The role of Yes-associated protein (YAP) in osteoblasts during subchondral bone remodeling in aberrant mechanical loading-induced OA was investigated.

BACKGROUND The outcomes of bone grafting for severe glenoid defects in reverse shoulder arthroplasty (RSA) are unpredictable. The purpose of this study was to describe the intermediate-term outcomes of glenoid bone grafting in RSA for severe glenoid defects utilizing a baseplate with a long central post. METHODS All patients who underwent glenoid bone grafting for severe glenoid defects during RSA

BACKGROUND The largest value-based payment system in the United States is the Merit-based Incentive Payment System (MIPS), implemented by the Centers for Medicare & Medicaid Services (CMS). MIPS was designed to adjust physician reimbursement based on performance across several categories. However, concerns arose that MIPS may inadvertently penalize physicians caring for patients of high social risk

➢ Three-dimensional (3D) printing and virtual modeling, using computed tomographic (CT) scans as a base for the 3D-printed model, help surgeons to visualize relevant anatomy, may provide a better understanding of fracture planes, may help to plan surgical approaches, and can possibly simulate surgical fixation options.➢ Navigation systems create real-time 3D maps of patient anatomy intraoperatively

BACKGROUND Patients with developmental dysplasia of the hip (DDH) can also present with deformities of the patellofemoral joint, such as femoral trochlear dysplasia. Although previous studies have reported that trochlear dysplasia is clinically important in some patients with DDH, the association between DDH and trochlear dysplasia is still unclear. QUESTIONS/PURPOSES (1) Is trochlear dysplasia more

Within the first phase of developing classification criteria for Early-stage Symptomatic Knee Osteoarthritis, among individuals with knee osteoarthritis (OA) we explored: 1) symptoms within the first year of noticing their knee(s); 2) features that indicated OA was the cause; and 3) timing and reasons that initially prompted seeking healthcare.

BACKGROUND The use of a 2-stage exchange remains a common management strategy for periprosthetic joint infection (PJI). The use of an "antibiotic holiday" before the second stage to confirm the clearance of infection is often employed, but there is little evidence to guide this practice. The aim of this review was to systematically map the literature reporting on the use of an antibiotic holiday as

Classification criteria for early-stage symptomatic knee osteoarthritis (EsSKOA) should discriminate individuals with EsSKOA from those with other causes of knee symptoms. We sought to identify conditions in the differential diagnosis of EsSKOA in adults with knee symptoms.

BACKGROUND An intraoperative midsubstance injury to the medial collateral ligament (MCL) is a devastating complication of total knee arthroplasty (TKA). No single treatment method has been shown to yield optimal stability. This cadaveric study compared primary MCL repair, increasing prosthetic constraint, and a combination of both techniques on tibiofemoral compartment gapping after an iatrogenic MCL

BACKGROUND Patients with apical spinal cord deformity have been shown to be at a greater risk for intraoperative neuromonitoring (IONM) alerts when undergoing posterior spinal instrumented fusion (PSF) for adolescent idiopathic scoliosis (AIS). The use of intraoperative traction during deformity correction has also been associated with an increased risk of IONM alerts. With use of the Spinal Cord Shape

BACKGROUND There has been weak consensus and a paucity of robust literature with regard to the best postoperative weight-bearing and immobilization regime for operatively treated ankle fractures. This trial compared immediate protected weight-bearing (IWB) with non-weight-bearing (NWB) with cast immobilization following ankle fracture fixation (open reduction and internal fixation [ORIF]), with a particular

BACKGROUND Previous studies have not compared airway resistance and morphological parameters before and after the treatment of severe scoliosis. In the present study, 3-dimensional (3D) computed tomographic (CT) reconstruction and impulse oscillometry (IOS) were used to evaluate the changes in airway dilation and airway resistance caused by posterior spinal fusion for the treatment of severe kyphoscoliosis

BACKGROUND The obesity epidemic has given rise to an orthopaedic patient subgroup with a body mass index (BMI) of ≥50 kg/m2. Without sound evidential guidance, arthroplasty surgeons and anesthesiologists do not know whether they can push the limits of the surgical feasibility of total knee arthroplasty (TKA) without risks of harm. METHODS In a retrospective cohort study of patients who had undergone

