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What can be learned when multiple analysts arrive at different estimates. Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-05-29
Julia M Rohrer,George Davey Smith,Marcus Munafò -
Dietary polyunsaturated fatty acid and risk of gout: a cohort study integrating genetic predisposition and metabolomics. Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-05-28
Li Chen,Tianqi Tan,Qi Wu,Feipeng Cui,Yashu Chen,Huimin Chen,Ying Zhao,Xia Xiang,Zhilei Shan,Yuhan Tang,Qianchun DengOBJECTIVES Gout is the most common inflammatory arthritis and affects quality of life. Dietary polyunsaturated fatty acids (PUFAs) have protective effects against various diseases, but its role in gout remains uncertain. Our study aims to assess the association between PUFAs intake and gout risk, the role of genetic factors, and the possible impact of metabolites. METHODS This study included 198,033
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Cancer risk after in utero exposure to diethylstilbestrol. Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-05-28
Naomi B Boekel,Janneke Verloop,Hester H van Boven,Elisabeth J M van Erp,Lieske Schrijver,Matti A Rookus,Flora E van LeeuwenIn utero exposure to diethylstilbestrol (DES) is associated with increased risk of clear cell adenocarcinoma (CCAC) of the vagina or cervix. It is not clear whether these risks remain increased at older ages, and if the risks of other cancer sites, including breast cancer, are increased. This nationwide cohort study included 12,249 DES-exposed women and 2,070 unexposed sisters. Hormone-related risk
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Postdiagnosis physical activity and dietary inflammatory and insulinemic potential with overall survival in men with nonmetastatic prostate cancer. Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-05-28
Dong Hoon Lee,Leandro F M Rezende,Gerson Ferrari,Yiwen Zhang,Qiao-Li Wang,Hannah Oh,NaNa Keum,Jinbo Hu,Justin Y Jeon,Lorelei A Mucci,Edward L GiovannucciInflammation and insulin resistance are associated with increased mortality in the general population. However, it remains unclear how physical activity and proinflammatory/hyperinsulinemic diets influence overall survival in prostate cancer patients. We analyzed 4779 men with nonmetastatic prostate cancer from the Health Professionals Follow-up Study. Postdiagnosis physical activity and diet were
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Keep asking: What do I want? What do I have? What do I do? : An approach for combining information to learn about a target population. Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-05-28
Lawson Ung,Issa J Dahabreh -
Changes in LDL-cholesterol levels following aromatase inhibitor treatment in early postmenopausal breast cancer Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-05-21
Marie Lund, Giulia Corn, Maj-Britt Jensen, Tonny Petersen, Kim Dalhoff, Bent Ejlertsen, Lars Køber, Jan Wohlfahrt, Mads MelbyeThere is an unsettled concern that treatment with aromatase inhibitors (AIT) may adversely affect lipid-levels. In light of the improved survival of women with breast cancer and increased risk of atherosclerotic cardiovascular disease in older people, unfavorable effects on lipid-levels may represent a significant health concern for this group of patients. We used linked data from nationwide registries
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The healthcare system in Sweden Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-05-19
Jonas F. Ludvigsson, David Bergman, Catharina Ihre Lundgren, Kristina Sundquist, Jean-Luc af Geijerstam, Anna H. Glenngård, Marie Lindh, Johan Sundström, Johan Kaarme, Jialu YaoThe Swedish population is characterized by high life expectancy and low avoidable mortality rates. This review outlines the Swedish healthcare system, which offers universal access to all residents and has a long tradition of reforms for social equity. Responsibility for healthcare is shared between the state, the regions, and the municipalities. The Ministry of Health and Social Affairs provides the
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Risk tools for predicting long-term sequelae based on symptom profiles after known and undetected SARS-CoV-2 infections in the population Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-05-19
Rieke Baumkötter, Simge Yilmaz, Julian Chalabi, Vincent ten Cate, Ayesha Syed Mamoor Alam, Sepehr Golriz Khatami, Daniela Zahn, Nora Hettich-Damm, Jürgen H. Prochaska, Irene Schmidtmann, Kristin Lehnert, Anke Steinmetz, Marcus Dörr, Norbert Pfeiffer, Thomas Münzel, Karl J. Lackner, Manfred E. Beutel, Philipp S. WildThe aim was to determine the profile of long-term symptoms after known and undetected SARS-CoV-2 infections and to generate tools for risk and diagnostic assessment of Post-COVID syndrome (PCS). In the population-based Gutenberg COVID-19 Study (N = 10,250), sequential, systematic screening for SARS-CoV-2 was performed in 2020/2021. Individuals received a standardized interview on newly occurred or
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Trends in kidney cancer: exploring the impact of sex and age on stage of disease, and prognosis during the past three decades in Denmark—a DaRenCa study Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-05-14
