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Clinical investigation on nebulized human umbilical cord MSC-derived extracellular vesicles for pulmonary fibrosis treatment Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-06-04
Meng Li, Huaping Huang, Xiaofei Wei, Huajuan Li, Jun Li, Bingchen Xie, Yuze Yang, Xingyue Fang, Lei Wang, Xiaona Zhang, Heyu Wang, Mengdi Li, Yuting Lin, Dezhi Wang, Yinyin Wang, Tongbiao Zhao, Jianqiu Sheng, Xinbao Hao, Muyang Yan, Lu Xu, Zhijie Chang -
Therapeutic potential of tumor-associated neutrophils: dual role and phenotypic plasticity Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-06-04
Yanting Zhou, Guobo Shen, Xikun Zhou, Jing Li -
Development and validation of dynamic clinical subphenotypes in acute pancreatitis patients using vital sign trajectories in intensive care units: a multinational cohort study Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-06-04
Zichen Wang, Wen Wang, Jiayue Xu, Qiao He, Che Sun, Shuangyi Xie, Kang Zou, Qing Xia, Xin Sun -
Advanced bioartificial organs: genetically modified pig liver as a promising bridge for human liver failure Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-06-02
Taeho Kwon, Sun-Uk Kim, Kyungjun Uh -
Neuro-immune crosstalk in cancer: mechanisms and therapeutic implications Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-06-02
Tianyi Pu, Jiazheng Sun, Guosheng Ren, Hongzhong Li -
Sulfide regulation and catabolism in health and disease Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-30
Yuanyuan Hou, Boyang Lv, Junbao Du, Min Ye, Hongfang Jin, Yang Yi, Yaqian Huang -
Arginase 1 drives mitochondrial cristae remodeling and PANoptosis in ischemia/hypoxia-induced vascular dysfunction Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-28
Han She, Jie Zheng, Guozhi Zhao, Yunxia Du, Lei Tan, Zhe-Sheng Chen, Yinyu Wu, Yong Li, Yiyan Liu, Yue Sun, Yi Hu, Deyu Zuo, Qingxiang Mao, Liangming Liu, Tao Li -
Neuron-targeted caveolin-1 overexpression attenuates cognitive loss and pathological transcriptome changes in symptomatic Alzheimer’s disease models Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-28
Dongsheng Wang, Andrei V. Chernov, Ryan Lam, Hongxia Wang, Wenxi Li, Xiaojing Li, Tiffany Duong, Shanshan Wang, Brian P. Head -
China Protocol for early screening, precise diagnosis, and individualized treatment of lung cancer Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-27
Chengdi Wang, Bojiang Chen, Shufan Liang, Jun Shao, Jingwei Li, Liuqing Yang, Pengwei Ren, Zhoufeng Wang, Wenxin Luo, Li Zhang, Dan Liu, Weimin Li -
De novo induction of tertiary lymphoid structures: an immunotherapeutic strategy in pancreatic cancer Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-26
Azaz Ahmed, Christoph Springfeld, Niels Halama -
Efficacy, safety and exploratory analysis of neoadjuvant tislelizumab (a PD-1 inhibitor) plus nab-paclitaxel followed by epirubicin/cyclophosphamide for triple-negative breast cancer: a phase 2 TREND trial Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-26
Qiang Zhang, Mozhi Wang, Yumeng Li, Hengjun Zhang, Yusong Wang, Xiuyun Chen, Litong Yao, Mingke Cui, Haoran Dong, Xiang Li, Jian Liu, Bo Zhu, Yingying Xu -
The immune system in cardiovascular diseases: from basic mechanisms to therapeutic implications Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-23
Xiaoyan Wang, Liming Chen, Jianming Wei, Hao Zheng, Ning Zhou, Xinjie Xu, Xin Deng, Tao Liu, Yunzeng Zou -
Porphyromonas gingivalis aggravates atherosclerotic plaque instability by promoting lipid-laden macrophage necroptosis Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-23
