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Biochemical analysis of PD-L1 ubiquitination by CRL3SPOP, ARIH1, and NEDD4 family ubiquitin ligases Structure (IF 4.4) Pub Date : 2025-06-04
Guojiao Xie, Lin Gao, Renee Lu, Linxia Tian, Tiantian Zheng, Xinning Li, Yongjun Dang, Philip A. Cole, Xian Yu, Hanjie Jiang, Zan Chen -
Remote on–off switching of protein activity by intrinsically disordered region Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-06-04
Tuo Ji, Piao Ge, Shan Zhang, Chanjuan Wan, Hailong Liu, Xiaozhan Qu, Feng Zhu, Qingguo Gong, Weiya Xu, Chao Wang, Yucai Wang, Chengdong Huang -
Substrate recognition and allosteric regulation of synaptic vesicle glutamate transporter VGLUT2 Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-06-03
Fei Li, Jacob Eriksen, Juan A. Oses-Prieto, Yessica K. Gomez, Hongfei Xu, Surabhi Hareendranath, Poulomi Das, Janet Finer-Moore, Phuong Nguyen, Alisa Bowen, Andrew Nelson, Alma Burlingame, Michael Grabe, Robert M. Stroud, Robert H. Edwards -
RNA helicase unravels the secrets of germ granules Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-06-02
Ekaterina VoroninaGerm granules contribute to the intergenerational transmission of small RNA-mediated silencing in germ cells. A study in Caenorhabditis elegans now investigates the function of the RNA helicase DDX-19 at the interface between the nuclear pore and the cytoplasmic germ granules.
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Enhanced intensity-based clustering of isomorphous multi-crystal data sets in the presence of subtle variations. Acta Cryst. D (IF 2.6) Pub Date : 2025-06-01
Amy J Thompson,James Beilsten-Edmands,Cicely Tam,Juan Sanchez-Weatherby,James Sandy,Halina Mikolajek,Danny Axford,Sofia Jaho,Michael A Hough,Graeme WinterMulti-crystal processing of X-ray diffraction data has become highly automated to keep pace with the current high-throughput capabilities afforded by beamlines. A significant challenge, however, is the automated clustering of such data based on subtle differences such as ligand binding or conformational shifts. Intensity-based hierarchical clustering has been shown to be a viable method of identifying
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Structural insights into the interaction of Hir2 and Hpc2 in the yeast Hir histone chaperone complex Structure (IF 4.4) Pub Date : 2025-05-30
Chu-Hsin Tseng, Wen-Lin Hsieh, Wesley Tien Chiang, Nien-Jen Hu, Chia-Liang Lin -
Distinct tau filament folds in human MAPT mutants P301L and P301T Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-29
Manuel Schweighauser, Yang Shi, Alexey G. Murzin, Holly J. Garringer, Ruben Vidal, Jill R. Murrell, M. Elena Erro, Harro Seelaar, Isidro Ferrer, John C. van Swieten, Bernardino Ghetti, Sjors H. W. Scheres, Michel Goedert -
Structural basis of GluK2 kainate receptor activation by a partial agonist Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-29
Guadalupe Segura-Covarrubias, Changping Zhou, Nebojša Bogdanović, Lisa Zhang, Nami Tajima -
Structure and activation of the human autophagy-initiating ULK1C:PI3KC3-C1 supercomplex Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-29
Minghao Chen, Thanh N. Nguyen, Xuefeng Ren, Grace Khuu, Annan S. I. Cook, Yuanchang Zhao, Ahmet Yildiz, Michael Lazarou, James H. Hurley -
A competitive regulatory mechanism of the Chd1 remodeler is integral to distorting nucleosomal DNA Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-28
Ilana M. Nodelman, Heather J. Folkwein, Wesley S. Glime, Jean-Paul Armache, Gregory D. Bowman -
The MIT domain of STAMBP autoinhibits its deubiquitination activity Structure (IF 4.4) Pub Date : 2025-05-28
Ziyue Chen, Guanchao Wang, Yifan Zhang, Jianping Ding -
Myricetin-bound crystal structure of the SARS-CoV-2 helicase NSP13 facilitates the discovery of novel natural inhibitors. Acta Cryst. D (IF 2.6) Pub Date : 2025-06-01
Patrick Kloskowski,Piotr Neumann,Priya Kumar,Annette Berndt,Matthias Dobbelstein,Ralf FicnerThe SARS-CoV-2 helicase NSP13 is a highly conserved and essential component of the viral replication machinery, making it a promising target for antiviral drug development. Here, we present the 2 Å resolution crystal structure of NSP13 bound to the natural flavonoid myricetin, revealing a conserved allosteric binding site. Guided by these structural findings, a virtual screening campaign identified
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Modulation of striated muscle contractility by a high affinity myosin-targeting peptide. Biophys. J. (IF 3.2) Pub Date : 2025-05-27
Thomas Kampourakis,Negar Aboonasrshiraz,Theodore J Kalogeris,Rohit Singh,Dua'a Quedan,Motamed Qadan,Mozammel Hossain,Nasrin Taei,Michael Bih,Alysha Joseph,Kerry S McDonald,Douglas D RootMyosin-based regulation has emerged as a fundamental new concept governing both cardiac and skeletal muscle contractile function during both health and disease states. Myosin-targeted therapeutics have the potential to treat both heart failure with systolic or diastolic dysfunction based on either activating or inhibiting the function of myosin. In this study we developed a striated muscle myosin-specific
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Exploring insulin-receptor dynamics: Stability and binding mechanisms Structure (IF 4.4) Pub Date : 2025-05-26
Amanda D. Stange, Lorena Zuzic, Birgit Schiøtt, Nils A. BerglundInsulin binding to the insulin receptor (IR) induces large conformational changes leading to receptor activation. Although there exists a considerable number of IR structures in different conformational and insulin-saturation states, they cannot provide dynamic information or the resolved order of events leading to receptor activation. In this study, we employed molecular dynamics (MD) simulations
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UFMylation of ARPC4 facilitates lamellipodia formation and promotes cancer metastasis Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-26
Miao Wang, Yu-Sheng Cong -
TRIP12 structures reveal HECT E3 formation of K29 linkages and branched ubiquitin chains Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-26
Samuel A. Maiwald, Laura A. Schneider, Ronnald Vollrath, Joanna Liwocha, Matthew D. Maletic, Kirby N. Swatek, Monique P. C. Mulder, Brenda A. Schulman -
Akt-phosphorylated UFL1 UFMylates ArpC4 to promote metastasis Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-26
Kailiang Zhao, Hao Hu, Debao Fang, Mingran Xie, Jiasheng Chen, Shan Zhang, Suyun Tang, Mingsheng Wu, Xiaorui Guo, Ning Yu, Bao Yao, Wenli Jiang, Chao Wang, Yide Mei -
TRIMming centrosomal assemblies Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-25
Renata Basto -
Mesoscale regulation of microtubule-organizing centers by the E3 ligase TRIM37 Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-25
Zhong Y. Yeow, Sonia Sarju, Fang-Chi Chang, Lance Y. Xu, Mark van Breugel, Andrew J. Holland -
TRIM37 prevents ectopic spindle pole assembly by peptide motif recognition and substrate-dependent oligomerization Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-25
Andrew Bellaart, Amanda Brambila, Jiawei Xu, Francisco Mendez Diaz, Amar Deep, John Anzola, Franz Meitinger, Midori Ohta, Kevin D. Corbett, Arshad Desai, Karen Oegema -
Extending MMPBSA for membrane proteins: Addressing P2Y12R conformational changes upon ligand binding. Biophys. J. (IF 3.2) Pub Date : 2025-05-24
Cizhang Zhao,Tianhong Wang,Ray LuoMembrane proteins play crucial roles in biological signaling and represent key targets in drug discovery, garnering significant experimental and computational attention. Recent advances in computational screening techniques have enabled the development of more accurate and efficient binding affinity calculation methods. Among these, the Molecular Mechanics Poisson Boltzmann Surface Area (MMPBSA) method
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Acquisition of quaternary trimer interaction as a key step in the lineage maturation of a broad and potent HIV-1 neutralizing antibody Structure (IF 4.4) Pub Date : 2025-05-23
Qingbo Liu, Ruth J. Parsons, Kevin Wiehe, Robert J. Edwards, Kevin O. Saunders, Peng Zhang, Huiyi Miao, Kedamawit Tilahun, Julia Jones, Yue Chen, Bhavna Hora, Wilton B. Williams, David Easterhoff, Xiao Huang, Katarzyna Janowska, Katayoun Mansouri, Barton F. Haynes, Priyamvada Acharya, Paolo Lusso -
Unprocessed BMP9 precursor is an intrinsic antagonist for its active growth factor Structure (IF 4.4) Pub Date : 2025-05-23
Weida Zhang, Yuanyuan Zhang, Weidong Mao, Tao Huang, Xinrong Yu, Xiaohong Qin, Li-Zhi Mi -