BACKGROUND Periprosthetic tibial fractures around a total knee replacement (TKR) remain challenging to manage, with little published information for guidance. The purpose of this study was to review the types, management techniques, and outcomes of periprosthetic tibial fractures in the largest series to date. METHODS We identified 300 periprosthetic tibial fractures (285 patients) around a TKR (43%

BACKGROUND Long-bone fractures in children can lead to premature physeal bar formation and growth disturbance. Bar excision has been studied, but data on prophylactic tissue interposition into physeal fractures are limited. This study used an established animal model to evaluate acute placement of fat autograft. The number of animals was selected to give 80% power on the basis of pilot data on induction

➢ Medical ethics education is a required component of orthopaedic surgery resident training per the Accreditation Council for Graduate Medical Education (ACGME) guidelines, although no standardized curriculum currently exists.➢ Beyond the 4 principles of bioethics (autonomy, beneficence, nonmaleficence, justice), additional ethical concepts relevant to orthopaedic care include utilitarianism, deontology

BACKGROUND Acute compartment syndrome (ACS) is a medical emergency and a cause of medical litigation across multiple specialties. We sought to compare the characteristics and outcomes of ACS-related litigation levied against surgeons in orthopaedics compared with other specialties. METHODS The Westlaw database was queried for ACS-related cases filed within the United States between 1980 and 2023 using

BACKGROUND Brachial plexus injury (BPI) leads to a variety of life-altering changes, both physically and mentally. While tremendous effort has been dedicated to improving patients' upper-extremity function through surgical and rehabilitation advances, patients' life experiences after BPI are largely understudied and poorly understood. Our study aims were to qualitatively assess the patient experience

Epigenetic clocks have emerged as powerful tools for quantifying biological aging. Degenerative musculoskeletal disorders (e.g., osteoarthritis [OA], osteoporosis) represent a group of age-related conditions characterized by progressive tissue deterioration. While their epidemiological association with aging is well-established, the precise relationship with epigenetic aging markers remains to be systematically

BACKGROUND Depression and anxiety are recognized as adverse prognostic factors in various orthopaedic surgical interventions. The aim of this study is to report the intermediate-term outcomes of hip arthroscopy for the treatment of femoroacetabular impingement (FAI) and labral tears in patients with depression and/or anxiety. METHODS Data were retrospectively analyzed for patients with a self-reported

To investigate the associations between total and regional fat-to-muscle mass ratio (FMR) and incident osteoarthritis among adults.

BACKGROUND Diagnosing iliopsoas tendinopathy is challenging because of nonspecific pain patterns and clinical signs overlapping with those of other hip conditions. Although peritendinous anesthetic injections provide the best diagnostic accuracy, they are invasive and resource intensive. Conventional clinical tests largely focus on hip flexion, potentially overlooking the diagnostic contribution of

To investigate associations between meniscal tear, bone marrow lesions (BMLs), and post-injury knee loading, with cartilage T2 relaxation times on knee magnetic resonance imaging (MRI) in the subacute phase following acute anterior cruciate ligament (ACL) injury.

Post-traumatic osteoarthritis (PTOA) is known to be influenced by sex. This study aimed to comprehensively characterize PTOA development in male and female mice following anterior cruciate ligament (ACL) injury through longitudinal mobility assessments, radiographic imaging, histologic evaluation, and untargeted proteomics.

BACKGROUND The calcaneonavicular distance has yet to be definitively defined on the basis of morphological studies and thus remains a somewhat elusive value for orthopaedists. The purposes of the present study were to measure the calcaneonavicular distance with use of magnetic resonance imaging (MRI) in a control pediatric population and to assess whether sex and age affected this distance. METHODS

BACKGROUND Although the modified Musculoskeletal Infection Society (MSIS) criteria are commonly used, the accurate and timely diagnosis of periprosthetic joint infection (PJI) remains challenging. Serum amyloid A, like C-reactive protein (CRP), is an acute-phase reactant and widely serves as a diagnostic tool for infectious diseases in adults and children. However, the role of serum amyloid A in diagnosing