Xiaofei Huang, Mengru Xie, Yixuan Wang, Xiaofeng Lu, Feng Mei, Kaiwen Zhang, Xinlong Yang, Guangjin Chen, Ying Yin, Guangxia Feng, Wencheng Song, Nianguo Dong, Xuliang Deng, Songling Wang, Lili Chen -
Harnessing local and system immune profiling delineating differential responders to first-line sintilimab (anti-PD-1 antibody) combined with chemotherapy in extensive-stage small cell lung cancer: an exploratory biomarker analysis of a phase II study Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-23
Mengqing Xie, Minwei Bao, Xiaorong Dong, Lin Wu, Li Liu, Jing Zhao, Xiangling Chu, Yan Wu, Xianxiu Ji, Yujia Fang, Xin Yu, Shiji Zhang, Qi Wang, Tao Hu, Jin Wang, Changbin Zhu, Chunxia Su -
Targeting conserved epitopes in structural proteins: a next-generation vaccine strategy against the newly identified HKU5-CoV-2 virus Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-21
Leonardo Pereira de Araújo, Evandro Neves Silva, André Luiz Caliari Costa, Patrícia Paiva Corsetti, Leonardo Augusto de Almeida -
PKMYT1 kinase ameliorates cisplatin sensitivity in osteosarcoma Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-21
Binfeng Liu, Wei Li, Wenchao Zhang, Chengyao Feng, Lu Wan, Shasha He, Ruiling Xu, Zheng Fu, Zhongyue Liu, Haodong Xu, Xin Jin, Chao Tu, Zhihong Li -
Large vesicles from ageing neutrophils: novel safeguards for the resolution of inflammation Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-19
Christopher Dietz-Fricke, Florian R. Greten -
Melatonin synergizes with prostaglandin E2 to enhance YAP-mediated regenerative epithelial cell emergence during intestinal repair Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-19
Yoojin Seo, Ji-Su Ahn, Hansong Lee, Yun Hak Kim, Hyung-Sik Kim -
Vascular endothelial growth factor signaling in health and disease: from molecular mechanisms to therapeutic perspectives Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-19
Chunsik Lee, Myung-Jin Kim, Anil Kumar, Han-Woong Lee, Yunlong Yang, Yonghwan Kim -
Deep mining in the dorsal raphe: cholecystokinin-expressing neurons encode satiation-related cues to regulate meal size Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-16
Niels Röhrdanz, Peer Wulff, Kira Balueva -
Anti-BCL2 therapy eliminates giant congenital melanocytic nevus by senolytic and immune induction Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-16
Boxuan Wei, Qingxiong Yu, Jiamin Jin, Danli Zhu, Bohan Lai, Jieyu Gu, Ran Yang, Huailiang Huang, Hongzhan Lin, Liang Zhang, Tao Zan, Feng Xie, Kang Zhang, Qingfeng Li -
Platelets and diseases: signal transduction and advances in targeted therapy Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-16
Yuchen Tian, Yao Zong, Yidan Pang, Zhikai Zheng, Yiyang Ma, Changqing Zhang, Junjie Gao -
Quantum biological convergence: quantum computing accelerates KRAS inhibitor design Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-14
Taeho Kwon, Hakjin Kim -
Loss of the aryl hydrocarbon receptor promotes cancer cell resistance to BRAFV600E targeted therapies Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-14
Mourad Zerfaoui, Dharmeshkumar Patel, Yueqi Zhang, Raymond F. Schinazi, Youssef Errami -
Exosomal transfer of pro-pyroptotic miR-216a-5p exacerbates anthracycline cardiotoxicity through breast cancer-heart pathological crosstalk Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-14
Yan Ma, Yongjun Wang, Renzheng Chen, Yabin Wang, Yan Fang, Cheng Qin, Tianhu Wang, Xiaoying Shen, Tingwen Zhou, Lei Tian, Ting Sun, Li Fan, Xiaoning Wang, Dong Han, Feng Cao -