Johanne Ahrenfeldt, Jesper Jespersen, Jens Ejrnæs Lyngstrand, Laura Iisager, Anna Krarup Keller, Niels Fristrup, Tinne Laurberg, Iben LyskjærRenal cell carcinoma (RCC) management has advanced due to increased imaging-based diagnoses and improved therapies for metastatic disease. This nationwide registry-based cohort study examines changes in the number of primary RCC cases, stage at diagnosis, prognosis during the past 30 years in Denmark, and how these are associated with sex and age. All Danish patients aged 18 and older diagnosed with
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The Longitudinal Aging Study Amsterdam: design and cohort update 2025 Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-05-14
Emiel O. Hoogendijk, Natasja M. van Schoor, Yuwei Qi, Marjolein Visser, Joukje C. Swinkels, Marjolein I. Broese van Groenou, Almar A. L. Kok, Tjalling J. Holwerda, H. Roeline W. Pasman, Bregje D. Onwuteaka-Philipsen, Sharon Remmelzwaal, Erik van Ingen, Theo G. van Tilburg, Aimée-Claire van Haaster, Marleen van der Horst, Jan Poppelaars, Dorly J. H. Deeg, Martijn HuismanThe Longitudinal Aging Study Amsterdam (LASA) is an ongoing prospective cohort study of older adults in the Netherlands, with data on multiple domains of functioning available over a period of more than 30 years of follow-up. The study started in 1992 with a nationally representative sample of older adults aged 55–84 years. Over the years, three refresher cohorts (two cohorts aged 55–64 years in 2002
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Outdoor air pollution, road traffic noise, and allostatic load in children aged 6–11 years: evidence from six European cohorts Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-05-14
Yuchan Mou, Michelle Sofia Wilhelmina Kusters, Oliver Robinson, Lea Maitre, Rosemary R. C. McEachan, Wen Lun Yuan, Norun Hjertager Krog, Sandra Andrušaitytė, Mariona Bustamante, Montserrat de Castro Pascual, Audrius Dedele, John Wright, Regina Grazuleviciene, Gunn Marit Aasvang, Johanna Lepeule, Mark Nieuwenhuijsen, Henning Tiemeier, Martine Vrijheid, Errol M. Thomson, Mònica GuxensEmerging evidence suggests that exposure to air pollutants and road traffic noise triggers stress responses, which mediate physiological responses in multiple organs and tissues. However, epidemiological study in children is sparse. We aimed to evaluate whether outdoor air pollution and road traffic noise are associated with physiological response measured by allostatic load in children. We studied
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Cohort profile: the CORDELIA study (Collaborative cOhorts Reassembled Data to study mEchanisms and Longterm Incidence of chronic diseAses) Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-05-12
Álvaro Hernáez, Anna Camps-Vilaró, Sara Polo-Alonso, Isaac Subirana, Rafel Ramos, Rafael de Cid, Fernando Rodríguez-Artalejo, Roberto Elosua, M. Dolores Chirlaque, Pilar Amiano, Marcelino Bermúdez-López, Marcela Guevara, Sergio Cinza-Sanjurjo, María-José Sánchez, Antonio Cabrera de León, Martín Laclaustra, Gemma Rojo-Martínez, María J. Guembe-Suescun, Beatriz Pérez-Gómez, Tomás Vega-Alonso, Pere Torán-MonserratThe CORDELIA Study (Collaborative Cohorts Reassembled Data to Study Mechanisms and Long-term Incidence of Chronic Diseases) combines 35 Spanish population cohorts to investigate the clinical, environmental, genetic, and omics determinants of cardiovascular disease in the Southern European population. It aims to conduct the largest genome-wide association study to date on cardiovascular disease in this
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Maternal cannabis use in pregnancy, perinatal outcomes, and cognitive development in offspring: a longitudinal analysis of the ALSPAC cohort using paternal cannabis use as a negative control exposure Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-05-12
Daniel J. Corsi, Tim T. Morris, Zoe E. Reed, George Davey SmithMaternal cannabis use in pregnancy is reported to be associated with perinatal and neurodevelopmental outcomes in offspring. Such associations, however, may be biased by residual confounding by socioeconomic position (SEP). To assess confounding, we use paternal cannabis use in pregnancy as a negative control exposure. We use data from 15,013 mother–father–child trios from the ALSPAC birth cohort,
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Possible selection bias in register-based obesity studies Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-05-12
Lena MS Carlsson, Markku Peltonen, Peter Jacobson, Johanna C Andersson-Assarsson, Per-Arne Svensson, Magdalena Taube, Cecilia Karlsson, Sofie Ahlin, Felipe M Kristensson, Rosie Perkins, Ida Arnetorp, Alexander Carlsson, Lucas Admeus, Elin Langegård, Björn Carlsson, Kajsa SjöholmSome studies of obesity treatments use control groups identified from real-world registers, which may differ from people with obesity in the general population. We evaluated whether such control groups affect the results. The SOS study examines long-term mortality post-bariatric surgery. Among volunteers with obesity, 2,007 individuals underwent surgery, while a control group of 2,040 individuals was
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Partial substitution of red or processed meat with plant-based foods and the risk of cardiovascular disease Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-05-12
