevalent reproductive, cardiometabolic, and psychological symptoms. Early signs of PCOS appear during infancy. This enabled Cotellessa et al.1 to develop and administer neutralizing antibody therapy during infancy in a female mouse model to eradicate PCOS symptomology.

Body physiology follows the daily rhythm driven by the circadian system, which underlies the emerging concept of chrono-medicine. In this issue, Chen et al.1 report that feeding timing modulates adipocyte AMP-activated protein kinase (AMPK) α2 signaling to enhance exercise performance in mice, paving the way for chronotherapeutic approaches of AMPK activators such as metformin.

The death of mammalian cells is generally regulated by a complex interplay amongst distinct molecular machineries that ultimately determines the kinetic and immunological consequences of the process. Recent data from Song et al. delineate a new metabolic circuitry through which apoptotic signals may actively suppress cell death via ferroptosis.

A crucial goal of sleep science is to uncover the molecular mechanisms that translate sleep need into neural pathways that discharge sleep/wake transitions. In a new study, Tian et al.1 provide support in living animals that peroxide in the substantia nigra is a critical driver of these states.

With the rising prevalence of T2D worldwide, peripheral artery disease (PAD) now affects >230 million individuals globally. In the recent STRIDE trial, Bonaca et al.1 demonstrated that semaglutide improved walking capacity and hemodynamic parameters and slowed PAD progression in patients with T2D. These results reveal an unanticipated vasculoprotective benefit of GLP-1RAs.

Acquisition of nonprofessional phagocytic cell fate plays an important role in sculpting functional metazoan organs and maintaining overall tissue homeostasis. Though physiologically highly relevant, how the normal epithelial cells acquire phagocytic fate is still mostly unclear. We have employed the Drosophila ovary model to demonstrate that the classical ecdysone signaling in the somatic epithelial

The formation of the primitive heart tube from cardiomyocytes and endocardial cells is a key event in mammalian development. Previous studies suggeste…

(Cancer Cell 39, 779–792.e1–e11; June 14, 2021)

Correction to: Nature Cell Biology https://doi.org/10.1038/s41556-025-01655-4, published online 21 April 2025.

Lipid droplets (LDs) are ubiquitous neutral lipid storage organelles that form at discrete subdomains in the ER bilayer. The assembly of these ER subdomains and the mechanism by which proteins are recruited to them is poorly understood. Here, we investigate the spatiotemporal distribution of Pex30 at the ER-LD membrane contact sites (MCSs). Pex30, an ER membrane-shaping protein, has a reticulon homology

(Cell Metabolism 37, 1–16.e1–e4; July 1, 2025)

(Cell Metabolism 36, 2367–2382.e1–e5; November 5, 2024)

In this Tools of the Trade article, Abdallah (Gilbert lab) describes the development of direct analysis of ribosome targeting (DART), a tool designed to explore 5' UTR sequences for their potential to efficiently initiate translation.

In this Tools of the Trade article, Zhang and Mille-Fragoso (Gao lab) describe a synthetic receptor platform that is activated by the binding of specific ligands, which triggers RNA editing, enabling the translation of an output protein.