Late-life diseases result from the poorly understood process of senescence (aging), which is largely genetically determined. According to a recently proposed evolutionary physiology-based account, the multifactorial model, senescence is largely caused by evolved but non-adaptive programmatic mechanisms specified by the wild-type (i.e. normal) genome. These act together with disruptions to wild-type

BACKGROUND Routine collection of patient-reported outcome measures (PROMs) is increasing within orthopaedic settings. Although PROMs have the potential to aid orthopaedic surgeons in clinical decision-making, surgeon engagement with and use of these data is limited. Identifying and addressing the facilitators and barriers to the use of PROMs data by orthopaedic surgeons may increase their usage in

BACKGROUND Patellar fractures represent approximately 0.5% to 1.5% of all trauma-related fractures, and patella baja, or an abnormally low-lying patella, may be a result of treatment. This complication is underappreciated, and although patella baja may result in patient discomfort, stiffness, and later degenerative changes, the association between fracture type, operative treatment, and this complication

BACKGROUND Osseointegration of a bone-anchored limb (BAL) establishes a direct skeletal interface for prosthesis attachment, simplifying the donning/doffing process. The Timed Up and Go (TUG) test reliably assesses mobility in individuals with lower-extremity amputation who use socket prostheses, but it does not account for the time required to don a prosthetic limb. The aim of this study was to develop

BACKGROUND Conventional sonication is a recommended method in the diagnosis of periprosthetic joint infection (PJI), but the accuracy of diagnosis is still not ideal. We have applied the use of a handheld ultrasonic device and the intraoperative direct sonication of prostheses and soft tissues retrieved during surgery to improve the efficacy of the microbiological diagnosis of PJI and the incubation

BACKGROUND Although TKA is one of the most commonly performed and successful orthopaedic interventions, its efficacy may be reduced in individuals living with dementia. Prior studies have not effectively accounted for confounding by indication or the use of intensive interventions, or considered the fact that cognitive impairment exists on a continuum and that patients with mild dementia may have different

To investigate the association between long-term exposure to ambient air pollution and the risk of developing osteoarthritis (OA) in a large nationwide cohort in Taiwan.

To evaluate the capabilities, opportunities, and motivations of community pharmacists and pharmacy assistants to deliver osteoarthritis (OA) care, aligned with the Australian Osteoarthritis of the Knee Clinical Care Standard.

The temporomandibular joint (TMJ) is essential for maxillofacial mechanics, with the condyle serving as the primary site for mandibular growth and development. Mechanical forces regulate condylar development and homeostasis, while aberrant loading contributes to temporomandibular joint osteoarthritis (TMJOA). Although mechanical stimuli are known to influence TMJ function, the role of mechanosensitive

➢ An at-risk lunate (due to anatomic factors) subjected to a trigger event (axial load, embolism, hypercoagulability) leads to the development of lunate osteonecrosis.➢ Children, adolescents, and elderly patients with Kienböck disease respond well to nonoperative treatments, and this should be considered before any surgical intervention.➢ For disease limited to the lunate, treatment decisions should

BACKGROUND Proximal tibial resection and reconstruction with a hinged knee megaprostheses may result in severe limb length discrepancy (LLD) in very young children because of the removal of the distal femoral and proximal physis. An alternative reconstruction using a proximal tibial hemiarthroplasty reconstruction has been proposed and reduces the degree of LLD because the distal femoral physis is

BACKGROUND Orthopaedic studies frequently include subjects with bilateral conditions. Failure to account for bilateral conditions can lead to spurious associations. The performance of different methods for addressing this issue, especially in populations that include subjects with unilateral and bilateral conditions, has not been rigorously evaluated. The purpose of the present study was to test 3

BACKGROUND The anatomic location of the anterolateral ligament (ALL) of the knee is critical to ALL reconstruction, but there is not a clear consensus about the location of its footprint. Knowledge of the anatomic footprint is necessary to assess intraoperative positioning and postoperative functional outcomes of ALL reconstruction. Furthermore, while racial and sex-related variations in the ACL have