Meri Simojoki, Niina E. Kaartinen, Mirkka Maukonen, Kennet Harald, Heli Tapanainen, Demetrius Albanes, Johan G. Eriksson, Pekka Jousilahti, Seppo Koskinen, Anne-Maria Pajari, Satu MännistöA shift towards more plant-based diets may promote human and planetary health. This modelling study aimed to assess the impact of moderate partial substitution of red or processed meat with plant-based foods on cardiovascular disease (CVD) risk. We used pooled data from five Finnish cohorts (42,868 participants aged ≥ 25 years, 78% men). Median follow-up time was 12.7 years, with 11,031 incident CVD
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Marital status and risk of cardiovascular disease – a multi-analyst study in epidemiology Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-05-05
Bernd Kowall, Linda Juel Ahrenfeldt, Jale Basten, Heiko Becher, Tilman Brand, Julia Braun, Swaantje Casjens, Heiner Claessen, Robin Denz, Hans H. Diebner, Sophie Diexer, Nora Eisemann, Eva Furrer, Wolfgang Galetzka, Carolin Girschik, André Karch, Rafael Mikolajczyk, Manuela Peters, Susanne Rospleszcz, Viktoria Rücker, Andreas Stang, Susanne Stolpe, Katherine J. Taylor, Nina Timmesfeld, Marianne TokicIn multi-analyst studies, several analysts use the same data to independently investigate identical research questions. Multi-analyst studies have been conducted mainly in psychology, social sciences, and neuroscience, but rarely in epidemiology. Sixteen analyst groups (24 researchers) with backgrounds mainly in statistics, mathematics, and epidemiology were asked to independently perform an analysis
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Uncertainty in the estimated effects of statin initiation on risk of dementia: using a multiverse analysis to assess sources of variability Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-05-03
Erin L. Ferguson, Scott C. Zimmerman, Chen Jiang, Minhyuk Choi, Travis J. Meyers, Thomas J. Hoffmann, Paola Gilsanz, Jingxuan Wang, Akinyemi Oni-Orisan, Rachel A. Whitmer, Neil Risch, Ronald M. Krauss, Chirag J. Patel, Catherine A. Schaefer, M. Maria GlymourMixed evidence on how statins affect dementia risk may reflect variability in model specifications. Alternate specifications are rarely systematically compared. Using an emulated trial design framework, we investigated variation in the estimated effect of statin initiation on dementia across alternative (1) eligibility criteria, (2) confounding variable sets, and (3) outcome definitions. Kaiser Permanente
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Tattoos and cutaneous squamous cell carcinoma: a population-based case-control study Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-04-25
Emelie Rietz Liljedahl, Malin Engfeldt, Kari Nielsen, Anna Jöud, Christel NielsenThe prevalence of tattoos in western countries is about 20%. Tattoo ink may contain carcinogenic compounds. The aim of this study was to investigate if tattoo exposure is associated with an increased risk of cutaneous squamous cell carcinoma in individuals. In this population-based case-control study, 2857 cases aged 20 to 60 years, diagnosed between 2014 and 2017, were identified in the Swedish Cancer
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Effect of colonoscopy screening on risks of colorectal cancer and related death: instrumental variable estimation of per-protocol effects Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-04-25
Joy Shi, Magnus Løberg, Mette Kalager, Paulina Wieszczy, Nastazja D. Pilonis, Hans-Olov Adami, Michal F. Kaminski, Michael Bretthauer, Miguel A. HernánBackground We recently reported per-protocol estimates of colonoscopy screening on colorectal cancer incidence and mortality in NordICC, a large-scale randomized trial. Our results may be affected by residual confounding due to lack of detailed information on confounders. Here, we supplement our per-protocol analyses with instrumental variable (IV) estimates whose validity relies on an alternate set
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The baseline examinations of the German National Cohort (NAKO): recruitment protocol, response, and weighting Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-04-22
Stefan Rach, Matthias Sand, Achim Reineke, Heiko Becher, Karin Halina Greiser, Kathrin Wolf, Kerstin Wirkner, Carsten Oliver Schmidt, Sabine Schipf, Karl-Heinz Jöckel, Lilian Krist, Wolfgang Ahrens, Hermann Brenner, Stefanie Castell, Sylvia Gastell, Volker Harth, Bernd Holleczek, Till Ittermann, Stefan Janisch-Fabian, André Karch, Thomas Keil, Carolina J. Klett-Tammen, Alexander Kluttig, Oliver KußThe German National Cohort (NAKO) is the largest population-based epidemiologic cohort study in Germany and investigates the causes of the most common chronic diseases. Between 2014 and 2019, a total of 1.3 million residents aged 20–69 years from 16 German regions were randomly selected from the general population and invited to participate following a highly standardized recruitment protocol. The
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When, why and how are estimated effects transported between populations? A scoping review of studies applying transportability methods Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-04-18
Fabian Manke-Reimers, Vincent Brugger, Till Bärnighausen, Stefan KohlerTransportability methods can improve the external validity of estimated effects by accounting for effect heterogeneity due to differently distributed covariates between populations. This scoping review aims to provide an overview of when, why and how transportability methods have been applied. We systematically searched MEDLINE (Ovid), Embase, Web of Science, EconLit and Google Scholar for studies
