上海中医药大学是中国领先的中医药高等教育和研究机构之一。学校设有14个学院和9所附属医院。

“中医药活性小分子（生物）合成中心”是一个新成立的研究中心，专注于有机合成，特别是具有潜在生物活性的天然产物的全合成以及其在药物中的应用。

申请者将参与萜类、生物碱类或肽类天然产物的全合成工作，或从事旨在促进这类天然产物合成的新方法学开发。研究项目主要聚焦于具有显著生物活性的天然产物，及其药用潜力（如类似物设计、结构–活性关系研究、临床前研究）及相关的生物学研究（如化学蛋白质组学、靶点验证等）。

学生将参与萜类、生物碱类或肽类等具有显著生物活性的天然产物的全合成研究。

“活性小分子生物合成与中医药研究中心”是一个中德合作项目，特别注重海外研究人员和教师的融合。该研究中心于2025年在塔尼亚-盖奇教授和法比安-施耐德教授的领导下成立，现有总共6位成员。研究中心总面积接近1700平方米，资金充足，配备了全新的、现代化的合成与生物学实验室。其综合分析设施包括600 MHz和400 MHz NMR谱仪（配备冷探头）、高分辨率质谱（HRMS）、液相色谱质谱（LCMS）、手性HPLC、分析性与制备性HPLC，以及自动化中压色谱系统。

我们计划招募多名博士研究生（4-5名），博士后研究生（4-5名）。研究助理（3-4名）对于特别优秀的博士，及博士后将有机会前往德国知名高校交流、深造。

法比安-施耐德 教授

Fabian Schneider 于2021年在康斯坦茨大学获得有机合成博士学位。之后，他在Scripps研究所与Phil Baran教授合作进行博士后研究，并于2025年开始加入上海中医药大学“活性小分子生物合成与中医药研究中心”开展独立研究工作，专注于萜类、生物碱和肽类天然产物的全合成研究。他获得了包括天然产物化学研究的DECHEMA奖以及由亚历山大•冯•洪堡基金会资助的Feodor-Lynen奖学金等多个奖项。目前为止在Science、Nature、JACS等国际著名期刊 上发表论文多篇。

申请者应具备基本的有机化学基础知识并能够将其应用于合成问题。

申请者还应具有浓厚的有机合成兴趣，并对研究工作充满热情。

• Pan L.,^‡ Schneider F.,^‡ Ottenbruch M., Wiechert R., List T., Schoch P.,Mertes B., Gaich T., A general strategy for the synthesis of taxane diterpenes, Nature 2024, 632, 543–549.

• Schneider F., Samarin K., Zanella S., Gaich T., Total synthesis of the complex taxane diterpene canataxpropellane, Science 2020, 367, 676-681.

• Schneider F.,^‡ Guo Y.,^‡ Lin Y.-C.,^‡ Eberle K. J., Chiodi D., Greene J. A., Lu C., Baran P. S., Total Synthesis of Dynobactin A, J. Am. Chem. Soc. 2024, 146, 6444-6448.

有意申请上海中医药大学“活性小分子生物合成与中医药研究中心”博士研究生及博士后可联系以下教授：（申请材料可以使用中文或英文撰写）

• 法比安-施耐德 (fschneider@scripps.edu, 微信: SchneiderF)

• 潘璐 （lu.pan@uni-konstanz.de, 微信：panlu_666）

上中医校园照片：

Position offered: PhD and Postdoctoral Recruitment – Research Center for Bioactive Small Molecule Synthesis and Chinese Medicine, Shanghai University of Chinese Medicine

Description: 

The Center for (bio)-synthesis of active small molecules in Chinese Medicine’ is a recently established research center focused on organic synthesis with a special focus on the total synthesis of natural products and exploration of their potential for medicinal applications.

Students will work on the total synthesis of terpene, alkaloid or peptide based natural products or methodology projects specifically aimed at facilitating synthetic access to these classes of natural products. Projects are specifically targeting natural products with potent biological application, aiming to subsequently enable further exploration of their medicinal potential (e.g. analogue generation, structure activity relationship, further preclinical studies) or biological investigation (e.g. chemoproteomics studies, target validation) in cooperation with partners of the research center.

The ‘Center for (bio)-synthesis of active small molecules in Chinese Medicine’ is a Chinese-German cooperation with a special emphasis on the integration of overseas researchers and faculty. Founded in 2025 under the tutelage of Prof. Fabian Schneider. The research center includes currently 6 faculty members with a highly successful record track in the field of organic synthesis. The research center spans nearly 1,700 square meters, is well-funded, and boasts brand-new, fully equipped state-of-the-art synthetic and biological laboratories. Its comprehensive analytical infrastructure includes 600 MHz and 400 MHz NMR spectrometers with cryoprobes, HRMS, LCMS, chiral HPLC, analytical and preparative HPLC, as well as automated medium-pressure chromatography systems.

The research center is located at the Shanghai University of Chinese Medicine which enables access to it’s 9 affiliated hospitals. In addition to it’s university labs, the research center is also present at the Longhua hospital which enables access to advanced biological research facilities and enables translational medicine studies. 

We plan to recruit multiple PhD students (4–5) and postdoctoral researchers (4–5). Outstanding candidates will have the opportunity to conduct collaborative research or pursue further training at leading universities in Germany.

Prof. Fabian Schneider (ORCID 0000-0001-6651-1127)

Fabian Schneider graduated with a PhD in organic synthesis from the University of Konstanz in 2021. After postdoctoral studies with Prof. Phil Baran at Scripps research in La Jolla, CA, USA he started his independent career 2025 at the Center for (bio)-synthesis of active small molecules in Chinese Medicine where he is currently holding a position as chair professor, focused on research in the total synthesis of terpene and peptide natural products. He received among others the DECHEMA Award for research in natural products chemistry and support by a Feodor-Lynen Fellowship by the Alexander von Humboldt Foundation. To date, he has published multiple papers in internationally renowned journals such as Science, Nature, and JACS.

Representative Faculty Publications (selection):

• Pan L.,‡ Schneider F.,‡ Ottenbruch M., Wiechert R., List T., Schoch P., Mertes B., Gaich T., A general strategy for the synthesis of taxane diterpenes, Nature 2024, 632, 543–549.

• Schneider F., Samarin K., Zanella S., Gaich T., Total synthesis of the complex taxane diterpene canataxpropellane, Science 2020, 367, 676-681.

• Schneider F.,‡ Guo Y.,‡ Lin Y.-C.,‡ Eberle K. J., Chiodi D., Greene J. A., Lu C., Baran P. S., Total Synthesis of Dynobactin A, J. Am. Chem. Soc. 2024, 146, 6444-6448.

Benefits: 

Shanghai University of Traditional Chinese Medicine will provide competitive salaries and stipends for PhD students and postdoctoral researchers in accordance with relevant university policies. Specific compensation details will be discussed during the interview process.

Requirements: 

Applicants should have a strong interest in organic synthesis and a genuine passion for research A solid foundation in organic chemistry and the ability to apply their knowledge to typical synthetic problems is advantageous.. Applications can be written in either Chinese or English.

Application: 

Prospective PhD students and postdoctoral researchers interested in joining the “Research Center for Bioactive Small Molecule Synthesis and Traditional Chinese Medicine” at Shanghai University of Traditional Chinese Medicine are encouraged to contact the following professors:

• Fabian Schneider (fschneider@scripps.edu, WeChat: SchneiderF)

• Lu Pan （lu.pan@uni-konstanz.de, WeChat: panlu_666）

Some more impressions: