The use of growth factors (GFs) has become a cornerstone of modern regenerative periodontology. While the extent to which GFs enhance tissue regeneration compared to other biomaterials was initially uncertain, it is now well established that GFs play a critical role in the regeneration of various tissue types. In the context of periodontal regeneration, enamel matrix derivative (EMD/Emdogain) has been

ObjectivesTo investigate the clinically acceptable deviation threshold and the factors associated with trueness across three computer‐assisted implant surgery (CAIS) approaches: static CAIS (s‐CAIS), dynamic CAIS (d‐CAIS), and robotic CAIS (r‐CAIS).Materials and MethodsA total of 314 implants in 194 patients were retrospectively included, with preoperative and postoperative CBCT scans collected. Outcome

ObjectiveTo evaluate the survival of teeth with class II furcation involvement (FI) ≥ 5 years after active periodontal treatment (APT) and to identify the prognostic factors.MethodsAll charts of patients having undergone APT at the Department of Periodontology of Goethe‐University Frankfurt, Germany, were screened for teeth with class II FI. APT had to be accomplished ≥ 5 years ago. Charts were analysed

AimTo evaluate the efficacy of the apically positioned flap (APF) with periosteal fenestration in increasing the width of the masticatory mucosa (MM, including attached and keratinized mucosa) and to assess the histological properties of the MM gained through this technique.Materials and MethodsSix mongrel dogs were treated using a split‐mouth design, with APF alone (control) and APF with periosteal

The development of craniofacial bones and teeth relies heavily on the Wnt signaling pathway, yet the specific mechanisms and Wnt variants involved remain under continual investigation. Using publicly available single-cell sequencing data from the mouse incisor, we reveal Wnt1 expression across dental structures and investigate its role using a Col1a1 -dependent Wnt1 transgenic mouse model. Inducing

ObjectiveThis study aimed to evaluate the accuracy of three‐dimensional printed individualised titanium mesh (3D‐PITM) placement in protected bone regeneration surgery for alveolar bone defects.Material and MethodsThis study included 15 patients with alveolar bone defects who underwent protected bone regeneration surgery using 3D‐PITM as a scaffold. The 3D‐PITM was removed 6–9 months post‐bone regeneration

BackgroundThis retrospective study aimed to assess the effect of horizontal bone augmentation using the circular cortical‐lamina anchoring technique (CCA) and modified split‐crest technique (MSC) on the knife ridge of the posterior mandible.MethodsPatients who underwent horizontal bone augmentation in posterior mandible sites between 2018 and 2023 were reviewed and divided into MSC and CCA groups based

The prevalence of childhood metabolic syndrome (MetS) and obesity is rising, with emerging evidence suggesting these conditions negatively affect oral health. However, the underlying molecular determinants are unclear. This study investigated the oral microbiome, inflammatory markers, and metabolites in children with obesity and MetS to explore the interrelationships between systemic disease and oral

Enamel produced by ameloblasts derived from the oral epithelium is the hardest and most mineralized tissue. Developmental enamel defects have significant clinical implications, such as enamel hypoplasia or opacities, increased tooth sensitivity, and impaired mastication. Yap1 is a transcriptional coactivator that has been shown to be involved in regulating cell proliferation and differentiation. Although

BackgroundDentin hypersensitivity (DH) is common, particularly among periodontal patients. This trial evaluated magnitude of desensitizing benefit, onset of action, and complete relief of three dentifrices with distinct desensitizing technologies.MethodsHealthy adults with DH were enrolled and randomized to one of four dentifrices in this randomized, controlled, double‐blind trial: marketed potassium

BackgroundThe aim of this study was to compare the sustainability of regular use of 2 different interdental cleaning tools in 24 weeks by periodontally healthy individuals as a component of primary prevention.MethodsPeriodontally healthy individuals were randomly assigned to dental floss or rubber interdental pick group. Participants received an oral care kit and a calendar to record the times they

BackgroundThis study evaluated the efficacy of L‐ and I‐shaped collagenated block bone substitutes (BBS) compared with particulate bone substitutes (PBS) in guided bone regeneration (GBR) of maxillary anterior peri‐implant dehiscence defects. It focused on radiographic, profilometric, esthetic, and patient‐reported outcomes over a 4‐year follow‐up period.MethodsFifty‐one peri‐implant defects were treated