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Life satisfaction as compared with traditional risk factors in relation to incident cardiovascular diseases Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-04-07
Minghao Kou, Xiang Li, Hao Ma, Xuan Wang, Yoriko Heianza, JoAnn E. Manson, Lu QiBackground Emerging evidence suggests a role of psychological well-being in the development of cardiovascular disease (CVD), but supportive data remain limited. This study assessed the prospective associations between life satisfaction and incident CVD, as well as the relative importance of life satisfaction compared to traditional risk factors. Methods The study included 153,810 participants free
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Association between aspirin use and the risk of incident nonalcoholic fatty liver disease Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-04-04
Hangkai Huang, Zhening Liu, Chengfu XuThis study aimed to investigate the association between aspirin use and the incidence of nonalcoholic fatty liver disease (NAFLD). We included 53,490 participants from the Nurses’ Health Study II, a prospective US cohort study. Cox proportional hazard regression analyses were performed to assess the association between time-updated aspirin use and the risk of incident NAFLD. The exposure data included
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Has the “obesity paradox” been resolved by semaglutide trials? Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-04-04
Zhu Liduzi Jiesisibieke, Mary Beth Terry, C. Mary Schooling -
Effects of salt substitution on cumulative blood pressure: a secondary analysis of the SSaSS Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-03-27
Xiaoxia Li, Liping Huang, Bo Zhou, Zhifang Li, Jixin Sun, Yan Yu, Hongyi Song, Maoyi Tian, Xuejun Yin, Bruce Neal, Yuhong Zhang, Yangfeng Wu, Yi ZhaoAbstract The effect of a potassium-enriched salt substitute on cumulative blood pressure (BP) remains unclear. This study aimed to assess the long-term effects of a potassium-enriched salt substitute versus regular salt on cumulative and conventional measures of systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP) and pulse pressure (PP). We analyzed data from the Salt Substitute and
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Survey sampling design in wave 1 of the Global Flourishing Study Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-03-27
R. Noah Padgett, Richard G. Cowden, Manas Chattopadhyay, Ying Han, John Honohan, Zacc Ritter, Rajesh Srinivasan, Byron R. Johnson, Tyler J. VanderWeeleThe Global Flourishing Study (GFS) is an international collaboration to develop a publicly accessible data resource to promote global research on human flourishing. These data include over 200,000 participants from 22 geographically and culturally diverse countries and one territory designed to be nationally representative of the adult population. The GFS is intended as a longitudinal panel study with
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Diagnostic accuracy in the Swedish national patient register: a review including diagnoses in the outpatient register Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-03-27
Åsa H. Everhov, Thomas Frisell, Mehdi Osooli, Hannah L. Brooke, Hanne K. Carlsen, Karin Modig, Karl Mårild, Jonathan Lindström, Karin Sköldin, Mona Heurgren, Jonas F. Ludvigsson, Ola OlénBackground The Swedish National Patient Register (NPR) is an important source of data for epidemiological research. A review in 2010 described the validity of recorded diagnoses for inpatient care, but did not include specialised outpatient care. Method Using systematic searches of medical literature databases (Embase, Medline), and reports from members of the Swedish Epidemiological Association, we
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Evidence triangulation in health research Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-03-27
Sirena Gutierrez, M. Maria Glymour, George Davey SmithFor many important questions about influences on clinical and public health outcomes, no single study can provide a decisive answer. The perfect study—a large, diverse, well-conducted trial randomizing all relevant versions of a treatment and comprehensively tracking all relevant health outcomes—is never feasible. Instead, we must draw conclusions by piecing together evidence from multiple imperfect
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Generalizability of trial criteria on amyloid-lowering therapy against Alzheimer’s disease to individuals with mild cognitive impairment or early Alzheimer’s disease in the general population Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-03-23
Jacqueline J. Claus, Ilse vom Hofe, Annekee van Ijlzinga Veenstra, Silvan Licher, Harro Seelaar, Frank J. de Jong, Julia Neitzel, Meike W. Vernooij, M. Arfan Ikram, Frank J. WoltersTreatment with anti-amyloid-β monoclonal antibodies slowed cognitive decline in recent RCTs in patients with mild cognitive impairment (MCI) and early dementia due to Alzheimer’s disease (AD). However, stringent trial eligibility criteria may affect generalisability to clinical practice. We extracted eligibility criteria for trials of aducanumab, lecanemab and donanemab, and applied these to participants