Multiple steps of dynein activation by Lis1 visualized by cryo-EM Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-23
Agnieszka A. Kendrick, Kendrick H. V. Nguyen, Wen Ma, Eva P. Karasmanis, Rommie E. Amaro, Samara L. Reck-Peterson, Andres E. Leschziner -
Syntaxin 1A transmembrane domain palmitoylation induces a fusogenic conformation Biophys. J. (IF 3.2) Pub Date : 2025-05-23
Dong An, Satyan Sharma, Manfred LindauNeurotransmitter release is triggered by the fusion of synaptic vesicles with the plasma membrane, orchestrated by SNARE proteins synaptobrevin 2 (Syb2), syntaxin 1A (Stx1A), and SNAP25. Recent experimental studies showed that Stx1A palmitoylation of C271/C272 promotes spontaneous neurotransmitter release. However, the mechanistic role of SNARE transmembrane domain (TMD) palmitoylation in membrane
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Structural elucidation of full-length Pfs48/45 in complex with potent monoclonal antibodies isolated from a naturally exposed individual Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-22
Iga Kucharska, Danton Ivanochko, Sophia Hailemariam, Maartje R. Inklaar, Hee Ryung Kim, Karina Teelen, Rianne Stoter, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Anthony Semesi, Brandon McLeod, Ahyoung Ki, Won-Kyu Lee, John L. Rubinstein, Matthijs M. Jore, Jean-Philippe Julien -
Characterization and structural basis for the brightness of mCLIFY: A novel monomeric and circularly permuted bright yellow fluorescent protein Biophys. J. (IF 3.2) Pub Date : 2025-05-22
Him Shweta, Kushol Gupta, Yufeng Zhou, Xiaonan Cui, Selene Li, Zhe Lu, Yale E. Goldman, Jody A. DantzigOngoing improvements of genetically encoded fluorescent proteins have enhanced cellular localization studies and performance of biosensors, such as environmentally or mechanically sensitive fluorescence resonance energy transfer pairs, in cell biological and biophysical research. The brightest yellow fluorescent protein, widely used in these studies is YPet, derived from the jellyfish Aequorea victoria
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Chloride binding does not influence prestin motor speed at very high frequencies in the mouse outer hair cell Structure (IF 4.4) Pub Date : 2025-05-21
Jun-Ping Bai, Chenou Zhang, Iman Bahader, Nicola Strenzke, Vijay Renigunta, Dominik Oliver, Dhasakumar Navaratnam, Oliver Beckstein, Joseph Santos-Sacchi -
The molecular mechanisms of visual chromophore release from cellular retinaldehyde-binding protein Structure (IF 4.4) Pub Date : 2025-05-21
Daniel Santos, Lorenzo Foglia, Philip D. Kiser, Alvin Yu -
The yin yang of transcriptional memory Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-21
Alejandra Laguillo-Diego, Effie Apostolou -
Pairwise encounters boost bacterial motion by transient velocity spikes Biophys. J. (IF 3.2) Pub Date : 2025-05-21
Pu Feng, Chen Gui, Gancheng Wang, Lingling Wang, Jinglei Hu, Xiangjun Gong, Guangzhao ZhangFor swimming bacteria near surfaces, pairwise encounters inevitably occur and impact their social behavior. However, we know little about how the encounter events influence bacterial dynamics due to the limitations in tracking interplaying bacteria in 3D. Herein, we elucidated the motions of encountering E. coli using a combination of 3D holographic tracking experiments and hydrodynamic simulations
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Extrinsic heterogeneity: Collectivity in isotropic conformational fluctuations of chromosomes Biophys. J. (IF 3.2) Pub Date : 2025-05-21
Takuya Nara, Haruko Takahashi, Akinori Awazu, Yutaka KikuchiEukaryotic interphase chromosomes maintain a three-dimensional conformation within the nucleus and undergo fluctuations. However, the analysis of chromosome conformational fluctuations has been mainly limited to chromosome conformation capture data that record the contact frequencies between chromosomal regions. Herein, we investigated chromosome fluctuations as polymers based on experimental data
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How we peer review structural data Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-19
We explain why we ask our authors to provide structural data prior to peer review.