The primary objective is to critically analyze approaches to local therapy for periodontal disease, particularly in light of its well‐established systemic implications. We specifically address common misconceptions and overestimations regarding the potential of local treatments in contrast to their actual clinical effectiveness. Historically, the therapeutic approach to periodontitis has concentrated

AimThis secondary analysis of a randomised clinical trial aimed to investigate vertical ridge augmentation (VRA) by comparing complication rates (primary outcome), times, costs and patient‐reported outcome measures (PROMs) between customised Ti‐reinforced PTFE mesh and customised CAD/CAM titanium mesh.Materials and MethodsPatients with vertical bone defects were randomly assigned to alveolar bone augmentation

BackgroundPeriodontitis is among the most prevalent chronic inflammatory conditions globally, and is associated with bone resorption, tooth loss, and systemic complications. While its treatment is largely standardized, individual outcomes vary, with some patients experiencing further disease progression despite adherence.MethodsWe developed a machine learning (ML) approach to predict individual outcomes

AimTo examine the accuracy of microbiological biomarkers in diagnosing periodontal diseases, specifically addressing three focus questions: (FQ1) distinguishing health from disease; (FQ2) predicting disease progression; and (FQ3) assessing treatment outcomes.Materials and MethodsA PRISMA‐guided search in MEDLINE, EMBAS and WEB OF SCIENCE included cross‐sectional and longitudinal studies (e.g., randomised

AimTo assess the clinical response to Non‐Surgical Periodontal Therapy (NSPT) between suprabony and intrabony defects.Materials and MethodsTotally 200 NSPT patients' records from the King's College London—Oral, Dental and Craniofacial Biobank were included. Periapical radiographs of sites with Periodontal Probing Depth (PPD) > 4 mm were assessed. Changes in periodontal measurements between baseline

AimTo investigate the influence and mechanism of exosomes derived from human gingival mesenchymal stem cells (GMSC‐Exo) regulating macrophage polarisation through metabolic reprogramming.Materials and MethodsHuman acute monocytic leukaemia cells (THP‐1)‐derived macrophages were treated with GMSC‐Exo or Porphyromonas gingivalis lipopolysaccharide (P.g‐LPS) in vitro. Metabolic inhibitors were used to

AimThis study aimed to evaluate the efficacy of the modified minimally invasive surgical technique (M‐MIST) combined with a collagen‐enriched bovine‐derived xenograft (CEBDX) for the treatment of isolated interdental intrabony defects.Materials and MethodsThis is a randomized controlled trial including 40 isolated interdental intrabony defects in 40 patients. The test group received M‐MIST and CEBDX

BackgroundThis study evaluated the efficacy of concentrated growth factor (CGF) sticky bone combined with guided tissue regeneration (GTR) in treating shallow infrabony defects and explored factors influencing clinical outcomes.MethodsThirteen patients with 31 shallow defects (≤3 mm) were treated using CGF sticky bone (CGF + deproteinized bovine bone mineral), covered with a collagen membrane and CGF

BackgroundSoft tissue grafting at dental implant sites has been proposed to enhance esthetic outcomes. A xenogeneic collagen matrix (XCM) was introduced as an alternative grafting material to connective tissue. Only short‐term results are yet available.MethodsSixty patients were treated in a randomized controlled trial with a connective tissue graft (n = 20, CTG group), an XCM (n = 20, XCM group),

AimThere is evidence linking tooth loss with dementia; however, similar findings for periodontitis are inconclusive.Material and MethodsWe conducted cross‐sectional (N = 4046) and longitudinal analyses (N = 2769) on data from the Health 2000 and 2011 surveys for establishing any associations of periodontal health with baseline cognition, 11‐year risk of cognitive decline and 15‐year risk of incident

It is with sadness that we report the passing of Richard (Dick) R. Ranney, DDS, MS, on November 13, 2024, at the age of 85. Dick conducted significant and unique research on early-onset periodontitis, focusing on the clinical, microbiological, and immunological aspects of the disease. He was a dean of 2 dental schools, University of Alabama at Birmingham School of Dentistry and University of Maryland

This prospective, multicenter, practice-based cohort study aimed to analyze factors associated with the success of all-ceramic inlays, onlays, and crowns. All-ceramic indirect restorations placed in a practice-based research network (Ceramic Success Analysis) were analyzed. Data were evaluated from 12,468 patients with restorations manufactured by CAD/CAM (computer-aided design/computer-aided manufacturing)