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Impact of childhood traumatic brain injury on educational attainment in Finland from 1998 to 2018: a retrospective register-based nationwide cohort study Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-03-23
Julius Möttönen, Ilari Kuitunen, Ville T. Ponkilainen, Ville M. MattilaPediatric traumatic brain injury (pTBI) can lead to considerable mortality, morbidity, mental impairment, and physical disability over time. The direct impact of pTBI on educational attainment is unclear. We included all pediatric 0- to 17-year-old patients who were at least 26 years old at the end of the follow-up with a diagnosis of TBI in the Finnish Care Registry for Health Care (years 1998 to
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Effects of childhood and adult height on later life cardiovascular disease risk estimated through Mendelian randomization Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-03-19
Tom G. Richardson, Helena Urquijo, Laurence J. Howe, Gareth Hawkes, John DePaolo, Scott M. Damrauer, Timothy M. Frayling, George Davey SmithTaller individuals are at elevated and protected risk of various cardiovascular disease endpoints. Whether this is due to a direct consequence of their height during childhood, a long-term effect of remaining tall throughout the lifecourse, or confounding by other factors, is unknown. We sought to address this by harnessing human genetic data from the UK Biobank to separate the independent effects
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The impact of the pandemic on non-COVID-19 causes of death in the United States: a multiple cause of death analysis Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-03-19
Yu Li, Hang Li, Tim AdairMultiple cause of death data allow for a more granular analysis of the pandemic’s impact on mortality from non-COVID-19 causes of death compared with analysis of a single underlying cause of each death because they are often a co-morbidity of COVID-19. This study estimates excess mortality in the US of non-COVID-19 causes measured as a multiple cause (reported anywhere on the death certificate). Death
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Epidemiology of first-time major lower extremity amputations– A Danish Nationwide cohort study from 2010 to 2021 Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-03-12
Anna Trier Heiberg Brix, Katrine Hass Rubin, Tine Nymark, Hagen Schmal, Martin Lindberg-LarsenBackground and Aim Major lower extremity amputations (MLEA) are common procedures. Potential changes in surgical strategy and patient characteristics over time have not been described previously. The aim of this study was to investigate the incidence rates and surgical strategies of first-time MLEAs over time from 2010 to 2021. Furthermore, to describe patient demographics, and their changes in the
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Identification of effect modifiers using a stratified Mendelian randomization algorithmic framework Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-03-12
Alice Man, Leona Knüsel, Josef Graf, Ricky Lali, Ann Le, Matteo Di Scipio, Pedrum Mohammadi-Shemirani, Michael Chong, Marie Pigeyre, Zoltán Kutalik, Guillaume ParéMendelian randomization (MR) is a technique which uses genetic data to uncover causal relationships between variables. With the growing availability of large-scale biobank data, there is increasing interest in elucidating nuances in these relationships using MR. Stratified MR techniques such as doubly-ranked MR (DRMR) and residual stratification MR have been developed to identify nonlinearity in causal
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Two-step pragmatic subgroup discovery for heterogeneous treatment effects analyses: perspectives toward enhanced interpretability Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-03-04
Toshiaki Komura, Falco J. Bargagli-Stoffi, Koichiro Shiba, Kosuke InoueEffect heterogeneity analyses using causal machine learning algorithms have gained popularity in recent years. However, the interpretation of estimated individualized effects requires caution because insights from these data-driven approaches might be misaligned with the contextual needs of a human audience. Thus, a practical framework that integrates advanced machine learning methods and decision-making
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Impact of lifestyle factors post-infectious mononucleosis on multiple sclerosis risk Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-03-04
Eva Johansson, Tomas Olsson, Lars Alfredsson, Anna Karin HedströmBackground Accumulating evidence suggest that Epstein-Barr virus (EBV) is crucial in the development of multiple sclerosis (MS), with inadequate infection control possibly contributing to disease onset. Past infectious mononucleosis (IM) has been found to interact with smoking, obesity, and sun exposure. We aimed to investigate potential interactions between a history of IM and the following risk factors
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Lipids, apolipoproteins, carbohydrates, and risk of hematological malignancies Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-03-04
Qianwei Liu, Dang Wei, Niklas Hammar, Yanping Yang, Maria Feychting, Zhe Zhang, Göran Walldius, Karin E. Smedby, Fang FangPrevious studies have investigated the role of metabolic factors in risk of hematological malignancies with contradicting findings. Existing studies are generally limited by potential concern of reverse causality and confounding by inflammation. Therefore, we aimed to investigate the associations of glucose, lipid, and apolipoprotein biomarkers with the risk of hematological malignancy. We performed