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Image-processing methods for electron microscopy of biological specimens. Acta Cryst. D (IF 2.6) Pub Date : 2025-06-01
Carlos Oscar S Sorzano,Albert Bartesaghi,Amit SingerThe focused issue on Image-processing methods for electron microscopy of biological specimens is introduced. The virtual issue is available at https://journals.iucr.org/special_issues/2025/imageprocessing.
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Membrane fusion and budding Biophys. J. (IF 3.2) Pub Date : 2025-05-20
Arun Anantharam, Michelle K. Knowles, Ling-Gang Wu -
Thermodynamics of arginine interactions with organic phosphates Biophys. J. (IF 3.2) Pub Date : 2025-05-20
Jiyeon Min, Madolyn Britt, Bernard R. Brooks, Sergei Sukharev, Jeffery B. KlaudaThe thermodynamics of arginine-phosphate binding is key to cellular signaling, protein-nucleic acid interactions, and membrane protein dynamics. In biomolecules, monoester phosphates are typically employed as strong electrostatic anchors strategically placed in switch domains to mediate specific interactions. In the diester configuration, phosphate groups act as ubiquitous connectors in all nucleic
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Structure, assembly and inhibition of the Toxoplasma gondii respiratory chain supercomplex Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-19
Andrew E. MacLean, Shikha Shikha, Mariana Ferreira Silva, Max J. Gramelspacher, Aaron Nilsen, Katherine M. Liebman, Sovitj Pou, Rolf W. Winter, Amit Meir, Michael K. Riscoe, J. Stone Doggett, Lilach Sheiner, Alexander Mühleip -
The molecular mechanism of ATP synthase constrains the evolutionary landscape of chemiosmosis Biophys. J. (IF 3.2) Pub Date : 2025-05-19
J. Emyr Macdonald, Paul D. AshbyATP synthase, the enzyme responsible for regenerating adenosine triphosphate (ATP) in the cell, comprises a proton-translocating motor in the cell membrane (labeled FO in bacteria, mitochondria, and chloroplasts), coupled by a common stalk to a catalytic motor F1 that synthesizes or hydrolyzes ATP, depending on the direction of rotation. The detailed mechanisms of FO, F1 and their coupling in ATP synthase
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An integrated multiscale computational framework deciphers SARS-CoV-2 resistance to sotrovimab Biophys. J. (IF 3.2) Pub Date : 2025-05-19
Akshit Sharma, Shweata Maurya, Shivank Kumar, Timir Tripathi, Rajiv K. Kar, Aditya K. PadhiThe emergence of resistance mutations in the SARS-CoV-2 spike (S) protein presents a challenge for monoclonal antibody treatments like sotrovimab. Understanding the structural, dynamic, and molecular features of these mutations is essential for therapeutic advancements. However, the intricate landscape of potential mutations and critical residues conferring resistance to mAbs like sotrovimab remains
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Structural study on human microbiome-derived polyketide synthases that assemble genotoxic colibactin Structure (IF 4.4) Pub Date : 2025-05-16
Minjae Kim, Jinwoo Kim, Gyu Sung Lee, Paul Dominic B. Olinares, Yougant Airan, Jasmine L. Chow, Jongseok Park, Yujin Jeong, Jiho Park, Brian T. Chait, Seth B. Herzon, Chung Sub Kim, Jin Young Kang -
Jerelle Joseph: seeing biomolecular condensates with computation Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-16
Melina CasadioJerelle Joseph is an assistant professor at the Department of Chemical and Biological Engineering and the Omenn–Darling Bioengineering Institute at Princeton University in New Jersey. We contacted Jerelle to learn about her research priorities, along with her thoughts about the biomolecular condensates field and how computational biology and molecular simulations can fuel discovery.