Dysregulation of the complement system plays a critical role in periodontitis progression. In addition to the harmful effects of biofilm, aberrant expression of complement regulatory proteins is also a potential cause of periodontitis. Pentraxin 3 (PTX3) is involved in complement activation and regulation, seeking a balance between amplifying complement-mediated immune responses and avoiding complement-mediated

AimsTo investigate whether restoring serum vitamin D levels in a population requiring supplementation affects matrix metalloproteinase‐9 (MMP‐9) levels in the gingival crevicular fluid (GCF) of individuals with periodontal health, gingivitis and periodontitis.Materials and MethodsThis prospective cohort study enrolled 101 participants with vitamin D deficiency, including those with periodontitis (34)

ObjectivesThe study aimed to investigate the relationship between cigarette smoking and macrophage polarization in peri‐implantitis (PI) lesions. Additionally, it sought to characterize clinical, radiological, microbiological, and immunological features of PI in smokers and non‐smokers.Materials and MethodsA cross‐sectional study included 40 patients (20 smokers, ≥ 10 cigarettes/day, and 20 non‐smokers)

Orofacial cleft (OFC) is a common congenital anomaly in humans with variable birth prevalence in different ethnic groups. Although genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with nonsyndromic OFC (nsOFC), understanding of the underlying biological mechanisms of causative SNPs and genes in nsOFC remains limited. Here, we report that the noncoding

AimTo evaluate the effect of prolonged fasting on the oral microbiome in patients with metabolic syndrome (MetS).Materials and MethodsThis follow‐up study evaluated changes in the oral microbiome in a sub‐cohort of 42 patients with MetS during prolonged fasting. Periodontal parameters such as bleeding on probing (BOP), plaque index (PI) and gingival crevicular fluid (GCF) measured in Periotron units

Challenges of access have sparked political debates about dental coverage in the Netherlands. So far, policy makers have been opposing an expansion of public coverage for the adult population, arguing that previous reductions of public coverage would not have led to reduced dental attendance within the Dutch population. To this end, this study aims to evaluate the effects of public coverage reductions

Due to the unclear etiology and pathogenesis of temporomandibular joint disorders (TMDs), current treatments often fail to provide long-term relief or halt disease progression. Therefore, this study aims to explore the underlying etiologic mechanisms by focusing on the causal relationship between the gut microbiome (GM) and TMD through a multi-omics approach. This includes mendelian randomization (MR)

The degradation of dentin bonding interfaces by enzymes, either originating from the dentin matrix or produced by oral biofilms, contributes to the failure of composite restorations. Proanthocyanidins (PAs) are effective collagen crosslinkers that help preserve collagen, but their interference with adhesive polymerization impairs clinical applications. Methacrylate-functionalized PA (MAPA) was developed

Allogeneic hematopoietic cell transplantation (allo-HCT) is a treatment modality for cancers and hematopoietic disorders. The number of allo-HCT survivors is increasing in the United States. Allo-HCT is associated with oral health problems that can affect the quality of posttransplantation life. We characterize clinical and patient-reported oral health outcomes from the time of allo-HCT through 2 y

The oral system is a highly complex mechanosensory structure that continuously adapts to changes in mechanical stimuli, exerting mechanical forces on cells and tissues. Understanding how these forces are converted into biochemical signals and how they mediate gene expression and cellular activities has been a significant focus in dentistry. Piezo channels, including Piezo1 and Piezo2, are mechanically

Enrichment of the oral microorganism Filifactor alocis is strongly associated with the progression of periodontitis. However, F. alocis is part of a complex dysbiotic microbial community, and the organism's direct pathogenic potential remains uncharacterized. Using the oral gavage model of experimental periodontitis, we revealed that F. alocis promotes alveolar bone loss, as well as significant overexpression

BackgroundGranulation tissue is routinely discarded in periodontal surgical procedures, but few studies have characterized it. The present study aimed to compare global gene expression in granulation tissue derived from different types of periodontal osseous defects.MethodsTotal RNA was isolated from granulation tissue harvested during routine periodontal surgical procedures. Nineteen sites were analyzed—seven

AimTo investigate the associations between periodontal inflammation—as determined by the periodontal inflamed surface area (PISA)—and serum inflammatory markers in community‐dwelling older adults in Japan.Materials and MethodsThis cross‐sectional study included 470 adults (mean age: 73.1 years). The composite inflammatory marker z‐score (CIMZ) was calculated as the sum of the participants' individual