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Increasing transparency of decision making in research practice: adding value or just more red tape? Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-02-24
Jenny T van der Steen,Lex M Bouter -
Association between maternal cancer and the incidence of cancer in offspring Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-02-17
Su-Min Jeong, Jihye Heo, Kyujin Choi, Park Taegyun, Soo-Young Oh, Jonghan Yu, Danbee KangDespite the growing population of young cancer survivors of reproductive age, the risk of cancer in offspring born to female cancer survivors has yielded inconsistent results. Therefore, this study aimed to investigate the risk of cancer among the offspring of female cancer survivors by maternal age at delivery, maternal age at cancer diagnosis, maternal cancer type, and the time interval between cancer
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Machine-learning approaches to predict individualized treatment effect using a randomized controlled trial Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-02-13
Rikuta Hamaya, Konan Hara, JoAnn E. Manson, Eric B. Rimm, Frank M. Sacks, Qiaochu Xue, Lu Qi, Nancy R. CookRecent advancements in machine learning (ML) for analyzing heterogeneous treatment effects (HTE) are gaining prominence within the medical and epidemiological communities, offering potential breakthroughs in the realm of precision medicine by enabling the prediction of individual responses to treatments. This paper introduces the methodological frameworks used to study HTEs, particularly based on a
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Cohort profile: The BiCoVac cohort - a nationwide Danish cohort to assess short and long-term symptoms following COVID-19 vaccination Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-02-07
Christina Bisgaard Jensen, Kristoffer Torp Hansen, Casper Mailund Nielsen, Stefan Nygaard Hansen, Henrik Nielsen, Charlotte Ulrikka Rask, Per Fink, Thomas Meinertz Dantoft, Torben Jørgensen, Bodil Hammer Bech, Sanne Møller Thysen, Dorte RytterBiCoVac is a population-based Danish cohort aiming to examine whether Coronavirus disease 2019 (COVID-19) vaccines are associated with non-specific symptoms beyond the specific protection of COVID-19. Data were collected by four questionnaire surveys between May 2021 and July 2022 and the questionnaire distribution was aligned with the Danish COVID-19 vaccination program. All surveys collected self-reported
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The 1001 nights-cohort – paving the way for future research on working hours, night work, circadian disruption, sleep, and health Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-02-07
Kirsten Nabe-Nielsen, Anne Emily Saunte Fiehn Arup, Mette Sallerup, Rikke Harmsen, Anna Sofie Ginty, Marie Tolver Nielsen, Anne-Sofie Rosenfeldt Jensen, Anders Aagaard, Vivi Schlünssen, Ann Dyreborg Larsen, Anne Helene GardeNight work and circadian disruption are linked to major public health challenges, e.g. cancer, cardiometabolic disease, and accidents. We established the 1001 nights-cohort to explore mechanisms underlying health effects of night work and circadian disruption. 1075 female hospital employees participated from September 2022 to April 2024. The data collection included a questionnaire, a blood sample
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Use of mortality tables by level of deprivation in the study of social inequalities in cancer survival Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-02-06
Sarah Wilson, Ophelie Merville, Olivier Dejardin, Josephine Gardy, Quentin Rollet, Valerie Jooste, Francim Network, Florence Molinie, Laure Tron, Guy LaunoyBackground Previous studies have reported lower net survival probabilities for socioeconomically deprived patients, using non-deprivation specific lifetables. Not accounting for the social gradient in background mortality could potentially overestimate the effect of deprivation on net survival. The aim of this study was to estimate the impact of taking into account the social gradient of expected mortality
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Risks and rates, and the mathematical link between them Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-01-29
James A. HanleyThe risk over a given time span can be calculated as one minus the exponentiated value of the negative of the integral of the incidence density function (or hazard rate function) over that time span. This relationship is widely used but, in the few instances where textbooks have presented it, the derivations of it tend to be purely mathematical. I first review the historical contexts, definitions,
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Cohort profile: the provincial opioid agonist treatment cohort in Ontario, Canada Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-01-27
Kristen A. Morin, Mark R. Tatangelo, Shreedhar Acharya, David C. MarshBackground Opioid Agonist Treatment (OAT) is the most effective intervention for opioid use disorder (OUD), but retention has decreased due to increasingly potent drugs like fentanyl. This cohort can be used retrospectively to observe trends in service utilization, healthcare integration, healthcare costs and patient outcomes. It also facilitates the design of observational studies to mimic a prospective