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DEK–nucleosome structure shows DEK modulates H3K27me3 and stem cell fate Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-16
Yunfan Shen, Yanhong Liu, Maochao Guo, Song Mao, Rui Chen, Mengran Wang, Zhengbo Li, Yue Li, Wan Chen, Fang Chen, Baixing Wu, Chongyuan Wang, Wei Chen, Huanhuan Cui, Kai Yuan, Hongda Huang -
The importance of physiological and disease contexts in capturing mRNA modifications Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-16
Audrey Penning, François Fuks -
GID4 recognition of Pro/N-degron peptides: Conformational selection and induced fit Biophys. J. (IF 3.2) Pub Date : 2025-05-16
Yanjun Zhang, Xule Zhao, Yuxin Tian, Shun Zhang, Feng Fan, Xiafei HaoThe N-degron pathway is essential for protein quality control and cellular homeostasis. GID4, a subunit of the GID ubiquitin ligase, is the main recognition component of the Pro/N-degron pathway. It binds protein substrates through their N-terminal proline, but its binding model and recognition of nonproline residues remain unclear. In this study, we performed molecular dynamics simulations and binding
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Measuring PARP1 mobility at DNA damage sites by segmented fluorescence correlation spectroscopy Biophys. J. (IF 3.2) Pub Date : 2025-05-16
Elisa Longo, Greta Paternò, Alberto Diaspro, Luca LanzanòSegmented fluorescence correlation spectroscopy (FCS) improves the accuracy of FCS measurements in cells by analyzing data in short temporal segments. We have recently demonstrated the possibility of performing segmented FCS using a commercial confocal laser scanning microscope, enabling the measurement of molecular diffusion in different subcellular regions. In this study, we apply segmented FCS to
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Structural clues about bridge-mediated lipid transfer Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-15
Pietro De Camilli, Karin M. Reinisch -
Insights into the degradation mechanism of GID4-based proteolysis-targeting chimeras Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-15
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Reciprocal stabilization of CtBP and TRIM28 represses autophagy to promote metastasis Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-15
Lixin Tai, Dongliang Zhu, Ping Tang, Jiajia Li, Junyi Li, Peipei Li, Zhonghua Tao, Haipeng Lei, Kai Miao, Hong-xia Wang, Shuhai Lin, Lei Zhang, Man Dou, Yu Han, Han-Ming Shen, Chuxia Deng, Li Wang, Li-jun Di -
Bonding under tension: Some cadherins are better than others Biophys. J. (IF 3.2) Pub Date : 2025-05-15
Eoin McEvoy -
Interplay of protein fluctuation and associated water dynamics in osmolyte-induced stabilization Biophys. J. (IF 3.2) Pub Date : 2025-05-15
Kuldeep Singh Negi, Subhajit Rana, Tanmoy Khan, Dipankar Mondal, Pratik SenThe mechanism behind osmolyte-induced protein stabilization remains elusive despite extensive research. Among various hypotheses, the associated water-modulation hypothesis has proved to be the most effective in explaining osmolyte-induced stabilization effects. Earlier, we demonstrated that osmolytes that slow down associated water dynamics enhance protein thermal stability, whereas those that accelerate
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A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV Structure (IF 4.4) Pub Date : 2025-05-14
Mohammad M. Sajadi, Abdolrahim Abbasi, Zahra Rikhtegaran Tehrani, Christine Siska, Rutilio Clark, Woo Chi, Michael S. Seaman, Dieter Mielke, Kshitij Wagh, Qingbo Liu, Taylor Jumpa, Randal R. Ketchem, Dung N. Nguyen, William D. Tolbert, Brian G. Pierce, Ben Atkinson, Derrick Deming, Megan Sprague, Andrew Asakawa, David Ferrer, Anthony DeVico -
