A facile bottom-up synthesis of a contorted polycyclic aromatic hydrocarbon (PAH) derivative was reported. The structure features three expanded heptagonal rings, constructed by structural extension of a triscycloheptenylene core with integration of three anthraquinone units into the π-conjugated architecture. This strategy enables gram-scale synthesis with decent yield under mild conditions. Single

In previous reports, the cross-couplings of diaryl disulfides with aryl halides in the presence of transition metal catalyst (e.g., Ni, Cu) and metal mediator (e.g., Mg, Zn) usually led to the corresponding aryl sulfides via old S-S bond cleavage and new C-S bond formation. In the present study, we found that the reductive cross-couplings of diaryl disulfides with aryl bromides proceeded via unusual

Photocatalytic radical-induced cyclization reactions offer an efficient paradigm for constructing aromatic rings due to their unique environmental friendliness, independence from electronic effects, and high functional group tolerance. However, the high reactivity of intermediates in radical reactions, particularly the challenges of controlling it proceeds in an orderly manner according to the expected

Dracomicins constitute a new class of oligosaccharide–nonribosomal peptide specialized metabolites isolated from the minor actinomycete genus Amycolatopsis. Their structures were determined by NMR, mass spectrometry, and chemical derivatization approaches. Along with their novel chemical scaffolds, dracomicins show unprecedented structural features, including previously unreported β-methyl amino acids

The authors retract this letter (DOI: 10.1021/acs.orglett.4c03235) following an institutional investigation into the authorship of this work by the University of Zurich. This investigation concluded that “This work was conceptualized by Prof. Michal Juríček at the University of Zurich and developed by Prof. Yong Yang during his postdoctoral stay in Prof. Juríček’s group, Prof. Joshua C. Walsh made

Organohalides represent a crucial class of compounds extensively employed as key precursors for organometallic reagents, bioactive molecules, and nucleophilic substitution reactions. Furthermore, the growing prominence of cross-coupling reactions has significantly enhanced the importance of aryl halides, positioning them as essential building blocks in organic synthesis. Recent advancements in C–H

Remote activating strategy enabled (RASE) π-bond migratory dealkylative C(sp3)-N and C(sp2)-N coupling with 2-alkoxylthiazole through C(sp3)-H and C(sp2)-H cleavage, giving N-benzyl or N-phenyl thiazol-2(3H)-one, respectively, are achieved under mild conditions. N-Fluorobenzenesulfonimide (NFSI) serves as a crucial bifunctional domino reagent which not only generates nitrogen-centred radical that initiates

Gelsepolycines A–F (1–6), six oligomeric monoterpenoid indole alkaloids with new skeletons, together with their biosynthetic precursors (7–8), were isolated from the flowers of Gelsemium elegans. Compounds 1 and 4–6 represented the first examples of trimeric Gelsemium alkaloids that featuring complex sterically compact frameworks with 17-19 chiral centers. Furthermore, these compounds were constructed

The asymmetric α-alkylation of simple ketones with unactivated alkyl halides remains a longstanding challenge in organic synthesis. Herein, we report a dinickel-catalyzed asymmetric α-alkylation of cyclic ketones using unactivated alkyl halides as alkylating agents. This methodology accommodates a broad range of substrates, including benzo-fused cyclic ketones, α-aryl and α-alkyl cyclic ketones, and

Retraction: A. Malik, N. Kishor Gour, S. Bhatt, R. Chandra Deka and S. L. Jain, “Visible Light-Induced Synthesis of 2-Oxazolidinones through One-Pot Coupling of Benzylamines, Epoxides and CO2,” European Journal of Organic Chemistry 2023, 26, e202201338, https://doi.org/10.1002/ejoc.202201338. The above article, published online on 08 February 2023 in Wiley Online Library (wileyonlinelibrary.com), has

The development of green and efficient C‐S bond formation methods has received significant attention from synthetic chemists because the C‐S bonds widely occurs in many important drugs and natural biological compounds. In recent years, photochemical organic conversion promoted by visible light has attracted the interest of many organic chemists. Compared with the traditional methods, visible light

Chemo-divergent approach enables to achieve regioselective and site-divergent transformations of multiple products by changing the parameter from identical, readily accessible starting materials are ideal but challenging due to the complexity of precisely controlling the chemo-diversity. Herein, we reported a novel FeCl₃-catalyzed one-pot strategy enabling the selective synthesis of 5-methyl-7-phenyldibenzo[b