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Associations of Global Burden of Diseases study-derived dietary scores with mortality and chronic disease risk: a comprehensive analysis from the prospective NutriNet-Santé study Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-01-24
Emmanuelle Kesse-Guyot, Julia Baudry, Justine Berlivet, Elie Perraud, Benjamin Allès, Chantal Julia, Léopold K. Fezeu, Serge Hercberg, François Mariotti, Mathilde Touvier, Hélène FouilletThe Global Burden of Diseases (GBD) network has proposed theoretical minimum risk exposure level (TMREL) for leading risk factors associated with diet that minimize the risk of morbimortality from chronic diseases. TMREL can be applied to develop follow-up or evaluation indicators in individual studies. The validity of these scores can be tested by assessing associations with health outcomes in prospective
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The associations of long-term physical activity in adulthood with later biological ageing and all-cause mortality – a prospective twin study Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-01-17
Anna Kankaanpää, Asko Tolvanen, Laura Joensuu, Katja Waller, Aino Heikkinen, Jaakko Kaprio, Miina Ollikainen, Elina SillanpääObjectives: The association between leisure-time physical activity (LTPA) and a lower risk of mortality is susceptible to bias from multiple sources. We investigated the potential of biological ageing to mediate the association between long-term LTPA and mortality and whether the methods used to account for reverse causality affect the interpretation of this association. Methods: Study participants
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Association between preconception and early pregnancy exposure to fine particulate matter and nervous system anomalies: a nested case-control study Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-01-13
Bao-Ru Chuang, Chung-Chin Lee, Yu-Ting Lin, Chau-Ren Jung, Mei-Ling Chen, Bing-Fang HwangAlthough several environmental factors may increase the risk of nervous system anomalies, the association between exposure to particulate matter with an aerodynamic diameter of ≤ 2.5 μm (PM2.5) and nervous system anomalies is not completely understood. This study aimed to examine the association between expoure to PM2.5 and nervous system anomalies, including specific phenotypes during preconception
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The Dutch Early-Stage Melanoma (D-ESMEL) study: a discovery set and validation cohort to predict the absolute risk of distant metastases in stage I/II cutaneous melanoma Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-01-09
Catherine Zhou, Antien L. Mooyaart, Thamila Kerkour, Marieke W. J. Louwman, Marlies Wakkee, Yunlei Li, Quirinus J. M. Voorham, Annette Bruggink, Tamar E. C. Nijsten, Loes M. HollesteinEarly-stage cutaneous melanoma patients generally have a favorable prognosis, yet a significant proportion of metastatic melanoma cases arise from this group, highlighting the need for improved risk stratification using novel prognostic biomarkers. The Dutch Early-Stage Melanoma (D-ESMEL) study introduces a robust, population-based methodology to develop an absolute risk prediction model for stage
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Unidirectional and bidirectional causation between smoking and blood DNA methylation: evidence from twin-based Mendelian randomisation Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-01-09
Madhurbain Singh, Conor V. Dolan, Dana M. Lapato, Jouke-Jan Hottenga, René Pool, Brad Verhulst, Dorret I. Boomsma, Charles E. Breeze, Eco J. C. de Geus, Gibran Hemani, Josine L. Min, Roseann E. Peterson, Hermine H. M. Maes, Jenny van Dongen, Michael C. NealeCigarette smoking is associated with numerous differentially-methylated genomic loci in multiple human tissues. These associations are often assumed to reflect the causal effects of smoking on DNA methylation (DNAm), which may underpin some of the adverse health sequelae of smoking. However, prior causal analyses with Mendelian Randomisation (MR) have found limited support for such effects. Here, we
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Infectious disease hospitalization after receipt of human papillomavirus vaccine: a nationwide register-based cohort study among Danish, Finnish, Norwegian, and Swedish girls Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-01-06
Ida Laake, Berit Feiring, Lise Gehrt, Hélène Englund, Mika Lahdenkari, Signe Sørup, Heta Nieminen, Lill TrogstadIt has been suggested that non-live vaccines may increase susceptibility to non-targeted infections and that such deleterious non-specific effects are more pronounced in girls. We investigated whether receipt of non-live vaccine against human papillomavirus (HPV) was associated with increased risk of infectious disease hospitalization. A nationwide cohort study based on detailed individual-level data
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The Stockholm early detection of cancer study (STEADY-CAN): rationale, design, data collection, and baseline characteristics for 2.7 million participants Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-01-05