Structural insights from active site variants and β-8 loop interactions in viperin-like enzymes Structure (IF 4.4) Pub Date : 2025-05-14
Jake C. Lachowicz, Steven Grudman, Jeffrey B. Bonanno, Andras Fiser, Tyler L. Grove -
STING to the lysosome’s rescue Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-13
Katarzyna A. CiazynskaSTING (stimulator of interferon genes) functions in innate immunity as an adaptor protein in a signaling cascade initiated upon detection of cytosolic DNA. STING is continuously transported to the lysosome, where it is degraded, to maintain homeostasis after activation, and STING signaling can induce lysosome biogenesis. Lysosome storage disorders (LSDs) can lead to pathogenic STING activation, where
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Visualizing RNA oligomers Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-13
Katarzyna MarcinkiewiczThe stability and function of many biological macromolecules are regulated by assembling several identical subunits into larger structures. So far, this phenomenon has been best studied in proteins. Now, in a study in Science, Wang et al. use single-particle cryo-electron microscopy (cryo-EM) to visualize several quaternary structures of RNA. The group selected four bacterial noncoding RNA families
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Decoupling chromatin hubs from gene control Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-13
Darío G. Lupiáñez -
CTCF depletion decouples enhancer-mediated gene activation from chromatin hub formation Nat. Struct. Mol. Biol. (IF 12.5) Pub Date : 2025-05-13
Magdalena A. Karpinska, Yi Zhu, Zahra Fakhraei Ghazvini, Shyam Ramasamy, Mariano Barbieri, T. B. Ngoc Cao, Natalie Varahram, Abrar Aljahani, Michael Lidschreiber, Argyris Papantonis, A. Marieke Oudelaar -
Mechanistic insight into O=O bond formation upon model-independent visualization of the coordination geometry and ligand composition of Mn4Ca cofactor in dark-adapted photosystem II structures. Acta Cryst. D (IF 2.6) Pub Date : 2025-06-01
Jimin WangThe Mn4Ca cofactor of photosystem II (PSII), which is found in its oxygen-evolving center (OEC), catalyzes the oxidation of water. Spectroscopic studies performed on dark-adapted PSII samples have led to two mutually incompatible hypotheses about the oxidation states of these manganese ions: Mn(III)4 or Mn(III)2Mn(IV)2. It should be possible to determine which is correct crystallographically because
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Coarse-grained chromatin dynamics by tracking multiple similarly labeled gene loci Biophys. J. (IF 3.2) Pub Date : 2025-05-13
Alexander Mader, Andrew I. Rodriguez, Tianyu Yuan, Ivan Surovtsev, Megan C. King, Simon G.J. MochrieThe “holy grail” of chromatin research would be to follow the chromatin configuration in individual live cells over time. One way to achieve this goal would be to track the positions of multiple loci arranged along the chromatin polymer with fluorescent labels. Using distinguishable labels would define each locus uniquely in a microscopic image but would restrict the number of loci that could be observed
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The enteric nervous system is 10 times stiffer than the brain Biophys. J. (IF 3.2) Pub Date : 2025-05-13
Nicolas R. Chevalier, Alexis Peaucelle, Thomas Guilbert, Pierre Bourdoncle, Wang XiNeural tissues of the central nervous system are among the softest and most fragile in the human body, protected from mechanical perturbation by the skull and the spine. In contrast, the enteric nervous system is embedded in a compliant, contractile tissue and subject to chronic, high-magnitude mechanical stress. Do neurons and glia of the enteric nervous system display specific mechanical properties