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Landmark trials using stem cells to treat Parkinson’s disease in the USA and Japan mark a turning point for cell therapy in neurodegeneration. Similar approaches to Alzheimer’s disease and amyotrophic lateral sclerosis are also showing early signs of promise.

I can’t stop thinking about the BMA’s recent warning that as many as 1000 newly qualified GPs may struggle to find jobs this year.1 It’s not just a number: it’s a stark symbol of a system that has lost its way. We’re training highly skilled generalists, encouraging them into a specialty we claim to value, only to tell them that there’s no work for them once they arrive. But this hasn’t come out of

Growing numbers of US physicians are joining unions, seeing them as a way to regain autonomy in the face of the corporatisation of healthcare. Ella Hubbard reports “They somehow found a way to upset every single physician in the hospital,” says Bryan Haimes, explaining why he and several hundred of his colleagues at the Christiana Care hospital network voted to unionise last year. The decision was

BackgroundRelacorilant, a first-in-class selective glucocorticoid receptor antagonist, increases a tumour's sensitivity to chemotherapy by reducing cortisol signalling. This study aimed to show whether the addition of relacorilant to nab-paclitaxel improves progression-free and overall survival in females with platinum-resistant ovarian cancer. MethodsThis randomised, controlled, open-label phase 3

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BackgroundDespite improved efficacy with first-line immune checkpoint inhibitors plus platinum-based chemotherapy for extensive-stage small-cell lung cancer (ES-SCLC), survival remains poor. In this study, we aimed to compare lurbinectedin plus atezolizumab and atezolizumab alone as maintenance therapies in patients with ES-SCLC without progression after induction therapy with atezolizumab, carboplatin

This seventh article in a seven part series presents the Core GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach for moving from evidence to recommendations or policy decisions. Core GRADE users make strong recommendations for an intervention versus a comparator when the desirable consequences clearly outweigh the undesirable consequences, and a conditional (weak) recommendation

The principles of Core GRADE provide an important basis for achieving successful AI assisted evidence certainty rating and recommendation formulation, write Jing Wu , Gordon Guyatt , and Liang Yao Artificial intelligence (AI) is rapidly reshaping how we conduct medical research, from synthesising evidence to developing clinical guidelines.1234 Tasks that once took months—or even years—can now be accelerated

A reset of the global aid system must be guided by key principles to respond to current challenges and rebuild global solidarity, argue Martin McKee and Kent Buse Donald Trump’s rejection of long established assumptions about development assistance have forced a global reassessment.1 In autumn 2025, David Lammy, the British foreign secretary, will convene a major conference that will contribute to

Tackling the trolling received by women doctors will help to promote more constructive online spaces and discourse, write Jane Dacre and Latifa Patel At a recent meeting between the British Medical Association and the Medical Women’s Federation, we celebrated the milestone of women on the General Medical Council register with a licence to practise outnumbering men.1 The discussion soon turned to social

McCartney expresses concern that “prescribing” parkrun implies a top-down approach,1 but in practice it legitimises group physical activity. Like all good medical management, prescribing anything should never be instructional, but a collaborative exploration driven by the patient’s wishes. Robust data confirm that community physical activity improves outcomes,2 yet many remain unaware of its effectiveness

For a moment, McCartney’s article had me questioning the role of a consultant in exercise medicine.1 Exercise isn’t a medication; we do not need to prescribe parkrun. These points are valid for people already enabled to be active. Parkrun as a community driven initiative has lowered the bar for access brilliantly. But what about those who can’t get to the start …

Hepatitis B virus infection remains a pervasive global health challenge, affecting an estimated 254 million people worldwide. This review summarizes the current landscape of hepatitis B, including its epidemiology and the clinical spectrum of acute and chronic infection. It discusses the interplay between host and virus that underlies the progression from acute hepatitis to chronic liver disease, cirrhosis

Lorna Benton and colleagues argue that including planetary health in guidance for researchers would help to prioritise effective responses to current environmental and human crises Human activity has pushed Earth’s natural systems beyond safe and just planetary boundaries, creating threats to human health and survival (box 1).1 Evidence shows that six out of nine identified planetary boundaries have

BackgroundCurrently, no worldwide approved therapies exist for adults with neurofibromatosis type 1 (NF1) and symptomatic, inoperable plexiform neurofibromas. The KOMET study aimed to evaluate selumetinib (ARRY-142886, AZD6244) efficacy and safety in this population. MethodsThis ongoing multicentre, international, randomised, placebo-controlled, phase 3, parallel, double-blind trial randomly assigned

The African Union (AU) has prioritized local production of health countermeasures since its inception, with heightened focus following the COVID-19 pandemic and challenges such as cholera, Ebola, malaria, mpox, Marburg and other emerging diseases. One of its efforts was the development of the Pharmaceutical Manufacturing Plan for Africa in 20071. The plan aims to strengthen the continental capacity