Elinor Nemlander, Eliya Abedi, Per Ljungman, Jan Hasselström, Axel C. Carlsson, Andreas RosenbladThe Stockholm Early Detection of Cancer Study (STEADY-CAN) cohort was established to investigate strategies for early cancer detection in a population-based context within Stockholm County, the capital region of Sweden. Utilising real-world data to explore cancer-related healthcare patterns and outcomes, the cohort links extensive clinical and laboratory data from both inpatient and outpatient care
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Association of mental health in childhood, adolescence and young adulthood with cardiovascular risk factors and carotid remodeling below age 30 - results from the KiGGS cohort study Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-01-03
Julia Charlotte Büschges, Ann-Kristin Beyer, Arno Schmidt-Trucksäss, Klaus Berger, Hannelore NeuhauserAn association of mental health and in particular depression with cardiovascular disease has been shown in adults and to a lesser extent in the young. Recently improved measurement methods of carotid-intima media thickness (CIMT) and carotid stiffness (CS) allow more differentiated analyses of this link. We examined 4,361 participants of the nationwide KiGGS cohort aged 3–17 years at baseline and 14–28
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Prevalence and incidence of mastocytosis in adults: a Danish nationwide register study Eur. J. Epidemiol. (IF 7.7) Pub Date : 2025-01-03
Maren Poulsgaard Jørgensen, Andreas Kiesbye Øvlisen, Jonas Faartoft Jensen, Tarec Christoffer El-Galaly, Maiken Glud Dalager, Hanne Vestergaard, Sigurd Broesby-Olsen, Marianne Tang SeverinsenIntroduction Mastocytosis is a group of rare heterogeneous diseases with a prevalence previously found to be 10–23 per 100,000 persons. More awareness and improvements in the diagnostic methods in later years have led to more patients being diagnosed. Here, we set out to present the prevalence and incidence rate of mastocytosis among the adult Danish population. By merging data from the Danish National
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Cohort profile: Guangzhou breast cancer study (GBCS) Eur. J. Epidemiol. (IF 7.7) Pub Date : 2024-12-16
Jiao Wang, Na Li, Cheng Kun Xiao, Shu Shu Han, Min Jie Lu, Xiao Yi Lin, Ze Fang Ren, Lin XuThe Guangzhou Breast Cancer Study (GBCS) is a patient-based prospective cohort study designed to identify risk factors and underlying mechanisms for breast cancer (BC) incidence and prognosis, specifically addressing the need for individualized prevention in South China, where BC incidence is notably high. Based in Guangzhou, China, the GBCS began recruitment in 2008, comprises three complementary
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Prescription drug use in Danish children and adolescents 2005–2023 Eur. J. Epidemiol. (IF 7.7) Pub Date : 2024-12-11
Helene Kildegaard, Morten Olesen, Tine Brink Henriksen, Lotte RasmussenContinuous monitoring of pediatric drug utilization is important for ensuring rational use and prioritizing research. This study provides an overview of pediatric prescription drug use among Danish children and adolescents from 2005–2023. Using Danish nationwide individual-level dispensing data, we identified all redeemed prescriptions for individuals < 18 years from January 2005–December 2023. We
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The association between pre-pregnancy and first-trimester hair cortisol and preterm birth: a causal inference model Eur. J. Epidemiol. (IF 7.7) Pub Date : 2024-12-11
Yinxian Chen, Richard G. Künzel, Sixto E. Sanchez, Marta B. Rondon, Nelida I. Pinto, Elena Sanchez, Clemens Kirschbaum, Linda Valeri, Karestan C. Koenen, Bizu GelayeAdverse life events and chronic psychological distress before and during pregnancy have frequently been associated with preterm birth but the biological underpinnings remain unclear. We investigated the association between corticosteroid levels in pre-pregnancy and first-trimester hair and the risk of preterm birth. We followed N = 1,807 pregnant women from a prospective pre-birth cohort study in Lima
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Dyslipidemia progression and increased lung cancer risk: a prospective cohort study Eur. J. Epidemiol. (IF 7.7) Pub Date : 2024-12-11
Yelin Shao, Wenyuan Li, Chi Pang Wen, Min Yang, Xian Ning, Kejia Hu, Xifeng WuObjectives To investigate the associations of changes in lipidemic profile with the risk of lung cancer incidence, and to elucidate how modifiable risk factors contribute to the associations. Design and participants The prospective study enrolled a cohort of 137,075 individuals with lipidemic profiles spanning from January 1, 1996 to December 31, 2006 in the Taiwan MJ Cohort. Follow-up was extended
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Gender issues in myopia: a changing paradigm in generations Eur. J. Epidemiol. (IF 7.7) Pub Date : 2024-12-11
Clair A. Enthoven, Annechien E. G. Haarman, Joanna Swierkowska-Janc, J. Willem L. Tideman, Jan Roelof Polling, Hein Raat, Virginie J.M. Verhoeven, Jeremy Labrecque, Caroline C. W. KlaverMyopia is becoming an important cause of visual impairment. Determining risk profiles will help to develop targeted prevention strategies. This study aims to explore the difference in myopia development between genders in two cohorts representing different generations, and to assess whether hypothetical interventions targeting education or lifestyle factors would reduce a gender gap. This study included