Enhancing the anti-aging potential of the nigrostriatal dopamine system to counteract age-related motor decline Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-12
Youngpyo Nam, Sehwan Kim, Jun-Yeong Lee, Jaekwang Kim, Sang Ryong Kim -
Cancer cell cooperation: tumor cells team up to scavenge nutrients to ensure proliferation despite starvation Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-12
Susanne Sebens, Lisa-Marie Philipp, Dieter Adam -
Viral oncogenesis in cancer: from mechanisms to therapeutics Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-12
Qing Xiao, Yi Liu, Tingting Li, Chaoyu Wang, Sanxiu He, Liuyue Zhai, Zailin Yang, Xiaomei Zhang, Yongzhong Wu, Yao Liu -
Viral blips and hidden infections: pitfalls in HIV-1 prophylaxis by broadly neutralizing antibodies Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-09
Fabian Zech, Frank Kirchhoff -
The molecular mechanism and therapeutic landscape of copper and cuproptosis in cancer Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-09
Ziyu Guo, Danyao Chen, Lei Yao, Yuming Sun, Daishi Li, Jiayuan Le, Yating Dian, Furong Zeng, Xiang Chen, Guangtong Deng -
Myeloid but not hepatocytic CD38 is a key driver for hepatic ischemia/reperfusion injury Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-09
Qi-Hang Zhao, Ya-Ting Zhang, Ke Wen, Qi Ding, Zi-Ying Chen, Dilinuer Tula, Jia-Hui Li, Juan Zhou, Yun-Fei Xiao, Xiao-Hui Guan, Ke-Yu Deng, Ling-Fang Wang, Hong-Bo Xin -
Oncogenic proteome of pancreatic cancer extracellular vesicles: sodium/myo-inositol cotransporter as a potential marker Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-07
Arunima Panda, Krish Ragunath, Marina Pajic, David W. Greening, Marco Falasca -
Protein kinases in neurodegenerative diseases: current understandings and implications for drug discovery Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-07
Xiaolei Wu, Zhangzhong Yang, Jinjun Zou, Huile Gao, Zhenhua Shao, Chuanzhou Li, Peng Lei -
First-line treatment of anti-EGFR monoclonal antibody cetuximab β plus FOLFIRI versus FOLFIRI alone in Chinese patients with RAS/BRAF wild-type metastatic colorectal cancer: a randomized, phase 3 trial Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-07
Yuankai Shi, Yi Ba, Junye Wang, Jianping Xiong, Kangsheng Gu, Yigui Chen, Zhendong Zheng, Zishu Wang, Weijian Guo, Ying Cheng, Xianli Yin, Yunpeng Liu, Yuxian Bai, Enxiao Li, Qi Li, Liangjun Zhu, Wei Li, Da Jiang, Jingdong He, Jiansi Chen, Jianguo Sun, Sheng Hou -
Targeting cancer: tumor-specific splicing events give rise to immunogenic, tumor-wide neoantigens Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-05
Nils Kosiol, Annkristin Heine, Peter Brossart -
Overexpressing natural killer group 2 member A drives natural killer cell exhaustion in relapsed acute myeloid leukemia Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-05
Juan Xie, Xue-Fei Liu, Tong Zhou, Long Liu, Rui-Qin Hou, Xing-Xing Yu, Ze-Ying Fan, Qian-Nan Shang, Ying-Jun Chang, Xiao-Su Zhao, Yu Wang, Lan-Ping Xu, Xiao-Hui Zhang, Xiao-Jun Huang, Xiang-Yu Zhao -
Meningeal lymphatic drainage: novel insights into central nervous system disease Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-05
Qiang Zhang, Yin Niu, Yingpei Li, Chenyang Xia, Zhi Chen, Yujie Chen, Hua Feng -
RNA-binding proteins: a novel target for modulating glucose and lipid metabolism Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-02
Yongjian Hu, Qian Sun -
Single-cell transcriptomic analysis reveals gut microbiota-immunotherapy synergy through modulating tumor microenvironment Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-05-02
