We report a non-biomimetic total synthesis of (+)-daphnepapytone A, an unprecedented member of the guaiane-derived sesquiterpenoids that displays moderate inhibitory activity against -glycosidase (IC50 = 159 ± 2.1 M) and possesses a highly strained bridging cyclobutane motif. Our de novo approach provided expedient access to the tetracyclic core of (+)-daphnepapytone A through an intramolecular allenyl

Perovskite solar cells (PSCs) have attracted significant attention owing to their prominent photovoltaic (PV) performance. Their multi-layered structure facilitates efficient charge separation in i-type-like perovskite photoabsorbers when sandwiched with a p-type hole transport material (HTM) and n-type electron transport material (i.e., n-i-p or p-i-n structures), enabling high PV performance. Since

TpBd-COFs with the different morphologies were synthesized by regulating the dynamic equilibrium of imine bond using acetic acid as a modulator. TpBd-COF nanosheet exhibits the higher photocatalytic H2 evolution activity than the TpBd-COF nanowires due to the enhanced light-harvesting ability, optimized energy levels and facilitated electron transfer.TpBd-COFs with the different morphologies were synthesized

Peptide and protein modifications, especially late-stage derivatization, are invaluable for the synthesis of new pharmaceuticals. Currently, cysteine-mediated peptide modification is mainly limited to bioconjugation and disulfide formation. Therefore, exploration of new cysteine mediated peptide modifications is of great interest. Herein, we present a practical strategy for the three-step, one-pot

We present a regioselective C(sp²)-carboboration of 1,3-diynes using CuI/Pd0 cooperative catalysis, enabling access to a diverse range of conjugated aryl-substituted boryl enynes. Furthermore, sequential proto-/ carbo-/di-boration strategies afforded highly conjugated multi-boron-substituted dienes. Cross-coupling of the boron end groups facilitated the modular synthesis of highly conjugated enynes

There were two mistakes in the chemical drawings in Table 2 in the published article. Compound 12o was mistakenly depicted as the 2-substituted pyridine derivative; however, the compound prepared was the 3-pyridine derivative. Furthermore, in compound 12z the methyl ester was mistakenly shown in the 6-position of the lactam, whereas it must be correctly depicted as the regioisomeric compound with the

In conventional studies, radicals and nonradicals were often considered independent mechanisms for organic pollutant oxidation, with their potential interaction between radicals and nonradicals largely overlooked in Fenton-like reactions. Herein, Cu-Co3O4 catalysts (x wt% Cu-Co3O4/OVs) featuring bifunctional bonding centers were fabricated, which enabled simultaneous co-capture of electron-rich contaminants

Intrinsically stretchable organic solar cells (IS-OSCs) are among the most promising technologies for wearable power applications. However, the development of electron acceptors that simultaneously meet the demands for high performance and mechanical stretchability remains a significant challenge. In this study, we creatively synthesized three oligomeric acceptors with flexible linkers (2YF-Br, 4YF-T

Ammonia (NH3) is an important feedstock for industry, an ideal energy carrier, and a perspective storage media for hydrogen. Recently, electrochemical NO3− reduction under acidic conditions has received considerable attention but it suffers from limited efficiency especially under low NO3− concentration. Here, we report an in-situ formed positively charged polyethyleneimine-modified Cu under acidic

Azobenzenes are versatile photoswitches that can be used to generate elaborate optical tools including photopharmaceuticals. However, the targeted application-guided design of new photoswitches with specific properties remains challenging. We have developed synthetic protocols for derivatives of the dfdc (di-ortho-fluoro-di-ortho-chloro) azobenzene scaffold with chemical alterations in the para-/ortho-positions

Accurately predicting the spin crossover (SCO) temperature (T1/2) in spin crossover compounds remains a significant challenge, due to their extreme sensitivity to minor variations in ligand and crystal structure. In this study, we uncover a critical link between the redox potential of ligands and SCO behavior within Hofmann-type clathrates {Fe(R-pbpy+)2[µ2-M(CN)4]2} (R = electron-donating or electron-withdrawing

Crosslinking strategies have emerged as an attractive technology for deciphering protein complexes and protein–protein interactions (PPIs). However, commonly used crosslinking strategies present significant challenges for the precise analysis of protein complexes and dynamic PPIs in native biological environments. Here, we report the development of the first visible-light-inducible lysine-specific

The inherent O2 sensitivity of Ni–Fe carbon monoxide dehydrogenases (CODHs), crucial for rapid CO to CO2 interconversion, presents substantial challenges for industrial application. Transforming CO/CO2, a prevalent anthropogenic air pollutant, into valuable carbon chemicals either directly or through intermediate steps via biocatalytic methods offers a promising pathway to achieve net-zero emissions

Understanding the hydrogenation behavior of *NO during electrochemical nitrate reduction reaction (NO3RR) is essential for designing catalysts with high selectivity toward ammonia (NH3) and valuable intermediates like hydroxylamine. Spinel cobalt oxides (Co3O4) are promising NO3RR electrocatalysts, yet the exact *NO hydrogenation mechanism remains unclear. Here, we integrate theoretical calculations

Antimicrobial resistance (AMR) is a severe threat to modern health care and must be addressed to prevent millions of deaths in the coming decades. Antimicrobial polymers (APs) do not provoke resistances and are promising alternatives to conventional antibiotics. Classic APs possess an amphiphilic structure (cationic and hydrophobic). Herein we question the necessity of amphiphilicity in APs and find

Luminescent emitters based on lanthanide ions are of ubiquitous importance in the biological sciences, but typically need sensitisation from a covalently attached adjacent chromophore – an “antenna” – to have suitable emission intensities. Here we show that the mechanical bond can be used to connect the antenna to the emitter, providing unique dynamic features and stimuli-responsiveness to the resulting

Recent advances in materials development for organic light-emitting diodes (OLEDs) have been driven by an emerging design concept known as multiple-resonance (MR), which provides the benefits of high efficiency and color purity required for commercial OLED displays. Borylation reaction constructing MR frameworks is a key step for developing new π-conjugated systems, while this reaction includes the

Chiral covalent organic frameworks (CCOFs) are promising candidates for chiral optoelectronics and sensing, but their weak solid-state fluorescence and chiroptical responses often limit practical utility. Here, we introduce a novel CCOF synthesized from achiral monomers, 2-hydroxy-1,3,5-benzenetricarbaldehyde and hydrazine, via imine condensation with chiral induction strategy, yielding salicylaldehyde

Achieving effective exciton dissociation and charge transport in linear polymer photocatalysts for H2O2 photosynthesis remains a formidable challenge. Herein, we fabricated three-motif cross-linked polymers by rationally introducing a third functional component into a two-motif linear polymer, which were employed for circulation-flow photocatalytic H2O2 production. By strategically modulating the third