BACKGROUND Transcatheter closure of patent foramen ovale (PFO) is a recommended stroke reduction option in patients ≤60 years of age with cryptogenic ischemic stroke, but data on clinical outcomes following PFO closure in patients >60 years of age are scarce. OBJECTIVES The aim of this real-world evidence study was to evaluate the clinical outcomes of PFO closure in patients >60 years of age in the

BACKGROUND Procedural complications, device-related thrombus, and peridevice leak may limit the benefit of transcatheter left atrial appendage occlusion (LAAO). Although next-generation devices incorporate design modifications meant to address these phenomena, the longer term impact of these modifications on outcomes has not been described. OBJECTIVES The aim of this study was to compare 1-year safety

BACKGROUND Tricuspid regurgitation (TR) leads to right heart congestion and increased mortality risk. Unlike secondary TR, primary TR results from leaflet degeneration. Transcatheter edge-to-edge repair (TEER) is widely used for TR. However, its feasibility primary TR remains uncertain. OBJECTIVES The aim of this study was to assess the safety and feasibility of TEER in patients with primary TR. METHODS

BACKGROUND Randomized trials support angiographic and physiology-guided complete revascularization (CR) vs incomplete revascularization (IR) in ST-segment elevation myocardial infarction (STEMI) with multivessel disease (MVD). The implementation of these strategies in clinical practice is uncertain. OBJECTIVES In patients undergoing percutaneous coronary intervention for STEMI with MVD, we assessed

BACKGROUND Coronary microvascular dysfunction appears to play a major role in the pathogenesis of Takotsubo Syndrome (TTS). However, the prognostic value of microvascular function measured in the acute phase of TTS is unclear. METHODS In a collaborative, pooled analysis of individual patient data from nine prospective TTS cohorts, invasive assessment of coronary microvascular function was performed

Transcatheter aortic valve replacement (TAVR) is approved across all risk profiles, including patients with bicuspid aortic valves. These patients are generally younger, with a higher chance of reintervention.

Bifurcation at the chronic total occlusion (CTO) distal cap is a key factor in the global CTO crossing algorithm.

In patients at high risk for coronary artery obstruction (CAO), intravascular ultrasound (IVUS) assessment of coronary ostia after transcatheter aortic valve replacement (TAVR) may detect signs of impending CAO.

Coronary radial wall strain (RWS) represents a novel approach enabling discrimination of vulnerable plaques with prognostic significance.

BACKGROUND No comparative data exist with the self-expanding Navitor (NAV) and the balloon-expandable SAPIEN 3 Ultra (ULTRA) transcatheter heart valves (THVs). OBJECTIVES This study sought to investigate the 1-year outcomes of transcatheter aortic valve replacement using the intra-annular NAV and the ULTRA THVs. METHODS The NAVULTRA (Navitor and SAPIEN 3 Ultra) registry included consecutive patients

The occurrence and clinical impact of transcatheter heart valve midframe underexpansion following transcatheter aortic valve replacement are not well understood.

Data regarding the proportion and clinical impact of achieving stent optimization by intravascular ultrasound (IVUS)– or optical coherence tomography (OCT)–guided percutaneous coronary intervention (PCI) remain limited.

Inflammation is a driver of atherosclerosis and susceptibility to cardiovascular events.

The association between myocardial infarction (MI) subtypes (procedural MI [PMI] and spontaneous MI [SMI]) and subsequent quality of life (QoL) is incompletely understood.

Chronic stent recoil can vary according to both stent materials and designs.