Minyuan Cao, Yun Deng, Qing Hao, Huayun Yan, Quan-Lin Wang, Chunyan Dong, Jing Wu, Yajiao He, Li-Bin Huang, Xuyang Xia, Yongchao Gao, Hai-Ning Chen, Wei-Han Zhang, Yan-Jing Zhang, Xiaozhen Zhuo, Lunzhi Dai, Hongbo Hu, Yong Peng, Feng Zhang, Zhaoqian Liu, Weihua Huang, Huiyuan Zhang, Li Yang, Yang Shu, Wei Zhang, Yan Zhang, Heng Xu -
Branched-chain amino acids alleviate sepsis-induced myocardial dysfunction via inhibition of protein tyrosine phosphatase-6 Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-30
Shu-Rui Pang, Yu-Tong Zhu, Hou-Zao Chen, Jian-Fei Pei, De-Pei Liu -
New perspectives: the impact of ketogenic diet on the immune system Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-30
Huanzhao Peng, Minyang Fu, Jiong Li -
Multipronged SMAD pathway targeting by lipophilic poly(β-amino ester) miR-590-3p nanomiRs inhibits mesenchymal glioblastoma growth and prolongs survival Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-30
Jack Korleski, Sophie Sall, Kathryn M. Luly, Maya K. Johnson, Amanda L. Johnson, Harmon Khela, Bachchu Lal, TC Taylor, Jean Micheal Ashby, Hector Alonso, Alice Li, Weiqiang Zhou, Karen Smith-Connor, Russell Hughes, Stephany Y. Tzeng, John Laterra, Jordan J. Green, Hernando Lopez-Bertoni -
You are what you eat: metabolic recycling of phagocytosed bacteria modulates macrophage immunity Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-28
Syamantak Basu, Manuela Rossol -
N-deglycosylation targeting chimera (DGlyTAC): a strategy for immune checkpoint proteins inactivation by specifically removing N-glycan Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-28
Li Li, Jiajia Wu, Weiqian Cao, Wei Zhang, Qi Wu, Yaxu Li, Yanrong Yang, Zezhi Shan, Zening Zheng, Xin Ge, Liang Lin, Ping Wang -
Nuclear mitochondrial acetyl-CoA acetyltransferase 1 orchestrates natural killer cell-dependent antitumor immunity in colorectal cancer Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-28
Chen Wei, Kun Liao, Hao-Jie Chen, Zi-Xuan Xiao, Qi Meng, Ze-Kun Liu, Yun-Xin Lu, Hui Sheng, Hai-Yu Mo, Qi-Nian Wu, Yi Han, Zhao-Lei Zeng, Xin-Yuan Guan, Hui-Yan Luo, Huai-Qiang Ju, Rui-Hua Xu -
Bio-barrier-adaptable biomimetic nanomedicines combined with ultrasound for enhanced cancer therapy Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-25
Juan Guo, Xueting Pan, Qingyuan Wu, Ping Li, Chaohui Wang, Shuang Liu, Haoyuan Zhang, Zezhong Huang, Xiaozhou Mou, Huiyu Liu, Jiajia Xue -
Diabetic neuropathy: cutting-edge research and future directions Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-25
Yang Yang, Bing Zhao, Yuanzhe Wang, Hongli Lan, Xinyu Liu, Yue Hu, Peng Cao -
A20 attenuates oxidized self-DNA-mediated inflammation in acute kidney injury Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-25
Hanwen Li, Yongyao Wu, Lisha Xiang, Qing Zhao, Lu Liu, Zhixiong Zhu, Weimin Lin, Zhan Li, Yang Yang, Yiting Ze, Lulu Zhang, Ping Fu, Yingqiang Guo, Ping Zhang, Bin Shao -
STING aggravates ferroptosis-dependent myocardial ischemia-reperfusion injury by targeting GPX4 for autophagic degradation Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-25
Xiaohong Wang, Tao Chen, Sizhe Chen, Jie Zhang, Liangyu Cai, Changhao Liu, Yujie Zhang, Xiao Wu, Na Li, Zhiyong Ma, Lei Cao, Qian Li, Chenghu Guo, Qiming Deng, Wenqian Qi, Yonghao Hou, Ruiqing Ren, Wenhai Sui, Haonan Zheng, Yun Zhang, Meng Zhang, Cheng Zhang -
Tumor immunology: a short IL18 cleavage product promotes cancer immunosurveillance Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-23
Emma Guilbaud, Lorenzo Galluzzi -