Richard Clarke, a good natured, mild mannered, and distinguished looking man, with a full mane of white hair, had a highly distinguished career in anaesthetics in Belfast. He played a key role in developing the regional intensive care and cardiac intensive care units after postgraduate training at St Bartholomew’s Hospital, London, involving early work in cardiopulmonary bypass. He was also Ireland’s

Consultant pathologist Debra Milne tells Helen Jones about her love of jazz—from performing in a band to helping to run a local music venue “I’ve always loved music but particularly jazz and the great singers,” says Debra Milne, a consultant pathologist at Gateshead Health NHS Foundation Trust. “One of my earliest memories of somebody singing what I recognised to be jazz is as a teenager listening

This study assesses colorectal neoplasia yields at screening colonoscopy in adults aged 45 to 49 years vs 50 to 54 years in a large US health system after the US Preventive Services Task Force (USPSTF) began recommending that average-risk adults begin colorectal cancer screening at age 45 years.

This JAMA Insights explores the spread of harmful algal blooms due to climate change and how exposure to toxic algae can negatively affect human health.

This study analyzes current US-marketed disposable e-cigarettes, US Food and Drug Administration (FDA)–approved products, and nicotine-free products for presence of the high-intensity artificial sweetener neotame.

This Viewpoint explores how a publicly searchable US Food and Drug Administration database of medical device labels could improve decision-making, transparency, and public health.

BackgroundClaudin-18 isoform 2 (CLDN18.2) has emerged as a promising therapeutic target in gastric or gastro-oesophageal junction cancer. Satricabtagene autoleucel (satri-cel; also known as CT041), an autologous CLDN18.2-specific chimeric antigen receptor (CAR) T-cell therapy, showed encouraging activity in previously treated patients with advanced gastric or gastro-oesophageal junction cancer in phase

A medicine stock-out is defined by the World Health Organization (WHO) as “any time when, at a defined moment in a given inventory, a needed medicine item is not in stock and orders or prescriptions cannot be filled.” The WHO has published a set of indicators for use in optimising the management of pharmaceutical stocks, in order to avoid stock-outs and the related but separate problem of overstocking

The number of people living with a history of cancer in the United States continues to rise because of the growth and aging of the population as well as improved survival through advances in early detection and treatment. To assist the public health community serve the needs of these survivors, the American Cancer Society and the National Cancer Institute collaborate triennially to estimate cancer

The publication of the American Cancer Society’s “Cancer Treatment and Survivorship Statistics, 2025” report affirms that the number of people living in the United States with a history of cancer is rising because of advances in detection and treatment that have improved survival.1, 2 In our opinion, it also presents a new opportunity to engage all stakeholders in the discourse on cancer survivorship

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Testicular cancer is the most common solid malignancy in people with testicles aged 15–44 years, accounting for 1–2% of all tumours in males of all ages. Approximately 95% of testicular cancers are testicular germ cell tumours. This Seminar focuses on testicular cancer, with an emphasis on testicular germ cell tumours. We delve into the epidemiology, clinical presentation, disease management, controversies

Paris L, Al-Jadba G, Zeidan W, et al. Deterioration of health outcomes in Gaza: 19 months of protracted conflict. Lancet 2025; published online May 22. https://doi.org/10.1016/S0140-6736(25)00812-8—In this Correspondence, the European Centre for Disease Prevention and Control affiliation should have read “ECDC Fellowship Programme, Field Epidemiology path (EPIET), European Centre for Disease Prevention

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Teenage pregnancies in Brazil have been stubbornly high for decades, but a range of efforts to tackle this inequality are finally bearing results. Luke Taylor reports For decades Brazil has struggled to bring down its stubbornly high rate of teenage pregnancy. The country has nearly twice as many adolescent births as the average upper middle income nation, and its absolute numbers are enormous owing

Urgent legislative action is needed to protect minors Areca nut, also known as betel nut, is the fibrous seed of the Areca catechu palm and has been consumed throughout the Asia-Pacific for thousands of years.1 The nut is chewed and placed in the buccal cavity, where psychoactive agents are absorbed trans-mucosally. Users experience a mild psychostimulant effect from arecoline, a muscarinic receptor

Some of the data in this paper by Wu and colleagues ( BMJ 2025;388:e082583, doi:10.1136/bmj-2024-082583, published 15 January 2025) have been updated. Disruptions to clinical service during the covid-19 pandemic affected the data verification process at some of the trial centres leading to inaccurate data being entered …

This Medical News article discusses the recent Exposome Moonshot Forum, a global meeting to accelerate research in exposomics—the study of the full range of environmental exposures that shape health and disease.