Rapavir, a novel inhibitor of sodium taurocholate cotransporting polypeptide, potently blocks hepatitis B virus entry Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-23
Jia He, Haibo Yu, Kunling Song, Ailong Huang, Yongjun Dang, Juan Chen, Zufeng Guo -
Glucosidase alpha neutral C promotes influenza virus replication by inhibiting proteosome-dependent degradation of hemagglutinin Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-23
Xinzhong Liao, Qian Xie, Minqi Liang, Qijun Liao, Bi Huang, Shengze Zhang, Feng Zhang, Liangliang Wang, Lifang Yuan, Xuejie Liu, Simin Wen, Chuming Luo, Dayan Wang, Yongkun Chen, Huanle Luo, Yuelong Shu -
IL-27: overclocking cytotoxic T lymphocytes to boost cancer immunotherapy Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-21
Silvia Dusi, Vincenzo Bronte, Francesco De Sanctis -
Conversion of Ku80 K568 crotonylation to SUMOylation facilitates DNA non-homologous end joining and cancer radioresistance Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-21
Hongling Zhao, Shanshan Gao, Yang Han, Dafei Xie, Lihui Xuan, Xin Huang, Jinhua Luo, Qian Ran, Gang Li, Hejiang Guo, Weixiang Hu, Jin Jia, Xiaochang Liu, Yuhao Liu, Jinpeng Tan, Chenjun Bai, Yongqing Gu, Teng Ma, Zhongjun Li, Hua Guan, Ruixue Huang, Ping-Kun Zhou -
Subnanomolar MAS-related G protein-coupled receptor-X2/B2 antagonists with efficacy in human mast cells and disease models Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-21
Ghazl Al Hamwi, Mohamad Wessam Alnouri, Sven Verdonck, Piotr Leonczak, Shaswati Chaki, Stefan Frischbutter, Pavel Kolkhir, Michaela Matthey, Constantin Kopp, Marek Bednarski, Yvonne K. Riedel, Daniel Marx, Sophie Clemens, Vigneshwaran Namasivayam, Susanne Gattner, Dominik Thimm, Katharina Sylvester, Katharina Wolf, Andreas E. Kremer, Steven De Jonghe, Daniela Wenzel, Magdalena Kotańska, Hydar Ali, -
Environment impacts sexual preference: dopamine sends signals under pressure to decide which sex you like Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-18
Rou Li, Lin Liu, Min Wu -
RNase1-driven ALK-activation is an oncogenic driver and therapeutic target in non-small cell lung cancer Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-18
Zhengyu Zha, Chunxiao Liu, Meisi Yan, Cong Chen, Cheng Yu, Yaohui Chen, Chenhao Zhou, Lu Li, Yi-Chuan Li, Hiro Yamaguchi, Leiguang Ye, Tong Liu, Ying-Nai Wang, Heng-Huan Lee, Wen-Hao Yang, Li-Chuan Chan, Baozhen Ke, Jennifer L. Hsu, Lieming Ding, Dong Ji, Peng Pan, Yiran Meng, Yue Pu, Lunxu Liu, Mien-Chie Hung -
Cancer chemoprevention: signaling pathways and strategic approaches Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-18
Junling Ren, Guangli Yan, Le Yang, Ling Kong, Yu Guan, Hui Sun, Chang Liu, Lei Liu, Ying Han, Xijun Wang -
Deep insight into cytokine storm: from pathogenesis to treatment Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-16
Jiali Nie, Ling Zhou, Weiwei Tian, Xiansheng Liu, Liping Yang, Xingcheng Yang, Yicheng Zhang, Shuang Wei, Dao Wen Wang, Jia Wei -
Meplazumab, a CD147 antibody, for severe COVID-19: a double-blind, randomized, placebo-controlled, phase 3 clinical trial Signal Transduct. Target Ther. (IF 40.8) Pub Date : 2025-04-14
Huijie Bian, Liang Chen, Zheng Zhang, Ai-Dong Wen, Zhao-Hui Zheng, Li-Qiang Song, Meng-Ying Yao, Ying-Xia Liu, Xi-Jing Zhang, Hong-Lin Dong, Jian-Qi Lian, Lei Pan, Yu Liu, Xing Gu, Hui Zhao, Jing-Wen Wang, Qing-Yi Wang, Kui Zhang, Jun-Feng Jia, Rong-Hua Xie, Xing Luo, Xiang-Hui Fu, Yan-Yan Jia, Jun-Na Hou, Qiu-Yue Tan, Xiao-Xia Chen, Liu-Qing Yang, Yuan-Long Lin, Xiao-Xia Wang, Lei Zhang, Qin-Jing